Mechanistic knowledge surrounding three biological phenomena: tau modification/aggregation, nicotinic receptor signalling, and proteostasis in the context of neurodegenerative disease
Each node in a BEL graph is assigned a type. Most nodes are then identified with a namespace:identifier pair, or a definition based on other nodes as in the case of complexes, composites, and chemical reactions.
| Reference | BEL |
|---|---|
| pmid:30046111 | tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | sec(a(CHEBI:"amyloid-beta")) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease") |
| pmid:14556719 | a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease") |
| pmid:29980653 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") association a(MESH:Macrophages) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") decreases bp(GO:"calcium ion homeostasis") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") association bp(MESH:"Oxidative Stress") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases bp(MESH:"Oxidative Stress") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases bp(GO:"apoptotic process") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases bp(GO:"JNK cascade") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases bp(GO:"Fas signaling pathway") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918)) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases p(HGNC:TNF) |
| pmid:29179999 | a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases p(HGNC:APP) |
| pmid:18930136 | a(CHEBI:"amyloid-beta") association deg(p(HGNC:APP)) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") regulates act(p(FPLX:PKC)) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") regulates bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) |
| pmid:24590577 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:21882945 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases a(CHEBI:"calcium(2+)") |
| pmid:28745240 | a(CHEBI:"amyloid-beta") increases act(a(MESH:Microglia)) |
| pmid:29179999 | a(CHEBI:"amyloid-beta") increases bp(GO:"glial cell activation") |
| pmid:29179999 | a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") |
| pmid:16566606 | a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") |
| pmid:29179999 | a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL1B)) |
| pmid:29179999 | a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL6)) |
| pmid:29179999 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:NFKB1)) |
| pmid:27288790 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:RELA)) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:APOE)) |
| pmid:26195256 | tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX)) |
| pmid:25652642 | a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins") |
| pmid:30232325 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases bp(GO:"positive regulation of neuron apoptotic process") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases complex(GO:"neurofibrillary tangle") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases path(MESH:Gliosis) |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies") |
| pmid:18650430 | a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association bp(GO:"MAPK cascade") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association bp(GO:"ERK1 and ERK2 cascade") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:memory) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases bp(GO:memory) |
| pmid:29758300 | sec(a(CHEBI:"amyloid-beta")) increases bp(GO:memory) |
| pmid:22908190 | a(CHEBI:"amyloid-beta") decreases bp(GO:memory) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:"long-term synaptic potentiation") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(GO:"cell death") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association a(CHEBI:"phorbol ester") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") decreases bp(GO:"learning or memory") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038) |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018) |
| pmid:30061532 | a(CHEBI:"amyloid-beta") association path(MESH:"Lewy Body Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA7) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA4) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases bp(GO:"intracellular receptor signaling pathway") |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) association p(HGNC:FYN) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:FYN)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:PI3K)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK8)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK14)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange path(HBP:Neurodegeneration) |
| pmid:29758300 | sec(a(CHEBI:"amyloid-beta")) decreases path(HBP:Neurodegeneration) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases bp(MESH:"Neuronal Outgrowth") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPK1, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:BCL2)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26813123 | a(CHEBI:"amyloid-beta") regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:JNK)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:ERK)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAD)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association bp(GO:"choline transport") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7, var("p.L250T"))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7, var("?"))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA3) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna4) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases r(RGD:Chrna7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(MGI:Chat) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases r(MGI:Chrna3) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") decreases a(CHEBI:acetylcholine) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") decreases sec(a(CHEBI:acetylcholine)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases act(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(CHEBI:"amyloid-beta") increases a(HBP:"amyloid-beta fibrils") |
| pmid:26813123 | act(a(CHEBI:"amyloid-beta")) association act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(CHEBI:"amyloid-beta") decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases act(a(HBP:"beta-2-containing nAChR")) |
| pmid:25514383 | act(a(CHEBI:"amyloid-beta")) negativeCorrelation a(HBP:"alpha-7 beta-2 nAChR") |
| pmid:25514383 | a(CHEBI:"amyloid-beta") regulates act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases bp(GO:"neuron cellular homeostasis") |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases a(GO:synapse) |
| pmid:22908190 | a(CHEBI:"amyloid-beta") decreases act(a(GO:synapse)) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") increases bp(GO:locomotion) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") decreases path(MESH:Anxiety) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") decreases path(MESH:"Interpersonal Relations") |
| pmid:26010758 | a(CHEBI:"amyloid-beta") increases p(HGNC:AIF1) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") increases p(HGNC:PTPRC) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:26010758 | a(CHEBI:"amyloid-beta") increases r(HGNC:BACE1) |
| pmid:12428809 | a(CHEBI:"amyloid-beta") association bp(GO:"axonal transport") |
| pmid:29758300 | a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"TOR complex")) |
| pmid:29758300 | a(CHEBI:"amyloid-beta") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP, pmod(Ph)) |
| pmid:29758300 | a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP) |
| pmid:29758300 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:PICALM) |
| pmid:29758300 | a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:SORL1) |
| pmid:14556719 | a(CHEBI:"amyloid-beta") decreases act(complex(GO:"proteasome complex")) |
| pmid:22908190 | a(CHEBI:"amyloid-beta") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:14556719 | a(CHEBI:"amyloid-beta") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:22908190 | a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | a(CHEBI:"amyloid-beta") positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25784053 | a(CHEBI:"amyloid-beta") decreases act(p(FPLX:Proteasome)) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "35kD")) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "24kD")) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HBP:"Tau C3") |
| pmid:30126037 | a(CHEBI:"amyloid-beta") causesNoChange p(MGI:Cdkn2a) |
| pmid:30985105 | a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(CHEBI:"amyloid-beta") association bp(GO:cognition) |
| pmid:26195256 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HBP:"APOE e4") |
| pmid:26631930 | a(CHEBI:"amyloid-beta") increases path(HBP:Excitotoxicity) |
| pmid:26631930 | a(CHEBI:"amyloid-beta") increases path(HBP:Excitotoxicity) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases bp(GO:"response to oxidative stress") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases bp(HBP:"mitochondrial dysfunction") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:aging) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Diabetes Mellitus") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP2)) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP3)) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP9)) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") decreases a(MESH:"Cerebrospinal Fluid") |
| pmid:29626319 | deg(a(CHEBI:"amyloid-beta")) association p(HGNC:AQP4) |
| pmid:19251756 | a(CHEBI:"amyloid-beta") positiveCorrelation complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| pmid:29221819 | a(CHEBI:"amyloid-beta") negativeCorrelation p(MGI:Dyrk1a) |
| pmid:25331948 | a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Syk) |
| pmid:26118667 | a(CHEBI:"amyloid-beta") negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | a(CHEBI:"amyloid-beta") increases p(INTERPRO:"Peptidase C2, calpain, catalytic domain") |
| pmid:22156579 | a(CHEBI:"amyloid-beta") increases p(HGNC:MARK4) |
| pmid:22156579 | a(CHEBI:"amyloid-beta") positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:24401760 | a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Bace1) |
| pmid:28855586 | act(a(CHEBI:"amyloid-beta")) negativeCorrelation composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:25378699 | a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(Sumo)) |
| pmid:28500862 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HBP:"Tau aggregates") |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases bp(GO:"innate immune response") |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases a(CHEBI:"nitric oxide") |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:NLRP3)) |
| pmid:27314526 | a(CHEBI:"amyloid-beta") association p(HGNC:NLRP3) |
| pmid:23702978 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:TLR)) |
| pmid:24561250 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:"amyloid-beta") increases bp(GO:phagocytosis) |
| pmid:24561250 | a(CHEBI:"amyloid-beta") decreases a(GO:lysosome) |
| pmid:30046111 | bp(GO:phagocytosis) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) association p(HGNC:TREM2) |
| pmid:29626319 | bp(GO:phagocytosis) association p(HGNC:ABCA7) |
| pmid:29626319 | bp(GO:phagocytosis) association p(HGNC:CD33) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:29626319 | bp(GO:phagocytosis) decreases p(HGNC:MAPT) |
| pmid:24561250 | bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:30046111 | a(MESH:Microglia) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | a(MESH:Microglia) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) |
| pmid:26195256 | act(a(MESH:Microglia)) decreases a(CHEBI:"amyloid-beta") |
| pmid:28745240 | act(a(MESH:Microglia)) increases p(HGNC:TNF) |
| pmid:28745240 | act(a(MESH:Microglia)) increases p(HGNC:IL1B) |
| pmid:28745240 | act(a(MESH:Microglia)) increases p(HGNC:IL6) |
| pmid:28745240 | act(a(MESH:Microglia)) increases p(HGNC:CXCL8) |
| pmid:28745240 | act(a(MESH:Microglia)) increases bp(GO:"neuron death") |
| pmid:25652642 | act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:23178521 | a(MESH:Microglia) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:23383175 | a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes) |
| pmid:23383175 | a(MESH:Microglia) negativeCorrelation a(GO:"myelin sheath") |
| pmid:29202785 | act(a(MESH:Microglia)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:29202785 | act(a(MESH:Microglia)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:28528849 | a(MESH:Microglia) regulates act(p(HBP:"Tau oligomers", var("p.Lys280del"))) |
| pmid:26195256 | act(a(MESH:Microglia)) increases a(MESH:Cytokines) |
| pmid:29626319 | a(MESH:Microglia) increases bp(GO:"immune response") |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(GO:"cytokine production involved in inflammatory response") |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(GO:"inflammatory response") |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(HBP:Neurodegeneration) |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(GO:phagocytosis) |
| pmid:29626319 | a(MESH:Microglia) increases bp(GO:phagocytosis) |
| pmid:29238289 | a(MESH:Microglia) increases sec(p(HGNC:MAPT)) |
| pmid:27314526 | a(MESH:Microglia) increases p(HGNC:NLRP3) |
| pmid:27314526 | a(MESH:Microglia) increases p(HGNC:P2RX7) |
| pmid:27314526 | a(MESH:Microglia) increases p(HGNC:TLR4) |
| pmid:30046111 | a(MESH:Monocytes) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30046111 | a(MESH:Macrophages) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:30046111 | a(MESH:Macrophages) association a(CHEBI:"amyloid-beta") |
| pmid:26195256 | a(MESH:Macrophages) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30046111 | a(HBP:HBP00018) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21718217 | a(HBP:HBP00018) association path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(HBP:HBP00018) decreases bp(GO:"neuron cellular homeostasis") |
| pmid:30046111 | a(HBP:HBP00018) increases path(MESH:"Problem Behavior") |
| pmid:29196815 | a(HBP:HBP00018) causesNoChange bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00018) causesNoChange bp(GO:"astrocyte activation") |
| pmid:22122372 | a(HBP:HBP00018) association a(MESH:"Amyloid beta-Peptides") |
| pmid:22122372 | a(HBP:HBP00018) increases path(MESH:"Plaque, Amyloid") |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00018) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") association a(HBP:HBP00018) |
| pmid:22040696 | path(MESH:"Alzheimer Disease") increases a(HBP:HBP00018) |
| pmid:30046111 | path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association sec(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") increases a(CHEBI:"amyloid-beta") |
| pmid:29980653 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30663117 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1, loc(GO:cytoplasm)) |
| pmid:30663117 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:"BACE1-AS") |
| pmid:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:MIR384) |
| pmid:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:"MIR153-1") |
| pmid:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:"MIR101-1") |
| pmid:30663117 | path(MESH:"Alzheimer Disease") association g(HGNC:"MIR9-1") |
| pmid:30663117 | path(MESH:"Alzheimer Disease") decreases g(HGNC:"MIR9-1") |
| pmid:21329555 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) |
| pmid:21329555 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BACE1) |
| pmid:10656250 | path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1) |
| pmid:21329555 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pmid:28745240 | path(MESH:"Alzheimer Disease") association p(HGNC:IL6) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6) |
| pmid:28745240 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) |
| pmid:29179999 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:NFkappaB) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(FPLX:NFkappaB)) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"regulation of synaptic plasticity") |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"reactive oxygen species") |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pmid:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pmid:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pmid:27314526 | path(MESH:"Alzheimer Disease") association p(HGNC:IL18) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CXCL10) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TGFB1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"MAPK cascade") |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:pentosidine) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:GLAP) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PTGS2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2) |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-146a") |
| pmid:27288790 | path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-155") |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens") |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:"MIR9-1") |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155) |
| pmid:25652642 | path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339) |
| pmid:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HSD17B10) |
| pmid:30444369 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PRDX2)) |
| pmid:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRDX2) |
| pmid:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") association p(HGNC:CDK5) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) |
| pmid:30444369 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SH3GL2) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29980653 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:cognition) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") increases bp(GO:"positive regulation of neuron apoptotic process") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Amyloid beta-Peptides") |
| pmid:22122372 | path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") association a(GO:"neurofibrillary tangle") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00076) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NGFR) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HBP:HBP00064) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:HBP00065) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ADAM10) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10)) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:HBP00067) |
| pmid:22122372 | path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly") |
| pmid:22122372 | path(MESH:"Alzheimer Disease") association bp(GO:"neuron death") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pmid:17009926 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:17009926 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:22040696 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:22122372 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00064) |
| pmid:22122372 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00065) |
| pmid:30061532 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30145931 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25374103 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pmid:22040696 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pmid:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:memory) |
| pmid:22040696 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Psychomotor Performance") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:Death) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(HBP:"amyloid-beta aggregates") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases a(HBP:"amyloid-beta aggregates") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association g(HGNC:CHAT) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association g(HGNC:ACHE) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association act(p(HGNC:INS)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association bp(GO:learning) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:learning) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:learning) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:27522251 | path(MESH:"Alzheimer Disease") increases path(MESH:"Cognitive Dysfunction") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7) |
| pmid:25881725 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Chrna7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") increases path(MESH:Depression) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Depression) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") increases path(MESH:Anxiety) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(MESH:Aging) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") increases deg(a(MESH:"Basal Nucleus of Meynert")) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Basal Nucleus of Meynert") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Apathy) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") association p(HGNC:ACHE) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:rivastigmine) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) |
| pmid:24590577 | path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:30126037 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:MAPT) |
| pmid:25374103 | path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:29980653 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"White Matter") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(MESH:"White Matter") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00030) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:ARG1) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") association p(HBP:HBP00030) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"alpha-4-containing nAChR") |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"alpha-7-containing nAChR") |
| pmid:11230871 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHRNA7) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA4) |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons) |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Memory, Episodic") |
| pmid:26837465 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT)) |
| pmid:21787755 | path(MESH:"Alzheimer Disease") association a(HBP:AβOs) |
| pmid:28901280 | path(MESH:"Alzheimer Disease") association p(MESH:"Receptors, Nicotinic") |
| pmid:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Il6) |
| pmid:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Tnf) |
| pmid:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(Ph)) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"protein aggregates") |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:AGRN) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:BAX) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:BGN) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:BRCA1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CADPS2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CCNB1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CDK1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CDK2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CDKN2A) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CXCR4) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:EIF4EBP1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:FOLH1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:HOMER1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:HRH1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:IGF2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:IGFBP2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:LDLR) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAOA) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:NEFH) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:NPDC1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:NRGN) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:PREP) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:PROS1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:SELENBP1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:TAGLN) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:TUBB3) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:VKORC1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CANX) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GCNT2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MMP1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:NFE2L2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:NR3C1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:PPARA) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:SLC6A6) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:SYVN1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:TSHZ1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:TXN) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ACLY) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ATAD2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:DHCR24) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:FGF2) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HTRA1) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:HTRA1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKCE) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKDC) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:SCD) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:TUBB) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") decreases p(HGNC:UNG) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:ATP1A1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:CTSD) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:GLRX) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GLRX) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:HMOX1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HMOX1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:IL6R) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:NPTX1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:NQO1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NQO1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:PHF1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCD) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1) |
| pmid:22020111 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") |
| pmid:23454242 | path(MESH:"Alzheimer Disease") increases p(HGNC:SET) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) |
| pmid:23454242 | path(MESH:"Alzheimer Disease") decreases act(p(FPLX:PPP2)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") association p(HGNC:GSK3B) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") association a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:24653673 | path(MESH:"Alzheimer Disease") association p(HGNC:GRM5) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CA) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:PPP2CA) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CA) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PPP2CA)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CB) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET, frag("?")) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PTPA) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:22253473 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22817713 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12428809 | path(MESH:"Alzheimer Disease") association a(HBP:"straight filaments") |
| pmid:12428809 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") |
| pmid:12428809 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") |
| pmid:12428809 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 198)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:27373205 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C, pmod(Me, Leu, 309)) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ICMT) |
| pmid:22299660 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1) |
| pmid:27491084 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:27491084 | path(MESH:"Alzheimer Disease") increases p(HGNC:HSPB1) |
| pmid:27491084 | path(MESH:"Alzheimer Disease") increases p(HGNC:CRYAB) |
| pmid:27491084 | path(MESH:"Alzheimer Disease") increases p(FPLX:HSPB) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:25784053 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") increases complex(a(GO:autophagosome), a(HBP:"dystrophic neurite")) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") association bp(GO:autophagy) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") association bp(GO:autophagy) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autolysosome) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal protein catabolic process") |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1, var("?")) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") increases a(GO:lysosome) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:lysosome) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:lysosome)) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") increases a(GO:autophagosome) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) |
| pmid:18930136 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) |
| pmid:18930136 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SNCA) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association a(HBP:"alpha-synuclein aggregates") |
| pmid:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"alpha-synuclein aggregates") |
| pmid:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:ceramide) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:TFEB) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BIN1) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:VPS35, var("?")) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") association p(HGNC:SORL1) |
| pmid:29758300 | path(MESH:"Alzheimer Disease") increases bp(GO:mitophagy) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") decreases bp(GO:"short-term memory") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1)) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA2)) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRKN) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:PRKN) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") |
| pmid:22908190 | path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") association p(HGNC:UBQLN1) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBQLN1, var("?")) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB7A) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB5A) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB4A) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"dystrophic neurite") |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) |
| pmid:22908190 | path(MESH:"Alzheimer Disease") association g(HBP:"APOE e4") |
| pmid:25784053 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:Proteasome)) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1) |
| pmid:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:PSEN1, var("?")) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"selenium(2+)") |
| pmid:30116051 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1)) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MME) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PLG) |
| pmid:29024336 | path(MESH:"Alzheimer Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29215007 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:PIN1) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:Microvessels)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:"Cerebrospinal Fluid")) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Neurons)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Astrocytes)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association bp(HBP:"APP processing") |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasomal protein catabolic process") |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Autophagosomes) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") decreases bp(MESH:Autophagy) |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:25887395 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pmid:21734277 | path(MESH:"Alzheimer Disease") association act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | path(MESH:"Alzheimer Disease") association act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBB) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBC) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBA52) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RPS27A) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:RNF182) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1, var("?")) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis) |
| pmid:29988016 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:27373205 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1) |
| pmid:30126037 | path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation") |
| pmid:22419736 | path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AK1) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:29191965 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:30985105 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:OGT)) |
| pmid:30985105 | path(MESH:"Alzheimer Disease") decreases p(HGNC:OGT) |
| pmid:25374103 | path(MESH:"Alzheimer Disease") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:25374103 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(HBP:misfolded)) |
| pmid:28877763 | path(MESH:"Alzheimer Disease") increases bp(GO:"microglial cell activation") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C)) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 68)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 69)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 71)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 113)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 123)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 153)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 175)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 184)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 185)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 191)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 208)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 210)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 237)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 238)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 258)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 289)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 403)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 409)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 435)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 427)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 433)) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:PSEN2, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:APP, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:TREM2, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:CLU, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Atrophy) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases path(MESH:Atrophy) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebral Cortex") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Cerebral Ventricles") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases bp(GO:"glucose metabolic process") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Neprilysin) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MMP2) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:LRP1) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ABCB1) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AGER) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(HBP:"perivascular drainage pathways") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebrospinal Fluid") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:AQP1)) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases path(MESH:"Calcification, Physiologic") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases path(MESH:Fibrosis) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"3R tau") |
| pmid:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 259)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 290)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 321)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 353)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:29276758 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:21427723 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(NGlyco)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(OGlyco)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:17050703 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:MAPT, pmod(Me)) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?")) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, frag("26_230")) |
| pmid:26631930 | path(MESH:"Alzheimer Disease") increases a(CHEBI:"iron(0)") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") association a(MESH:"Neuropil Threads") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE)) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2)) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) |
| pmid:27260836 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) |
| pmid:23531502 | path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein)) |
| pmid:19251756 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"canonical glycolysis") |
| pmid:19251756 | path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) |
| pmid:19251756 | path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) |
| pmid:11738469 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:8985134 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:9099822 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:TGM2)) |
| pmid:20096481 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2651206) |
| pmid:21548880 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) |
| pmid:20096481 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs10807287) |
| pmid:20096481 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7764257) |
| pmid:23666762 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MARK4) |
| pmid:26118667 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"CDK5R1 p25") |
| pmid:21910444 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1) |
| pmid:21910444 | path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB) |
| pmid:24401760 | path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB) |
| pmid:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt1) |
| pmid:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3) |
| pmid:21427723 | path(MESH:"Alzheimer Disease") isA path(HBP:"4R tauopathy") |
| pmid:19732809 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"O-GlcNAcylation") |
| pmid:27716675 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SUMO1) |
| pmid:19765634 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs761059) |
| pmid:29281045 | path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1) |
| pmid:29281045 | path(MESH:"Alzheimer Disease") increases p(ECCODE:"3.1.1.89") |
| pmid:23157676 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"cis p-tau") |
| pmid:24561250 | path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex") |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex") |
| pmid:27314526 | path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") |
| pmid:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) |
| pmid:25514383 | bp(GO:"neuron cellular homeostasis") association complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) |
| pmid:30046111 | bp(GO:aging) decreases bp(GO:"cerebrospinal fluid circulation") |
| pmid:30046111 | bp(GO:aging) decreases act(a(HP:"interstitial fluid")) |
| pmid:30046111 | bp(GO:aging) increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | bp(GO:aging) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(GO:aging) decreases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30046111 | bp(GO:aging) association bp(GO:"immune response") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"inflammatory response") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"phospholipid metabolic process") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"extracellular matrix organization") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"cell adhesion") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"endothelial tube morphogenesis") |
| pmid:30046111 | bp(GO:aging) decreases p(MGI:Cdk5r1) |
| pmid:30046111 | bp(GO:aging) decreases p(MGI:Adamts3) |
| pmid:30046111 | bp(GO:aging) decreases p(MGI:Fgfr3) |
| pmid:29196815 | bp(GO:aging) increases path(MESH:"Alzheimer Disease") |
| pmid:24561250 | bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | bp(GO:aging) increases a(HBP:HBP00074) |
| pmid:25514383 | bp(GO:aging) association path(MESH:Dementia) |
| pmid:27522251 | bp(GO:aging) association p(MGI:Chrna7) |
| pmid:11230871 | bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) |
| pmid:11230871 | bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) |
| pmid:11230871 | bp(GO:aging) causesNoChange r(HGNC:CHRNA3) |
| pmid:11230871 | bp(GO:aging) negativeCorrelation a(HBP:"alpha-4-containing nAChR") |
| pmid:11230871 | bp(GO:aging) negativeCorrelation a(HBP:"alpha-7-containing nAChR") |
| pmid:23454242 | bp(GO:aging) increases p(HGNC:PPP2R2C) |
| pmid:23454242 | bp(GO:aging) decreases p(HGNC:PPP2R2B) |
| pmid:28083634 | bp(GO:aging) increases p(MGI:Otub1) |
| pmid:27491084 | bp(GO:aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:27491084 | bp(GO:aging) decreases p(FPLX:HSPA) |
| pmid:27491084 | bp(GO:aging) increases p(FPLX:HSPB) |
| pmid:14556719 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:22908190 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:22908190 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:14556719 | bp(GO:aging) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | bp(GO:aging) increases p(HGNC:PRNP) |
| pmid:23746257 | bp(GO:aging) decreases bp(HBP:Proteostasis) |
| pmid:23746257 | bp(GO:aging) decreases bp(HBP:Proteostasis) |
| pmid:24563850 | bp(GO:aging) positiveCorrelation bp(HBP:"non-enzymatic protein modification") |
| pmid:24563850 | bp(GO:aging) association bp(GO:"protein oxidation") |
| pmid:30145931 | bp(GO:aging) increases p(HGNC:MAPT) |
| pmid:30145931 | bp(GO:aging) decreases p(HGNC:MAPT) |
| pmid:21882945 | bp(GO:aging) negativeCorrelation deg(p(HGNC:MAPT)) |
| pmid:29238289 | bp(GO:aging) increases p(HGNC:MAPT) |
| pmid:30116051 | bp(GO:aging) negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:30116051 | bp(GO:aging) decreases a(CHEBI:"NAD(+)") |
| pmid:29024336 | bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29024336 | bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") |
| pmid:21882945 | bp(GO:aging) positiveCorrelation p(HGNC:FKBP5) |
| pmid:29191965 | bp(GO:aging) decreases bp(GO:locomotion) |
| pmid:28877763 | bp(GO:aging) increases p(MGI:Syk, pmod(Ph)) |
| pmid:28877763 | bp(GO:aging) increases p(MGI:Syk, pmod(Ph)) |
| pmid:28877763 | bp(GO:aging) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | bp(GO:aging) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:28877763 | bp(GO:aging) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:29626319 | bp(GO:aging) negativeCorrelation p(HGNC:IDE) |
| pmid:25681682 | bp(GO:aging) negativeCorrelation p(HGNC:AGER) |
| pmid:29421605 | bp(GO:aging) increases p(RGD:Ptpn1) |
| pmid:24561250 | bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | bp(GO:aging) increases p(HGNC:IL1B) |
| pmid:24561250 | bp(GO:aging) increases p(HGNC:IL18) |
| pmid:30046111 | bp(GO:"cerebrospinal fluid circulation") decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(HP:"interstitial fluid")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis) |
| pmid:30046111 | a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(MESH:"Lymphatic Vessels") decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(HBP:HBP00018) |
| pmid:30046111 | tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | a(CHEBI:verteporfin) decreases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30126037 | bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu")) |
| pmid:30126037 | bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease") |
| pmid:30126037 | bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction") |
| pmid:30046111 | p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30046111 | p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space")) |
| pmid:30046111 | p(MGI:Aqp4) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | p(MGI:Aqp4) increases bp(GO:cognition) |
| pmid:26195256 | p(MGI:Aqp4) increases act(a(HBP:"Glymphatic System")) |
| pmid:19126755 | bp(GO:cognition) positiveCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19126755 | bp(GO:cognition) association act(p(HGNC:CHRNA7)) |
| pmid:19721446 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19126755 | bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:cognition) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:cognition) association path(MESH:Schizophrenia) |
| pmid:19721446 | bp(GO:cognition) association path(MESH:Schizophrenia) |
| pmid:24511233 | bp(GO:cognition) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:cognition) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | bp(GO:cognition) association p(HGNC:CHRM1) |
| pmid:24511233 | bp(GO:cognition) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pmid:24511233 | bp(GO:cognition) association a(MESH:"Prefrontal Cortex") |
| pmid:26813123 | bp(GO:cognition) association bp(GO:"synaptic transmission, glutamatergic") |
| pmid:26813123 | bp(GO:cognition) association a(CHEBI:acetylcholine) |
| pmid:11230871 | bp(GO:cognition) negativeCorrelation a(CHEBI:acetylcholine) |
| pmid:25514383 | bp(GO:cognition) association a(HP:"cholinergic neuron") |
| pmid:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pmid:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pmid:11230871 | bp(GO:cognition) association p(FPLX:CHRN) |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:11230871 | bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:11230871 | bp(GO:cognition) association a(CHEBI:neurotransmitter) |
| pmid:22908190 | bp(GO:cognition) positiveCorrelation act(a(GO:synapse)) |
| pmid:24027553 | bp(GO:cognition) negativeCorrelation p(HBP:"Tau C3") |
| pmid:21882945 | bp(GO:cognition) negativeCorrelation path(MESH:Tauopathies) |
| pmid:21882945 | bp(GO:cognition) positiveCorrelation a(PUBCHEM:134222899) |
| pmid:21882945 | bp(GO:cognition) positiveCorrelation a(CHEBI:"NMDA receptor antagonist") |
| pmid:30985105 | bp(GO:cognition) association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) |
| pmid:24511233 | bp(GO:memory) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:memory) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:memory) association a(MESH:Hippocampus) |
| pmid:19721446 | bp(GO:memory) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:memory) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:memory) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:memory) association bp(GO:"long-term synaptic potentiation") |
| pmid:24511233 | bp(GO:memory) association a(MESH:"Prefrontal Cortex") |
| pmid:17009926 | bp(GO:memory) association p(FPLX:CHRN) |
| pmid:11230871 | bp(GO:memory) association p(FPLX:CHRN) |
| pmid:26813123 | bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:memory) positiveCorrelation a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:memory) association a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:memory) positiveCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | bp(GO:memory) negativeCorrelation bp(HBP:Neurodegeneration) |
| pmid:26813123 | bp(GO:memory) association bp(MESH:"Synaptic Transmission") |
| pmid:26813123 | bp(GO:memory) association p(HGNC:SYP) |
| pmid:24590577 | bp(GO:memory) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:24590577 | bp(GO:memory) association p(HGNC:CHRM1) |
| pmid:19721446 | bp(GO:memory) association p(HGNC:CHRNA7) |
| pmid:19721446 | bp(GO:memory) association a(MESH:"Entorhinal Cortex") |
| pmid:30106381 | bp(GO:memory) association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:memory) association a(PUBCHEM:9832404) |
| pmid:22908190 | bp(GO:memory) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:28775333 | bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") |
| pmid:28775333 | bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:24355211 | bp(GO:memory) negativeCorrelation p(HGNC:GSK3B) |
| pmid:27041503 | bp(GO:memory) positiveCorrelation bp(MESH:"Long-Term Potentiation") |
| pmid:29540553 | bp(GO:memory) positiveCorrelation p(HGNC:SIRT1) |
| pmid:28771976 | bp(GO:memory) association a(HBP:RGFP966) |
| pmid:21843595 | bp(GO:memory) negativeCorrelation p(MGI:Sumo3) |
| pmid:30046111 | bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30663117 | path(MESH:"Huntington Disease") association path(MESH:Chorea) |
| pmid:30663117 | path(MESH:"Huntington Disease") association path(MESH:Dementia) |
| pmid:30663117 | path(MESH:"Huntington Disease") association path(MESH:"Deglutition Disorders") |
| pmid:30663117 | path(MESH:"Huntington Disease") association path(MESH:Aphasia) |
| pmid:30663117 | path(MESH:"Huntington Disease") association path(MESH:Seizures) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR196A1) |
| pmid:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR196A1) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR206) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR301B) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR92B) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR378B) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR208B) |
| pmid:30663117 | path(MESH:"Huntington Disease") association g(HGNC:MIR449A) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(NCBIGENE:406915) |
| pmid:30663117 | path(MESH:"Huntington Disease") increases g(MIRBASE:"hsa-mir-10b") |
| pmid:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR196B) |
| pmid:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR615) |
| pmid:30663117 | path(MESH:"Huntington Disease") increases g(HGNC:MIR1247) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir22) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir29c) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:"Mir128-1") |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir132) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:"Mir138-1") |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:"Mir218-1") |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(MGI:Mir222) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(NCBIGENE:723931) |
| pmid:30663117 | path(MESH:"Huntington Disease") decreases g(NCBIGENE:732489) |
| pmid:26813123 | path(MESH:"Huntington Disease") negativeCorrelation act(p(HGNC:CHAT)) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:TCP1) |
| pmid:14556719 | path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:25784053 | path(MESH:"Huntington Disease") positiveCorrelation p(FPLX:HSPA) |
| pmid:25784053 | path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6) |
| pmid:18930136 | path(MESH:"Huntington Disease") increases p(HGNC:CTSD) |
| pmid:18930136 | path(MESH:"Huntington Disease") positiveCorrelation a(GO:autolysosome) |
| pmid:29024336 | path(MESH:"Huntington Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29311797 | path(MESH:"Huntington Disease") association p(HGNC:STUB1) |
| pmid:30046111 | path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30663117 | path(MESH:"Parkinson Disease") association a(HBP:"alpha-synuclein aggregates") |
| pmid:30663117 | path(MESH:"Parkinson Disease") association g(HGNC:MIR132) |
| pmid:30663117 | path(MESH:"Parkinson Disease") association g(NCBIGENE:406950) |
| pmid:30663117 | path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) |
| pmid:24113872 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2) |
| pmid:30663117 | path(MESH:"Parkinson Disease") decreases g(HGNC:MIR205) |
| pmid:30663117 | path(MESH:"Parkinson Disease") decreases p(HGNC:PARK7) |
| pmid:30663117 | path(MESH:"Parkinson Disease") increases g(HGNC:MIR494) |
| pmid:30663117 | path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34B) |
| pmid:30663117 | path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34C) |
| pmid:19126755 | path(MESH:"Parkinson Disease") association p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) |
| pmid:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Tremor) |
| pmid:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Hypokinesia) |
| pmid:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Muscle Rigidity") |
| pmid:19126755 | path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:17009926 | path(MESH:"Parkinson Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Parkinson Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Parkinson Disease") association p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:"Parkinson Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:24590577 | path(MESH:"Parkinson Disease") association p(HGNC:CHRM4) |
| pmid:24590577 | path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:24762290 | path(MESH:"Parkinson Disease") decreases path(MESH:Memory) |
| pmid:24762290 | path(MESH:"Parkinson Disease") association path(MESH:Memory) |
| pmid:24762290 | path(MESH:"Parkinson Disease") association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:28901280 | path(MESH:"Parkinson Disease") association p(MESH:"Receptors, Nicotinic") |
| pmid:22020111 | path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:"protein aggregates") |
| pmid:29758300 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:29758300 | path(MESH:"Parkinson Disease") association p(HGNC:VPS35, var("?")) |
| pmid:29758300 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:14556719 | path(MESH:"Parkinson Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:14556719 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") |
| pmid:14556719 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("?")) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("p.Ile93Met")) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association a(MESH:"Lewy Bodies") |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala30Pro")) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:22908190 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, pmod(Ub)) |
| pmid:22908190 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1) |
| pmid:18930136 | path(MESH:"Parkinson Disease") positiveCorrelation a(GO:autophagosome) |
| pmid:28803412 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA) |
| pmid:29980653 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA) |
| pmid:28803412 | path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00093) |
| pmid:27075649 | path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00016) |
| pmid:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?")) |
| pmid:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?")) |
| pmid:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?")) |
| pmid:29024336 | path(MESH:"Parkinson Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:30985105 | path(MESH:"Parkinson Disease") positiveCorrelation deg(a(HBP:"Dopaminergic cell groups")) |
| pmid:30985105 | path(MESH:"Parkinson Disease") association complex(p(HGNC:SNCA), p(HGNC:SNCA)) |
| pmid:30985105 | path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:30985105 | path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:29311797 | path(MESH:"Parkinson Disease") association p(HGNC:STUB1) |
| pmid:26751493 | path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738) |
| pmid:26751493 | path(MESH:"Parkinson Disease") association g(DBSNP:rs242557) |
| pmid:26631930 | path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)") |
| pmid:29980653 | path(MESH:"Parkinson Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29980653 | path(MESH:"Parkinson Disease") isA path(MESH:"Lewy Body Disease") |
| pmid:30046111 | bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:19293145 | bp(GO:learning) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:learning) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:learning) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:learning) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:learning) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:learning) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:learning) association bp(GO:"long-term synaptic potentiation") |
| pmid:24511233 | bp(GO:learning) association a(MESH:"Prefrontal Cortex") |
| pmid:17009926 | bp(GO:learning) association p(FPLX:CHRN) |
| pmid:26813123 | bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:learning) positiveCorrelation bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:learning) association a(CHEBI:acetylcholine) |
| pmid:24590577 | bp(GO:learning) association p(HGNC:CHRM1) |
| pmid:19721446 | bp(GO:learning) association p(HGNC:CHRNA7) |
| pmid:30106381 | bp(GO:learning) association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:learning) association a(PUBCHEM:9832404) |
| pmid:22908190 | bp(GO:learning) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:24808823 | bp(GO:learning) negativeCorrelation p(MGI:Ttbk1) |
| pmid:24808823 | bp(GO:learning) negativeCorrelation p(MGI:Cdk5) |
| pmid:24808823 | bp(GO:learning) positiveCorrelation surf(p(MGI:Grin2b)) |
| pmid:24355211 | bp(GO:learning) negativeCorrelation p(HGNC:GSK3B) |
| pmid:29540553 | bp(GO:learning) positiveCorrelation p(HGNC:SIRT1) |
| pmid:21843595 | bp(GO:learning) negativeCorrelation p(MGI:Sumo3) |
| pmid:30046111 | bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:24590577 | bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1) |
| pmid:11230871 | bp(GO:"response to oxidative stress") negativeCorrelation p(FPLX:CHRN) |
| pmid:14556719 | bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(Ub), var("?")) |
| pmid:14556719 | bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(HBP:misfolding), var("?")) |
| pmid:23746257 | bp(GO:"response to oxidative stress") increases a(MESH:"Heat-Shock Proteins") |
| pmid:23746257 | bp(GO:"response to oxidative stress") association bp(HBP:Proteostasis) |
| pmid:18930136 | bp(GO:"response to oxidative stress") increases p(HGNC:SQSTM1) |
| pmid:18930136 | bp(GO:"response to oxidative stress") increases r(HGNC:SQSTM1) |
| pmid:24563850 | bp(GO:"response to oxidative stress") decreases act(p(HGNC:KEAP1)) |
| pmid:24563850 | bp(GO:"response to oxidative stress") increases p(HGNC:NFE2L2) |
| pmid:24563850 | bp(GO:"response to oxidative stress") increases act(p(FPLX:PRDX)) |
| pmid:27671637 | bp(GO:"response to oxidative stress") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:23528736 | bp(GO:"response to oxidative stress") increases bp(GO:autophagy) |
| pmid:22419736 | bp(GO:"response to oxidative stress") increases p(HGNC:AK1) |
| pmid:26751493 | bp(GO:"response to oxidative stress") association a(CHEBI:"methylene blue") |
| pmid:26751493 | bp(GO:"response to oxidative stress") association a(CHEBI:"azure A") |
| pmid:26751493 | bp(GO:"response to oxidative stress") association a(CHEBI:"azure B") |
| pmid:30126037 | bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) |
| pmid:30046111 | bp(GO:"immune response") association bp(GO:aging) |
| pmid:27288790 | bp(GO:"immune response") association m(MIRBASE:"hsa-mir-146a") |
| pmid:30106381 | bp(GO:"immune response") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"immune response") association a(PUBCHEM:9832404) |
| pmid:23746257 | bp(GO:"immune response") association p(FPLX:HSP90) |
| pmid:30046111 | bp(GO:"inflammatory response") association bp(GO:aging) |
| pmid:29179999 | bp(GO:"inflammatory response") association act(p(FPLX:NFkappaB)) |
| pmid:27522251 | bp(GO:"inflammatory response") causesNoChange path(MESH:"Memory Disorders") |
| pmid:23746257 | bp(GO:"inflammatory response") association bp(HBP:Proteostasis) |
| pmid:24563850 | bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") |
| pmid:8940412 | bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh)) |
| pmid:8940412 | bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:antalarmin) |
| pmid:30126037 | bp(GO:"inflammatory response") association bp(GO:"cellular senescence") |
| pmid:18494933 | bp(GO:"inflammatory response") increases p(HGNC:DKK1) |
| pmid:16566606 | bp(GO:"inflammatory response") increases a(CHEBI:peroxynitrite) |
| pmid:30046111 | bp(GO:"phospholipid metabolic process") association bp(GO:aging) |
| pmid:30046111 | bp(GO:"extracellular matrix organization") association bp(GO:aging) |
| pmid:30046111 | bp(GO:"cell adhesion") association bp(GO:aging) |
| pmid:21214928 | bp(GO:"cell adhesion") association p(HGNC:APP) |
| pmid:28901280 | bp(GO:"cell adhesion") association a(MESH:Acetylcholine) |
| pmid:30106381 | bp(GO:"cell adhesion") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"cell adhesion") association a(PUBCHEM:9832404) |
| pmid:30046111 | bp(GO:"endothelial tube morphogenesis") association bp(GO:aging) |
| pmid:27087442 | p(MGI:Cdk5r1) negativeCorrelation p(MGI:Cdk5) |
| pmid:27087442 | p(MGI:Cdk5r1) positiveCorrelation act(a(MESH:Neurons)) |
| pmid:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases path(MESH:"Spatial Learning") |
| pmid:30046111 | p(MGI:Vegfc) increases bp(GO:"stem cell proliferation") |
| pmid:30046111 | p(MGI:Vegfc) increases bp(GO:cognition) |
| pmid:30046111 | p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology") |
| pmid:30046111 | composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc, var("p.Cys156Ser")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:Brain)) |
| pmid:30046111 | path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:21329555 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21329555 | path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling") |
| pmid:27288790 | path(MESH:Inflammation) association p(FPLX:NFkappaB) |
| pmid:22040696 | path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") |
| pmid:30106381 | path(MESH:Inflammation) association p(HGNC:ADNP) |
| pmid:24027553 | path(MESH:Inflammation) increases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:26195256 | path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26195256 | path(MESH:Inflammation) decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29255009 | p(MGI:Fkbp1b) increases path(MESH:Memory) |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Eif3g)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:S100b)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Snapc2)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion") |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(GO:"ectoderm development") |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization") |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases")) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins")) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development") |
| pmid:29255009 | p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement") |
| pmid:29255009 | p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle") |
| pmid:29255009 | p(MGI:Fkbp1b) decreases tloc(a(CHEBI:"calcium(2+)")) |
| pmid:29255009 | p(MGI:Fkbp1b) regulates p(MGI:Capn1) |
| pmid:29255009 | p(MGI:Fkbp1b) regulates p(MGI:Ppp3cc) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases p(MGI:Hif1an) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) |
| pmid:24762290 | path(MESH:Memory) association path(MESH:"Parkinson Disease") |
| pmid:24762290 | path(MESH:Memory) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:28901280 | path(MESH:Memory) association p(MESH:"Receptors, Nicotinic") |
| pmid:29255009 | p(HBP:"AAV-FKBP1B") increases p(MGI:Fkbp1b, loc(MESH:Hippocampus)) |
| pmid:29255009 | bp(MESH:Aging) decreases p(MGI:Map2) |
| pmid:29255009 | bp(MESH:Aging) regulates p(MGI:Capn1) |
| pmid:29255009 | bp(MESH:Aging) regulates p(MGI:Ppp3cc) |
| pmid:24511233 | bp(MESH:Aging) association path(MESH:"Alzheimer Disease") |
| pmid:23528736 | bp(MESH:Aging) increases path(MESH:"Alzheimer Disease") |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:27491084 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:27491084 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25784053 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:25437566 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:27491084 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:25784053 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:25437566 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:25437566 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:27491084 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:25784053 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPD1) |
| pmid:27491084 | bp(MESH:Aging) decreases p(HGNC:HSPD1) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:HSPA2) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:DNAJB2) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA12A) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:TOMM70) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSP90AB1) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA8) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA14) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:TCP1) |
| pmid:25784053 | bp(MESH:Aging) regulates bp(HBP:Proteostasis) |
| pmid:25784053 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90) |
| pmid:29311797 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pmid:29311797 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pmid:23528736 | bp(MESH:Aging) decreases bp(GO:autophagy) |
| pmid:23528736 | bp(MESH:Aging) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:28420982 | bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) |
| pmid:28420982 | bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) |
| pmid:29311797 | bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases") |
| pmid:29311797 | bp(MESH:Aging) decreases bp(GO:"protein folding") |
| pmid:29311797 | bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | bp(MESH:Aging) decreases bp(MESH:Proteolysis) |
| pmid:29311797 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pmid:29311797 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pmid:29311797 | bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29311797 | bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPID) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPID) |
| pmid:29311797 | bp(MESH:Aging) increases p(HGNC:FKBP5) |
| pmid:29311797 | bp(MESH:Aging) increases p(HGNC:FKBP5) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPP5C) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPP5C) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:AHSA1) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:AHSA1) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:FKBP4) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:STIP1) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PTGES3) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph)) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ac)) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(NO)) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ub)) |
| pmid:29255009 | p(MGI:Eif3g) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:Pla2g7) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:S100b) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:Snapc2) increases bp(MESH:Aging) |
| pmid:29255009 | path(MESH:Aging) decreases bp(MESH:"Facilitated Diffusion") |
| pmid:29255009 | path(MESH:Aging) decreases bp(GO:"ectoderm development") |
| pmid:29255009 | path(MESH:Aging) decreases bp(GO:"regulation of actin cytoskeleton organization") |
| pmid:29255009 | path(MESH:Aging) decreases act(p(MESH:"Mitogen-Activated Protein Kinases")) |
| pmid:29255009 | path(MESH:Aging) increases act(p(MESH:"Membrane Transport Proteins")) |
| pmid:29255009 | path(MESH:Aging) increases bp(GO:"blood vessel development") |
| pmid:29255009 | path(MESH:Aging) increases bp(GO:"regulation of cellular component movement") |
| pmid:29255009 | path(MESH:Aging) increases a(GO:"cytoplasmic vesicle") |
| pmid:29255009 | path(MESH:Aging) increases p(MGI:Hif1an) |
| pmid:29255009 | path(MESH:Aging) increases p(MGI:Nfkb1) |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:Aging) decreases p(MGI:Chrna4) |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(MGI:Chrna4) |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(MGI:Chrna7) |
| pmid:26195256 | path(MESH:Aging) increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:Aging) negativeCorrelation a(MESH:"Cerebrospinal Fluid") |
| pmid:26195256 | path(MESH:Aging) negativeCorrelation act(p(HGNC:AQP1)) |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(FPLX:CREB), ma(tscript)) |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide) |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"signal release") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron migration") |
| pmid:22040696 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) increases bp(GO:"neuron migration") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation") |
| pmid:19293145 | a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) |
| pmid:23038257 | a(CHEBI:"calcium(2+)") increases act(p(MESH:"Receptors, Nicotinic")) |
| pmid:17009926 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(GO:cytosol)) |
| pmid:26472524 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") |
| pmid:26472524 | a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") regulates p(FPLX:CHRN) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:serotonin), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:noradrenaline), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26088141 | a(CHEBI:"calcium(2+)") association act(a(MESH:"Calcium Channels")) |
| pmid:19721446 | a(CHEBI:"calcium(2+)") increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | a(CHEBI:"calcium(2+)") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:24027553 | a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:2123288 | a(CHEBI:"calcium(2+)") increases act(p(FPLX:CALM)) |
| pmid:2833519 | a(CHEBI:"calcium(2+)") increases act(p(HGNC:S100B)) |
| pmid:10537045 | a(CHEBI:"calcium(2+)") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pmid:23702978 | a(CHEBI:"calcium(2+)") association p(HGNC:MAP3K7) |
| pmid:23702978 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNC:NLRP3)) |
| pmid:29255009 | a(CHEBI:sirolimus) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:30061532 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pmid:29758300 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pmid:18930136 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pmid:30985105 | a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) |
| pmid:30061532 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30061532 | a(CHEBI:sirolimus) decreases p(HGNC:SNCA, pmod(HBP:misfolded)) |
| pmid:30061532 | a(CHEBI:sirolimus) decreases p(HGNC:TARDBP, pmod(HBP:misfolded)) |
| pmid:30061532 | a(CHEBI:sirolimus) increases path(MESH:"Interpersonal Relations") |
| pmid:30061532 | a(CHEBI:sirolimus) increases bp(GO:behavior) |
| pmid:30061532 | a(CHEBI:sirolimus) decreases act(a(CHEBI:methamphetamine)) |
| pmid:30061532 | a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") |
| pmid:30061532 | a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") |
| pmid:30061532 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:29758300 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:22908190 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:22908190 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:18930136 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:sirolimus) decreases path(MESH:Schizophrenia) |
| pmid:29758300 | a(CHEBI:sirolimus) increases bp(GO:cognition) |
| pmid:29758300 | a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:22908190 | a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pmid:29758300 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pmid:26751493 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pmid:29758300 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:sirolimus) increases deg(p(HGNC:MAPT)) |
| pmid:29758300 | a(CHEBI:sirolimus) increases bp(GO:"motor behavior") |
| pmid:22908190 | a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) |
| pmid:22908190 | a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) |
| pmid:25784053 | a(CHEBI:sirolimus) decreases act(p(FPLX:mTORC1)) |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") |
| pmid:18930136 | a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Machado-Joseph Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Alzheimer Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Parkinson Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:18930136 | a(CHEBI:sirolimus) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:27594586 | a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling") |
| pmid:27594586 | a(CHEBI:sirolimus) increases r(HGNC:MMP9) |
| pmid:27594586 | a(CHEBI:sirolimus) increases r(HGNC:MMP2) |
| pmid:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:SNCA) |
| pmid:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:FUS) |
| pmid:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:HTT) |
| pmid:24027553 | a(CHEBI:sirolimus) increases bp(MESH:Autophagy) |
| pmid:29626319 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29255009 | bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) |
| pmid:28745240 | bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:29255009 | act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:29255009 | act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:29255009 | p(MGI:Fkbp1a) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:30126037 | act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival") |
| pmid:30126037 | act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response") |
| pmid:30663117 | r(HGNC:BACE1, loc(GO:cytoplasm)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30663117 | r(HGNC:BACE1) increases path(MESH:"Alzheimer Disease") |
| pmid:30663117 | r(HGNC:"BACE1-AS") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:30663117 | r(HGNC:"BACE1-AS") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30663117 | r(HGNC:"BACE1-AS") increases r(HGNC:BACE1) |
| pmid:27288790 | r(HGNC:"BACE1-AS") regulates r(HGNC:BACE1) |
| pmid:27288790 | r(HGNC:"BACE1-AS") decreases deg(r(HGNC:BACE1)) |
| pmid:30663117 | r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta") |
| pmid:30663117 | r(HGNC:"BACE1-AS") increases path(MESH:"Plaque, Amyloid") |
| pmid:27288790 | r(HGNC:"BACE1-AS") regulates p(HGNC:BACE1) |
| pmid:27288790 | r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25652642 | path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") |
| pmid:25652642 | path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens") |
| pmid:29196815 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") |
| pmid:26195256 | path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") increases bp(HBP:neuroinflammation) |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") |
| pmid:24590577 | path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:25514383 | path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pmid:29758300 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:14556719 | path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") |
| pmid:24027553 | path(MESH:"Plaque, Amyloid") association p(HGNC:MAP1LC3A) |
| pmid:28420982 | path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) |
| pmid:26195256 | path(MESH:"Plaque, Amyloid") negativeCorrelation act(p(HGNC:MMP2)) |
| pmid:26195256 | path(MESH:"Plaque, Amyloid") increases act(a(MESH:Astrocytes)) |
| pmid:23531502 | path(MESH:"Plaque, Amyloid") positiveCorrelation act(a(CHEBI:acrolein)) |
| pmid:18562203 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:26400044 | path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:18239272 | path(MESH:"Plaque, Amyloid") association p(HBP:"Tau epitope, AT8") |
| pmid:28877763 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(MGI:Syk, pmod(Ph)) |
| pmid:28877763 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph)) |
| pmid:24401760 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) |
| pmid:24401760 | path(MESH:"Plaque, Amyloid") partOf a(HBP:"dystrophic neurite") |
| pmid:30663117 | g(HGNC:"MIR124-1") decreases p(HGNC:BACE1) |
| pmid:21329555 | p(HGNC:BACE1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:10656250 | p(HGNC:BACE1) increases sec(a(HBP:"sAPP-beta")) |
| pmid:24590577 | p(HGNC:BACE1) increases a(HBP:"sAPP-beta") |
| pmid:10656250 | p(HGNC:BACE1) causesNoChange sec(a(HBP:"sAPP-alpha")) |
| pmid:10656250 | p(HGNC:BACE1) causesNoChange p(HGNC:APP) |
| pmid:10656250 | p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) association p(HGNC:APP, loc(GO:"endoplasmic reticulum")) |
| pmid:24590577 | p(HGNC:BACE1) increases deg(p(HGNC:APP)) |
| pmid:21718217 | p(HGNC:BACE1) decreases p(HGNC:APP) |
| pmid:10656250 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_770")) |
| pmid:10656250 | p(HGNC:BACE1) association a(HBP:APP695) |
| pmid:10656250 | p(HGNC:BACE1) association a(HBP:APP751) |
| pmid:30444369 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) |
| pmid:18650430 | act(p(HGNC:BACE1), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("11_*")), p(HGNC:APP, frag("1_10")))) |
| pmid:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE1) increases bp(GO:"neuron death") |
| pmid:21214928 | p(HGNC:BACE1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:21214928 | p(HGNC:BACE1) decreases bp(GO:memory) |
| pmid:21214928 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_713")) |
| pmid:21214928 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_711")) |
| pmid:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) |
| pmid:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) |
| pmid:22122372 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24590577 | p(HGNC:BACE1) increases a(HBP:C99) |
| pmid:21718217 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29758300 | p(HGNC:BACE1) increases p(HGNC:APP, frag("?")) |
| pmid:14556719 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) |
| pmid:30663117 | complex(g(HGNC:"MIR124-1"), r(HGNC:BACE1)) decreases act(r(HGNC:BACE1)) |
| pmid:30663117 | complex(g(HGNC:MIR15B), r(HGNC:BACE1)) decreases p(HGNC:BACE1) |
| pmid:30663117 | complex(g(HGNC:MIR339), r(HGNC:BACE1)) decreases p(HGNC:BACE1) |
| pmid:30663117 | complex(g(HGNC:MIR384), r(HGNC:BACE1)) decreases p(HGNC:BACE1) |
| pmid:30663117 | g(HGNC:MIR384) association path(MESH:"Alzheimer Disease") |
| pmid:30663117 | complex(g(HGNC:MIR384), r(HGNC:APP)) decreases p(HGNC:APP) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:WNT3A)) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:WNT5A)) |
| pmid:30232325 | p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pmid:11230871 | act(p(HGNC:APP)) association p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:DKK1)) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:DKK1)) |
| pmid:30232325 | p(HGNC:APP) increases bp(HBP:HBP00061) |
| pmid:10656250 | p(HGNC:APP, loc(GO:"endoplasmic reticulum")) association p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) |
| pmid:18650430 | p(HGNC:APP) increases bp(GO:"regulation of cell growth") |
| pmid:18650430 | p(HGNC:APP) increases bp(GO:"synapse assembly") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"synapse assembly") |
| pmid:18650430 | p(HGNC:APP) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:21214928 | p(HGNC:APP) association bp(MESH:"Neuronal Outgrowth") |
| pmid:18650430 | p(HGNC:APP) increases bp(GO:"cell adhesion") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"cell adhesion") |
| pmid:22122372 | p(HGNC:APP) increases bp(GO:"cell adhesion") |
| pmid:18650430 | p(HGNC:APP) regulates act(p(HGNC:SLC5A7)) |
| pmid:21214928 | p(HGNC:APP) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:APP) increases a(CHEBI:"amyloid-beta") |
| pmid:18930136 | deg(p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"signal transduction") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"calcium ion homeostasis") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"protein transport") |
| pmid:21214928 | p(HGNC:APP) regulates bp(GO:"protein transport") |
| pmid:21214928 | p(HGNC:APP) association p(HGNC:ITGB1) |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"anterograde axonal protein transport") |
| pmid:22122372 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:29758300 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:14556719 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:22122372 | p(HGNC:APP) association a(HBP:HBP00078) |
| pmid:22122372 | p(HGNC:APP) association a(HBP:HBP00079) |
| pmid:22122372 | p(HGNC:APP) association a(MESH:"Receptors, Cell Surface") |
| pmid:12428809 | p(HGNC:APP) association bp(GO:"axonal transport") |
| pmid:12428809 | sec(p(HGNC:APP)) association bp(GO:"regulation of neuronal synaptic plasticity") |
| pmid:12428809 | sec(p(HGNC:APP)) association bp(GO:"negative regulation of neuron apoptotic process") |
| pmid:22908190 | p(HGNC:APP) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | p(HGNC:APP) positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | p(HGNC:APP) increases a(GO:endosome) |
| pmid:22908190 | p(HGNC:APP) association a(GO:autophagosome) |
| pmid:26631930 | surf(p(HGNC:APP)) increases complex(p(HGNC:APP), p(HGNC:SLC40A1)) |
| pmid:27094130 | p(HGNC:APP) association p(HGNC:DAPK1, frag("637_1423")) |
| pmid:27094130 | p(HGNC:APP) association p(HGNC:DAPK1, frag("848_1423")) |
| pmid:27094130 | p(HGNC:APP) association p(HGNC:DAPK1, frag("1271_1423")) |
| pmid:30663117 | complex(g(HGNC:"MIR153-1"), r(HGNC:BACE1)) decreases p(HGNC:APP) |
| pmid:30663117 | g(HGNC:"MIR153-1") decreases p(HGNC:APP) |
| pmid:30663117 | g(HGNC:"MIR153-1") decreases a(CHEBI:"amyloid-beta") |
| pmid:30663117 | g(HGNC:"MIR153-1") association path(MESH:"Alzheimer Disease") |
| pmid:30663117 | g(HGNC:"MIR153-1") regulates p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:"MIR153-1") regulates p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:"MIR153-1") decreases path(MESH:"Parkinson Disease") |
| pmid:30663117 | p(HGNC:RANBP9) increases p(HGNC:APP) |
| pmid:30663117 | g(HGNC:"MIR101-1") decreases p(HGNC:APP) |
| pmid:30663117 | g(HGNC:"MIR101-1") decreases act(p(HGNC:APP)) |
| pmid:30663117 | g(HGNC:"MIR101-1") decreases act(p(HGNC:RANBP9)) |
| pmid:30663117 | g(HGNC:"MIR101-1") association path(MESH:"Alzheimer Disease") |
| pmid:30663117 | g(HGNC:"MIR101-1") decreases path(MESH:"Alzheimer Disease") |
| pmid:30663117 | act(p(HGNC:CAMKK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30663117 | act(p(HGNC:CAMKK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30663117 | p(HGNC:CAMKK2) increases act(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) |
| pmid:30663117 | p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") |
| pmid:21214928 | p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") |
| pmid:22122372 | p(HGNC:MAPT, pmod(Ph)) association bp(GO:"neurofibrillary tangle assembly") |
| pmid:19293145 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:FYN) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph)) association p(FPLX:PPP2, pmod(Me, Tyr, 307)) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) increases path(MESH:"Alzheimer Disease") |
| pmid:8282104 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29191965 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29191965 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29311797 | p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) decreases act(complex(GO:"proteasome complex")) |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) association complex(GO:"proteasome complex") |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) association bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MTOR) |
| pmid:29758300 | deg(p(HGNC:MAPT, pmod(Ph))) decreases bp(GO:"neuron death") |
| pmid:29758300 | deg(p(HGNC:MAPT, pmod(Ph))) decreases path(HBP:neuroinflammation) |
| pmid:29758300 | deg(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:cognition) |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:TREM2) |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ph)) decreases act(a(CHEBI:Thrombin)) |
| pmid:17403556 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(HBP:Neurodegeneration) |
| pmid:22611162 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:24760868 | p(HGNC:MAPT, pmod(Ph)) association act(p(HGNC:MAPT)) |
| pmid:26195256 | p(HGNC:MAPT, pmod(Ph)) decreases deg(p(HGNC:MAPT)) |
| pmid:21734277 | p(HGNC:MAPT, pmod(Ph)) association p(HBP:"AT8 tau", pmod(Ph)) |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:30985105 | p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | deg(p(HGNC:MAPT, pmod(Ph))) association p(HGNC:BAG2) |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(FPLX:AMPK)) |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(FPLX:AMPK) |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Retinal Degeneration") |
| pmid:29191965 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph)) decreases complex(a(MESH:Actins), p(HGNC:MAPT)) |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Pick body") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Cajal body") |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pmid:10464280 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pmid:19363271 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(FPLX:HSP90) |
| pmid:14963027 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:HSPB1) |
| pmid:14963027 | p(HGNC:MAPT, pmod(Ph)) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | act(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:"neuron apoptotic process") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph)) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pmid:17954934 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1) |
| pmid:23943618 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) |
| pmid:16630055 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:25378699 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:29062069 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(HGNC:PPP2CA)) |
| pmid:19401603 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation complex(GO:"tubulin complex") |
| pmid:24760868 | act(p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:26195256 | p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) |
| pmid:19293145 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles") |
| pmid:27574109 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pmid:26813123 | act(p(HGNC:MAPT)) association act(p(HGNC:CHRM1)) |
| pmid:24590577 | p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring") |
| pmid:24590577 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pmid:12428809 | p(HGNC:MAPT) association bp(GO:"axonal transport") |
| pmid:12428809 | p(HGNC:MAPT) increases bp(GO:"axonal transport") |
| pmid:21734277 | tloc(p(HGNC:MAPT)) causesNoChange bp(GO:"axonal transport") |
| pmid:28420982 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pmid:26631930 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pmid:25514383 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30126037 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29238289 | p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:29980653 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26837465 | p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(tscript)) |
| pmid:10391244 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:19277525 | p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:12428809 | p(HGNC:MAPT) increases bp(GO:"microtubule cytoskeleton organization") |
| pmid:12428809 | p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization") |
| pmid:12428809 | p(HGNC:MAPT) increases bp(GO:"axon development") |
| pmid:25378699 | deg(p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:24905733 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:29758300 | p(HGNC:MAPT) increases complex(a(GO:cytoskeleton), a(GO:microtubule)) |
| pmid:29758300 | p(HGNC:MAPT) increases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | p(HGNC:MAPT) causesNoChange bp(GO:"anterograde axonal protein transport") |
| pmid:29758300 | p(HGNC:MAPT) increases bp(GO:"retrograde axonal protein transport") |
| pmid:27373205 | p(HGNC:MAPT) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:29758300 | p(HGNC:MAPT) association path(MESH:Tauopathies) |
| pmid:29980653 | p(HGNC:MAPT) positiveCorrelation path(MESH:Tauopathies) |
| pmid:29758300 | p(HGNC:MAPT) association path(MESH:"Frontotemporal Dementia") |
| pmid:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:29758300 | p(HGNC:MAPT) association path(MESH:"Niemann-Pick Diseases") |
| pmid:29758300 | p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:30126037 | p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:29758300 | p(HGNC:MAPT) association p(HGNC:NBR1) |
| pmid:29758300 | p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2) |
| pmid:14556719 | p(HGNC:MAPT) association a(GO:microtubule) |
| pmid:25374103 | p(HGNC:MAPT) regulates act(a(GO:microtubule)) |
| pmid:28420982 | p(HGNC:MAPT) increases a(GO:microtubule) |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) negativeCorrelation a(GO:microtubule) |
| pmid:29626319 | p(HGNC:MAPT) increases a(GO:microtubule) |
| pmid:22908190 | p(HGNC:MAPT) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HGNC:MAPT) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HGNC:MAPT) association a(GO:"Lewy body") |
| pmid:22908190 | p(HGNC:MAPT) association a(GO:"Pick body") |
| pmid:27574109 | p(HGNC:MAPT) association a(GO:"Pick body") |
| pmid:22908190 | p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:26751493 | p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:22908190 | deg(p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) |
| pmid:30145931 | p(HGNC:MAPT) increases p(HGNC:SQSTM1) |
| pmid:30145931 | p(HGNC:MAPT, loc(MESH:Dendrites)) decreases a(MESH:"Dendritic Spines") |
| pmid:30116051 | p(HGNC:MAPT) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23528736 | deg(p(HGNC:MAPT)) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29215007 | p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") |
| pmid:24027553 | p(HGNC:MAPT) negativeCorrelation act(a(MESH:Neurons)) |
| pmid:26631930 | p(HGNC:MAPT) regulates act(a(MESH:Neurons)) |
| pmid:26631930 | p(HGNC:MAPT) increases a(MESH:Neurons) |
| pmid:26631930 | p(HGNC:MAPT) increases act(a(MESH:Neurons)) |
| pmid:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons)) |
| pmid:29238289 | sec(p(HGNC:MAPT)) increases act(a(MESH:Neurons)) |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:pretangles) |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:"Braak_Stage I") |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:"Braak_Stage II") |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:29590627 | p(HGNC:MAPT) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:26195256 | p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) |
| pmid:26195256 | p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) |
| pmid:26631930 | p(HGNC:MAPT) positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) positiveCorrelation p(HGNC:MAPT) |
| pmid:24760868 | p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity") |
| pmid:24760868 | p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity") |
| pmid:24760868 | p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:17187063 | p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | p(HGNC:MAPT) increases complex(complex(GO:"actin filament bundle"), p(HGNC:MAPT)) |
| pmid:24760868 | p(HGNC:MAPT) association complex(GO:"filamentous actin") |
| pmid:17187063 | p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin") |
| pmid:24760868 | p(HGNC:MAPT, loc(GO:synapse)) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:28528849 | p(HGNC:MAPT) causesNoChange a(GO:synapse) |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) decreases act(a(GO:synapse)) |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) decreases act(a(GO:synapse)) |
| pmid:26631930 | p(HGNC:MAPT) negativeCorrelation act(a(GO:synapse)) |
| pmid:25887395 | p(HGNC:MAPT) causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:29980653 | tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau fibrils") |
| pmid:25887395 | p(HGNC:MAPT) causesNoChange a(HBP:"Tau aggregates") |
| pmid:25374103 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(HBP:"Tau aggregates") |
| pmid:28420982 | sec(p(HGNC:MAPT)) association a(HBP:"Tau aggregates") |
| pmid:27373205 | p(HGNC:MAPT) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:29191965 | p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | deg(p(HGNC:MAPT)) negativeCorrelation bp(GO:aging) |
| pmid:21882945 | p(HGNC:MAPT) increases path(HBP:neurotoxicity) |
| pmid:21882945 | deg(p(HGNC:MAPT)) negativeCorrelation p(HGNC:AKT1) |
| pmid:30126037 | p(HGNC:MAPT) association path(MESH:"Brain Injuries, Traumatic") |
| pmid:22419736 | p(HGNC:MAPT) increases path(MESH:"Retinal Degeneration") |
| pmid:29191965 | p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBA1A)) |
| pmid:29191965 | p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBB)) |
| pmid:29191965 | p(HGNC:MAPT) association a(GO:"cell body") |
| pmid:25374103 | p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") |
| pmid:26631930 | p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") |
| pmid:28420982 | p(HGNC:MAPT) regulates bp(GO:"generation of neurons") |
| pmid:28420982 | p(HGNC:MAPT) increases bp(HP:Neurodegeneration) |
| pmid:28420982 | p(HGNC:MAPT) increases bp(GO:"cell death") |
| pmid:28420982 | p(HGNC:MAPT) association bp(GO:behavior) |
| pmid:28420982 | p(HGNC:MAPT) decreases bp(GO:"synaptic signaling") |
| pmid:28420982 | p(HGNC:MAPT) association bp(GO:"intracellular signal transduction") |
| pmid:28420982 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging) |
| pmid:28420982 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging) |
| pmid:28420982 | sec(p(HGNC:MAPT)) association a(MESH:Exosomes) |
| pmid:29238289 | p(HGNC:MAPT) association act(a(MESH:Exosomes)) |
| pmid:28420982 | sec(p(HGNC:MAPT)) association a(GO:microvesicle) |
| pmid:28420982 | p(HGNC:MAPT) increases a(CHEBI:"calcium(2+)") |
| pmid:28420982 | p(HGNC:MAPT) increases bp(GO:"neuron death") |
| pmid:29238289 | p(HGNC:MAPT) causesNoChange bp(GO:"neuron death") |
| pmid:26751493 | p(HGNC:MAPT) decreases act(p(HGNC:HDAC6)) |
| pmid:28760828 | p(HGNC:MAPT) positiveCorrelation p(HGNC:HDAC6) |
| pmid:26751493 | p(HGNC:MAPT) regulates bp(MESH:"Transcription, Genetic") |
| pmid:26751493 | p(HGNC:MAPT) decreases bp(GO:autophagy) |
| pmid:26751493 | p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pmid:26751493 | p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pmid:27373205 | p(HGNC:MAPT) increases a(HBP:"Tau oligomers") |
| pmid:26631930 | p(HGNC:MAPT) directlyIncreases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:18680553 | p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT) directlyIncreases p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) association path(HBP:Neurodegeneration) |
| pmid:26631930 | act(p(HGNC:MAPT)) decreases path(HBP:Neurodegeneration) |
| pmid:26631930 | p(HGNC:MAPT) association act(a(MESH:Dyneins)) |
| pmid:26631930 | p(HGNC:MAPT) association act(a(MESH:Kinesin)) |
| pmid:26631930 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pmid:22817713 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pmid:26631930 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pmid:22817713 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pmid:26631930 | p(HGNC:MAPT) decreases bp(GO:"retrograde axonal transport") |
| pmid:26631930 | p(HGNC:MAPT) increases act(p(HGNC:GSK3B)) |
| pmid:26631930 | p(HGNC:MAPT) increases act(p(HGNC:PPP1R8)) |
| pmid:26631930 | p(HGNC:MAPT) directlyIncreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:8391280 | p(HGNC:MAPT) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT) increases a(MESH:Neurites) |
| pmid:26631930 | p(HGNC:MAPT) association bp(GO:"regulation of synaptic plasticity") |
| pmid:26631930 | p(HGNC:MAPT) increases path(HBP:Excitotoxicity) |
| pmid:26631930 | p(HGNC:MAPT) association bp(GO:neurogenesis) |
| pmid:26631930 | p(HGNC:MAPT) increases bp(GO:neurogenesis) |
| pmid:26631930 | p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") |
| pmid:26631930 | p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") |
| pmid:26631930 | p(HGNC:MAPT) increases bp(GO:locomotion) |
| pmid:26631930 | p(HGNC:MAPT) increases tloc(p(HGNC:APP), fromLoc(GO:cytoplasm), toLoc(GO:"cell surface")) |
| pmid:26631930 | p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") |
| pmid:26631930 | p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") |
| pmid:26631930 | p(HGNC:MAPT) directlyIncreases complex(a(MESH:Actins), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT) increases act(a(MESH:Brain)) |
| pmid:26631930 | p(HGNC:MAPT) negativeCorrelation path(MESH:Dementia) |
| pmid:26631930 | p(HGNC:MAPT) increases bp(GO:"iron ion transport") |
| pmid:26631930 | p(HGNC:MAPT) increases bp(GO:"DNA protection") |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) regulates act(a(CHEBI:"amyloid-beta")) |
| pmid:26631930 | p(HGNC:MAPT) increases act(a(CHEBI:"amyloid-beta")) |
| pmid:26631930 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:26631930 | p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) |
| pmid:22817713 | p(HGNC:MAPT) association bp(GO:"regulation of microtubule cytoskeleton organization") |
| pmid:29626319 | p(HGNC:MAPT) decreases p(HGNC:PSMD7) |
| pmid:29238289 | p(HGNC:MAPT) association bp(GO:"microtubule polymerization") |
| pmid:2123288 | act(p(HGNC:MAPT)) increases bp(GO:"microtubule polymerization") |
| pmid:19459590 | act(p(HGNC:MAPT)) positiveCorrelation bp(GO:"microtubule polymerization") |
| pmid:29238289 | p(HGNC:MAPT) association a(MESH:Microtubules) |
| pmid:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) increases path(MESH:"Cytotoxicity, Immunologic") |
| pmid:29238289 | sec(p(HGNC:MAPT)) association p(HGNC:RAB7A) |
| pmid:29238289 | sec(p(HGNC:MAPT)) association p(HGNC:RAB1A) |
| pmid:29238289 | sec(p(HGNC:MAPT)) association a(MESH:"Transport Vesicles") |
| pmid:29238289 | p(HGNC:MAPT) decreases tloc(p(HBP:"Tau aggregates"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:1918161 | p(HGNC:MAPT) directlyIncreases complex(GO:microtubule) |
| pmid:6543144 | p(HGNC:MAPT) association complex(GO:microtubule) |
| pmid:10464280 | p(HGNC:MAPT) association complex(GO:microtubule) |
| pmid:1918161 | p(HGNC:MAPT) positiveCorrelation complex(GO:axon) |
| pmid:1918161 | p(HGNC:MAPT) positiveCorrelation complex(GO:"neuron projection") |
| pmid:6543144 | p(HGNC:MAPT) association complex(GO:neurofilament) |
| pmid:2446784 | p(HGNC:MAPT) association complex(GO:"polysomal ribosome") |
| pmid:11812770 | p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pmid:18680553 | p(HGNC:MAPT) association p(HGNC:FYN) |
| pmid:18680553 | p(HGNC:MAPT) association bp(GO:myelination) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145")) |
| pmid:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851")) |
| pmid:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57")) |
| pmid:18467332 | p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79")) |
| pmid:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pmid:10464280 | p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT)) |
| pmid:17954934 | p(HGNC:MAPT) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:17954934 | p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) |
| pmid:8391280 | p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein")) |
| pmid:20071522 | p(HGNC:MAPT) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:21367866 | deg(p(HGNC:MAPT)) negativeCorrelation act(p(FPLX:HSP90)) |
| pmid:2123288 | p(HGNC:MAPT) isA complex(p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | act(p(HGNC:MAPT)) negativeCorrelation complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2833519 | p(HGNC:MAPT) association p(HGNC:S100B) |
| pmid:2833519 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) |
| pmid:12551948 | p(HGNC:MAPT) association p(HGNC:YWHAZ) |
| pmid:12551948 | p(HGNC:MAPT) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pmid:21339331 | p(HGNC:MAPT) association p(HGNC:ANXA2) |
| pmid:21339331 | p(HGNC:MAPT) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:21131359 | p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA") |
| pmid:21131359 | p(HGNC:MAPT) isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pmid:21131359 | p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature") |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me2, Lys, 311)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 259)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 353)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 24)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 44)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 67)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 190)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 163)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 174)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 180)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 254)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Ub, Lys, 254)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 267)) |
| pmid:19251756 | p(HGNC:MAPT) association p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) |
| pmid:19251756 | p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| pmid:10537045 | p(HGNC:MAPT) positiveCorrelation p(HGNC:TGM2) |
| pmid:10537045 | p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pmid:24853415 | p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1) |
| pmid:24853415 | p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| pmid:19459590 | act(p(HGNC:MAPT)) negativeCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:25031639 | deg(p(HGNC:MAPT)) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:29540553 | p(HGNC:MAPT) negativeCorrelation p(MGI:Sirt3) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 16)) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 65)) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ac, Lys, 46)) |
| pmid:25652642 | a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:29196815 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") |
| pmid:24653673 | a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(Me, Tyr, 307)) |
| pmid:29758300 | a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?")) |
| pmid:22908190 | a(GO:"neurofibrillary tangle") association a(HBP:"paired helical filaments") |
| pmid:22908190 | a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin) |
| pmid:22908190 | a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:22908190 | a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation")) |
| pmid:22908190 | a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") |
| pmid:22908190 | a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:18930136 | a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1) |
| pmid:27671637 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") |
| pmid:30985105 | deg(a(GO:"neurofibrillary tangle")) negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) |
| pmid:23531502 | a(GO:"neurofibrillary tangle") positiveCorrelation act(a(CHEBI:acrolein)) |
| pmid:12578227 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) |
| pmid:12578227 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) |
| pmid:9099822 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNC:TGM2)) |
| pmid:11089576 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:11738469 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:8985134 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:18239272 | a(GO:"neurofibrillary tangle") association p(HBP:"Tau epitope, AT8") |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") |
| pmid:26118667 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"CDK5R1 p25") |
| pmid:22002427 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22002427 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) |
| pmid:30663117 | g(HGNC:"MIR9-1") decreases a(GO:"neurofibrillary tangle") |
| pmid:30663117 | g(HGNC:"MIR9-1") decreases act(p(HGNC:MAP2K2)) |
| pmid:30663117 | g(HGNC:"MIR9-1") association path(MESH:"Alzheimer Disease") |
| pmid:30663117 | act(p(HGNC:MAP2K2)) increases a(GO:"neurofibrillary tangle") |
| pmid:30663117 | a(MESH:"RNA, Long Noncoding") increases bp(GO:"apoptotic process") |
| pmid:28745240 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA) |
| pmid:27288790 | bp(GO:"apoptotic process") association p(FPLX:NFkappaB) |
| pmid:19293145 | bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:24653673 | bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK)) |
| pmid:24027553 | bp(GO:"apoptotic process") increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | bp(GO:"apoptotic process") increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) |
| pmid:26304819 | bp(GO:"apoptotic process") association r(HGNC:GAPDH) |
| pmid:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:30663117 | g(HGNC:EBF3) isA a(MESH:"RNA, Long Noncoding") |
| pmid:30663117 | bp(GO:"neuron death") increases g(MGI:Ebf3) |
| pmid:30444369 | bp(GO:"neuron death") association p(HGNC:SH3GL2) |
| pmid:29196815 | bp(GO:"neuron death") positiveCorrelation a(HBP:HBP00074) |
| pmid:21214928 | bp(GO:"neuron death") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) |
| pmid:22122372 | bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") |
| pmid:17009926 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25514383 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21787755 | bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR") |
| pmid:29758300 | bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases") |
| pmid:14556719 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:22908190 | bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A)) |
| pmid:24027553 | bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) |
| pmid:21882945 | bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) |
| pmid:28420982 | bp(GO:"neuron death") association path(MESH:Tauopathies) |
| pmid:30663117 | a(HBP:"alpha-synuclein aggregates") association path(MESH:"Parkinson Disease") |
| pmid:30663117 | a(HBP:"alpha-synuclein aggregates") increases path(MESH:"Parkinson Disease") |
| pmid:30663117 | a(HBP:"alpha-synuclein aggregates") decreases a(MESH:"Dopaminergic Neurons") |
| pmid:30663117 | a(HBP:"alpha-synuclein aggregates") negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") |
| pmid:29758300 | a(HBP:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | a(HBP:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") |
| pmid:14556719 | a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | a(HBP:"alpha-synuclein aggregates") decreases complex(GO:"proteasome complex") |
| pmid:30985105 | a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"neuron death") |
| pmid:30985105 | a(HBP:"alpha-synuclein aggregates") negativeCorrelation a(HBP:"alpha-synuclein oligomers") |
| pmid:21482353 | a(MESH:"Dopaminergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) |
| pmid:28901280 | a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) |
| pmid:14556719 | a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) |
| pmid:30663117 | p(HGNC:SNCA) association bp(GO:"synaptic transmission, dopaminergic") |
| pmid:30663117 | p(HGNC:SNCA) positiveCorrelation a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) |
| pmid:29758300 | p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:SNCA) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA) association path(MESH:"Parkinson Disease") |
| pmid:29980653 | p(HGNC:SNCA) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:29758300 | p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy") |
| pmid:14556719 | p(HGNC:SNCA) association p(HGNC:SNCAIP) |
| pmid:22908190 | p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) |
| pmid:14556719 | p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") |
| pmid:14556719 | p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") |
| pmid:30985105 | p(HGNC:SNCA) association bp(GO:"dopamine secretion") |
| pmid:14556719 | p(HGNC:SNCA) positiveCorrelation bp(HBP:"Alpha-synuclein Oligomerization") |
| pmid:14556719 | p(HGNC:SNCA) increases bp(GO:"apoptotic process") |
| pmid:14556719 | act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(Ub)) |
| pmid:14556719 | act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(Ub)) |
| pmid:14556719 | act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") |
| pmid:14556719 | p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") |
| pmid:22908190 | p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA)) |
| pmid:25784053 | p(HGNC:SNCA) decreases bp(GO:autophagy) |
| pmid:25784053 | p(HGNC:SNCA) decreases p(HGNC:RAB1A) |
| pmid:30985105 | p(HGNC:SNCA) regulates a(GO:"synaptic vesicle") |
| pmid:30985105 | p(HGNC:SNCA) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:29980653 | tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:30663117 | bp(GO:"synaptic transmission, dopaminergic") association p(HGNC:SNCA) |
| pmid:14556719 | bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:30663117 | p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") |
| pmid:18930136 | p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") |
| pmid:30985105 | p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") |
| pmid:30061532 | p(HGNC:SNCA, var("?")) association path(MESH:"Psychotic Disorders") |
| pmid:27491084 | p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration) |
| pmid:29758300 | p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy") |
| pmid:14556719 | p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") |
| pmid:18930136 | p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) |
| pmid:30116051 | p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") |
| pmid:30116051 | p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") |
| pmid:30116051 | p(HGNC:SNCA, var("?")) decreases complex(GO:"proteasome complex") |
| pmid:30663117 | a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) positiveCorrelation p(HGNC:SNCA) |
| pmid:22908190 | a(GO:"Lewy body") association a(MESH:Ubiquitin) |
| pmid:22908190 | a(GO:"Lewy body") association a(MESH:Ubiquitin) |
| pmid:22908190 | a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) |
| pmid:22908190 | a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) |
| pmid:22908190 | a(GO:"Lewy body") association p(HGNC:MAPT) |
| pmid:18930136 | a(GO:"Lewy body") association p(HGNC:SQSTM1) |
| pmid:30663117 | g(HGNC:"MIR7-1") regulates p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:"MIR7-1") decreases p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:"MIR7-1") regulates p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:"MIR7-1") decreases path(MESH:"Parkinson Disease") |
| pmid:30663117 | complex(g(HGNC:"MIR153-1"), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) |
| pmid:30663117 | complex(g(HGNC:"MIR153-1"), r(HGNC:SNCA)) decreases p(HGNC:SNCA) |
| pmid:30663117 | complex(g(HGNC:"MIR7-1"), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) |
| pmid:30663117 | complex(g(HGNC:"MIR7-1"), r(HGNC:SNCA)) decreases p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:MIR34B) increases p(HGNC:PARK7) |
| pmid:30663117 | g(HGNC:MIR34C) increases p(HGNC:PARK7) |
| pmid:30663117 | g(HGNC:MIR132) regulates p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:MIR132) decreases p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:MIR132) regulates p(HGNC:SNCA) |
| pmid:30663117 | g(HGNC:MIR132) association path(MESH:"Parkinson Disease") |
| pmid:30663117 | g(HGNC:MIR132) decreases path(MESH:"Parkinson Disease") |
| pmid:30663117 | g(HGNC:MIR132) association p(HGNC:NR4A2) |
| pmid:26631930 | g(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26631930 | g(HGNC:MIR132) decreases p(HBP:"4R tau") |
| pmid:30663117 | p(HGNC:NR4A2) association g(HGNC:MIR132) |
| pmid:30663117 | g(NCBIGENE:406950) association path(MESH:"Parkinson Disease") |
| pmid:30663117 | g(NCBIGENE:406950) decreases a(MESH:"HSP70 Heat-Shock Proteins") |
| pmid:30663117 | g(NCBIGENE:406950) negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") |
| pmid:30663117 | g(NCBIGENE:406950) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30663117 | a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation a(HBP:"alpha-synuclein aggregates") |
| pmid:30663117 | a(MESH:"HSP70 Heat-Shock Proteins") decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30663117 | a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation g(NCBIGENE:406950) |
| pmid:25374103 | a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) |
| pmid:30663117 | complex(a(MESH:"HSP70 Heat-Shock Proteins"), g(NCBIGENE:406950)) regulates act(a(MESH:"HSP70 Heat-Shock Proteins")) |
| pmid:30663117 | g(HGNC:MIR133B) decreases path(MESH:"Parkinson Disease") |
| pmid:30663117 | g(HGNC:MIR133B) regulates p(HGNC:SNCA) |
| pmid:30663117 | p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") |
| pmid:24113872 | p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:30663117 | p(HGNC:LRRK2) decreases g(HGNC:MIRLET7A1) |
| pmid:30663117 | p(HGNC:LRRK2) decreases act(g(HGNC:MIRLET7A1)) |
| pmid:30663117 | p(HGNC:LRRK2) decreases g(HGNC:MIR184) |
| pmid:30663117 | p(HGNC:LRRK2) decreases act(g(HGNC:MIR184)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates") |
| pmid:30663117 | p(HGNC:LRRK2, var("?")) increases bp(GO:"neuron death") |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) association bp(HBP:"APP processing") |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30663117 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") |
| pmid:30663117 | g(HGNC:MIR205) regulates p(HGNC:LRRK2) |
| pmid:30663117 | g(HGNC:MIR205) regulates p(HGNC:LRRK2) |
| pmid:30663117 | g(HGNC:MIRLET7A1) decreases p(HGNC:E2F1) |
| pmid:30663117 | g(HGNC:MIRLET7A1) decreases act(p(HGNC:E2F1)) |
| pmid:30663117 | g(HGNC:MIRLET7A1) decreases p(HGNC:TFDP1) |
| pmid:30663117 | g(HGNC:MIRLET7A1) decreases act(p(HGNC:TFDP1)) |
| pmid:30663117 | g(HGNC:MIR184) decreases p(HGNC:E2F1) |
| pmid:30663117 | g(HGNC:MIR184) decreases act(p(HGNC:E2F1)) |
| pmid:30663117 | g(HGNC:MIR184) decreases p(HGNC:TFDP1) |
| pmid:30663117 | g(HGNC:MIR184) decreases act(p(HGNC:TFDP1)) |
| pmid:30663117 | p(HGNC:PARK7) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30663117 | p(HGNC:PARK7) decreases bp(GO:"apoptotic process") |
| pmid:30663117 | p(HGNC:PARK7) decreases bp(GO:"neuron death") |
| pmid:30663117 | path(MESH:Chorea) association path(MESH:"Huntington Disease") |
| pmid:30663117 | path(MESH:Dementia) association path(MESH:"Huntington Disease") |
| pmid:19126755 | path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pmid:26813123 | path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:25514383 | path(MESH:Dementia) association bp(GO:aging) |
| pmid:29758300 | path(MESH:Dementia) association path(MESH:Tauopathies) |
| pmid:22908190 | path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") |
| pmid:22908190 | path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") |
| pmid:22908190 | path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) |
| pmid:26631930 | path(MESH:Dementia) negativeCorrelation p(HGNC:MAPT) |
| pmid:27314526 | path(MESH:Dementia) association sec(a(MESH:Interleukins)) |
| pmid:27314526 | path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) |
| pmid:27314526 | path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) |
| pmid:30663117 | path(MESH:"Deglutition Disorders") association path(MESH:"Huntington Disease") |
| pmid:30663117 | path(MESH:Aphasia) association path(MESH:"Huntington Disease") |
| pmid:30663117 | path(MESH:Seizures) association path(MESH:"Huntington Disease") |
| pmid:21787755 | path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR") |
| pmid:30663117 | p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases a(HBP:"huntingtin aggregates") |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases bp(GO:"cell cycle arrest") |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases act(p(HBP:"20 S Proteasome")) |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases sec(a(CHEBI:"cytochrome c")) |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") |
| pmid:25784053 | p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) |
| pmid:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pmid:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") |
| pmid:14556719 | p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) |
| pmid:30985105 | p(HGNC:HTT) association bp(GO:"vesicle transport along microtubule") |
| pmid:30985105 | p(HGNC:HTT) association p(HGNC:BDNF) |
| pmid:30985105 | p(HGNC:HTT) decreases bp(GO:"apoptotic process") |
| pmid:30663117 | g(HGNC:MIR196A1) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR206) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR301B) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR92B) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR378B) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR208B) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR449A) association path(MESH:"Huntington Disease") |
| pmid:30663117 | g(HGNC:MIR22) decreases bp(GO:"neuron death") |
| pmid:25681350 | a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| pmid:25681350 | r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha") |
| pmid:25681350 | r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6") |
| pmid:25681350 | r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1") |
| pmid:25681350 | r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 1 alpha") |
| pmid:25681350 | p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 6") |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases p(MGI:"signal transducer and activator of transcription 3") |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3")) |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma) |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") regulates p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases bp(GO:memory) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases bp(GO:learning) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918)) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(HBP:nitration)) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:ITGB1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES1) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES5) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases sec(a(CHEBI:"amyloid-beta")) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:"amyloid-beta") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:"amyloid-beta") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) |
| pmid:21958873 | complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) |
| pmid:25331948 | complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates bp(HBP:"APP processing") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(HBP:"APP processing") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HBP:C99) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) |
| pmid:28745240 | complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) |
| pmid:28745240 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") |
| pmid:28745240 | complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:25652642 | complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta") |
| pmid:25652642 | complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) |
| pmid:25652642 | act(complex(GO:"NF-kappaB complex")) increases path(HBP:neurotoxicity) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:"MIR9-1") |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155) |
| pmid:25652642 | complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339) |
| pmid:21958873 | complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP) |
| pmid:25331948 | complex(GO:"NF-kappaB complex") regulates r(HGNC:BACE1) |
| pmid:25681350 | p(MGI:"signal transducer and activator of transcription 3") association p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"signal transducer and activator of transcription 3") increases p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha")) |
| pmid:25681350 | act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"oncostatin M")) |
| pmid:25681350 | p(MGI:"oncostatin M") increases complex(GO:"NF-kappaB complex") |
| pmid:25681350 | p(MGI:"oncostatin M") increases p(MGI:"signal transducer and activator of transcription 3") |
| pmid:25681350 | p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) |
| pmid:25681350 | p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) |
| pmid:25681350 | p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"oncostatin M") increases path(MESH:Glioblastoma) |
| pmid:25681350 | p(MGI:"oncostatin M") regulates p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"oncostatin M") increases p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"oncostatin M") increases complex(p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha")) |
| pmid:25681350 | p(MGI:"oncostatin M") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") decreases p(MGI:"chemokine (C-X-C motif) ligand 15") |
| pmid:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") |
| pmid:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") |
| pmid:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") |
| pmid:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"signal transducer and activator of transcription 3") |
| pmid:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"reticuloendotheliosis oncogene") |
| pmid:25681350 | p(MGI:"chitinase-like 1") association p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") |
| pmid:25681350 | p(MGI:"chitinase-like 1") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | p(MGI:"chitinase-like 1") increases complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha")) |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"oncostatin M")) |
| pmid:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha")) |
| pmid:25681350 | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"oncostatin M")) |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") regulates p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha")) |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"oncostatin M")) |
| pmid:25681350 | p(MGI:"reticuloendotheliosis oncogene") association p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") association p(MGI:"chitinase-like 1") |
| pmid:25681350 | p(HGNC:IL1A) increases p(HGNC:RELB) |
| pmid:25681350 | p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1) |
| pmid:25681350 | p(HGNC:IL1A) causesNoChange r(HGNC:RELB) |
| pmid:28745240 | act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") |
| pmid:23702978 | p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) |
| pmid:23702978 | p(HGNC:IL1A) increases bp(GO:"inflammatory response") |
| pmid:25681350 | p(HGNC:RELB) causesNoChange p(HGNC:CHI3L1) |
| pmid:25681350 | p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25681350 | p(MGI:"tumor necrosis factor") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) |
| pmid:25681350 | p(MGI:"tumor necrosis factor") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) |
| pmid:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) regulates p(MGI:"chitinase-like 1") |
| pmid:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases p(MGI:"chitinase-like 1") |
| pmid:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:25681350 | complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:21718217 | r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25681350 | p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1) |
| pmid:25681350 | p(HGNC:OSM) causesNoChange r(HGNC:RELB) |
| pmid:25681350 | p(HGNC:RELA) causesNoChange p(HGNC:CHI3L1) |
| pmid:21329555 | p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21329555 | p(HGNC:RELA) increases r(HGNC:BACE1) |
| pmid:21329555 | p(HGNC:RELA) increases p(HGNC:BACE1) |
| pmid:21329555 | p(HGNC:RELA) increases p(HBP:C99) |
| pmid:21329555 | p(HGNC:RELA) causesNoChange p(HGNC:APP) |
| pmid:21329555 | p(HGNC:RELA) increases a(CHEBI:"amyloid-beta") |
| pmid:28745240 | p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") |
| pmid:28745240 | p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation") |
| pmid:28745240 | p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:27288790 | act(p(HGNC:RELA)) increases bp(GO:"apoptotic process") |
| pmid:27288790 | p(HGNC:RELA) decreases bp(GO:"neuron apoptotic process") |
| pmid:25681350 | p(HGNC:STAT3) causesNoChange p(HGNC:CHI3L1) |
| pmid:28745240 | p(HGNC:STAT3) increases bp(GO:"astrocyte development") |
| pmid:19293145 | act(p(HGNC:STAT3)) association p(HGNC:JAK2) |
| pmid:19293145 | act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine)) |
| pmid:30116051 | p(HGNC:STAT3) decreases bp(GO:macroautophagy) |
| pmid:25681350 | path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1") |
| pmid:25681350 | path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| pmid:25681350 | composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) |
| pmid:21329555 | complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) regulates r(HGNC:BACE1) |
| pmid:21329555 | act(p(FPLX:NFkappaB), ma(tscript)) increases r(HGNC:BACE1) |
| pmid:29179999 | act(p(FPLX:NFkappaB)) association bp(GO:"inflammatory response") |
| pmid:29179999 | tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases bp(GO:"inflammatory response") |
| pmid:27288790 | p(FPLX:NFkappaB) regulates bp(GO:"inflammatory response") |
| pmid:29179999 | p(FPLX:NFkappaB) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | act(p(FPLX:NFkappaB)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29179999 | act(p(FPLX:NFkappaB)) association path(HP:Neurodegeneration) |
| pmid:29179999 | act(p(FPLX:NFkappaB)) regulates p(FPLX:"NADPH_oxidase") |
| pmid:29179999 | act(p(FPLX:NFkappaB)) regulates p(HGNC:PTGS2) |
| pmid:27288790 | p(FPLX:NFkappaB) regulates p(HGNC:PTGS2) |
| pmid:29179999 | act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins) |
| pmid:29179999 | act(p(FPLX:NFkappaB)) regulates p(FPLX:SOD) |
| pmid:29179999 | act(p(FPLX:NFkappaB)) increases p(HGNC:BACE1) |
| pmid:27288790 | p(FPLX:NFkappaB) association path(MESH:Inflammation) |
| pmid:27288790 | p(FPLX:NFkappaB) association bp(GO:"negative regulation of neuron apoptotic process") |
| pmid:27288790 | p(FPLX:NFkappaB) association bp(GO:"neuron differentiation") |
| pmid:27288790 | p(FPLX:NFkappaB) association bp(GO:"apoptotic process") |
| pmid:27288790 | p(FPLX:NFkappaB) association bp(MESH:"Neuronal Outgrowth") |
| pmid:27288790 | p(FPLX:NFkappaB) association bp(GO:"regulation of synaptic plasticity") |
| pmid:27288790 | act(p(FPLX:NFkappaB)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | act(p(FPLX:NFkappaB)) increases complex(a(MESH:DNA), p(FPLX:NFkappaB)) |
| pmid:27288790 | act(p(FPLX:NFkappaB)) increases p(HGNC:IL1B) |
| pmid:27288790 | act(p(FPLX:NFkappaB)) increases p(HGNC:TNF) |
| pmid:27288790 | act(p(FPLX:NFkappaB)) decreases p(HGNC:UCHL1) |
| pmid:27288790 | p(FPLX:NFkappaB) regulates act(p(HGNC:NOS2)) |
| pmid:27288790 | act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) |
| pmid:27288790 | act(p(FPLX:NFkappaB)) increases a(MESH:Chemokines) |
| pmid:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-1") |
| pmid:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-2") |
| pmid:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-146a") |
| pmid:27288790 | p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-155") |
| pmid:27288790 | act(p(FPLX:NFkappaB), ma(tscript)) increases m(MIRBASE:"hsa-mir-155") |
| pmid:30640040 | p(FPLX:NFkappaB) association a(PUBCHEM:5318517) |
| pmid:26118667 | p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) |
| pmid:21329555 | complex(g(HGNC:BACE1), p(HGNC:RELA)) increases r(HGNC:BACE1) |
| pmid:21329555 | p(HGNC:NFKBIA) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) |
| pmid:21329555 | bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation) |
| pmid:21329555 | bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") |
| pmid:21329555 | path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") |
| pmid:21329555 | p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling") |
| pmid:21329555 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pmid:21329555 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pmid:25331948 | p(HGNC:TNF) increases r(HGNC:BACE1) |
| pmid:21329555 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(tscript)) |
| pmid:29179999 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) |
| pmid:28745240 | p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:21958873 | p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28745240 | p(HGNC:TNF) increases path(HBP:neurotoxicity) |
| pmid:28745240 | p(HGNC:TNF) increases bp(GO:"neuron death") |
| pmid:27288790 | p(HGNC:TNF) increases p(FPLX:"IKK_complex", pmod(Ph)) |
| pmid:27288790 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:27288790 | p(HGNC:TNF) decreases p(FPLX:IKB) |
| pmid:27288790 | p(HGNC:TNF) increases a(MESH:Cytokines) |
| pmid:27288790 | p(HGNC:TNF) increases a(MESH:Chemokines) |
| pmid:27288790 | p(HGNC:TNF) increases act(p(HGNC:BACE1)) |
| pmid:21958873 | p(HGNC:TNF) increases p(HGNC:BACE1) |
| pmid:25331948 | p(HGNC:TNF) increases p(HGNC:BACE1) |
| pmid:27288790 | p(HGNC:TNF) increases act(p(FPLX:ERK)) |
| pmid:27288790 | p(HGNC:TNF) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:25652642 | p(HGNC:TNF) increases p(HGNC:NGF) |
| pmid:25652642 | p(HGNC:TNF) increases p(HGNC:BCL2) |
| pmid:19126755 | p(HGNC:TNF) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | p(HGNC:TNF) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) |
| pmid:23178521 | p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:25331948 | p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:21329555 | a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) |
| pmid:21329555 | a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) |
| pmid:21329555 | a(CHEBI:"acetylsalicylic acid") isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pmid:21329555 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases r(HGNC:BACE1) |
| pmid:27288790 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:BACE1)) |
| pmid:19126755 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) |
| pmid:19126755 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) |
| pmid:21329555 | a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pmid:27288790 | a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pmid:21329555 | a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) |
| pmid:27288790 | a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) |
| pmid:27288790 | a(CHEBI:ibuprofen) decreases a(CHEBI:"amyloid-beta") |
| pmid:21329555 | a(PUBCHEM:3715) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pmid:21329555 | a(PUBCHEM:3715) decreases r(HGNC:BACE1) |
| pmid:28745240 | p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) |
| pmid:26813123 | p(HGNC:SYP) association bp(GO:memory) |
| pmid:28745240 | p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation") |
| pmid:28745240 | p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") |
| pmid:28745240 | p(HGNC:NFKB1) increases bp(GO:learning) |
| pmid:28745240 | p(HGNC:NFKB1) increases path(MESH:Anxiety) |
| pmid:27288790 | act(p(HGNC:NFKB1)) increases bp(GO:"apoptotic process") |
| pmid:23702978 | p(HGNC:NFKB1) increases p(HGNC:IL1B) |
| pmid:28745240 | a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) |
| pmid:30061532 | act(a(GO:synapse)) association path(HBP:Neurodegeneration) |
| pmid:30061532 | a(GO:synapse) association p(HGNC:DISC1) |
| pmid:26813123 | a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:25514383 | a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28445721 | act(a(GO:synapse)) regulates p(FPLX:CHRN) |
| pmid:30106381 | act(a(GO:synapse)) association p(HGNC:ADNP) |
| pmid:30106381 | act(a(GO:synapse)) association a(PUBCHEM:9832404) |
| pmid:22908190 | act(a(GO:synapse)) positiveCorrelation bp(GO:cognition) |
| pmid:22908190 | act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid") |
| pmid:22908190 | act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) |
| pmid:26631930 | act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse")) |
| pmid:26631930 | act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT) |
| pmid:27807169 | a(GO:synapse) positiveCorrelation p(RGD:Cdk5r2) |
| pmid:22156579 | a(GO:synapse) negativeCorrelation p(HGNC:MARK4) |
| pmid:28745240 | complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) |
| pmid:28745240 | complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) |
| pmid:25652642 | act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") |
| pmid:21214928 | bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta") |
| pmid:26813123 | bp(MESH:"Synaptic Transmission") association bp(GO:memory) |
| pmid:14556719 | bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) |
| pmid:28745240 | bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1) |
| pmid:28745240 | bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA) |
| pmid:19126755 | bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") |
| pmid:24511233 | bp(GO:"long-term synaptic potentiation") association bp(GO:learning) |
| pmid:24511233 | bp(GO:"long-term synaptic potentiation") association bp(GO:memory) |
| pmid:21787755 | bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR") |
| pmid:22908190 | bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") decreases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.T205A"), loc(MESH:"Dendritic Spines")) |
| pmid:21882945 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) |
| pmid:28745240 | p(HGNC:REL) increases bp(GO:"long-term synaptic depression") |
| pmid:28745240 | bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) |
| pmid:28745240 | bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) |
| pmid:22908190 | bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) |
| pmid:28745240 | a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) |
| pmid:25652642 | a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) |
| pmid:25652642 | a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) |
| pmid:16273023 | a(CHEBI:"glutamate(1-)") association path(MESH:D013850) |
| pmid:16273023 | a(CHEBI:"glutamate(1-)") association path(MESH:D008568) |
| pmid:27087442 | a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25") |
| pmid:28745240 | act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | path(HBP:Excitotoxicity) increases bp(GO:"neuron death") |
| pmid:24027553 | path(HBP:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:24027553 | path(HBP:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:28745240 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") |
| pmid:28745240 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) |
| pmid:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064) |
| pmid:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065) |
| pmid:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064) |
| pmid:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065) |
| pmid:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063) |
| pmid:25514383 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:24653673 | a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") |
| pmid:26751493 | a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") |
| pmid:27796283 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) |
| pmid:27796283 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph)) |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8") |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, PHF1") |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, AT180") |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases a(HBP:"Tau epitope, AT100") |
| pmid:28745240 | bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A)) |
| pmid:28745240 | bp(GO:"calcium ion import") increases act(p(FPLX:PKC)) |
| pmid:28745240 | bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex")) |
| pmid:28745240 | bp(GO:"calcium ion import") increases act(p(FPLX:AKT)) |
| pmid:26813123 | bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) |
| pmid:28745240 | act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex")) |
| pmid:28745240 | act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) |
| pmid:22122372 | p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:26631930 | p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex")) |
| pmid:28745240 | act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) |
| pmid:18650430 | p(FPLX:PKC) increases sec(p(HGNC:APP)) |
| pmid:24590577 | act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) |
| pmid:26813123 | p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(Ph)) |
| pmid:26813123 | p(FPLX:PKC) increases p(FPLX:CHRN, pmod(Ph)) |
| pmid:24590577 | act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) |
| pmid:24590577 | act(p(FPLX:PKC)) increases p(HGNC:BACE1) |
| pmid:24590577 | act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) |
| pmid:17493042 | p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:28745240 | act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex")) |
| pmid:28745240 | act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) |
| pmid:28745240 | act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex")) |
| pmid:28745240 | act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) |
| pmid:27288790 | act(p(FPLX:AKT)) increases p(HGNC:RELA) |
| pmid:30061532 | p(FPLX:AKT) regulates act(p(HGNC:MTOR)) |
| pmid:19293145 | act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") |
| pmid:23454242 | p(FPLX:AKT) regulates bp(GO:"apoptotic process") |
| pmid:19293145 | p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") |
| pmid:25514383 | act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) |
| DOI:10.4172/2168-975X.1000126 | p(FPLX:AKT) directlyIncreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25331948 | p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29121589 | p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:23454242 | p(FPLX:AKT) regulates bp(GO:"cell growth") |
| pmid:23454242 | p(FPLX:AKT) regulates bp(GO:"cell population proliferation") |
| pmid:29121589 | p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) |
| pmid:28745240 | act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(MESH:"I-kappa B Kinase", pmod(Ph)) increases act(complex(GO:"IkappaB kinase complex")) |
| pmid:24511233 | bp(GO:behavior) association path(MESH:Schizophrenia) |
| pmid:24511233 | bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:28420982 | bp(GO:behavior) association p(HGNC:MAPT) |
| pmid:17009926 | path(MESH:Anxiety) association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:Anxiety) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:28901280 | path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") |
| pmid:28775333 | path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) |
| pmid:28745240 | act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) |
| pmid:21214928 | p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta") |
| pmid:8282104 | p(HGNC:PRKACA) association a(GO:microtubule) |
| pmid:8282104 | p(HGNC:PRKACA) association a(HBP:HBP00006) |
| pmid:28745240 | act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") |
| pmid:28745240 | bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:21214928 | bp(GO:"calcium ion homeostasis") association p(HGNC:APP) |
| pmid:19293145 | bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:29758300 | bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1) |
| pmid:28745240 | bp(MESH:"Oxidative Stress") association a(CHEBI:"amyloid-beta") |
| pmid:28745240 | bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") |
| pmid:25652642 | bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") |
| pmid:27623715 | bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") |
| pmid:22020111 | bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") |
| pmid:22020111 | bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | bp(MESH:"Oxidative Stress") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | bp(MESH:"Oxidative Stress") increases path(MESH:Aging) |
| pmid:26195256 | bp(MESH:"Oxidative Stress") decreases bp(GO:"establishment of blood-brain barrier") |
| pmid:21131359 | bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pmid:27623715 | bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) |
| pmid:27623715 | bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") |
| pmid:27623715 | bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) |
| pmid:27623715 | bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") |
| pmid:27623715 | bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") |
| pmid:23722080 | bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) |
| pmid:24355211 | bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) |
| pmid:8226987 | bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:7667312 | bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments") |
| pmid:28745240 | bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") |
| pmid:28745240 | bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") |
| pmid:28745240 | bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918)) |
| pmid:28745240 | p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") |
| pmid:30444369 | p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") |
| pmid:25652642 | act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:28745240 | p(HGNC:BCL2) decreases bp(GO:"apoptotic process") |
| pmid:30444369 | p(HGNC:BCL2) decreases bp(GO:"apoptotic process") |
| pmid:23528736 | p(HGNC:BCL2) decreases bp(GO:autophagy) |
| pmid:28745240 | p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process") |
| pmid:28745240 | a(CHEBI:etoposide) increases bp(GO:"apoptotic process") |
| pmid:29196815 | a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") |
| pmid:18650430 | a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") |
| pmid:22122372 | a(MESH:"Amyloid beta-Peptides") association a(HBP:HBP00018) |
| pmid:11230871 | a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) |
| pmid:14556719 | a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") |
| pmid:28745240 | p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress") |
| pmid:28745240 | p(HGNC:SOD2) decreases bp(GO:"apoptotic process") |
| pmid:25652642 | act(p(HGNC:SOD2)) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:24563850 | p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) |
| pmid:28745240 | a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(HBP:nitration)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:21210655 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:formylation, Lys)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(Ph)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:nitration)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:27314526 | a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") |
| pmid:27314526 | a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") |
| pmid:28745240 | composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) |
| pmid:28745240 | composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) |
| pmid:19293145 | bp(MESH:Neuroprotection) association p(HGNC:FYN) |
| pmid:19293145 | bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | bp(MESH:Neuroprotection) association a(MESH:Calcineurin) |
| pmid:19293145 | bp(MESH:Neuroprotection) association p(HGNC:JAK2) |
| pmid:19721446 | bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) |
| pmid:19721446 | bp(MESH:Neuroprotection) association a(CHEBI:nicotine) |
| pmid:28745240 | composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) |
| pmid:28745240 | composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) |
| pmid:24653673 | bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK)) |
| pmid:26631930 | bp(GO:neurogenesis) association p(HGNC:MAPT) |
| pmid:28745240 | p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:26304819 | p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28745240 | path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis) |
| pmid:28745240 | path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis) |
| pmid:30126037 | path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) |
| pmid:26195256 | path(MESH:"Brain Injuries, Traumatic") association p(HBP:"tau aggregates") |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") |
| pmid:24561250 | path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") |
| pmid:28745240 | a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis) |
| pmid:29179999 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:PKC)) |
| pmid:29179999 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:ERK)) |
| pmid:29179999 | a(CHEBI:"reactive oxygen species") increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") regulates act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex")) |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") association bp(MESH:"Membrane Fluidity") |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") association bp(GO:"ion transport") |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") decreases bp(GO:autophagy) |
| pmid:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"reactive oxygen species") negativeCorrelation bp(GO:autophagy) |
| pmid:27288790 | a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:30061532 | a(CHEBI:"reactive oxygen species") association path(MESH:Schizophrenia) |
| pmid:24563850 | a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response") |
| pmid:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia") |
| pmid:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation") |
| pmid:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation") |
| pmid:24563850 | a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation") |
| pmid:28528849 | a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NADPH oxidase complex")) |
| pmid:23702978 | a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) |
| pmid:23702978 | a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") |
| pmid:28745240 | path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | path(MESH:Hypoxia) increases bp(GO:neurogenesis) |
| pmid:28745240 | p(HBP:"sAPP-alpha") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HBP:"sAPP-alpha") increases bp(GO:neurogenesis) |
| pmid:28745240 | a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis) |
| pmid:28745240 | a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis) |
| pmid:29559585 | a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(NO)) |
| pmid:27601475 | a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP") |
| pmid:23702978 | a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO)) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") |
| pmid:28745240 | path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:cognition) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:learning) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:learning) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:memory) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:memory) |
| pmid:24590577 | a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) |
| pmid:26195256 | a(MESH:"Cerebral Cortex") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28745240 | p(HGNC:IL6) increases bp(GO:"astrocyte development") |
| pmid:28745240 | p(HGNC:IL6) increases p(HGNC:STAT3) |
| pmid:28745240 | p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1") |
| pmid:28745240 | p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:IL6) association path(MESH:"Alzheimer Disease") |
| pmid:25652642 | p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28745240 | p(HGNC:IL6) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28745240 | p(HGNC:IL6) increases bp(GO:"neuron death") |
| pmid:28745240 | a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development") |
| pmid:28745240 | p(HGNC:LIF) increases bp(GO:"astrocyte development") |
| pmid:28745240 | p(HGNC:LIF) increases p(HGNC:STAT3) |
| pmid:28745240 | p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1") |
| pmid:28745240 | p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:CNTF) increases bp(GO:"astrocyte development") |
| pmid:28745240 | p(HGNC:CNTF) increases p(HGNC:STAT3) |
| pmid:28745240 | p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") |
| pmid:28745240 | p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | p(HGNC:CNTF) increases act(p(HGNC:LCK)) |
| pmid:28745240 | bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(Ph, Ser, 536)) |
| pmid:27288790 | bp(MESH:"Neuronal Outgrowth") association p(FPLX:NFkappaB) |
| pmid:21214928 | bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) |
| pmid:23383175 | act(a(GO:axon)) decreases path(MESH:Paralysis) |
| pmid:23383175 | act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") |
| pmid:28745240 | p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:BDNF) increases act(p(HGNC:SRC)) |
| pmid:22040696 | p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") |
| pmid:22040696 | p(HGNC:BDNF) regulates bp(GO:"central nervous system development") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") |
| pmid:22040696 | p(HGNC:BDNF) association p(HGNC:CHRNA7) |
| pmid:22040696 | p(HGNC:BDNF) increases p(HGNC:CHRNA7) |
| pmid:22040696 | p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7)) |
| pmid:30985105 | p(HGNC:BDNF) association p(HGNC:HTT) |
| pmid:28632203 | p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28745240 | act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) |
| pmid:19293145 | p(HGNC:SRC) increases bp(MESH:Neuroprotection) |
| pmid:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) |
| pmid:29191965 | p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:26751493 | p(HGNC:SRC) association p(HBP:"projection domain") |
| pmid:18467332 | p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pmid:26751493 | p(HGNC:SRC) association a(HBP:"projection domain") |
| pmid:28745240 | p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) |
| pmid:30640040 | p(HGNC:LCK) association a(PUBCHEM:4878) |
| pmid:29191965 | p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:26751493 | p(HGNC:LCK) association p(HBP:"projection domain") |
| pmid:26631930 | p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26751493 | p(HGNC:LCK) association a(HBP:"projection domain") |
| pmid:28745240 | p(HGNC:RELA, pmod(Ph, Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth") |
| pmid:28745240 | bp(GO:"axon guidance") increases bp(GO:neurogenesis) |
| pmid:28745240 | bp(GO:"axon guidance") increases a(GO:axon) |
| pmid:28745240 | p(HGNC:ITGB1) increases bp(GO:"axon guidance") |
| pmid:28745240 | p(HGNC:ITGB1) increases a(GO:axon) |
| pmid:21214928 | p(HGNC:ITGB1) association p(HGNC:APP) |
| pmid:28745240 | p(HGNC:NCAM1) increases a(GO:axon) |
| pmid:28745240 | p(HGNC:SLITRK1) increases a(GO:axon) |
| pmid:28745240 | p(HGNC:GFRA1) increases a(GO:axon) |
| pmid:28745240 | p(HGNC:TIAM1) increases a(GO:axon) |
| pmid:22020111 | act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") |
| pmid:28745240 | p(HGNC:HES1) increases a(GO:"dendritic branch") |
| pmid:28745240 | p(HGNC:HES1) increases a(MESH:"Dendritic Cells") |
| pmid:28745240 | p(HGNC:HES5) increases a(GO:"dendritic branch") |
| pmid:28745240 | p(HGNC:HES5) increases a(MESH:"Dendritic Cells") |
| pmid:28745240 | p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells") |
| pmid:28745240 | p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") |
| pmid:30061532 | p(HGNC:MAP2) increases a(GO:microtubule) |
| pmid:30061532 | p(HGNC:MAP2) increases bp(GO:"dendritic spine organization") |
| pmid:30061532 | p(HGNC:MAP2) increases bp(GO:"cytoskeleton organization") |
| pmid:28745240 | complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:IL1B) increases bp(GO:"neuron death") |
| pmid:27288790 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24561250 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27314526 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | p(HGNC:IL1B) increases p(FPLX:"IKK_complex", pmod(Ph)) |
| pmid:27288790 | p(HGNC:IL1B) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:27288790 | p(HGNC:IL1B) decreases p(FPLX:IKB) |
| pmid:27288790 | p(HGNC:IL1B) increases a(MESH:Cytokines) |
| pmid:27288790 | p(HGNC:IL1B) increases a(MESH:Chemokines) |
| pmid:23702978 | act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") |
| pmid:24561250 | p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") |
| pmid:24561250 | p(HGNC:IL1B) increases bp(GO:"inflammatory response") |
| pmid:27314526 | p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) |
| pmid:27314526 | p(HGNC:IL1B) increases bp(GO:"microglial cell activation") |
| pmid:27314526 | p(HGNC:IL1B) increases bp(GO:"astrocyte activation") |
| pmid:27314526 | sec(p(HGNC:IL1B)) increases p(HGNC:APP) |
| pmid:27314526 | sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta") |
| pmid:28745240 | bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:25514383 | bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates") |
| pmid:27314526 | bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") |
| pmid:30145931 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn") |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26118667 | complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) |
| pmid:28745240 | act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:30444369 | p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:CDK5) association path(MESH:"Alzheimer Disease") |
| pmid:8282104 | p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30444369 | p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(Ph, Thr, 89)) |
| pmid:22122372 | p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:30061532 | p(HGNC:CDK5) regulates p(HGNC:DPYSL2) |
| pmid:30061532 | p(HGNC:CDK5) positiveCorrelation a(GO:"dendritic spine") |
| pmid:30061532 | p(HGNC:CDK5) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25001178 | act(p(HGNC:CDK5), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30061532 | act(p(HGNC:CDK5)) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:CDK5R1) |
| pmid:24653673 | act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") |
| pmid:24653673 | act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton") |
| pmid:24653673 | act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(Ph)) |
| pmid:24653673 | act(p(HGNC:CDK5)) negativeCorrelation bp(HBP:"APP processing") |
| pmid:24653673 | act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis) |
| pmid:24653673 | act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") |
| pmid:24653673 | act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process") |
| pmid:12428809 | p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29758300 | p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27314526 | p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HBP:HBP00053, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(HGNC:CDK5) association a(GO:microtubule) |
| pmid:8282104 | p(HGNC:CDK5) association a(HBP:HBP00006) |
| pmid:8282104 | p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) |
| pmid:21882945 | p(HGNC:CDK5) increases act(p(HGNC:MARK2)) |
| pmid:21367866 | act(p(HGNC:CDK5)) positiveCorrelation p(HGNC:CDC37) |
| pmid:27796283 | p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(Ph, Thr, 345)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) |
| pmid:8702879 | act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) |
| pmid:8702879 | act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553)) |
| pmid:26118667 | p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) |
| pmid:25001178 | act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin)) |
| pmid:30061532 | p(HGNC:CDK5R1) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:CDK5R1) negativeCorrelation act(p(HGNC:CDK5)) |
| pmid:21548880 | p(HGNC:CDK5R1) increases act(p(HGNC:CDK5)) |
| pmid:26118667 | p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) |
| pmid:26118667 | p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25") |
| pmid:19126755 | path(HBP:neurotoxicity) association a(CHEBI:nicotine) |
| pmid:19293145 | path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers") |
| pmid:19293145 | path(HBP:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:22908190 | path(HBP:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24027553 | path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:25652642 | bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:24653673 | bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | bp(HBP:"APP processing") negativeCorrelation act(p(FPLX:ERK)) |
| pmid:30116051 | bp(HBP:"APP processing") association p(HGNC:LRRK2, var("?")) |
| pmid:24027553 | bp(HBP:"APP processing") association p(HGNC:HTRA1) |
| pmid:24027553 | bp(HBP:"APP processing") association path(MESH:"Alzheimer Disease") |
| pmid:28745240 | complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1) |
| pmid:28745240 | complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) |
| pmid:28745240 | complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1) |
| pmid:28745240 | complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1) |
| pmid:28745240 | complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL)) |
| pmid:28745240 | complex(GO:"gamma-secretase complex") regulates p(HBP:C99) |
| pmid:29758300 | complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?")) |
| pmid:14556719 | complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) |
| pmid:14556719 | act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) |
| pmid:14556719 | act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) |
| pmid:21214928 | p(HGNC:PSEN1) regulates p(HGNC:APP) |
| pmid:19293145 | p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration) |
| pmid:19293145 | p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis") |
| pmid:29758300 | p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH") |
| pmid:22908190 | p(HGNC:PSEN1) increases bp(GO:"pH reduction") |
| pmid:22908190 | p(HGNC:PSEN1) increases act(a(MESH:Cathepsins)) |
| pmid:22908190 | p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(NGlyco)) |
| pmid:24027553 | p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") |
| pmid:28745240 | act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:28745240 | p(HGNC:SIRT1) decreases path(HBP:neurotoxicity) |
| pmid:22020111 | p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(Ac)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) negativeCorrelation bp(GO:aging) |
| pmid:26631930 | p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac, Lys)) |
| pmid:20869593 | act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) |
| pmid:20869593 | act(p(HGNC:SIRT1)) negativeCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:29540553 | act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:29540553 | act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading") |
| pmid:29540553 | act(p(HGNC:SIRT1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29540553 | p(HGNC:SIRT1) positiveCorrelation bp(GO:learning) |
| pmid:29540553 | p(HGNC:SIRT1) positiveCorrelation bp(GO:memory) |
| pmid:29226865 | act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(Ac, Lys, 52)) |
| pmid:28745240 | a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:19293145 | a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(MESH:Calcineurin) association bp(MESH:Neuroprotection) |
| pmid:28745240 | p(HGNC:CXCL8) increases bp(GO:"neuron death") |
| pmid:27288790 | p(FPLX:ERK) increases act(p(FPLX:NFkappaB)) |
| pmid:19293145 | p(FPLX:ERK) association a(CHEBI:nicotine) |
| pmid:24653673 | act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") |
| pmid:24653673 | act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton") |
| pmid:24653673 | act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(Ph)) |
| pmid:24653673 | act(p(FPLX:ERK)) negativeCorrelation bp(HBP:"APP processing") |
| pmid:24653673 | act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis) |
| pmid:24653673 | act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") |
| pmid:24653673 | act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process") |
| pmid:12428809 | p(FPLX:ERK) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(FPLX:ERK) association a(GO:microtubule) |
| pmid:8282104 | p(FPLX:ERK) association a(HBP:HBP00006) |
| pmid:8282104 | p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) |
| pmid:8282104 | p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27594586 | p(FPLX:ERK) regulates p(HGNC:MMP9) |
| pmid:24686445 | act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B)) |
| pmid:29179999 | path(HP:Neurodegeneration) association act(p(FPLX:NFkappaB)) |
| pmid:27491084 | path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?")) |
| pmid:27491084 | path(HP:Neurodegeneration) association p(HGNC:AR, var("?")) |
| pmid:27491084 | path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?")) |
| pmid:23528736 | path(HP:Neurodegeneration) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:24563850 | act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) |
| pmid:24563850 | act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species") |
| pmid:24563850 | act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive nitrogen species") |
| pmid:27288790 | p(HGNC:PTGS2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | p(HGNC:PTGS2) association a(HBP:"amyloid-beta aggregates") |
| pmid:27288790 | p(HGNC:PTGS2) increases path(MESH:Inflammation) |
| pmid:19126755 | act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") |
| pmid:19126755 | p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") |
| pmid:19126755 | p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") |
| pmid:19126755 | p(HGNC:PTGS2) association p(HGNC:CHRNA4) |
| pmid:27314526 | sec(a(MESH:Interleukins)) association path(MESH:Dementia) |
| pmid:27314526 | sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) |
| pmid:29179999 | a(CHEBI:curcumin) decreases bp(GO:"inflammatory response") |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:LOX) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:NOS2) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:TNF) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL1A) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL2) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL6) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:CXCL8) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:IL12B) |
| pmid:29179999 | a(CHEBI:curcumin) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA)) |
| pmid:29179999 | a(CHEBI:curcumin) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:28803412 | a(CHEBI:curcumin) decreases a(HBP:HBP00092) |
| pmid:28803412 | a(CHEBI:curcumin) decreases a(HBP:HBP00016) |
| pmid:28803412 | a(CHEBI:curcumin) decreases a(HBP:HBP00018) |
| pmid:30116051 | a(CHEBI:curcumin) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) |
| pmid:30116051 | a(CHEBI:curcumin) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30116051 | a(CHEBI:curcumin) decreases a(HBP:"amyloid-beta oligomers") |
| pmid:30116051 | a(CHEBI:curcumin) decreases a(HBP:"Tau oligomers") |
| pmid:27288790 | p(HGNC:NOS2) increases path(MESH:Inflammation) |
| pmid:23702978 | act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") |
| pmid:27314526 | act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") |
| pmid:27288790 | p(HGNC:NFKBIA, pmod(Ph)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:TNF) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases a(MESH:Interleukins) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(FPLX:"IKK_complex", pmod(Ph)) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:STAT1, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases a(CHEBI:"nitric oxide") |
| pmid:29179999 | a(CHEBI:resveratrol) decreases p(HGNC:NOS2) |
| pmid:29179999 | a(CHEBI:resveratrol) decreases a(CHEBI:"prostaglandin E2") |
| pmid:22020111 | a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) |
| pmid:30116051 | a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) |
| pmid:22020111 | a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) |
| pmid:30116051 | a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:HTT) |
| pmid:30116051 | a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases act(a(MESH:"amyloid beta-protein (25-35)")) |
| pmid:30116051 | a(CHEBI:resveratrol) increases p(FPLX:ATG4) |
| pmid:30116051 | a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:AGER) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:MMP9) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29062069 | a(CHEBI:resveratrol) directlyIncreases act(p(HGNC:PPP2CA)) |
| pmid:29062069 | a(CHEBI:resveratrol) directlyDecreases p(HGNC:MID1) |
| pmid:27288790 | act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(Ph)) |
| pmid:23702978 | act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) |
| pmid:23178521 | p(HGNC:STAT3, pmod(Ph)) association a(CHEBI:nicotine) |
| pmid:29179999 | a(CHEBI:pterostilbene) regulates p(HGNC:PPARA) |
| pmid:29179999 | a(CHEBI:pterostilbene) regulates p(FPLX:NFkappaB) |
| pmid:29179999 | a(CHEBI:pterostilbene) regulates p(FPLX:JNK, pmod(Ph)) |
| pmid:21718217 | p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") |
| pmid:21718217 | p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") |
| pmid:18494933 | p(FPLX:JNK, pmod(Ph)) positiveCorrelation act(p(FPLX:JNK)) |
| pmid:18494933 | act(p(FPLX:JNK)) positiveCorrelation p(FPLX:JNK, pmod(Ph)) |
| pmid:18494933 | p(FPLX:JNK) positiveCorrelation act(p(HGNC:AGER)) |
| pmid:18494933 | p(FPLX:JNK) increases p(HGNC:DKK1) |
| pmid:18494933 | act(p(FPLX:JNK)) increases p(HGNC:DKK1) |
| pmid:27068745 | act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1") |
| pmid:27068745 | act(p(FPLX:JNK)) association p(HGNC:CASP3) |
| pmid:29179999 | a(PUBCHEM:44584733) decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(PUBCHEM:44584733) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) |
| pmid:29179999 | a(PUBCHEM:44584733) decreases bp(GO:"inflammatory response") |
| pmid:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling") |
| pmid:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:MAPK14, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(Ph)) |
| pmid:27288790 | p(HGNC:MAPK14) increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:27288790 | act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:27288790 | act(p(HGNC:MAPK14)) increases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:30640040 | act(p(HGNC:MAPK14)) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | p(HGNC:MAPK14) association a(PUBCHEM:11570805) |
| pmid:30640040 | p(HGNC:MAPK14) association a(PUBCHEM:156422) |
| pmid:30640040 | p(HGNC:MAPK14) association a(PUBCHEM:10341154) |
| pmid:11943212 | p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:27594586 | p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9)) |
| pmid:27594586 | p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9)) |
| pmid:24686445 | p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) |
| pmid:29179999 | a(CHEBI:Salidroside) increases bp(GO:cognition) |
| pmid:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:TXN) |
| pmid:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:TXNIP) |
| pmid:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:RELA) |
| pmid:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA) |
| pmid:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:CHUK) |
| pmid:29179999 | a(CHEBI:Salidroside) regulates p(HGNC:IKBKB) |
| pmid:29179999 | a(PUBCHEM:155160) increases bp(GO:memory) |
| pmid:29179999 | a(PUBCHEM:155160) decreases a(HBP:"amyloid-beta aggregates") |
| pmid:29179999 | a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress") |
| pmid:29179999 | a(PUBCHEM:155160) decreases path(MESH:Inflammation) |
| pmid:29179999 | a(PUBCHEM:155160) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29179999 | a(PUBCHEM:155160) decreases act(p(FPLX:"Gamma_secretase")) |
| pmid:29179999 | a(PUBCHEM:155160) decreases act(p(HGNC:BACE1)) |
| pmid:29179999 | a(PUBCHEM:155160) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(HBP:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex")) |
| pmid:27288790 | a(HBP:"amyloid-beta aggregates") association p(HGNC:PTGS2) |
| pmid:30444369 | a(HBP:"amyloid-beta aggregates") increases path(HBP:"mitochondrial dysfunction") |
| pmid:30444369 | a(HBP:"amyloid-beta aggregates") decreases act(p(FPLX:COX)) |
| pmid:30444369 | a(HBP:"amyloid-beta aggregates") association p(HGNC:CSNK1A1) |
| pmid:19293145 | a(HBP:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") |
| pmid:24590577 | a(HBP:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | a(HBP:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") |
| pmid:26195256 | a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") |
| pmid:17009926 | a(HBP:"amyloid-beta aggregates") association p(HGNC:CHRNA7) |
| pmid:27491084 | a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB1) |
| pmid:27491084 | a(HBP:"amyloid-beta aggregates") association p(HGNC:CRYAB) |
| pmid:27491084 | a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB6) |
| pmid:27491084 | a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8) |
| pmid:28877763 | a(HBP:"amyloid-beta aggregates") positiveCorrelation p(MGI:Syk, pmod(Ph)) |
| pmid:28877763 | a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(MGI:Syk)) |
| pmid:28877763 | a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) |
| pmid:26195256 | a(HBP:"amyloid-beta aggregates") association path(MESH:"Cerebral Amyloid Angiopathy") |
| pmid:26195256 | a(HBP:"amyloid-beta aggregates", loc(GO:"extracellular region")) negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) |
| pmid:26195256 | a(HBP:"amyloid-beta aggregates") decreases a(MESH:"Cerebrospinal Fluid") |
| pmid:29179999 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"neuron death") |
| pmid:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 32)) |
| pmid:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 36)) |
| pmid:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) |
| pmid:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:BACE1) |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) |
| pmid:27288790 | a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:"BACE1-AS") |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:RELA)) |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death") |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia)) |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity") |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway") |
| pmid:25652642 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(Ph)) |
| pmid:29196815 | a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) |
| pmid:22908190 | a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(HBP:neurotoxicity) |
| pmid:22908190 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) |
| pmid:14556719 | a(CHEBI:"amyloid-beta polypeptide 42") increases a(HBP:"amyloid-beta fibrils") |
| pmid:22908190 | tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(HBP:"APOE e4") |
| pmid:22908190 | tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") |
| pmid:22908190 | a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(FPLX:AMPK) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange act(p(HGNC:AK3)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 231)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Thr, 235)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(Ph)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation a(HBP:"amyloid-beta aggregates", loc(GO:"extracellular region")) |
| pmid:29626319 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) |
| pmid:30444369 | p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) |
| pmid:26195256 | p(FPLX:"Gamma_secretase") increases deg(a(HBP:"APP C-terminally truncated carboxyl-terminal fragments")) |
| pmid:29179999 | a(CHEBI:lycopene) increases path(MESH:"Spatial Learning") |
| pmid:29179999 | a(CHEBI:lycopene) increases bp(GO:memory) |
| pmid:29179999 | a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling") |
| pmid:29179999 | a(CHEBI:genistein) decreases p(HGNC:TLR4) |
| pmid:29179999 | a(CHEBI:genistein) decreases p(FPLX:NFkappaB) |
| pmid:29179999 | a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:genistein) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) |
| pmid:19293145 | a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:19293145 | a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) |
| pmid:17009926 | a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) |
| pmid:17009926 | a(CHEBI:genistein) causesNoChange surf(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:genistein) regulates p(FPLX:CHRN) |
| pmid:27314526 | p(HGNC:TLR4) increases bp(GO:"cytokine secretion") |
| pmid:29179999 | a(PUBCHEM:45270574) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:29179999 | a(CHEBI:"gallic acid") decreases act(p(FPLX:MYST)) |
| pmid:29179999 | a(CHEBI:"gallic acid") decreases p(HGNC:RELA, pmod(Ac)) |
| pmid:29179999 | a(CHEBI:"gallic acid") decreases path(MESH:Inflammation) |
| pmid:29179999 | a(CHEBI:"gallic acid") decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:"gallic acid") decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:29179999 | a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) |
| pmid:19126755 | a(CHEBI:galanthamine) decreases p(HGNC:ACHE) |
| pmid:11230871 | a(CHEBI:galanthamine) increases act(p(HGNC:ACHE)) |
| pmid:29179999 | a(CHEBI:galanthamine) increases a(CHEBI:acetylcholine) |
| pmid:29179999 | a(CHEBI:galanthamine) increases sec(a(CHEBI:acetylcholine)) |
| pmid:29179999 | a(CHEBI:galanthamine) increases act(p(HGNC:HMOX1)) |
| pmid:29179999 | a(CHEBI:galanthamine) increases act(p(FPLX:NFkappaB)) |
| pmid:30444369 | a(CHEBI:galanthamine) increases bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:galanthamine) increases bp(GO:cognition) |
| pmid:30444369 | a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase)) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration) |
| pmid:19126755 | a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:19293145 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pmid:19293145 | a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:galanthamine) increases p(HGNC:BCL2) |
| pmid:24511233 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:17009926 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:17009926 | a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | a(CHEBI:galanthamine) decreases path(MESH:Death) |
| pmid:25881725 | a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) |
| pmid:25881725 | a(CHEBI:galanthamine) increases bp(GO:learning) |
| pmid:25881725 | a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) |
| pmid:25881725 | a(CHEBI:galanthamine) increases p(MGI:Chrna7) |
| pmid:25881725 | a(CHEBI:galanthamine) increases p(MGI:Chrna7) |
| pmid:19721446 | a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) |
| pmid:19721446 | a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) |
| pmid:19126755 | p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) |
| pmid:17009926 | act(p(HGNC:ACHE), ma(pep)) directlyIncreases deg(a(CHEBI:acetylcholine)) |
| pmid:26813123 | p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) |
| pmid:21482353 | p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) |
| pmid:23038257 | p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) |
| pmid:17009926 | act(p(HGNC:ACHE), ma(pep)) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pmid:26813123 | p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pmid:26813123 | p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | p(HGNC:ACHE) increases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") |
| pmid:21482353 | act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:18986241 | p(HGNC:ACHE) association path(MESH:D058225) |
| pmid:18986241 | p(HGNC:ACHE) increases bp(GO:"GO:1990000") |
| pmid:19126755 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:24590577 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:24590577 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:acetylcholine) decreases path(MESH:"Heart Rate") |
| pmid:19126755 | a(CHEBI:acetylcholine) association bp(GO:signaling) |
| pmid:24511233 | a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) |
| pmid:24511233 | act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM1)) |
| pmid:17009926 | deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") |
| pmid:26813123 | a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) |
| pmid:26813123 | a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates bp(GO:memory) |
| pmid:26813123 | a(CHEBI:acetylcholine) association bp(GO:memory) |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") |
| pmid:26813123 | a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26813123 | a(CHEBI:acetylcholine) increases bp(GO:"response to auditory stimulus") |
| pmid:26813123 | a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) |
| pmid:26813123 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) |
| pmid:21482353 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pmid:21787755 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") |
| pmid:26813123 | a(CHEBI:acetylcholine) association bp(GO:learning) |
| pmid:26813123 | a(CHEBI:acetylcholine) association bp(GO:cognition) |
| pmid:11230871 | a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) |
| pmid:16273023 | a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| pmid:25514383 | tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") |
| pmid:25514383 | a(CHEBI:acetylcholine) increases act(a(HBP:"beta-2-containing nAChR")) |
| pmid:25514383 | act(a(CHEBI:acetylcholine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:acetylcholine) increases act(a(HBP:"alpha-7-containing nAChR")) |
| pmid:19721446 | a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") |
| pmid:29179999 | complex(a(CHEBI:galanthamine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") |
| pmid:17009926 | p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") |
| pmid:17009926 | p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Attention) |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:learning) |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:memory) |
| pmid:11230871 | p(FPLX:CHRN) association bp(GO:memory) |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"developmental process") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pmid:21482353 | act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:"Autistic Disorder") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") |
| pmid:26472524 | act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:26472524 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:25514383 | act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | p(FPLX:CHRN) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:26472524 | act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | p(FPLX:CHRN) increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:17009926 | p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:"Parkinson Disease") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"response to pain") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Anxiety) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Anxiety) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Depression) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Depression) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases path(MESH:Arousal) |
| pmid:28445721 | p(FPLX:CHRN) association path(MESH:Arousal) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26813123 | p(FPLX:CHRN) increases bp(GO:cognition) |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:cognition) |
| pmid:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pmid:28445721 | p(FPLX:CHRN) increases bp(GO:cognition) |
| pmid:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pmid:11230871 | p(FPLX:CHRN) association bp(GO:cognition) |
| pmid:26813123 | p(FPLX:CHRN) decreases bp(HBP:Neurodegeneration) |
| pmid:25514383 | p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") |
| pmid:25514383 | act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") |
| pmid:25514383 | p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") |
| pmid:28445721 | p(FPLX:CHRN) association path(MESH:Motivation) |
| pmid:28445721 | act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:28445721 | p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:28445721 | p(FPLX:CHRN) increases bp(GO:"dopamine secretion") |
| pmid:28445721 | p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:11230871 | act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:21482353 | act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) |
| pmid:21482353 | surf(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) |
| pmid:21482353 | p(FPLX:CHRN) regulates p(HGNC:LYNX1) |
| pmid:21482353 | act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) |
| pmid:21482353 | act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) |
| pmid:21482353 | p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") |
| pmid:21482353 | p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) |
| pmid:21482353 | p(FPLX:CHRN) increases act(p(FPLX:NOS)) |
| pmid:11230871 | p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") |
| pmid:21787755 | p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") |
| pmid:21787755 | p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") |
| pmid:22020111 | p(HGNC:HMOX1) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29179999 | a(PUBCHEM:14193399) decreases a(CHEBI:"nitric oxide") |
| pmid:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:TNF) |
| pmid:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:IL1A) |
| pmid:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(PUBCHEM:14193399) decreases p(HGNC:NOS2) |
| pmid:29179999 | a(PUBCHEM:14193399) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(PUBCHEM:14193399) decreases act(p(HGNC:MAPK14)) |
| pmid:29179999 | a(PUBCHEM:14193399) decreases a(CHEBI:"reactive oxygen species") |
| pmid:29179999 | a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(PUBCHEM:73078) decreases a(MESH:Cytokines) |
| pmid:29179999 | a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) |
| pmid:29179999 | a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:29179999 | a(PUBCHEM:73078) decreases act(p(HGNC:CHUK)) |
| pmid:29179999 | a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB)) |
| pmid:29179999 | a(PUBCHEM:73078) increases path(MESH:"Spatial Learning") |
| pmid:29179999 | a(PUBCHEM:73078) increases bp(GO:memory) |
| pmid:29179999 | a(PUBCHEM:73078) decreases p(HGNC:IL1B) |
| pmid:29179999 | a(PUBCHEM:73078) decreases p(HGNC:TNF) |
| pmid:27288790 | a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex")) |
| pmid:27288790 | a(MESH:Cytokines) increases m(MIRBASE:"hsa-mir-155") |
| pmid:29179999 | a(CHEBI:berberine) decreases path(MESH:Inflammation) |
| pmid:29179999 | a(CHEBI:berberine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:berberine) decreases p(HGNC:RELA) |
| pmid:29179999 | a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:berberine) decreases act(p(HGNC:MAPK14)) |
| pmid:29179999 | a(CHEBI:berberine) decreases act(p(FPLX:ERK)) |
| pmid:29179999 | a(CHEBI:berberine) decreases act(p(FPLX:AKT)) |
| pmid:29179999 | a(CHEBI:oridonin) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:oridonin) increases bp(GO:cognition) |
| pmid:29179999 | a(CHEBI:oridonin) decreases path(MESH:Inflammation) |
| pmid:29179999 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pmid:22807490 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") |
| pmid:26010758 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29179999 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21958873 | a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:22807490 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pmid:23178521 | a(CHEBI:Anatabine) regulates bp(GO:"inflammatory response") |
| pmid:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pmid:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pmid:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") |
| pmid:22807490 | a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") |
| pmid:22807490 | a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) |
| pmid:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) |
| pmid:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:NOS2) |
| pmid:22807490 | a(CHEBI:Anatabine) decreases p(HGNC:PTGS2) |
| pmid:22807490 | a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation") |
| pmid:21958873 | a(CHEBI:Anatabine) causesNoChange sec(p(HGNC:LDHA)) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases sec(p(HBP:"sAPP-beta")) |
| pmid:21958873 | a(CHEBI:Anatabine) causesNoChange sec(p(HBP:"sAPP-alpha")) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases r(HGNC:BACE1) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases r(HGNC:BACE1) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases p(HGNC:BACE1) |
| pmid:21958873 | a(CHEBI:Anatabine) decreases p(HGNC:CRP) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Tnf) |
| pmid:23383175 | a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Il6) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il6) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases a(MESH:Cytokines) |
| pmid:23383175 | a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases path(MESH:Paralysis) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases path(MESH:Paralysis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il1b) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il1b) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il17a) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il17a) |
| pmid:23383175 | a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Ifng) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases a(MESH:Microglia) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) increases bp(GO:"motor behavior") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) increases bp(GO:"motor behavior") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases path(MESH:Anxiety) |
| pmid:26010758 | a(CHEBI:Anatabine) increases path(MESH:Anxiety) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) increases path(MESH:"Spatial Learning") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) causesNoChange p(HGNC:MAPT) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases a(GO:"neurofibrillary tangle") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers") |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| DOI:10.4172/2168-975X.1000126 | a(CHEBI:Anatabine) increases p(FPLX:AKT, pmod(Ph, Ser, 473)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases path(MESH:Gliosis) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26010758 | a(CHEBI:Anatabine) increases act(p(HGNC:CHRNA7)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases bp(GO:locomotion) |
| pmid:26010758 | a(CHEBI:Anatabine) increases path(MESH:"Interpersonal Relations") |
| pmid:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:AIF1) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases bp(GO:"microglial cell activation") |
| pmid:26010758 | a(CHEBI:Anatabine) decreases p(HGNC:PTPRC) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases r(HGNC:PTGS2) |
| pmid:26010758 | a(CHEBI:Anatabine) decreases r(HGNC:NOS2) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:14556719 | a(CHEBI:"amyloid-beta polypeptide 40") increases a(HBP:"amyloid-beta fibrils") |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 40") isA a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(CHEBI:"vitamin D") decreases p(FPLX:NFkappaB, pmod(Ph)) |
| pmid:29179999 | a(CHEBI:"vitamin D") decreases a(CHEBI:"reactive oxygen species") |
| pmid:29179999 | a(CHEBI:"vitamin D") decreases path(MESH:Inflammation) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"reactive oxygen species") |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases a(MESH:Cytokines) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"nitric oxide") |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") increases bp(GO:memory) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases path(MESH:"Oxidative Stress") |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases p(HGNC:NOS2) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL6) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL1B) |
| pmid:29179999 | a(CHEBI:"alpha-tocopherol") decreases bp(GO:"microglial cell activation") |
| pmid:21718217 | bp(GO:"microglial cell activation") association a(HBP:HBP00089) |
| pmid:21718217 | bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089) |
| pmid:26010758 | bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1) |
| pmid:28877763 | bp(GO:"microglial cell activation") positiveCorrelation act(p(MGI:Syk)) |
| pmid:28877763 | bp(GO:"microglial cell activation") positiveCorrelation p(MGI:Syk, pmod(Ph)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2)) |
| pmid:29179999 | a(PUBCHEM:444795) decreases path(MESH:Inflammation) |
| pmid:29179999 | a(PUBCHEM:444795) decreases p(HGNC:IL6) |
| pmid:29179999 | a(PUBCHEM:444795) decreases p(HGNC:IL12B) |
| pmid:29179999 | a(PUBCHEM:444795) decreases p(HGNC:TNF) |
| pmid:29179999 | a(PUBCHEM:444795) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(PUBCHEM:444795) decreases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:29179999 | a(PUBCHEM:444795) decreases p(HGNC:BACE1) |
| pmid:29179999 | a(PUBCHEM:3086007) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(PUBCHEM:441921) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(PUBCHEM:9918693) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(PUBCHEM:441923) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TLR3) |
| pmid:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TLR3) |
| pmid:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TLR4) |
| pmid:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TLR4) |
| pmid:29179999 | a(PUBCHEM:441923) decreases p(FPLX:NFkappaB) |
| pmid:29179999 | a(PUBCHEM:441923) decreases r(HGNC:TRAF6) |
| pmid:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TRAF6) |
| pmid:29179999 | a(PUBCHEM:441923) decreases p(HGNC:TNF) |
| pmid:29179999 | a(PUBCHEM:441923) decreases p(HGNC:IFNB1) |
| pmid:29179999 | a(PUBCHEM:24721561) decreases bp(GO:"neuron death") |
| pmid:29179999 | a(PUBCHEM:24721561) increases bp(GO:learning) |
| pmid:29179999 | a(PUBCHEM:24721561) increases bp(GO:memory) |
| pmid:29179999 | a(PUBCHEM:24721561) decreases act(p(FPLX:NFkappaB)) |
| pmid:26631930 | p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(UbK63)) |
| pmid:29179999 | a(PUBCHEM:164676) decreases act(p(HGNC:NOS2)) |
| pmid:29179999 | a(PUBCHEM:164676) decreases act(p(HGNC:MMP2)) |
| pmid:29179999 | a(PUBCHEM:164676) decreases act(p(HGNC:RELA)) |
| pmid:29179999 | a(PUBCHEM:164676) decreases path(MESH:"Alzheimer Disease") |
| pmid:29179999 | a(PUBCHEM:164676) decreases bp(GO:"apoptotic process") |
| pmid:29179999 | a(PUBCHEM:164676) decreases path(MESH:Inflammation) |
| pmid:29179999 | a(PUBCHEM:164676) decreases bp(GO:"neuron death") |
| pmid:29179999 | a(PUBCHEM:164676) decreases p(HGNC:GFAP) |
| pmid:29179999 | a(PUBCHEM:164676) decreases p(FPLX:NFkappaB) |
| pmid:29179999 | a(PUBCHEM:164676) increases p(HGNC:RBFOX3) |
| pmid:29179999 | a(PUBCHEM:164676) increases a(MESH:"Nissl Bodies") |
| pmid:29179999 | a(PUBCHEM:164676) increases p(FPLX:IKB) |
| pmid:27594586 | act(p(HGNC:MMP2)) increases bp(GO:"neuron death") |
| pmid:27594586 | p(HGNC:MMP2) increases bp(GO:"neuron death") |
| pmid:26195256 | p(HGNC:MMP2) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:29626319 | act(p(HGNC:MMP2)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:MMP2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | act(p(HGNC:MMP2)) negativeCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:25652642 | p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1) |
| pmid:27288790 | deg(p(FPLX:IKB)) increases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:"(+)-artemisinin") decreases path(MESH:Inflammation) |
| pmid:29179999 | a(CHEBI:"(+)-artemisinin") decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:"(+)-artemisinin") decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(CHEBI:"(+)-artemisinin") decreases bp(GO:"NLRP3 inflammasome complex assembly") |
| pmid:28019679 | a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) |
| pmid:28019679 | a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") |
| pmid:29179999 | a(PUBCHEM:440312) decreases a(CHEBI:"nitric oxide") |
| pmid:29179999 | a(PUBCHEM:440312) decreases p(HGNC:TNF) |
| pmid:29179999 | a(PUBCHEM:440312) decreases a(CHEBI:"prostaglandin E2") |
| pmid:29179999 | a(PUBCHEM:440312) decreases p(HGNC:NOS2) |
| pmid:29179999 | a(PUBCHEM:440312) decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(PUBCHEM:440312) decreases act(p(HGNC:LOX)) |
| pmid:29179999 | a(PUBCHEM:440312) decreases a(CHEBI:"reactive oxygen species") |
| pmid:29179999 | a(PUBCHEM:440312) decreases act(p(FPLX:ERK)) |
| pmid:29179999 | a(PUBCHEM:440312) decreases act(p(HGNC:MAPK14)) |
| pmid:29179999 | a(PUBCHEM:440312) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:Geniposide) decreases act(p(FPLX:ERK)) |
| pmid:29179999 | a(CHEBI:Geniposide) decreases act(p(FPLX:IKB)) |
| pmid:29179999 | a(CHEBI:Geniposide) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:Geniposide) decreases p(HGNC:TNF) |
| pmid:29179999 | a(CHEBI:Geniposide) decreases p(HGNC:IL1B) |
| pmid:29179999 | a(CHEBI:Geniposide) decreases a(CHEBI:"amyloid-beta") |
| pmid:29179999 | a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory") |
| pmid:29179999 | a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress") |
| pmid:29179999 | a(PUBCHEM:102336202) decreases p(HGNC:NOS2) |
| pmid:29179999 | a(PUBCHEM:102336202) decreases a(CHEBI:nitrotyrosine) |
| pmid:29179999 | a(PUBCHEM:102336202) increases r(HGNC:IL4) |
| pmid:29179999 | a(PUBCHEM:102336202) decreases a(MESH:Cytokines) |
| pmid:29179999 | a(PUBCHEM:102336202) decreases a(CHEBI:"nitric oxide") |
| pmid:29179999 | a(PUBCHEM:102336202) decreases p(HGNC:IL1B) |
| pmid:29179999 | a(PUBCHEM:102336202) decreases p(HGNC:TNF) |
| pmid:29179999 | a(PUBCHEM:102336202) decreases act(p(FPLX:ERK)) |
| pmid:29179999 | a(PUBCHEM:102336202) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") increases bp(GO:memory) |
| pmid:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases bp(GO:"neuron death") |
| pmid:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:ERK)) |
| pmid:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(HGNC:MAPK14)) |
| pmid:29179999 | a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases a(CHEBI:"reactive oxygen species") |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases a(CHEBI:"nitric oxide") |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases p(HGNC:TNF) |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases p(HGNC:IL1B) |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases p(HGNC:IL6) |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases p(HGNC:NOS2) |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases p(HGNC:PTGS2) |
| pmid:29179999 | a(CHEBI:"1,8-cineole") decreases p(FPLX:NFkappaB) |
| pmid:29179999 | a(PUBCHEM:442534) increases bp(GO:memory) |
| pmid:29179999 | a(PUBCHEM:442534) decreases a(HBP:"amyloid-beta aggregates") |
| pmid:29179999 | a(PUBCHEM:442534) decreases path(MESH:"Alzheimer Disease") |
| pmid:29179999 | a(PUBCHEM:442534) decreases act(p(FPLX:GSK3)) |
| pmid:29179999 | a(PUBCHEM:442534) decreases act(p(FPLX:NFkappaB)) |
| pmid:29179999 | a(PUBCHEM:442534) decreases bp(GO:"NLRP3 inflammasome complex assembly") |
| pmid:29179999 | a(PUBCHEM:442534) decreases p(HGNC:TNF) |
| pmid:29179999 | a(PUBCHEM:442534) decreases p(HGNC:IL1B) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(FPLX:GSK3) association a(GO:microtubule) |
| pmid:8282104 | p(FPLX:GSK3) association a(HBP:HBP00006) |
| pmid:8282104 | p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) |
| pmid:8282104 | p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | bp(GO:"negative regulation of neuron apoptotic process") association p(FPLX:NFkappaB) |
| pmid:12428809 | bp(GO:"negative regulation of neuron apoptotic process") association sec(p(HGNC:APP)) |
| pmid:27288790 | bp(GO:"neuron differentiation") association p(FPLX:NFkappaB) |
| pmid:24590577 | bp(GO:"neuron differentiation") association p(HGNC:CHRM1) |
| pmid:28884684 | bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin)) |
| pmid:27288790 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:NFkappaB) |
| pmid:27288790 | bp(GO:"regulation of synaptic plasticity") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30444369 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) |
| pmid:17009926 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) |
| pmid:17009926 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) |
| pmid:24590577 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) |
| pmid:30106381 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4) |
| pmid:22908190 | bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:22908190 | bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis) |
| pmid:22908190 | bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy) |
| pmid:26631930 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT) |
| pmid:27288790 | p(FPLX:IKB, pmod(Ph)) increases deg(p(FPLX:IKB)) |
| pmid:27288790 | p(FPLX:IKB, pmod(Ph)) increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) increases act(p(HGNC:RELA)) |
| pmid:27288790 | bp(MESH:"Membrane Fluidity") association a(CHEBI:"reactive oxygen species") |
| pmid:27288790 | bp(GO:"ion transport") association a(CHEBI:"reactive oxygen species") |
| pmid:30061532 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association path(MESH:"Lewy Body Disease") |
| pmid:30061532 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease") |
| pmid:30145931 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17403556 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25374103 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24401760 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:30061532 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:30061532 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CDK5) |
| pmid:17009926 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) |
| pmid:17009926 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) |
| pmid:11230871 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) |
| pmid:26837465 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) |
| pmid:19277525 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle") |
| pmid:22908190 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(GO:"neurofibrillary tangle") |
| pmid:22299660 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") |
| pmid:22299660 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation act(p(FPLX:PPP2)) |
| pmid:29758300 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:29758300 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") |
| pmid:26458742 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") |
| pmid:29758300 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") |
| pmid:30145931 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies) |
| pmid:22611162 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") |
| pmid:22611162 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"synaptic signaling") |
| pmid:22611162 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure") |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(p(HGNC:MAPT)) |
| pmid:26195256 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau oligomers") |
| pmid:26195256 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(MESH:"Neurofibrillary Tangles") |
| pmid:26195256 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(MESH:"Neuropil Threads") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(GO:"filamentous actin") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(HBP:Neurodegeneration) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(a(GO:synapse)) |
| pmid:23487739 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases a(GO:microtubule) |
| pmid:19732809 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30061532 | bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) |
| pmid:30061532 | bp(GO:autophagy) decreases path(MESH:"Neurodegenerative Diseases") |
| pmid:18930136 | bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") |
| pmid:18930136 | bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases") |
| pmid:30061532 | bp(GO:autophagy) negativeCorrelation act(p(HGNC:MTOR)) |
| pmid:30061532 | bp(GO:autophagy) regulates act(p(HGNC:MTOR)) |
| pmid:30106381 | bp(GO:autophagy) association p(HGNC:MTOR) |
| pmid:29758300 | bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) |
| pmid:18930136 | bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) |
| pmid:30061532 | bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) |
| pmid:30061532 | bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) |
| pmid:30061532 | bp(GO:autophagy) decreases sec(a(CHEBI:dopamine)) |
| pmid:30061532 | bp(GO:autophagy) decreases sec(a(CHEBI:dopamine)) |
| pmid:30061532 | bp(GO:autophagy) association bp(GO:"dopamine secretion, neurotransmission") |
| pmid:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | bp(GO:autophagy) association p(HGNC:BECN1) |
| pmid:30061532 | bp(GO:autophagy) association p(HGNC:ULK2) |
| pmid:30061532 | bp(GO:autophagy) association p(HGNC:ATG3) |
| pmid:30061532 | bp(GO:autophagy) negativeCorrelation path(MESH:Hallucinations) |
| pmid:30106381 | bp(GO:autophagy) association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:autophagy) association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:autophagy) association a(PUBCHEM:9832404) |
| pmid:22020111 | bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pmid:29758300 | bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | bp(GO:autophagy) association path(MESH:"Alzheimer Disease") |
| pmid:22908190 | bp(GO:autophagy) association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") |
| pmid:22908190 | bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") |
| pmid:29758300 | bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:18930136 | bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:29758300 | bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) |
| pmid:29758300 | bp(GO:autophagy) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:29758300 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29758300 | bp(GO:autophagy) association a(HBP:"Tau aggregates") |
| pmid:29758300 | bp(GO:autophagy) increases deg(p(HGNC:SNCA)) |
| pmid:18930136 | bp(GO:autophagy) increases deg(p(HGNC:SNCA)) |
| pmid:30985105 | bp(GO:autophagy) increases act(p(HGNC:SNCA)) |
| pmid:30985105 | bp(GO:autophagy) increases p(HGNC:SNCA) |
| pmid:29758300 | bp(GO:autophagy) decreases a(CHEBI:lipid) |
| pmid:29758300 | bp(GO:autophagy) increases deg(a(CHEBI:lipid)) |
| pmid:29758300 | bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid) |
| pmid:29758300 | bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate)) |
| pmid:29758300 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:30145931 | bp(GO:autophagy) decreases p(HGNC:MAPT) |
| pmid:24027553 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:23528736 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:25374103 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pmid:18930136 | bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pmid:18930136 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pmid:18930136 | bp(GO:autophagy) increases deg(a(GO:organelle)) |
| pmid:22908190 | bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process") |
| pmid:22908190 | bp(GO:autophagy) increases deg(p(HBP:"protein aggregates", pmod(Ub))) |
| pmid:22908190 | bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) |
| pmid:22908190 | bp(GO:autophagy) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | bp(GO:autophagy) decreases path(MESH:Tauopathies) |
| pmid:22908190 | bp(GO:autophagy) decreases path(HBP:neurotoxicity) |
| pmid:22908190 | bp(GO:autophagy) increases path(HBP:neurotoxicity) |
| pmid:30145931 | bp(GO:autophagy) decreases path(HBP:neurotoxicity) |
| pmid:22908190 | bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity") |
| pmid:23746257 | bp(GO:autophagy) increases bp(GO:"protein catabolic process") |
| pmid:26195256 | bp(GO:autophagy) increases bp(GO:"protein catabolic process") |
| pmid:23746257 | bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") |
| pmid:18930136 | bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process") |
| pmid:18930136 | bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis") |
| pmid:18930136 | bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pmid:18930136 | bp(GO:autophagy) increases deg(a(MESH:Proteins)) |
| pmid:18930136 | bp(GO:autophagy) regulates bp(GO:"metabolic process") |
| pmid:18930136 | bp(GO:autophagy) association bp(GO:"antigen processing and presentation") |
| pmid:18930136 | bp(GO:autophagy) decreases bp(MESH:Microbiota) |
| pmid:18930136 | bp(GO:autophagy) regulates bp(GO:"cell death") |
| pmid:18930136 | bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?"))) |
| pmid:18930136 | bp(GO:autophagy) increases deg(a(HBP:"alpha-synuclein aggregates")) |
| pmid:18930136 | bp(GO:autophagy) increases deg(a(HBP:"alpha-synuclein oligomers")) |
| pmid:18930136 | bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis") |
| pmid:18930136 | bp(GO:autophagy) decreases path(HBP:Neurodegeneration) |
| pmid:18930136 | bp(GO:autophagy) decreases path(HBP:Neurodegeneration) |
| pmid:18930136 | bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:18930136 | bp(GO:autophagy) increases deg(p(HGNC:APP)) |
| pmid:18930136 | bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:28803412 | bp(GO:autophagy) increases a(HBP:HBP00093) |
| pmid:30145931 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) |
| pmid:30116051 | bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:30116051 | bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:23528736 | bp(GO:autophagy) negativeCorrelation a(CHEBI:"reactive oxygen species") |
| pmid:23702978 | bp(GO:autophagy) regulates bp(GO:"apoptotic process") |
| pmid:23702978 | bp(GO:autophagy) regulates complex(GO:"inflammasome complex") |
| pmid:23702978 | bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) |
| pmid:23702978 | bp(GO:autophagy) decreases sec(p(HGNC:IL1B)) |
| pmid:27288790 | a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:ERK)) |
| pmid:27288790 | a(CHEBI:"hydrogen peroxide") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:14556719 | a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") |
| pmid:23531502 | act(a(CHEBI:"hydrogen peroxide")) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:23722080 | a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") |
| pmid:23722080 | a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) |
| pmid:27288790 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24561250 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27314526 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27314526 | p(HGNC:IL18) association path(MESH:"Alzheimer Disease") |
| pmid:27288790 | p(HGNC:IL18) increases act(p(FPLX:NFkappaB)) |
| pmid:24561250 | p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") |
| pmid:24561250 | p(HGNC:IL18) increases bp(GO:"inflammatory response") |
| pmid:27314526 | p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) |
| pmid:27314526 | p(HGNC:IL18) increases bp(GO:"microglial cell activation") |
| pmid:27314526 | p(HGNC:IL18) increases bp(GO:"astrocyte activation") |
| pmid:27314526 | p(HGNC:IL18) increases a(CHEBI:"amyloid-beta") |
| pmid:27314526 | p(HGNC:IL18) increases p(HGNC:GSK3B) |
| pmid:27314526 | p(HGNC:IL18) increases p(HGNC:CDK5) |
| pmid:27288790 | p(HGNC:CXCL10) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | p(HGNC:TGFB1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26304819 | p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:21718217 | p(HGNC:TGFB1) decreases a(MESH:Macrophages) |
| pmid:27288790 | bp(GO:"protein kinase B signaling") increases act(p(FPLX:NFkappaB)) |
| pmid:30061532 | bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) |
| pmid:30061532 | bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) |
| pmid:30061532 | bp(GO:"protein kinase B signaling") association p(HGNC:NRG1) |
| pmid:14556719 | bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) |
| pmid:29311797 | bp(GO:"neuron apoptotic process") decreases bp(GO:cognition) |
| pmid:14963027 | bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) |
| pmid:27068745 | bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) |
| pmid:27288790 | bp(GO:"MAPK cascade") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(Ph)) |
| pmid:21214928 | bp(GO:"MAPK cascade") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | bp(GO:"MAPK cascade") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) |
| pmid:24590577 | bp(GO:"MAPK cascade") increases p(HGNC:BACE1) |
| pmid:27288790 | bp(GO:"ERK1 and ERK2 cascade") increases act(p(FPLX:NFkappaB)) |
| pmid:21214928 | bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:"amyloid-beta") |
| pmid:19126755 | bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process") |
| pmid:24590577 | bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) |
| pmid:24590577 | bp(GO:"ERK1 and ERK2 cascade") regulates bp(HBP:"APP processing") |
| pmid:27594586 | bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) |
| pmid:27288790 | a(CHEBI:"SB-239063") decreases act(p(HGNC:MAPK14)) |
| pmid:27288790 | a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") decreases p(FPLX:JNK) |
| pmid:27288790 | a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases act(p(HGNC:MAPK14)) |
| pmid:27288790 | a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:27288790 | a(CHEBI:"advanced glycation end-product") decreases bp(GO:memory) |
| pmid:27288790 | a(CHEBI:"advanced glycation end-product") increases bp(GO:"cellular protein catabolic process") |
| pmid:27288790 | a(CHEBI:"advanced glycation end-product") decreases bp(GO:"long-term synaptic potentiation") |
| pmid:25681682 | a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) |
| pmid:24183963 | a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) |
| pmid:24183963 | a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) |
| pmid:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:22798221 | a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Mapk14), ma(kin)) |
| pmid:8063802 | a(CHEBI:"advanced glycation end-product") decreases act(p(HGNC:MAPT)) |
| pmid:8063802 | a(CHEBI:"advanced glycation end-product") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:18930136 | bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") |
| pmid:18930136 | bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms) |
| pmid:18930136 | bp(GO:"cellular protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) |
| pmid:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) |
| pmid:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) |
| pmid:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) |
| pmid:27671637 | bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) |
| pmid:27288790 | a(CHEBI:pentosidine) isA a(CHEBI:"advanced glycation end-product") |
| pmid:27288790 | a(CHEBI:pentosidine) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | a(HBP:GLAP) isA a(CHEBI:"advanced glycation end-product") |
| pmid:27288790 | a(HBP:GLAP) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases p(HGNC:BACE1) |
| pmid:27288790 | complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade") |
| pmid:26195256 | p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Cardiovascular System"), toLoc(MESH:"Extracellular Space")) |
| pmid:29626319 | p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26195256 | p(HGNC:AGER) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:18494933 | act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK) |
| pmid:25681682 | p(HGNC:AGER) negativeCorrelation bp(GO:aging) |
| pmid:25681682 | p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") |
| pmid:24183963 | act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:18494933 | act(p(HGNC:AGER)) increases p(HGNC:MAPK8, pmod(Ph)) |
| pmid:27288790 | complex(a(HBP:GLAP), p(HGNC:AGER)) increases p(HGNC:BACE1) |
| pmid:27288790 | complex(a(HBP:GLAP), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | p(HGNC:GSK3B) increases p(HGNC:BACE1) |
| pmid:30444369 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12428809 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29758300 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12551948 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24183963 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:18494933 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29121589 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:10998059 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27314526 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22122372 | p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| DOI:10.4172/2168-975X.1000126 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:25331948 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:29844403 | act(p(HGNC:GSK3B)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| DOI:10.4172/2168-975X.1000126 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:25331948 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| DOI:10.4172/2168-975X.1000126 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| DOI:10.4172/2168-975X.1000126 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:25331948 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:21734277 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:24653673 | p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease") |
| pmid:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") |
| pmid:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton") |
| pmid:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(Ph)) |
| pmid:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation bp(HBP:"APP processing") |
| pmid:24653673 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis) |
| pmid:24653673 | act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") |
| pmid:24653673 | act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process") |
| pmid:24653673 | act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) |
| pmid:24653673 | act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1)) |
| pmid:24653673 | act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1)) |
| pmid:24653673 | act(p(HGNC:GSK3B)) increases p(HGNC:SET) |
| pmid:12428809 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:18494933 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:12428809 | p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) |
| pmid:12428809 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:12428809 | p(HGNC:GSK3B) increases a(MESH:Axons) |
| pmid:12428809 | p(HGNC:GSK3B) association bp(GO:"axonal transport") |
| pmid:21882945 | p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) |
| pmid:22419736 | act(p(HGNC:GSK3B)) negativeCorrelation p(FPLX:AMPK) |
| pmid:30640040 | p(HGNC:GSK3B) association a(PUBCHEM:71295844) |
| pmid:29191965 | p(HGNC:GSK3B) association path(MESH:Tauopathies) |
| pmid:11812770 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244")) |
| pmid:11812770 | p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:21734277 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:18494933 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") |
| pmid:12551948 | p(HGNC:GSK3B) association p(HGNC:YWHAZ) |
| pmid:12551948 | p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pmid:29121589 | p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(Ph)) |
| pmid:29121589 | p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) |
| pmid:24355211 | p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) |
| pmid:29121589 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:DPYSL2, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:CREB, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MBP, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSN3, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:PPP1R2, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSNK2B, pmod(Ph)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:21734277 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:9089387 | act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph)) |
| pmid:9089387 | p(HGNC:GSK3B) isA p(ECCODE:"2.7.11.26") |
| pmid:26501932 | p(HGNC:GSK3B) partOf a(HBP:"GVD bodies") |
| pmid:25331948 | act(p(HGNC:GSK3B), ma(kin)) increases a(HBP:"Tau epitope, PHF1") |
| pmid:25331948 | act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation act(p(HGNC:SYK)) |
| pmid:28176663 | act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") |
| pmid:28176663 | act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") |
| pmid:28176663 | act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V") |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HBP:"Tau epitope, AT8") |
| pmid:24355211 | p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") |
| pmid:24355211 | p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) |
| pmid:24355211 | p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) |
| pmid:24355211 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:24355211 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) |
| pmid:25546293 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) |
| pmid:25546293 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) |
| pmid:25546293 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) |
| pmid:27288790 | p(HGNC:GSK3A) causesNoChange p(HGNC:BACE1) |
| pmid:30640040 | p(HGNC:GSK3A) association a(PUBCHEM:71295844) |
| pmid:22817713 | p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27288790 | composite(p(HGNC:GSK3B), p(HGNC:RELA)) increases r(HGNC:BACE1) |
| pmid:27288790 | p(HGNC:UCHL1) decreases p(HGNC:BACE1) |
| pmid:27288790 | act(p(HGNC:UCHL1)) decreases p(HGNC:BACE1) |
| pmid:14556719 | p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub)) |
| pmid:14556719 | p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") |
| pmid:14556719 | p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") |
| pmid:14556719 | p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") |
| pmid:22908190 | p(HGNC:UCHL1) association path(MESH:"Parkinson Disease") |
| pmid:22908190 | p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:UCHL1) increases act(a(GO:synapse)) |
| pmid:22908190 | p(HGNC:UCHL1) increases bp(GO:memory) |
| pmid:27288790 | a(MESH:Lipopolysaccharides) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:27288790 | a(MESH:Lipopolysaccharides) increases p(HGNC:TNF) |
| pmid:27288790 | a(MESH:Lipopolysaccharides) increases sec(p(HGNC:TNF)) |
| pmid:27288790 | a(MESH:Lipopolysaccharides) increases p(HGNC:IL1B) |
| pmid:27288790 | a(MESH:Lipopolysaccharides) increases sec(p(HGNC:IL1B)) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:ALOX15) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:VDR) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5R1)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5), ma(kin)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK3), ma(kin)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:PPP1CA)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:DUSP6)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:BCL2L2)) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:ALOX15) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:VDR) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-146a") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | m(MIRBASE:"hsa-mir-146a") association r(HGNC:IRAK1) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-146a") association bp(GO:"immune response") |
| pmid:27288790 | m(MIRBASE:"hsa-mir-146a") increases path(HP:Neurodegeneration) |
| pmid:27288790 | m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27288790 | m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Multiple Sclerosis") |
| pmid:27288790 | r(HGNC:IRAK1) association m(MIRBASE:"hsa-mir-146a") |
| pmid:27288790 | path(MESH:"Multiple Sclerosis") positiveCorrelation m(MIRBASE:"hsa-mir-155") |
| pmid:27288790 | a(CHEBI:"(+)-Tetrandrine") decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:NOS2) |
| pmid:27288790 | a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:PTGS2) |
| pmid:27288790 | a(MESH:Morphine) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(MESH:Morphine) increases p(FPLX:IKB) |
| pmid:27288790 | a(PUBCHEM:439378) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:27288790 | a(PUBCHEM:439378) decreases p(FPLX:ERK) |
| pmid:27288790 | a(PUBCHEM:439378) decreases p(HGNC:MAPK14) |
| pmid:27288790 | a(PUBCHEM:439378) decreases p(FPLX:NFkappaB) |
| pmid:27288790 | a(PUBCHEM:3968) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) |
| pmid:27288790 | a(PUBCHEM:3968) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:melatonin) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) |
| pmid:27288790 | a(CHEBI:melatonin) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:naproxen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") |
| pmid:27288790 | a(CHEBI:naproxen) decreases r(HGNC:BACE1) |
| pmid:27288790 | a(CHEBI:naproxen) decreases a(CHEBI:"amyloid-beta") |
| pmid:27288790 | a(CHEBI:hydroxytyrosol) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(CHEBI:nicorandil) decreases bp(GO:"apoptotic process") |
| pmid:27288790 | a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress") |
| pmid:27288790 | a(CHEBI:nicorandil) decreases p(HBP:APP695) |
| pmid:27288790 | a(CHEBI:nicorandil) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:27288790 | a(PUBCHEM:6440944) decreases act(p(FPLX:ERK)) |
| pmid:27288790 | a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(Ph)) |
| pmid:27288790 | a(PUBCHEM:6440944) decreases p(FPLX:NFkappaB, pmod(Ph)) |
| pmid:27288790 | a(PUBCHEM:6440944) decreases act(p(FPLX:NFkappaB)) |
| pmid:27288790 | a(PUBCHEM:6440944) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27288790 | a(PUBCHEM:6440944) decreases p(HGNC:APP) |
| pmid:27288790 | a(PUBCHEM:6440944) decreases a(CHEBI:"amyloid-beta") |
| pmid:27288790 | a(PUBCHEM:6440944) decreases sec(a(CHEBI:"amyloid-beta")) |
| pmid:25652642 | complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA)) increases act(complex(GO:"NF-kappaB p50/p65 complex")) |
| pmid:25652642 | bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:17009926 | bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:26813123 | bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) |
| pmid:26813123 | bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) |
| pmid:26813123 | bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) |
| pmid:25652642 | bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:24511233 | bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) |
| pmid:26813123 | bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) |
| pmid:26813123 | bp(GO:"synaptic transmission, glutamatergic") association bp(HBP:Neurodegeneration) |
| pmid:30106381 | bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation a(PUBCHEM:9832404) |
| pmid:25652642 | bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:19126755 | bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:22040696 | bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") |
| pmid:22040696 | bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) |
| pmid:25652642 | a(MESH:"I-kappa B Proteins") decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) |
| pmid:25652642 | act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") |
| pmid:19293145 | p(HGNC:APOE) association bp(GO:"lipid metabolic process") |
| pmid:19293145 | p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:21718217 | p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") |
| pmid:21718217 | p(HGNC:APOE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:APOE)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | act(p(HGNC:APOE)) regulates a(CHEBI:"amyloid-beta") |
| pmid:26195256 | tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pmid:26195256 | p(HGNC:APOE) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:30106381 | p(HGNC:APOE) association a(PUBCHEM:9832404) |
| pmid:30106381 | p(HGNC:APOE) increases path(MESH:"Alzheimer Disease") |
| pmid:25652642 | composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:TNF)) |
| pmid:25652642 | composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:NGF)) |
| pmid:25652642 | composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:BDNF)) |
| pmid:25652642 | a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:19126755 | act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") |
| pmid:19126755 | act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) |
| pmid:19126755 | p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:18986241 | p(HGNC:NGF) isA a(MESH:D009414) |
| pmid:18986241 | act(p(HGNC:NGF)) increases bp(GO:"GO:0000165") |
| pmid:18986241 | p(HGNC:NGF) causesNoChange path(MESH:D003929) |
| pmid:18986241 | p(HGNC:NGF) causesNoChange path(MESH:D016263) |
| pmid:18986241 | p(HGNC:NGF) causesNoChange path(MESH:D000544) |
| pmid:18986241 | p(HGNC:NGF) association bp(GO:"GO:0060384") |
| pmid:18986241 | p(HGNC:NGF) association bp(GO:"GO:0007269") |
| pmid:18986241 | p(HGNC:NGF) association bp(GO:"GO:0048485") |
| pmid:18986241 | p(HGNC:NGF) association path(MESH:D002100) |
| pmid:18986241 | p(HGNC:NGF) association path(MESH:D006930) |
| pmid:18986241 | p(HGNC:NGF) decreases path(MESH:D060825) |
| pmid:24686445 | p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph)) |
| pmid:24686445 | p(HGNC:NGF) increases act(p(HGNC:KAT2B)) |
| pmid:25652642 | p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) |
| pmid:25652642 | p(HGNC:GRM5) increases act(p(HGNC:SOD2)) |
| pmid:25652642 | p(HGNC:GRM5) increases act(p(HGNC:BCL2L1)) |
| pmid:24653673 | p(HGNC:GRM5) association path(MESH:"Alzheimer Disease") |
| pmid:25652642 | complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:14556719 | bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) |
| pmid:23746257 | bp(GO:"cell death") negativeCorrelation bp(HBP:Proteostasis) |
| pmid:18930136 | bp(GO:"cell death") negativeCorrelation a(GO:aggresome) |
| pmid:24561250 | bp(GO:"cell death") increases sec(a(CHEBI:ATP)) |
| pmid:25652642 | complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) |
| pmid:26813123 | act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:memory) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) |
| pmid:28901280 | a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) |
| pmid:19293145 | tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") |
| pmid:25652642 | bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia)) |
| pmid:25652642 | bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia)) |
| pmid:25652642 | p(MESH:"I-kappa B Proteins", pmod(Ph)) increases act(a(MESH:Microglia)) |
| pmid:25652642 | a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid") |
| pmid:25652642 | a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | m(HGNC:"MIR9-1") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP) |
| pmid:25652642 | m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM) |
| pmid:25652642 | m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A) |
| pmid:25652642 | m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25652642 | p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1) |
| pmid:25652642 | p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1) |
| pmid:30126037 | p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:30126037 | p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) |
| pmid:30126037 | p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") |
| pmid:30232325 | act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | act(p(HGNC:WNT3A)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | act(p(HGNC:WNT3A)) increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6) |
| pmid:30232325 | bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation") |
| pmid:30232325 | act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2) |
| pmid:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation") |
| pmid:30232325 | p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pmid:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases a(CHEBI:"amyloid-beta") |
| pmid:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) association act(p(HGNC:APP)) |
| pmid:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases path(MESH:"Plaque, Amyloid") |
| pmid:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) negativeCorrelation p(FPLX:CHRN) |
| pmid:30232325 | bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A)) |
| pmid:30232325 | act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | act(p(HGNC:DKK1)) increases act(p(HGNC:WNT5A)) |
| pmid:30232325 | act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | p(HGNC:DKK1) increases bp(HBP:HBP00061) |
| pmid:30232325 | p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") |
| pmid:30232325 | p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") |
| pmid:30232325 | p(HGNC:DKK1) increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | p(HGNC:DKK1) increases bp(GO:"amyloid-beta formation") |
| pmid:18494933 | p(HGNC:DKK1) increases act(p(HGNC:GSK3B)) |
| pmid:18494933 | p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:18494933 | p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway") |
| pmid:18494933 | p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1)) |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:DKK1)) decreases a(MESH:"Dendritic Spines") |
| pmid:24760868 | a(MESH:"Dendritic Spines") increases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) |
| pmid:27796283 | a(MESH:"Dendritic Spines") positiveCorrelation bp(GO:"dendritic spine development") |
| pmid:27796283 | a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA)) |
| pmid:30232325 | a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:30232325 | a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:30232325 | composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines") |
| pmid:30232325 | composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:19293145 | a(HBP:"sAPP-beta") decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:10656250 | p(HGNC:BACE1, var("p.?")) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:24590577 | a(HBP:"sAPP-alpha") increases bp(MESH:Neuroprotection) |
| pmid:10656250 | p(HGNC:CTSD) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:18930136 | p(HGNC:CTSD) isA a(GO:autolysosome) |
| pmid:18930136 | p(HGNC:CTSD) decreases path(HBP:Neurodegeneration) |
| pmid:18930136 | p(HGNC:CTSD) negativeCorrelation a(GO:lysosome) |
| pmid:18930136 | p(HGNC:CTSD) negativeCorrelation a(GO:autophagosome) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD")) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) |
| pmid:23528736 | p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(Ph)) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection) |
| pmid:24027553 | act(p(HGNC:CTSD)) decreases path(HBP:neurotoxicity) |
| pmid:10656250 | a(HBP:APP695) association p(HGNC:BACE1) |
| pmid:10656250 | a(HBP:APP751) association p(HGNC:BACE1) |
| pmid:22791904 | a(PUBCHEM:11249342) increases path(MESH:Nausea) |
| pmid:22791904 | a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea) |
| pmid:22791904 | a(PUBCHEM:11249342) increases path(MESH:Vomiting) |
| pmid:22791904 | a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HBP:"sAPP-alpha") |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HBP:"sAPP-beta") |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:MAPT) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:C3) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:CCL2) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:CHI3L1) |
| pmid:22791904 | a(PUBCHEM:11249342) causesNoChange p(HGNC:CFH) |
| pmid:19721446 | path(MESH:Nausea) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") |
| pmid:19721446 | path(MESH:Vomiting) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") |
| pmid:21718217 | p(HGNC:CCL2) increases bp(GO:"microglial cell activation") |
| pmid:30444369 | a(CHEBI:tacrine) increases bp(GO:cognition) |
| pmid:30444369 | a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase)) |
| pmid:19293145 | a(CHEBI:tacrine) increases p(HGNC:BCL2) |
| pmid:19293145 | act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) |
| pmid:24511233 | a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:11230871 | a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) |
| pmid:11230871 | a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) |
| pmid:11230871 | a(CHEBI:tacrine) increases p(FPLX:CHRN) |
| pmid:30444369 | a(CHEBI:donepezil) increases bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:donepezil) increases bp(GO:cognition) |
| pmid:30444369 | a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase)) |
| pmid:19126755 | a(CHEBI:donepezil) decreases p(HGNC:ACHE) |
| pmid:11230871 | a(CHEBI:donepezil) increases act(p(HGNC:ACHE)) |
| pmid:19293145 | a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pmid:19293145 | a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:donepezil) increases p(HGNC:CHRNA4) |
| pmid:19293145 | a(CHEBI:donepezil) increases p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:donepezil) increases p(HGNC:BCL2) |
| pmid:24511233 | a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:18986241 | a(CHEBI:donepezil) increases act(a(MESH:D005625)) |
| pmid:29626319 | a(CHEBI:donepezil) increases p(HGNC:ABCB1) |
| pmid:29626319 | a(CHEBI:donepezil) increases p(HGNC:LRP1) |
| pmid:29626319 | a(CHEBI:donepezil) decreases a(CHEBI:"amyloid-beta") |
| pmid:30444369 | a(CHEBI:rivastigmine) increases bp(GO:cognition) |
| pmid:30444369 | a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase)) |
| pmid:19126755 | a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) |
| pmid:11230871 | a(CHEBI:rivastigmine) increases act(p(HGNC:ACHE)) |
| pmid:19293145 | a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pmid:19293145 | a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") |
| pmid:26813123 | a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:24511233 | a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:29626319 | a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) |
| pmid:29626319 | a(CHEBI:rivastigmine) increases p(HGNC:LRP1) |
| pmid:29626319 | a(CHEBI:rivastigmine) decreases a(CHEBI:"amyloid-beta") |
| pmid:30444369 | a(CHEBI:memantine) increases bp(GO:cognition) |
| pmid:30444369 | a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:19293145 | a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") |
| pmid:19293145 | a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") |
| pmid:23722080 | a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") |
| pmid:26813123 | a(CHEBI:memantine) decreases a(HBP:Excitotoxicity) |
| pmid:16273023 | a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:16273023 | a(CHEBI:memantine) causesNoChange bp(MESH:D009435) |
| pmid:23722080 | a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:23722080 | a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:23722080 | a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) |
| pmid:24511233 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") |
| pmid:24511233 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) |
| pmid:16273023 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) |
| pmid:30444369 | g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:29196815 | g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:30444369 | g(HGNC:APP, var("?")) increases p(HGNC:MAPT) |
| pmid:30116051 | g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) |
| pmid:30116051 | g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) |
| pmid:30116051 | g(HGNC:APP, var("?")) increases p(HBP:C99) |
| pmid:30444369 | g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pmid:29758300 | g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pmid:22908190 | g(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") |
| pmid:30116051 | g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pmid:30444369 | g(HBP:"APOE e4") decreases deg(p(HGNC:APP)) |
| pmid:29758300 | g(HBP:"APOE e4") increases bp(GO:"cholesterol metabolic process") |
| pmid:29758300 | g(HBP:"APOE e4") regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | g(HBP:"APOE e4") increases act(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | g(HBP:"APOE e4") regulates bp(GO:"cholesterol transport") |
| pmid:22908190 | g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | g(HBP:"APOE e4") positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | g(HBP:"APOE e4") increases a(GO:endosome) |
| pmid:22908190 | g(HBP:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pmid:30116051 | g(HBP:"APOE e4") increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:22908190 | g(HBP:"APOE e4") increases path(HBP:Neurodegeneration) |
| pmid:22908190 | g(HBP:"APOE e4") increases bp(GO:"apoptotic process") |
| pmid:30116051 | g(HBP:"APOE e4") increases p(HGNC:LGMN) |
| pmid:30444369 | g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:29196815 | g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) |
| pmid:30444369 | g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:29196815 | g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP) |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol) |
| pmid:22908190 | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis) |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") decreases a(CHEBI:ATP) |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") increases p(HGNC:MAPT) |
| pmid:29758300 | path(HBP:"mitochondrial dysfunction") increases bp(GO:mitophagy) |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning) |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX)) |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP) |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3)) |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process") |
| pmid:30444369 | complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) |
| pmid:30444369 | p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) |
| pmid:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) |
| pmid:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) |
| pmid:30444369 | act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) |
| pmid:30444369 | act(p(HGNC:HSD17B10)) association p(FPLX:GABR) |
| pmid:30116051 | a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) |
| pmid:30116051 | a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) |
| pmid:30444369 | a(PUBCHEM:5757) decreases a(HBP:"amyloid-beta aggregates") |
| pmid:30444369 | a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30444369 | a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B)) |
| pmid:30444369 | a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(Ph)) |
| pmid:30444369 | a(PUBCHEM:5757) increases p(HGNC:BCL2) |
| pmid:30444369 | a(PUBCHEM:5757) increases p(HGNC:BCL2L1) |
| pmid:30444369 | a(PUBCHEM:5757) decreases p(HGNC:BCL2L11) |
| pmid:30444369 | a(PUBCHEM:5757) increases p(HGNC:SOD2) |
| pmid:30444369 | a(PUBCHEM:5757) increases p(FPLX:GPX) |
| pmid:30444369 | p(FPLX:GABR) association act(p(HGNC:HSD17B10)) |
| pmid:30444369 | a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) |
| pmid:30444369 | a(CHEBI:"methylene blue") decreases path(HBP:"mitochondrial dysfunction") |
| pmid:30444369 | a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) |
| pmid:30444369 | a(CHEBI:"methylene blue") decreases a(HBP:"amyloid-beta aggregates") |
| pmid:29758300 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding)) |
| pmid:29758300 | a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) |
| pmid:29758300 | a(CHEBI:"methylene blue") increases p(HGNC:BECN1) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:BECN1) |
| pmid:29758300 | a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) |
| pmid:29758300 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) |
| pmid:30116051 | a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) |
| pmid:23528736 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) |
| pmid:29758300 | a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:SQSTM1) |
| pmid:30116051 | a(CHEBI:"methylene blue") decreases a(HBP:"Tau oligomers") |
| pmid:30116051 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) |
| pmid:24027553 | a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) |
| pmid:24027553 | a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) |
| pmid:22611162 | a(CHEBI:"methylene blue") increases bp(GO:locomotion) |
| pmid:29191965 | a(CHEBI:"methylene blue") increases bp(GO:locomotion) |
| pmid:22611162 | a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") |
| pmid:23528736 | a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") |
| pmid:29191965 | a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") |
| pmid:23528736 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23528736 | a(CHEBI:"methylene blue") increases bp(GO:cognition) |
| pmid:21882945 | a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:"methylene blue") increases bp(GO:"protein catabolic process") |
| pmid:26751493 | a(CHEBI:"methylene blue") association bp(GO:"response to oxidative stress") |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) |
| pmid:23666762 | a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin)) |
| pmid:23666762 | a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) |
| pmid:28287136 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac)) |
| pmid:25437566 | a(CHEBI:ATP) association act(p(FPLX:HSP90)) |
| pmid:23746257 | a(CHEBI:ATP) regulates act(p(FPLX:HSP90)) |
| pmid:25437566 | a(CHEBI:ATP) association act(p(FPLX:HSPA)) |
| pmid:23746257 | a(CHEBI:ATP) regulates act(p(FPLX:HSPA)) |
| pmid:25437566 | a(CHEBI:ATP) association act(p(HGNC:HSPD1)) |
| pmid:23746257 | a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins)) |
| pmid:23746257 | a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB)) |
| pmid:23746257 | a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) |
| pmid:24457024 | a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) |
| pmid:27671637 | a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion) |
| pmid:24561250 | a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:29758300 | p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?")) |
| pmid:30116051 | act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) |
| pmid:24027553 | act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") |
| pmid:24027553 | act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") |
| pmid:24027553 | act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) |
| pmid:26631930 | p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) |
| pmid:29238289 | act(p(HGNC:CASP3)) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) |
| pmid:27068745 | p(HGNC:CASP3) association act(p(FPLX:JNK)) |
| pmid:27068745 | p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) |
| pmid:27068745 | p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") |
| pmid:27314526 | act(p(HGNC:CASP3)) increases bp(GO:"neuron death") |
| pmid:30444369 | p(HGNC:BCL2L11) increases bp(GO:"apoptotic process") |
| pmid:23528736 | p(HGNC:BCL2L11) decreases bp(GO:autophagy) |
| pmid:30444369 | act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30444369 | p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30444369 | p(HGNC:PRDX2, pmod(Ph, Thr, 89)) decreases act(p(HGNC:PRDX2)) |
| pmid:30444369 | p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") |
| pmid:30444369 | p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30444369 | p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) |
| pmid:30444369 | p(HGNC:SH3GL2) association bp(GO:"neuron projection development") |
| pmid:30444369 | p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") |
| pmid:30444369 | p(HGNC:SH3GL2) association bp(GO:"neuron death") |
| pmid:30444369 | bp(GO:"neuron projection development") association p(HGNC:SH3GL2) |
| pmid:20133804 | bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) |
| pmid:30444369 | a(HBP:AG18051) decreases act(p(HGNC:HSD17B10)) |
| pmid:30444369 | a(HBP:AG18051) decreases act(a(HBP:"amyloid-beta aggregates")) |
| pmid:30444369 | a(HBP:"RM-532-46") decreases act(p(HGNC:HSD17B10)) |
| pmid:30444369 | a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) |
| pmid:30444369 | a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) |
| pmid:30444369 | p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30444369 | p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase")) |
| pmid:30444369 | p(HGNC:CSNK1A1) association a(HBP:"amyloid-beta aggregates") |
| pmid:25974414 | act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) |
| pmid:25673844 | p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) |
| pmid:25546293 | p(HGNC:CSNK1A1) increases p(HGNC:CTNNB1, pmod(Ph, Ser, 35)) |
| pmid:30444369 | a(PUBCHEM:208907) decreases act(p(HGNC:MAOA)) |
| pmid:30444369 | a(PUBCHEM:208907) causesNoChange act(p(HGNC:CSNK1A1)) |
| pmid:30061532 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation act(p(HGNC:MTOR)) |
| pmid:22040696 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) |
| pmid:29758300 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(HBP:"protein aggregates") |
| pmid:29758300 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death") |
| pmid:22908190 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") |
| pmid:25784053 | path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") |
| pmid:18930136 | path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(HBP:misfolding)) |
| pmid:18930136 | path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) |
| pmid:18930136 | path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy) |
| pmid:29024336 | path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29024336 | path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:24027553 | path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) |
| pmid:29191965 | path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly") |
| pmid:29311797 | path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) |
| pmid:29311797 | path(MESH:"Neurodegenerative Diseases") negativeCorrelation act(p(FPLX:Proteasome)) |
| pmid:29311797 | path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:"chaperone-mediated autophagy") |
| pmid:29196815 | path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") |
| pmid:21482353 | path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") |
| pmid:22807490 | path(MESH:Smoking) association path(MESH:"Hashimoto Disease") |
| pmid:22807490 | path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative") |
| pmid:22807490 | path(MESH:Smoking) negativeCorrelation p(HGNC:TPO) |
| pmid:28391535 | path(MESH:Smoking) increases a(MESH:"Blood Glucose") |
| pmid:29196815 | path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") |
| pmid:29196815 | path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") |
| pmid:29626319 | path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) |
| pmid:29626319 | path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29196815 | g(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") |
| pmid:26837465 | complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) |
| pmid:26837465 | complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) |
| pmid:24368848 | complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) |
| pmid:23407988 | complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") |
| pmid:10391244 | complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pmid:10391244 | complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) |
| pmid:12714745 | complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation bp(GO:"neuron death") |
| pmid:21718217 | a(HBP:HBP00074) increases bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00074) decreases a(MESH:Synapses) |
| pmid:29196815 | a(HBP:HBP00074) decreases a(MESH:Synapses) |
| pmid:29196815 | a(HBP:HBP00074) decreases a(MESH:Synapses) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:memory) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:memory) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:memory) |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction") |
| pmid:29196815 | a(HBP:HBP00074) increases path(MESH:Dementia) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"signal release from synapse") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"long term synaptic depression") |
| pmid:29196815 | a(HBP:HBP00074) increases p(HGNC:APP, pmod(Ph)) |
| pmid:29196815 | a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"microglial cell activation") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"astrocyte activation") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation bp(GO:"astrocyte activation") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril") |
| pmid:29196815 | a(HBP:HBP00074) increases act(p(HGNC:GRIN1)) |
| pmid:29196815 | a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29196815 | a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29196815 | a(HBP:HBP00074) increases act(p(HGNC:NGFR)) |
| pmid:29196815 | a(HBP:HBP00074) decreases p(HGNC:INSR) |
| pmid:29196815 | a(HBP:HBP00074) negativeCorrelation a(HBP:HBP00352) |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:21718217 | a(HBP:HBP00074) decreases bp(GO:"synaptic signaling") |
| pmid:19293145 | a(MESH:Synapses) increases bp(GO:cognition) |
| pmid:29196815 | a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) |
| pmid:29196815 | a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074) |
| pmid:24653673 | p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(FPLX:ERK)) |
| pmid:24653673 | p(HGNC:APP, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine) |
| pmid:24653673 | p(HGNC:APP, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:29196815 | bp(GO:"astrocyte activation") positiveCorrelation a(HBP:HBP00074) |
| pmid:27671637 | bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B)) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6)) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18)) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2)) |
| pmid:29196815 | act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) |
| pmid:29196815 | act(p(HGNC:GRIN1)) increases path(HBP:HBP00068) |
| pmid:29196815 | act(p(HGNC:GRIN1)) increases path(HBP:HBP00037) |
| pmid:29196815 | act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) |
| pmid:24760868 | p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | a(HBP:HBP00075) decreases p(MGI:Adrb2) |
| pmid:29196815 | a(HBP:HBP00075) increases bp(GO:"microglial cell activation") |
| pmid:29196815 | a(HBP:HBP00075) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | complex(a(HBP:HBP00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") |
| pmid:29196815 | p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") |
| pmid:14556719 | p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) |
| pmid:14556719 | tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) |
| pmid:28420982 | p(HGNC:PRNP) association a(HBP:"Tau oligomers") |
| pmid:29196815 | a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)") |
| pmid:29196815 | a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) |
| pmid:29196815 | a(HBP:HBP00023) decreases bp(GO:"signal release from synapse") |
| pmid:29196815 | p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:18986241 | p(HGNC:NGFR) association bp(GO:"GO:1901214") |
| pmid:18986241 | p(HGNC:NGFR) increases act(p(HGNC:BACE1)) |
| pmid:18986241 | p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | act(p(HGNC:NGFR)) association bp(GO:"GO:0006665") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0007254") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0038061") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0000165") |
| pmid:22142809 | p(HGNC:NGFR) association p(HBP:RAC1b) |
| pmid:29196815 | a(HBP:HBP00352) negativeCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) |
| pmid:19293145 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers") |
| pmid:19293145 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pmid:26813123 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) |
| pmid:26813123 | path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) |
| pmid:26813123 | path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) |
| pmid:27522251 | path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") |
| pmid:21482353 | path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) |
| pmid:11230871 | path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) |
| pmid:24027553 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) |
| pmid:30108137 | path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) |
| pmid:30126037 | path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) |
| pmid:30126037 | path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") |
| pmid:19765634 | path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) |
| pmid:19765634 | path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) |
| pmid:29196815 | a(HBP:HBP00076) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(HBP:HBP00076) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:18650430 | p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:18650430 | p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") |
| pmid:14556719 | p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates") |
| pmid:22908190 | p(HGNC:APP, var("?")) increases bp(GO:endocytosis) |
| pmid:22908190 | p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites)) |
| pmid:28420982 | path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pmid:18650430 | act(p(HGNC:ADAM17), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM17) increases a(HBP:HBP00067) |
| pmid:18650430 | act(p(HGNC:ADAM9), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:22122372 | p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM9) increases a(HBP:HBP00067) |
| pmid:18650430 | act(p(HGNC:ADAM10), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:ADAM10) increases p(HBP:HBP00067) |
| pmid:21214928 | p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:21214928 | p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | p(HGNC:ADAM10) increases sec(p(HGNC:APP)) |
| pmid:24590577 | p(HGNC:ADAM10) increases deg(p(HGNC:APP)) |
| pmid:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067), a(HBP:HBP00072))) |
| pmid:22122372 | p(HGNC:ADAM10) increases a(HBP:HBP00067) |
| pmid:22122372 | p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha") |
| pmid:18650430 | act(p(HGNC:BACE2), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:18650430 | complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") |
| pmid:18650430 | complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00024)), products(a(CHEBI:"amyloid-beta"), a(HBP:HBP00072))) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HBP:HBP00024, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080))) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides"))) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) |
| pmid:24590577 | complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99)) |
| pmid:24590577 | complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | complex(FPLX:"Gamma_secretase") increases a(HBP:AICD) |
| pmid:21718217 | p(HGNC:APH1A) decreases p(HGNC:APP) |
| pmid:21718217 | p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:18650430 | p(HGNC:APBA1) decreases a(CHEBI:"amyloid-beta") |
| pmid:18650430 | p(HGNC:APBA1) decreases a(HBP:HBP00018) |
| pmid:18650430 | p(HGNC:APBA1) regulates bp(HBP:HBP00073) |
| pmid:21214928 | bp(HBP:HBP00073) association p(HGNC:RAB6A) |
| pmid:22122372 | bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:18650430 | p(HGNC:APBA2) decreases a(CHEBI:"amyloid-beta") |
| pmid:18650430 | p(HGNC:APBA2) decreases a(HBP:HBP00018) |
| pmid:18650430 | p(HGNC:APBA2) regulates bp(HBP:HBP00073) |
| pmid:18650430 | p(HGNC:APBB1) decreases a(CHEBI:"amyloid-beta") |
| pmid:18650430 | p(HGNC:APBB1) decreases a(HBP:HBP00018) |
| pmid:18650430 | p(HGNC:APBB1) regulates bp(HBP:HBP00073) |
| pmid:18650430 | p(HGNC:APBB1) increases a(HBP:HBP00071) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1) |
| pmid:21214928 | a(HBP:HBP00071) increases bp(GO:"apoptotic process") |
| pmid:18650430 | p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | p(HGNC:SORL1) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29758300 | p(HGNC:SORL1) association path(MESH:"Alzheimer Disease") |
| pmid:21214928 | bp(GO:"synapse assembly") association p(HGNC:APP) |
| pmid:30106381 | bp(GO:"synapse assembly") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"synapse assembly") association a(PUBCHEM:9832404) |
| pmid:18650430 | composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) |
| pmid:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | p(HGNC:SLC5A7) increases a(CHEBI:choline) |
| pmid:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases a(HBP:"sAPP-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha") |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases a(HBP:"sAPP-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha") |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) |
| pmid:21214928 | rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) association p(HGNC:BACE2) |
| pmid:21214928 | a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:26813123 | a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") |
| pmid:14556719 | a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070))) |
| pmid:22122372 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) |
| pmid:29215007 | a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) |
| pmid:21214928 | bp(HBP:HBP00077) increases p(HBP:HBP00063) |
| pmid:21214928 | bp(HBP:HBP00077) increases p(HBP:HBP00064) |
| pmid:21214928 | bp(HBP:HBP00077) increases p(HBP:HBP00065) |
| pmid:22122372 | bp(HBP:HBP00077) increases a(HBP:HBP00063) |
| pmid:22122372 | bp(HBP:HBP00077) increases a(HBP:HBP00064) |
| pmid:21214928 | p(HBP:HBP00064) association p(UNIPROT:A0A293M1A7) |
| pmid:21214928 | p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | p(HBP:HBP00065) association p(UNIPROT:A0A293M1A7) |
| pmid:21214928 | p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | p(UNIPROT:A0A293M1A7) association p(HBP:HBP00064) |
| pmid:21214928 | p(UNIPROT:A0A293M1A7) association p(HBP:HBP00065) |
| pmid:21214928 | r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | bp(GO:"signal transduction") association p(HGNC:APP) |
| pmid:17403556 | bp(GO:"signal transduction") increases complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) |
| pmid:29311797 | bp(GO:"signal transduction") association p(HGNC:HSP90AB1) |
| pmid:21214928 | bp(GO:"protein transport") association p(HGNC:APP) |
| pmid:23746257 | bp(GO:"protein transport") association p(FPLX:HSP90) |
| pmid:22122372 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) |
| pmid:27068745 | p(HGNC:NTN1) decreases p(HGNC:UNC5C, var("p.Thr835Met")) |
| pmid:21214928 | bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) |
| pmid:21734277 | bp(GO:"anterograde axonal protein transport") association p(HBP:"6D tau", frag("2_18")) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) |
| pmid:19491104 | p(HGNC:KIF5B) isA complex(GO:"kinesin complex") |
| pmid:19491104 | p(HGNC:KIF5B) association complex(GO:microtubule) |
| pmid:26813123 | complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) |
| pmid:21214928 | a(HBP:HBP00067) decreases bp(HBP:HBP00061) |
| pmid:22122372 | a(HBP:HBP00067) decreases bp(HBP:HBP00061) |
| pmid:22122372 | sec(a(HBP:HBP00067)) decreases bp(HBP:HBP00061) |
| pmid:21214928 | a(HBP:HBP00067) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity") |
| pmid:21214928 | a(HBP:HBP00067) regulates bp(GO:"central nervous system formation") |
| pmid:21214928 | a(HBP:HBP00067) decreases bp(HBP:HBP00068) |
| pmid:21214928 | a(HBP:HBP00067) decreases bp(HBP:HBP00068) |
| pmid:21214928 | a(HBP:HBP00067) regulates bp(GO:"stem cell proliferation") |
| pmid:21214928 | a(HBP:HBP00067) decreases act(p(HGNC:CDK5)) |
| pmid:21214928 | a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | a(HBP:HBP00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | a(HBP:HBP00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association a(CHEBI:"phorbol ester") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:"cell adhesion") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:"synapse assembly") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:learning) |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:memory) |
| pmid:21214928 | composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases a(HBP:HBP00067) |
| pmid:21214928 | a(CHEBI:"phorbol ester") association sec(a(HBP:HBP00067)) |
| pmid:21214928 | a(CHEBI:"phorbol ester") association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) |
| pmid:21214928 | bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067) |
| pmid:12428809 | bp(GO:"regulation of neuronal synaptic plasticity") association sec(p(HGNC:APP)) |
| pmid:21214928 | complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:19126755 | bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") |
| pmid:24511233 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pmid:24511233 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) |
| pmid:24511233 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) |
| pmid:17009926 | bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) |
| pmid:22040696 | bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(HBP:Neurodegeneration) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) |
| pmid:24590577 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) |
| pmid:11230871 | bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pmid:27094130 | sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) |
| pmid:29540553 | p(HGNC:APP, frag("672_713")) negativeCorrelation p(MGI:Sirt3) |
| pmid:29559585 | p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(Ac)) |
| pmid:29559585 | p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") |
| pmid:22122372 | p(HGNC:APP, frag("672_711")) decreases bp(HBP:HBP00061) |
| pmid:27094130 | sec(p(HGNC:APP, frag("672_711"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) |
| pmid:24401760 | p(HGNC:APP, frag("672_711")) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:21214928 | path(MESH:"Down Syndrome") increases a(HBP:HBP00018) |
| pmid:17009926 | path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:22299660 | path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2) |
| pmid:22908190 | path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") |
| pmid:21214928 | p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) |
| pmid:21214928 | complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") |
| pmid:21214928 | complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") |
| pmid:21214928 | a(HBP:HBP00042) increases p(HGNC:TTR) |
| pmid:21214928 | a(HBP:HBP00042) increases p(HGNC:KL) |
| pmid:22122372 | a(HBP:HBP00042) increases bp(HBP:HBP00061) |
| pmid:21214928 | bp(GO:"synapse pruning") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) |
| pmid:21214928 | a(HBP:HBP00024) increases bp(HBP:HBP00027) |
| pmid:22122372 | act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:22122372 | p(HBP:HBP00071) increases bp(GO:"cell death") |
| pmid:22122372 | p(HBP:HBP00071) increases p(HGNC:TP53) |
| pmid:22122372 | p(HBP:HBP00071) increases act(p(HGNC:TP53)) |
| pmid:22122372 | p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis") |
| pmid:22122372 | a(HBP:HBP00069) increases bp(HBP:HBP00061) |
| pmid:22122372 | a(HBP:HBP00069) increases act(p(HGNC:CASP3)) |
| pmid:22122372 | a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713")) |
| pmid:22122372 | a(HBP:HBP00070) increases bp(HBP:HBP00061) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) |
| pmid:21214928 | p(HGNC:BSG) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:BSG) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:TMED10) regulates a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(a(HBP:HBP00024), complex(FPLX:"Gamma_secretase"), p(HGNC:GSAP)) increases a(CHEBI:"amyloid-beta") |
| pmid:30061532 | p(HGNC:ERBB4) association path(MESH:Schizophrenia) |
| pmid:21718217 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | act(p(HGNC:MME)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:28250274 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | act(p(HGNC:MME)) decreases path(MESH:"Plaque, Amyloid") |
| pmid:29626319 | p(HGNC:MME) increases bp(GO:behavior) |
| pmid:28250274 | p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) |
| pmid:24653673 | p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) |
| pmid:30640040 | p(HGNC:EGFR) association a(PUBCHEM:24756910) |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pmid:29626319 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:LRP1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) |
| pmid:21214928 | complex(a(HBP:HBP00069), p(HGNC:APP)) increases bp(HBP:HBP00061) |
| pmid:22122372 | bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:22122372 | bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") |
| pmid:28420982 | bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pmid:19363271 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90) |
| pmid:23531502 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation act(a(CHEBI:"hydrogen peroxide")) |
| pmid:26655600 | bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") |
| pmid:17050703 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16816118 | bp(GO:"neurofibrillary tangle assembly") negativeCorrelation act(p(HBP:"20 S Proteasome")) |
| pmid:22122372 | a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid") |
| pmid:21718217 | a(HBP:HBP00038) increases p(HGNC:CCL2) |
| pmid:21718217 | a(HBP:HBP00038) increases bp(GO:"microglial cell activation") |
| pmid:21718217 | act(a(HBP:HBP00038)) increases bp(GO:phagocytosis) |
| pmid:28019679 | a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:24561250 | a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:21718217 | a(HBP:HBP00022) decreases bp(GO:"synaptic signaling") |
| pmid:21718217 | a(HBP:HBP00022) increases bp(GO:"neuron death") |
| pmid:21214928 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:DNM1)) decreases bp(HBP:HBP00061) |
| pmid:19721446 | p(HGNC:DNM1) association p(HGNC:CHRNB2) |
| pmid:29590627 | act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:21214928 | a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067) |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067)) |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association a(HBP:HBP00067) |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(HBP:HBP00067)) |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association a(HBP:HBP00067) |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(HBP:HBP00067)) |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | p(HGNC:RAB6A) association bp(HBP:HBP00073) |
| pmid:21214928 | bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) |
| pmid:26751493 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) |
| pmid:26751493 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) |
| pmid:26751493 | bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:27260836 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) |
| pmid:21214928 | complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1B)) increases sec(a(HBP:HBP00067)) |
| pmid:21214928 | a(CHEBI:estrogen) decreases a(CHEBI:"amyloid-beta") |
| pmid:19293145 | a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:11230871 | a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | a(CHEBI:estrogen) increases sec(a(HBP:HBP00067)) |
| pmid:19293145 | a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4")) |
| pmid:11230871 | a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") |
| pmid:21214928 | act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067)) |
| pmid:21214928 | p(HGNC:PRKCA) increases sec(a(HBP:HBP00067)) |
| pmid:21214928 | p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655)) |
| pmid:22122372 | p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:21214928 | p(HGNC:RAB11A) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | a(CHEBI:testosterone) decreases r(HGNC:BACE1) |
| pmid:21214928 | a(CHEBI:testosterone) decreases p(HGNC:BACE1) |
| pmid:21214928 | a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) |
| pmid:21214928 | a(CHEBI:testosterone) decreases p(HGNC:PSEN1) |
| pmid:22122372 | a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | a(HBP:HBP00078) association p(HGNC:APP) |
| pmid:22122372 | a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) |
| pmid:22122372 | a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) |
| pmid:22122372 | a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) |
| pmid:22122372 | a(HBP:HBP00079) association p(HGNC:APP) |
| pmid:22122372 | a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") |
| pmid:29221819 | p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:22122372 | p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pmid:29758300 | p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) |
| pmid:14556719 | p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) |
| pmid:14556719 | p(HGNC:PSEN1, var("?")) increases a(CHEBI:"amyloid-beta") |
| pmid:22908190 | p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process") |
| pmid:22908190 | p(HGNC:PSEN1, var("?")) decreases act(a(HBP:Neurites)) |
| pmid:22908190 | p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction") |
| pmid:22908190 | p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites)) |
| pmid:24027553 | p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer disease, familial, type 3") |
| pmid:22122372 | p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pmid:14556719 | p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) |
| pmid:14556719 | p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) |
| pmid:22122372 | complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) |
| pmid:22122372 | complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) |
| pmid:22122372 | complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") |
| pmid:22122372 | complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") |
| pmid:12428809 | p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport") |
| pmid:19491104 | act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) |
| pmid:19491104 | p(HGNC:KLC1) isA complex(GO:"kinesin complex") |
| pmid:19491104 | p(HGNC:KLC1) association p(HGNC:MAPK8IP1) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBA1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071)) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071)) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071)) |
| pmid:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) |
| pmid:22122372 | act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(Ph, Thr, 668)) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) association a(HBP:HBP00073) |
| pmid:19491104 | act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) |
| pmid:19491104 | p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") |
| pmid:19491104 | p(HGNC:MAPK8IP1) association p(HGNC:KLC1) |
| pmid:27094130 | p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_711"))) |
| pmid:27094130 | p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_713"))) |
| pmid:22122372 | a(HBP:HBP00073) association complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") |
| pmid:18494933 | deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) |
| pmid:29311797 | deg(p(MESH:Proteins, pmod(HBP:misfolded))) association a(MESH:"Molecular Chaperones") |
| pmid:30061532 | act(p(HGNC:MTOR)) regulates deg(p(MESH:Proteins, pmod(HBP:misfolded))) |
| pmid:30061532 | act(p(HGNC:MTOR)) negativeCorrelation bp(GO:autophagy) |
| pmid:30061532 | act(p(HGNC:MTOR)) decreases bp(GO:autophagy) |
| pmid:30061532 | p(HGNC:MTOR) decreases bp(GO:autophagy) |
| pmid:30106381 | p(HGNC:MTOR) association bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) |
| pmid:22908190 | p(HGNC:MTOR) regulates bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) |
| pmid:30061532 | act(p(HGNC:MTOR)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pmid:30061532 | act(p(HGNC:MTOR)) increases a(CHEBI:"amyloid-beta") |
| pmid:30061532 | act(p(HGNC:MTOR)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30061532 | act(p(HGNC:MTOR)) increases path(MESH:"Alzheimer Disease") |
| pmid:30061532 | act(p(HGNC:MTOR)) increases a(HBP:"Tau aggregates") |
| pmid:30061532 | act(p(HGNC:MTOR)) decreases bp(GO:cognition) |
| pmid:30061532 | act(p(HGNC:MTOR)) association act(g(HGNC:DISC1)) |
| pmid:30061532 | act(p(HGNC:MTOR)) association act(g(HGNC:NRG1)) |
| pmid:30061532 | act(p(HGNC:MTOR)) association act(g(HGNC:DPYSL2)) |
| pmid:30061532 | act(p(HGNC:MTOR)) increases act(a(CHEBI:methamphetamine)) |
| pmid:30061532 | act(p(HGNC:MTOR)) association p(HGNC:MAP6) |
| pmid:30061532 | act(p(HGNC:MTOR)) association p(HGNC:NRG1) |
| pmid:30061532 | act(p(HGNC:MTOR)) association path(MESH:Schizophrenia) |
| pmid:30061532 | act(p(HGNC:MTOR)) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30106381 | p(HGNC:MTOR) association bp(GO:translation) |
| pmid:30106381 | p(HGNC:MTOR) association a(GO:"actin cytoskeleton") |
| pmid:29758300 | p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:30985105 | act(p(HGNC:MTOR)) decreases p(HGNC:SNCA) |
| pmid:30061532 | path(MESH:"Lewy Body Disease") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30061532 | path(MESH:"Lewy Body Disease") association a(CHEBI:"amyloid-beta") |
| pmid:17009926 | path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:27075649 | path(MESH:"Lewy Body Disease") positiveCorrelation a(HBP:HBP00016) |
| pmid:29980653 | path(MESH:"Lewy Body Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:24590577 | a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") |
| pmid:28083634 | a(HBP:"Tau aggregates") negativeCorrelation p(HGNC:OTUB1) |
| pmid:29758300 | a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23528736 | a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29758300 | a(HBP:"Tau aggregates") association bp(GO:autophagy) |
| pmid:29758300 | a(HBP:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) |
| pmid:22908190 | a(HBP:"Tau aggregates") increases p(HBP:"Tau aggregates", pmod(Ub)) |
| pmid:22908190 | a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | a(HBP:"Tau aggregates") decreases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:30116051 | a(HBP:"Tau aggregates") decreases deg(a(HBP:"Tau oligomers")) |
| pmid:30116051 | a(HBP:"Tau aggregates") decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:24027553 | a(HBP:"Tau aggregates") positiveCorrelation path(HBP:neurotoxicity) |
| pmid:24027553 | a(HBP:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:24027553 | a(HBP:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) |
| pmid:24027553 | a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, frag("561_685")) |
| pmid:27574109 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:26751493 | a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:29590627 | a(HBP:"Tau aggregates") association a(GO:"early endosome") |
| pmid:29590627 | a(HBP:"Tau aggregates") association a(GO:"late endosome") |
| pmid:29590627 | a(HBP:"Tau aggregates") association a(GO:lysosome) |
| pmid:22611162 | a(HBP:"Tau aggregates") increases path(HBP:proteotoxicity) |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") |
| pmid:26631930 | a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure") |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases p(UNIPROT:O02495) |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria") |
| pmid:22611162 | a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion") |
| pmid:28528849 | a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death") |
| pmid:26458742 | a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death") |
| pmid:28528849 | a(HBP:"Tau aggregates") causesNoChange a(GO:membrane) |
| pmid:29988016 | a(HBP:"Tau aggregates") negativeCorrelation a(CHEBI:heparin) |
| pmid:29988016 | a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27373205 | a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21882945 | a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) |
| pmid:29311797 | a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) |
| pmid:30640040 | a(HBP:"Tau aggregates") increases bp(GO:"cell killing") |
| pmid:29191965 | a(HBP:"Tau aggregates") decreases act(a(GO:synapse)) |
| pmid:29191965 | a(HBP:"Tau aggregates") decreases a(GO:presynapse) |
| pmid:29191965 | a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:30985105 | a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation", Ser, 400)) |
| pmid:25374103 | a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") |
| pmid:28420982 | a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") |
| pmid:28877763 | a(HBP:"Tau aggregates") association p(MGI:Syk, pmod(Ph, Tyr, 525)) |
| pmid:28877763 | a(HBP:"Tau aggregates") association p(MGI:Syk, pmod(Ph, Tyr, 526)) |
| pmid:28877763 | a(HBP:"Tau aggregates") association p(HGNC:SYK, pmod(Ph)) |
| pmid:28877763 | a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:SYK, pmod(Ph)) |
| pmid:28420982 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:28420982 | a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") |
| pmid:28420982 | a(HBP:"Tau aggregates") association sec(p(HGNC:MAPT)) |
| pmid:28420982 | a(HBP:"Tau aggregates") association a(CHEBI:dextran) |
| pmid:29311797 | a(HBP:"Tau aggregates") association p(HGNC:HDAC6) |
| pmid:29311797 | a(HBP:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") |
| pmid:26458742 | a(HBP:"Tau aggregates") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) |
| pmid:27373205 | a(HBP:"Tau aggregates") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:26631930 | a(HBP:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | a(HBP:"Tau aggregates") positiveCorrelation bp(GO:aging) |
| pmid:26631930 | a(HBP:"Tau aggregates") decreases bp(GO:"microtubule polymerization") |
| pmid:26631930 | a(HBP:"Tau aggregates") decreases act(a(MESH:Neurons)) |
| pmid:26631930 | a(HBP:"Tau aggregates") increases path(HBP:Neurodegeneration) |
| pmid:22817713 | a(HBP:"Tau aggregates") increases act(p(HGNC:PPP1CA)) |
| pmid:22817713 | a(HBP:"Tau aggregates") increases act(p(HGNC:GSK3A)) |
| pmid:22817713 | a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22817713 | a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:25125464 | a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1) |
| pmid:30061532 | p(HGNC:TARDBP, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pmid:30061532 | p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pmid:29980653 | p(HGNC:TARDBP) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:29980653 | p(HGNC:TARDBP) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:29334120 | act(p(HGNC:TARDBP)) increases p(HBP:"4R tau") |
| pmid:30061532 | a(CHEBI:"mTOR inhibitor") decreases act(p(HGNC:MTOR)) |
| pmid:30061532 | a(CHEBI:"mTOR inhibitor") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30061532 | a(CHEBI:"mTOR inhibitor") decreases p(HGNC:SNCA, pmod(HBP:misfolded)) |
| pmid:30061532 | a(CHEBI:"mTOR inhibitor") decreases p(HGNC:TARDBP, pmod(HBP:misfolded)) |
| pmid:30061532 | path(HBP:Neurodegeneration) association act(a(GO:synapse)) |
| pmid:19126755 | path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) |
| pmid:30106381 | path(HBP:Neurodegeneration) association p(HGNC:WFS1) |
| pmid:29758300 | path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process") |
| pmid:17403556 | path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | path(HBP:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases bp(GO:"dopamine secretion, neurotransmission") |
| pmid:30061532 | a(CHEBI:methamphetamine) association bp(GO:"dopamine secretion, neurotransmission") |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNCGENEFAMILY:"Dopamine receptors")) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNC:DRD1)) |
| pmid:30061532 | a(CHEBI:methamphetamine) association p(HGNC:DRD1) |
| pmid:30061532 | a(CHEBI:methamphetamine) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pmid:30061532 | a(CHEBI:methamphetamine) increases path(MESH:Hallucinations) |
| pmid:30061532 | a(CHEBI:methamphetamine) increases path(MESH:Delusions) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(g(HGNC:DISC1)) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(g(HGNC:NRG1)) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(g(HGNC:DPYSL2)) |
| pmid:30061532 | a(CHEBI:methamphetamine) increases path(MESH:"Psychoses, Substance-Induced") |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC6A3)) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases p(HGNC:SLC6A3) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases sec(a(CHEBI:dopamine)) |
| pmid:30061532 | a(CHEBI:methamphetamine) increases a(CHEBI:dopamine, loc(GO:cytosol)) |
| pmid:30061532 | a(CHEBI:methamphetamine) association sec(a(CHEBI:dopamine)) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC18A2)) |
| pmid:30061532 | a(CHEBI:methamphetamine) negativeCorrelation p(HGNC:SLC18A2) |
| pmid:30061532 | a(CHEBI:methamphetamine) increases bp(GO:"response to oxidative stress") |
| pmid:30061532 | a(CHEBI:methamphetamine) increases act(p(FPLX:AKT)) |
| pmid:30061532 | a(CHEBI:methamphetamine) increases act(p(HGNC:MTOR)) |
| pmid:19293145 | act(a(CHEBI:methamphetamine)) increases bp(HBP:Neurodegeneration) |
| pmid:30061532 | bp(GO:"dopamine secretion, neurotransmission") association a(CHEBI:methamphetamine) |
| pmid:30061532 | bp(GO:"dopamine secretion, neurotransmission") association bp(GO:autophagy) |
| pmid:30061532 | bp(GO:"dopamine secretion, neurotransmission") association p(HGNC:DISC1) |
| pmid:30061532 | act(p(HGNC:DRD1)) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) |
| pmid:30061532 | act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) |
| pmid:30061532 | act(p(HGNC:DRD1)) decreases bp(GO:autophagy) |
| pmid:30061532 | p(HGNC:DRD1) association a(CHEBI:methamphetamine) |
| pmid:30061532 | act(p(HGNC:DRD1)) increases act(p(FPLX:AKT)) |
| pmid:30061532 | act(p(HGNC:DRD1)) increases g(HGNC:CDK5) |
| pmid:30061532 | act(p(HGNC:DRD1)) increases p(HGNC:CDK5) |
| pmid:30061532 | p(HGNC:DRD1) increases p(HGNC:CDK5) |
| pmid:30061532 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) |
| pmid:19721446 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pmid:30061532 | path(MESH:Hallucinations) negativeCorrelation bp(GO:autophagy) |
| pmid:30061532 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) |
| pmid:19721446 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pmid:30061532 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pmid:19721446 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pmid:30061532 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pmid:19721446 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pmid:30061532 | path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:DRD1)) |
| pmid:30061532 | path(MESH:Schizophrenia) association g(HGNC:DISC1) |
| pmid:30061532 | path(MESH:Schizophrenia) association g(HGNC:DISC1) |
| pmid:30061532 | path(MESH:Schizophrenia) association g(HGNC:NRG1) |
| pmid:30061532 | path(MESH:Schizophrenia) association g(HGNC:DPYSL2) |
| pmid:30061532 | path(MESH:Schizophrenia) association g(HGNC:DPYSL2) |
| pmid:30061532 | path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") |
| pmid:30061532 | path(MESH:Schizophrenia) increases path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") |
| pmid:30061532 | path(MESH:Schizophrenia) positiveCorrelation a(CHEBI:dopamine) |
| pmid:30061532 | path(MESH:Schizophrenia) association sec(a(CHEBI:dopamine)) |
| pmid:30061532 | path(MESH:Schizophrenia) increases a(CHEBI:dopamine) |
| pmid:30061532 | path(MESH:Schizophrenia) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Nerve Endings"), toLoc(MESH:"Limbic System")) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:SLC6A3) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:SLC18A2) |
| pmid:30061532 | path(MESH:Schizophrenia) association a(CHEBI:"reactive oxygen species") |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:"cytoskeleton organization") |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:"neuron-neuron synaptic transmission") |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:MAP2) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases a(GO:dendrite) |
| pmid:30061532 | path(MESH:Schizophrenia) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30061532 | path(MESH:Schizophrenia) increases p(HGNC:MAPT, loc(MESH:Neurons)) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases bp(GO:"oligodendrocyte development") |
| pmid:30061532 | path(MESH:Schizophrenia) association path(MESH:Catatonia) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:DISC1) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:DISC1) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:DTNBP1) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:DTNBP1) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:DPYSL2) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation act(a(GO:microtubule)) |
| pmid:30061532 | path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") |
| pmid:30061532 | path(MESH:Schizophrenia) decreases bp(GO:"protein kinase B signaling") |
| pmid:30061532 | path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(FPLX:AKT) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:NRG1) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:NRG1) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:ERBB4) |
| pmid:30061532 | path(MESH:Schizophrenia) association act(p(HGNC:MTOR)) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation act(p(HGNC:MTOR)) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CDK5R1) |
| pmid:30061532 | path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:CDK5)) |
| pmid:30061532 | path(MESH:Schizophrenia) association p(HGNC:ULK1, var("?")) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) |
| pmid:30061532 | path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:BECN1) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:BECN1) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:BECN1) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ULK2) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ATG3) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ADNP) |
| pmid:30061532 | path(MESH:Schizophrenia) decreases p(HGNC:ADNP2) |
| pmid:19126755 | path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") |
| pmid:19126755 | path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:cognition) |
| pmid:19721446 | path(MESH:Schizophrenia) association bp(GO:cognition) |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:behavior) |
| pmid:24511233 | path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:Attention) |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Executive Function") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") |
| pmid:17009926 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) |
| pmid:11230871 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) |
| pmid:21482353 | path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") |
| pmid:21482353 | path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) |
| pmid:21482353 | path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) |
| pmid:21482353 | path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) |
| pmid:11230871 | path(MESH:Schizophrenia) negativeCorrelation a(HBP:"alpha-7-containing nAChR") |
| pmid:11230871 | path(MESH:Schizophrenia) causesNoChange a(HBP:"alpha-4-containing nAChR") |
| pmid:19721446 | path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") |
| pmid:19721446 | path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) |
| pmid:22040696 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) |
| pmid:22040696 | path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) |
| pmid:30061532 | g(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pmid:30061532 | g(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pmid:30061532 | act(g(HGNC:DISC1)) association act(p(HGNC:MTOR)) |
| pmid:30061532 | g(HGNC:NRG1) association path(MESH:Schizophrenia) |
| pmid:30061532 | act(g(HGNC:NRG1)) association act(p(HGNC:MTOR)) |
| pmid:21482353 | g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:30061532 | g(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pmid:30061532 | g(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pmid:30061532 | act(g(HGNC:DPYSL2)) association act(p(HGNC:MTOR)) |
| pmid:30061532 | g(HGNC:DPYSL2) increases p(HGNC:DPYSL2) |
| pmid:30061532 | path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) |
| pmid:30061532 | path(MESH:"Psychotic Disorders") association p(HGNC:SNCA, var("?")) |
| pmid:30061532 | path(MESH:"Psychotic Disorders") association path(MESH:"Frontotemporal Lobar Degeneration") |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) |
| pmid:22040696 | path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) |
| pmid:30061532 | a(CHEBI:dopamine) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | sec(a(CHEBI:dopamine)) association path(MESH:Schizophrenia) |
| pmid:30061532 | a(CHEBI:dopamine) regulates bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:dopamine) association p(HGNC:SLC18A2) |
| pmid:30061532 | a(CHEBI:dopamine) increases bp(GO:"response to oxidative stress") |
| pmid:30061532 | sec(a(CHEBI:dopamine)) association a(CHEBI:methamphetamine) |
| pmid:19126755 | a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") |
| pmid:21787755 | sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) |
| pmid:21787755 | sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) |
| pmid:28391535 | a(CHEBI:dopamine) regulates path(MESH:Pleasure) |
| pmid:28391535 | a(CHEBI:dopamine) regulates path(MESH:Motivation) |
| pmid:27075649 | a(CHEBI:dopamine) increases a(HBP:HBP00093) |
| pmid:27075649 | a(CHEBI:dopamine) increases a(HBP:HBP00093) |
| pmid:30061532 | p(HGNC:SLC6A3) increases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) |
| pmid:30061532 | a(CHEBI:"lithium(1+)") decreases act(p(HGNC:MTOR)) |
| pmid:30061532 | a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) |
| pmid:30061532 | a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) |
| pmid:30061532 | a(CHEBI:"lithium(1+)") decreases path(MESH:"Psychotic Disorders") |
| pmid:18930136 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pmid:18930136 | a(CHEBI:"lithium(1+)") decreases path(HBP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") |
| pmid:30061532 | p(HGNC:SLC18A2) association a(CHEBI:dopamine) |
| pmid:30061532 | p(HGNC:SLC18A2) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:SLC18A2) negativeCorrelation a(CHEBI:methamphetamine) |
| pmid:30061532 | bp(GO:"cytoskeleton organization") negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | bp(GO:"cytoskeleton organization") increases bp(GO:"neuron-neuron synaptic transmission") |
| pmid:30061532 | bp(GO:"cytoskeleton organization") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) |
| pmid:23454242 | bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A) |
| pmid:23454242 | bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B) |
| pmid:23454242 | bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C) |
| pmid:29311797 | bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) |
| pmid:30061532 | bp(GO:"microtubule polymerization") increases bp(GO:"cytoskeleton organization") |
| pmid:29238289 | bp(GO:"microtubule polymerization") association p(HGNC:MAPT) |
| pmid:19459590 | bp(GO:"microtubule polymerization") positiveCorrelation act(p(HGNC:MAPT)) |
| pmid:20133804 | bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) |
| pmid:30061532 | complex(a(GO:microtubule), a(MESH:"Microtubule-Associated Proteins")) increases bp(GO:"microtubule polymerization") |
| pmid:30061532 | act(a(GO:microtubule)) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:14556719 | a(GO:microtubule) association p(HGNC:MAPT) |
| pmid:26631930 | a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:18930136 | a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") |
| pmid:8282104 | a(GO:microtubule) association p(HGNC:CDK5) |
| pmid:8282104 | a(GO:microtubule) association p(HGNC:PRKACA) |
| pmid:8282104 | a(GO:microtubule) association p(FPLX:ERK) |
| pmid:8282104 | a(GO:microtubule) association p(FPLX:GSK3) |
| pmid:23487739 | a(GO:microtubule) negativeCorrelation act(p(HGNC:HDAC6)) |
| pmid:30061532 | bp(GO:"neuron-neuron synaptic transmission") negativeCorrelation path(MESH:Schizophrenia) |
| pmid:30061532 | a(GO:dendrite) association p(HGNC:DISC1) |
| pmid:30061532 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:12428809 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HBP:"4R tau") |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HBP:"4R tau") |
| pmid:22299660 | path(MESH:"Frontotemporal Dementia") association p(FPLX:PPP2) |
| pmid:22299660 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("?")) |
| pmid:29758300 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) |
| pmid:29758300 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) |
| pmid:29024336 | path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:24027553 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.P301L")) |
| pmid:24027553 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:LAMP1) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) |
| pmid:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) |
| pmid:26631930 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:29980653 | path(MESH:"Frontotemporal Dementia") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29980653 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP) |
| pmid:8391280 | path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) |
| pmid:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:"Psychotic Disorders") |
| pmid:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:Catatonia) |
| pmid:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(GO:"inclusion body")) |
| pmid:30061532 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) |
| pmid:22908190 | path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) |
| pmid:26631930 | path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) |
| pmid:30061532 | path(MESH:Catatonia) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pmid:30061532 | path(MESH:Catatonia) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DISC1) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DISC1) increases a(HBP:"protein aggregates") |
| pmid:30061532 | p(HGNC:DISC1) association bp(MESH:Neurogenesis) |
| pmid:30061532 | p(HGNC:DISC1) association bp(GO:"neuron migration") |
| pmid:30061532 | p(HGNC:DISC1) association bp(GO:"axon development") |
| pmid:30061532 | p(HGNC:DISC1) association a(GO:dendrite) |
| pmid:30061532 | p(HGNC:DISC1) association a(GO:synapse) |
| pmid:30061532 | p(HGNC:DISC1) association bp(GO:"dopamine secretion, neurotransmission") |
| pmid:30061532 | p(HGNC:DISC1) decreases act(p(HGNC:CCDC88A)) |
| pmid:22020111 | a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22020111 | a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:22020111 | a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:29758300 | a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pmid:14556719 | a(HBP:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29980653 | a(HBP:"protein aggregates", loc(MESH:"Central Nervous System")) increases path(HBP:Neurodegeneration) |
| pmid:29980653 | a(HBP:"protein aggregates") increases path(HBP:Neurodegeneration) |
| pmid:30061532 | p(HGNC:DTNBP1) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DTNBP1) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DTNBP1) increases a(HBP:"protein aggregates") |
| pmid:30061532 | p(HGNC:DTNBP1) association a(GO:"microtubule cytoskeleton") |
| pmid:30061532 | p(HGNC:DTNBP1) association act(a(GO:cytoskeleton)) |
| pmid:30061532 | p(HGNC:DTNBP1) association bp(GO:"synaptic vesicle transport") |
| pmid:30106381 | a(GO:"actin cytoskeleton") association p(HGNC:MTOR) |
| pmid:30061532 | p(HGNC:DPYSL2) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DPYSL2) association bp(GO:"axon development") |
| pmid:30061532 | p(HGNC:DPYSL2) regulates a(GO:"dendritic spine") |
| pmid:30061532 | a(GO:"microtubule cytoskeleton") association p(HGNC:DTNBP1) |
| pmid:24653673 | a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) |
| pmid:30061532 | act(a(GO:cytoskeleton)) association p(HGNC:DTNBP1) |
| pmid:30061532 | bp(GO:"synaptic vesicle transport") association p(HGNC:DTNBP1) |
| pmid:14556719 | bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(Ub)) |
| pmid:30061532 | p(HGNC:MAP6) association act(p(HGNC:MTOR)) |
| pmid:30061532 | bp(MESH:Neurogenesis) association p(HGNC:DISC1) |
| pmid:30061532 | bp(GO:"neuron migration") association p(HGNC:DISC1) |
| pmid:30061532 | bp(GO:"axon development") association p(HGNC:DISC1) |
| pmid:30061532 | bp(GO:"axon development") association p(HGNC:DPYSL2) |
| pmid:30061532 | p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:DISC1, var("?")) decreases sec(a(CHEBI:dopamine)) |
| pmid:30061532 | p(HGNC:DISC1, var("?")) increases act(p(FPLX:AKT)) |
| pmid:30061532 | p(HGNC:DISC1, var("?")) increases act(p(HGNC:MTOR)) |
| pmid:30061532 | p(HGNC:DISC1, var("?")) decreases bp(GO:autophagy) |
| pmid:30061532 | p(HGNC:CCDC88A) increases act(p(FPLX:AKT)) |
| pmid:30061532 | complex(p(FPLX:AKT), p(HGNC:CCDC88A)) increases act(p(FPLX:AKT)) |
| pmid:30061532 | complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) |
| pmid:30061532 | complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) |
| pmid:30061532 | complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(HGNC:MTOR)) |
| pmid:30061532 | p(MGI:Rictor) decreases bp(GO:"protein kinase B signaling") |
| pmid:30061532 | p(HGNC:NRG1) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:NRG1) association path(MESH:Schizophrenia) |
| pmid:30061532 | p(HGNC:NRG1) regulates p(HGNC:DISC1) |
| pmid:30061532 | p(HGNC:NRG1) association bp(GO:"protein kinase B signaling") |
| pmid:30061532 | p(HGNC:NRG1) association act(p(HGNC:MTOR)) |
| pmid:30061532 | complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"generation of neurons") |
| pmid:30061532 | complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pmid:30061532 | act(complex(p(HGNC:ERBB4), p(HGNC:NRG1))) increases sec(a(CHEBI:dopamine)) |
| pmid:21482353 | bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:30061532 | complex(p(FPLX:PI3K), p(HGNC:ERBB4)) increases act(p(FPLX:PI3K)) |
| pmid:30061532 | act(p(FPLX:PI3K), ma(kin)) increases p(FPLX:AKT, pmod(Ph)) |
| pmid:30061532 | act(p(FPLX:PI3K)) increases act(p(FPLX:AKT)) |
| pmid:19293145 | p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) |
| pmid:19293145 | act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) |
| pmid:19293145 | p(FPLX:PI3K) increases act(a(MESH:Synapses)) |
| pmid:19293145 | act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) |
| pmid:22040696 | act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") |
| pmid:30116051 | act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") |
| pmid:25514383 | p(FPLX:AKT, pmod(Ph)) decreases bp(GO:"apoptotic process") |
| pmid:30985105 | p(FPLX:AKT, pmod(Ph)) decreases bp(GO:autophagy) |
| pmid:30061532 | a(GO:"dendritic spine") positiveCorrelation p(HGNC:CDK5) |
| pmid:27671637 | a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27807169 | a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) |
| pmid:22156579 | a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) |
| pmid:30061532 | a(CHEBI:amphetamine) increases g(HGNC:CDK5) |
| pmid:30061532 | a(CHEBI:amphetamine) increases p(HGNC:CDK5) |
| pmid:24511233 | act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) |
| pmid:30061532 | p(HGNC:CDK5R1, frag("?")) increases act(p(HGNC:CDK5)) |
| pmid:30061532 | complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association bp(GO:"cytoskeleton organization") |
| pmid:30061532 | complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association path(MESH:"Mental Disorders") |
| pmid:30061532 | path(MESH:"Mental Disorders") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) |
| pmid:30061532 | p(HGNC:ULK1, var("?")) association path(MESH:Schizophrenia) |
| pmid:30116051 | p(HGNC:ULK1) increases bp(GO:macroautophagy) |
| pmid:30116051 | act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(Ph)) |
| pmid:30116051 | act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(Ph)) |
| pmid:23528736 | p(HGNC:ULK1) increases bp(GO:autophagy) |
| pmid:30061532 | p(HGNC:BECN1) association bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:BECN1) increases bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides") |
| pmid:29758300 | p(HGNC:BECN1) association bp(GO:macroautophagy) |
| pmid:29758300 | p(HGNC:BECN1) association bp(GO:endocytosis) |
| pmid:29758300 | p(HGNC:BECN1) increases bp(GO:phagocytosis) |
| pmid:30116051 | act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") |
| pmid:27260836 | p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) |
| pmid:30061532 | p(HGNC:ULK2) association bp(GO:autophagy) |
| pmid:30061532 | p(HGNC:ATG3) association bp(GO:autophagy) |
| pmid:30061532 | p(HGNC:ADNP) increases bp(GO:"brain development") |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:autophagy) |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:autophagy) |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"cell adhesion") |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"immune response") |
| pmid:30106381 | p(HGNC:ADNP) association path(MESH:"Autistic Disorder") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Autistic Disorder") |
| pmid:30106381 | p(HGNC:ADNP) association act(a(GO:synapse)) |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"nervous system development") |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"synapse assembly") |
| pmid:30106381 | p(HGNC:ADNP) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") |
| pmid:30106381 | p(HGNC:ADNP) regulates bp(GO:"synapse organization") |
| pmid:30106381 | p(HGNC:ADNP) regulates bp(GO:"cell communication") |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"AMPA glutamate receptor clustering") |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:learning) |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:memory) |
| pmid:30664622 | p(HGNC:ADNP) increases bp(GO:memory) |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"social behavior") |
| pmid:30664622 | p(HGNC:ADNP) increases bp(GO:"social behavior") |
| pmid:30106381 | p(HGNC:ADNP) regulates bp(GO:"ion transport") |
| pmid:30106381 | p(HGNC:ADNP) association bp(GO:"vocalization behavior") |
| pmid:30106381 | p(HGNC:ADNP) regulates p(HGNC:APOE) |
| pmid:30106381 | p(HGNC:ADNP) association g(HGNC:"IQCJ-SCHIP1") |
| pmid:30106381 | p(HGNC:ADNP) association p(HGNC:NLGN2) |
| pmid:30106381 | p(HGNC:ADNP) regulates p(HGNC:PAX6) |
| pmid:30106381 | p(HGNC:ADNP) association p(HGNC:WFS1) |
| pmid:30106381 | p(HGNC:ADNP) association path(MESH:Inflammation) |
| pmid:30106381 | p(HGNC:ADNP) association path(MESH:Intelligence) |
| pmid:30106381 | p(HGNC:ADNP) regulates p(HGNC:MTOR) |
| pmid:30664622 | p(HGNC:ADNP) decreases path(MESH:"Motor Skills Disorders") |
| pmid:30664622 | p(HGNC:ADNP) increases a(MESH:"Nerve Fibers, Myelinated") |
| pmid:30664622 | act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse") |
| pmid:30664622 | p(HGNC:ADNP) increases a(GO:"dendritic spine") |
| pmid:30664622 | act(p(HGNC:ADNP)) association p(HGNC:DLG4) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Intellectual Disability") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Developmental Disabilities") |
| pmid:29724491 | p(HGNC:ADNP) increases bp(GO:"motor behavior") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Muscle Hypotonia") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Muscle Hypertonia") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Language Development Disorders") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Seizures) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Epilepsy) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Autism Spectrum Disorder") |
| pmid:29724491 | p(HGNC:ADNP) increases bp(GO:"sensory processing") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Compulsive Behavior") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Mood Disorders") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Anxiety) |
| pmid:29724491 | p(HGNC:ADNP) increases path(MESH:Morale) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Self-Injurious Behavior") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Aggression) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pmid:29724491 | p(HGNC:ADNP) increases bp(GO:sleep) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:"Malformations of Cortical Development") |
| pmid:29724491 | p(HGNC:ADNP) increases path(MESH:"Vision, Ocular") |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Hyperopia) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Strabismus) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Myopia) |
| pmid:29724491 | p(HGNC:ADNP) decreases path(MESH:Astigmatism) |
| pmid:30985105 | bp(GO:"brain development") association p(HGNC:OGT) |
| pmid:30061532 | p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome assembly") |
| pmid:30061532 | p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome maturation") |
| pmid:24027553 | p(HGNC:MAP1LC3A) association path(MESH:"Plaque, Amyloid") |
| pmid:30061532 | a(PUBCHEM:9832404) increases r(HGNC:BECN1) |
| pmid:30061532 | a(PUBCHEM:9832404) increases r(HGNC:ADNP) |
| pmid:30061532 | a(PUBCHEM:9832404) increases complex(p(HGNC:ADNP), p(HGNC:MAP1LC3A)) |
| pmid:30061532 | a(PUBCHEM:9832404) decreases bp(GO:"neuron death") |
| pmid:30061532 | a(PUBCHEM:9832404) increases bp(GO:cognition) |
| pmid:30061532 | a(PUBCHEM:9832404) decreases path(MESH:"Mental Disorders") |
| pmid:30106381 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pmid:30106381 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pmid:30106381 | a(PUBCHEM:9832404) increases a(GO:"dendritic spine") |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:DLG4) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:DLG4) |
| pmid:30106381 | a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4) |
| pmid:30106381 | a(PUBCHEM:9832404) increases p(HGNC:DLG4) |
| pmid:30664622 | act(a(PUBCHEM:9832404)) association p(HGNC:DLG4) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") |
| pmid:30106381 | a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") |
| pmid:30106381 | a(PUBCHEM:9832404) increases a(GO:"excitatory synapse") |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:autophagy) |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"cell adhesion") |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"immune response") |
| pmid:30106381 | a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder") |
| pmid:30106381 | a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder") |
| pmid:30106381 | a(PUBCHEM:9832404) association act(a(GO:synapse)) |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"nervous system development") |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"synapse assembly") |
| pmid:30106381 | a(PUBCHEM:9832404) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") |
| pmid:30106381 | a(PUBCHEM:9832404) regulates bp(GO:"synapse organization") |
| pmid:30106381 | a(PUBCHEM:9832404) regulates bp(GO:"cell communication") |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"AMPA glutamate receptor clustering") |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:learning) |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:memory) |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"social behavior") |
| pmid:30106381 | a(PUBCHEM:9832404) increases bp(GO:"social behavior") |
| pmid:30664622 | a(PUBCHEM:9832404) increases bp(GO:"social behavior") |
| pmid:30664622 | a(PUBCHEM:9832404) increases bp(GO:"social behavior") |
| pmid:30106381 | a(PUBCHEM:9832404) regulates bp(GO:"ion transport") |
| pmid:30106381 | a(PUBCHEM:9832404) association bp(GO:"vocalization behavior") |
| pmid:30106381 | a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) |
| pmid:30106381 | a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) |
| pmid:30106381 | a(PUBCHEM:9832404) increases p(HGNC:FPR3) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:TUBB1) |
| pmid:30106381 | a(PUBCHEM:9832404) association p(HGNC:APOE) |
| pmid:30106381 | a(PUBCHEM:9832404) association g(HGNC:"IQCJ-SCHIP1") |
| pmid:30106381 | a(PUBCHEM:9832404) association p(HGNC:NLGN2) |
| pmid:30106381 | a(PUBCHEM:9832404) association p(HGNC:PAX6) |
| pmid:30106381 | a(PUBCHEM:9832404) regulates p(HGNC:WFS1) |
| pmid:30106381 | a(PUBCHEM:9832404) increases p(HGNC:HIST1H3B) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:ABCF3) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:BMP4) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:CDH17) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:KDM5D) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:KLF1) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:PER1) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:AKT1) |
| pmid:30106381 | a(PUBCHEM:9832404) decreases p(HGNC:AIF1) |
| pmid:30106381 | a(PUBCHEM:9832404) regulates p(HGNC:MTOR) |
| pmid:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") |
| pmid:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") |
| pmid:30106381 | a(PUBCHEM:9832404) decreases path(MESH:"Vestibular Diseases") |
| pmid:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Motor Activity") |
| pmid:30106381 | a(PUBCHEM:9832404) increases bp(MESH:"Hand Strength") |
| pmid:30106381 | a(PUBCHEM:9832404) increases path(MESH:"Recognition (Psychology)") |
| pmid:30106381 | a(PUBCHEM:9832404) increases path(MESH:Smell) |
| pmid:30664622 | a(PUBCHEM:9832404) causesNoChange bp(GO:behavior) |
| pmid:30664622 | a(PUBCHEM:9832404) decreases path(MESH:"Motor Skills Disorders") |
| pmid:30664622 | a(PUBCHEM:9832404) decreases path(HBP:Excitotoxicity) |
| pmid:30664622 | act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse") |
| pmid:30664622 | a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) |
| pmid:30664622 | a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) |
| pmid:30664622 | a(PUBCHEM:9832404) increases p(HGNC:SLC17A7) |
| pmid:30664622 | a(PUBCHEM:9832404) increases r(HGNC:SLC17A7) |
| pmid:30664622 | a(PUBCHEM:9832404) decreases r(HGNC:SLC17A7) |
| pmid:30008470 | a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP)) |
| pmid:30008470 | a(PUBCHEM:9832404) increases act(p(HGNC:ADNP)) |
| pmid:30061532 | a(MESH:"Antipsychotic Agents") decreases path(MESH:Schizophrenia) |
| pmid:30061532 | a(MESH:"Antipsychotic Agents") decreases path(MESH:"Psychotic Disorders") |
| pmid:24590577 | a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") |
| pmid:30061532 | a(PUBCHEM:3396) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:trifluoperazine) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:pimozide) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:pimozide) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:pimozide) increases act(p(HGNC:PRKAA1)) |
| pmid:30061532 | a(CHEBI:pimozide) decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:30061532 | act(p(HGNC:PRKAA1)) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:29758300 | p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:30061532 | p(HGNC:ULK1, pmod(Ph)) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:chlorpromazine) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:chlorpromazine) decreases bp(GO:"protein kinase B signaling") |
| pmid:30061532 | a(CHEBI:chlorpromazine) decreases act(p(HGNC:MTOR)) |
| pmid:23038257 | a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:23038257 | a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) |
| pmid:30061532 | a(CHEBI:sertindole) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:clozapine) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:clozapine) increases bp(GO:autophagy) |
| pmid:30061532 | a(CHEBI:clozapine) increases p(HGNC:PRKAA1, pmod(Ph)) |
| pmid:30061532 | a(CHEBI:clozapine) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:30061532 | a(CHEBI:clozapine) increases p(HGNC:BECN1, pmod(Ph)) |
| pmid:30061532 | a(CHEBI:clozapine) increases a(GO:autophagosome) |
| pmid:30061532 | a(CHEBI:clozapine) decreases a(CHEBI:"amyloid-beta") |
| pmid:19721446 | a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(CHEBI:clozapine) association p(HGNC:CHRNA7) |
| pmid:30116051 | p(HGNC:BECN1, pmod(Ph)) increases act(p(HGNC:BECN1)) |
| pmid:22908190 | a(GO:autophagosome) association a(HBP:"dystrophic neurite") |
| pmid:22908190 | a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | a(GO:autophagosome) increases a(GO:organelle) |
| pmid:22908190 | a(GO:autophagosome) association p(HGNC:APP) |
| pmid:18930136 | a(GO:autophagosome) increases bp(GO:autophagy) |
| pmid:18930136 | a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") |
| pmid:18930136 | a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) |
| pmid:18930136 | a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) |
| pmid:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:18930136 | a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome") |
| pmid:18930136 | a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD) |
| pmid:18930136 | a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?")) |
| pmid:24027553 | p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration) |
| pmid:30126037 | p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a) |
| pmid:19491104 | p(MGI:Mapt, pmod(Ph)) association p(MGI:Mapk8ip1) |
| pmid:19491104 | p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Mapk8ip1)) |
| pmid:19491104 | p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Klc1)) |
| pmid:28173111 | p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l) |
| pmid:29024336 | p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29202785 | p(MGI:Mapt) increases bp(GO:"neuron migration") |
| pmid:29202785 | p(MGI:Mapt) increases bp(GO:"neuron differentiation") |
| pmid:29202785 | p(MGI:Mapt) increases bp(GO:"neuron maturation") |
| pmid:30126037 | p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(MGI:Mapt) increases bp(HP:Neurodegeneration) |
| pmid:30126037 | p(MGI:Mapt) increases p(MGI:Cdkn2a) |
| pmid:30126037 | p(MGI:Mapt) increases bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Mapt) increases path(HP:"Brain atrophy") |
| pmid:28408124 | tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau aggregates") |
| pmid:18096814 | p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") |
| pmid:26400044 | p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:25995053 | p(MGI:Mapt) association p(MGI:Dapk1) |
| pmid:25995053 | p(MGI:Mapt) partOf complex(p(MGI:Dapk1), p(MGI:Mapt)) |
| pmid:29221819 | p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:28877763 | p(MGI:Mapt) positiveCorrelation p(MGI:Syk) |
| pmid:30061532 | a(CHEBI:haloperidol) decreases a(HBP:"huntingtin aggregates") |
| pmid:24706768 | a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") |
| pmid:24706768 | a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases bp(GO:"response to nicotine") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates sec(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(HBP:neurotoxicity) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(HBP:neurotoxicity) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:dopamine)) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:serotonin)) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") |
| pmid:19126755 | a(TAXONOMY:41956) increases a(CHEBI:Muscarine) |
| pmid:19126755 | a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(TAXONOMY:33113) increases a(CHEBI:atropine) |
| pmid:19126755 | a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(CHEBI:atropine) decreases bp(GO:"cell adhesion") |
| pmid:26813123 | a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) |
| pmid:26751493 | p(FPLX:PLC) association p(HBP:"projection domain") |
| pmid:26751493 | p(FPLX:PLC) association a(HBP:"projection domain") |
| pmid:29626319 | a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) |
| pmid:29758300 | a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) |
| pmid:19126755 | a(CHEBI:nicotine) association path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:nicotine) decreases path(HBP:neurotoxicity) |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") |
| pmid:18174175 | a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-4 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PKA)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PKC)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) association a(MESH:Skin) |
| pmid:19126755 | act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") |
| pmid:23178521 | a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") |
| pmid:19126755 | a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") |
| pmid:19126755 | a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") |
| pmid:19126755 | a(CHEBI:nicotine) decreases sec(p(HGNC:TNF)) |
| pmid:19293145 | a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) |
| pmid:19126755 | a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398")) |
| pmid:19126755 | a(CHEBI:nicotine) decreases bp(GO:"neuron death") |
| pmid:19126755 | a(CHEBI:nicotine) decreases bp(GO:"neuron death") |
| pmid:19126755 | a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | a(CHEBI:nicotine) decreases sec(a(CHEBI:dopamine)) |
| pmid:21482353 | a(CHEBI:nicotine) decreases a(CHEBI:dopamine) |
| pmid:21482353 | a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) |
| pmid:19721446 | a(CHEBI:nicotine) regulates sec(a(CHEBI:dopamine)) |
| pmid:28391535 | a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) |
| pmid:28391535 | a(CHEBI:nicotine) increases act(a(CHEBI:dopamine)) |
| pmid:19126755 | a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") |
| pmid:19126755 | a(CHEBI:nicotine) increases path(MESH:Craving) |
| pmid:19126755 | a(CHEBI:nicotine) increases path(MESH:Anxiety) |
| pmid:19126755 | a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7) |
| pmid:17009926 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pmid:26472524 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR") |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) |
| pmid:19721446 | a(CHEBI:nicotine) association bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) |
| pmid:19293145 | a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) |
| pmid:19293145 | a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) |
| pmid:19293145 | a(CHEBI:nicotine) increases p(HGNC:BAX, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pmid:25514383 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(p(HGNC:BAD)) |
| pmid:19293145 | a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(g(HGNC:NIN)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(g(HGNC:PTGS2)) |
| pmid:19293145 | a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)") |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) |
| pmid:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) |
| pmid:19293145 | a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) |
| pmid:19293145 | a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") |
| pmid:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") |
| pmid:19293145 | a(CHEBI:nicotine) association p(FPLX:ERK) |
| pmid:19293145 | act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) |
| pmid:19293145 | a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") |
| pmid:19293145 | a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta")) |
| pmid:19293145 | a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma") |
| pmid:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:28445721 | a(CHEBI:nicotine) regulates p(FPLX:CHRN) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | a(CHEBI:nicotine) increases p(FPLX:CHRN) |
| pmid:21482353 | a(CHEBI:nicotine) increases p(FPLX:CHRN) |
| pmid:21482353 | a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) |
| pmid:21787755 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:25514383 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:11230871 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:11230871 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:17009926 | a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") |
| pmid:26813123 | a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:21958873 | a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:28391535 | a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta") |
| pmid:21958873 | a(CHEBI:nicotine) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:25514383 | a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:25514383 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") |
| pmid:25514383 | a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(HBP:"amyloid-beta oligomers") |
| pmid:25514383 | a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") |
| pmid:25514383 | a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") |
| pmid:25514383 | a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") |
| pmid:25514383 | a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") |
| pmid:19721446 | a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") |
| pmid:25514383 | a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") |
| pmid:21482353 | a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") |
| pmid:28445721 | a(CHEBI:nicotine) increases surf(p(HBP:HBP00174)) |
| pmid:28445721 | a(CHEBI:nicotine) increases a(HBP:HBP00174) |
| pmid:21482353 | a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) |
| pmid:21482353 | a(CHEBI:nicotine) increases bp(GO:cognition) |
| pmid:19721446 | a(CHEBI:nicotine) increases bp(GO:cognition) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:18174175 | a(CHEBI:nicotine) increases a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:21482353 | a(CHEBI:nicotine) causesNoChange a(HBP:"alpha-4-containing nAChR") |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases tloc(a(HBP:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) |
| pmid:21482353 | a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) |
| pmid:21482353 | a(CHEBI:nicotine) decreases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:11230871 | a(CHEBI:nicotine) increases bp(GO:learning) |
| pmid:11230871 | a(CHEBI:nicotine) increases path(MESH:Attention) |
| pmid:19721446 | a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | act(a(CHEBI:nicotine)) association p(HGNC:CHRNB4) |
| pmid:19721446 | act(a(CHEBI:nicotine)) association p(HGNC:CHRNA2) |
| pmid:19721446 | act(a(CHEBI:nicotine)) association p(HGNC:CHRNA5) |
| pmid:19721446 | act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) |
| pmid:22040696 | a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) |
| pmid:18174175 | a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") |
| pmid:21958873 | a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-beta")) |
| pmid:21958873 | a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-alpha")) |
| pmid:21958873 | a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex")) |
| pmid:23178521 | a(CHEBI:nicotine) decreases act(p(FPLX:NFkappaB)) |
| pmid:28391535 | a(CHEBI:nicotine) increases act(a(MESH:"Adrenal Glands")) |
| pmid:28391535 | a(CHEBI:nicotine) increases sec(a(CHEBI:adrenaline)) |
| pmid:28391535 | a(CHEBI:nicotine) decreases sec(a(CHEBI:"insulin (human)")) |
| pmid:28391535 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) |
| pmid:28391535 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) |
| pmid:28391535 | a(CHEBI:nicotine) negativeCorrelation path(MESH:"Motor Activity") |
| pmid:28391535 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"Receptors, Nicotinic")) |
| pmid:28391535 | a(CHEBI:nicotine) causesNoChange act(a(CHEBI:Mecamylamine)) |
| pmid:28391535 | act(a(CHEBI:nicotine)) negativeCorrelation a(CHEBI:Hexamethonium) |
| pmid:19126755 | a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:21482353 | a(HBP:"alpha-Bungarotoxin") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19126755 | bp(GO:signaling) association a(CHEBI:acetylcholine) |
| pmid:19126755 | act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pmid:26813123 | p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pmid:19293145 | p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) |
| pmid:26813123 | act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") |
| pmid:26813123 | act(p(HGNC:CHAT)) decreases path(MESH:Dementia) |
| pmid:16273023 | act(p(HGNC:CHAT), ma(cat)) increases a(CHEBI:acetylcholine) |
| pmid:24590577 | p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) |
| pmid:25514383 | act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) |
| pmid:18986241 | act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) |
| pmid:19721446 | p(HGNC:CHAT) increases a(CHEBI:acetylcholine) |
| pmid:18986241 | act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration) |
| pmid:28002468 | a(CHEBI:"acetyl-CoA") increases a(HBP:"cystein-dependent auto-acetylation") |
| pmid:17009926 | a(CHEBI:choline) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | a(CHEBI:choline) increases a(CHEBI:acetylcholine) |
| pmid:26088141 | act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) |
| pmid:26088141 | a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) |
| pmid:26088141 | a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pmid:26088141 | a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) |
| pmid:21482353 | a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | a(CHEBI:choline) increases act(a(HBP:"alpha-7-containing nAChR")) |
| pmid:19721446 | a(CHEBI:choline) increases bp(MESH:Neuroprotection) |
| pmid:19721446 | a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) |
| pmid:26813123 | p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNA2) association act(a(CHEBI:nicotine)) |
| pmid:26813123 | p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") |
| pmid:11230871 | p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19721446 | p(HGNC:CHRNA3) association path(MESH:Craving) |
| pmid:19721446 | p(HGNC:CHRNA3) association path(MESH:Recurrence) |
| pmid:19126755 | p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HGNC:CHRNA4) association p(HGNC:PTGS2) |
| pmid:19293145 | p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:17009926 | p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19293145 | act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:19293145 | act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) |
| pmid:19721446 | p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") |
| pmid:23038257 | p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") |
| pmid:23038257 | p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") |
| pmid:17009926 | p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26813123 | p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") |
| pmid:11230871 | p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) |
| pmid:19126755 | p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") |
| pmid:26813123 | p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNA5) association act(a(CHEBI:nicotine)) |
| pmid:26813123 | p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") |
| pmid:21787755 | p(HGNC:CHRNA6) association path(MESH:Reward) |
| pmid:21787755 | p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") |
| pmid:21787755 | p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) |
| pmid:19126755 | p(HGNC:CHRNA7) association a(MESH:Neurons) |
| pmid:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) |
| pmid:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pmid:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") |
| pmid:19126755 | act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:22040696 | p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") |
| pmid:19126755 | act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pmid:19126755 | act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) |
| pmid:19126755 | p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:19126755 | p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) association bp(GO:cognition) |
| pmid:19721446 | p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) |
| pmid:19721446 | act(p(HGNC:CHRNA7)) increases bp(GO:cognition) |
| pmid:19126755 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22040696 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29191965 | p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:19293145 | p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNC:CHRNA7) association a(CHEBI:"amyloid-beta") |
| pmid:17009926 | p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29191965 | p(HGNC:CHRNA7) regulates act(a(CHEBI:"amyloid-beta")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) |
| pmid:19126755 | p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) |
| pmid:19293145 | p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:CHRNA7) increases a(CHEBI:nicotine) |
| pmid:19126755 | p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") |
| pmid:19293145 | p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium")) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) |
| pmid:19293145 | p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") |
| pmid:19293145 | act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) |
| pmid:17009926 | p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") |
| pmid:22040696 | p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:17009926 | act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:17009926 | p(HGNC:CHRNA7) association a(HBP:"amyloid-beta aggregates") |
| pmid:17009926 | p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26813123 | p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26088141 | p(HGNC:CHRNA7) increases bp(HBP:"nAChR assembly") |
| pmid:26088141 | p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) |
| pmid:26088141 | p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) |
| pmid:18986241 | p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) |
| pmid:18986241 | p(HGNC:CHRNA7) increases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19721446 | p(HGNC:CHRNA7) association a(MESH:Hippocampus) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(GO:memory) |
| pmid:19721446 | act(p(HGNC:CHRNA7)) decreases bp(GO:memory) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(GO:learning) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) |
| pmid:19721446 | act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") |
| pmid:19721446 | p(HGNC:CHRNA7) association a(CHEBI:clozapine) |
| pmid:22040696 | p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") |
| pmid:22040696 | p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pmid:22040696 | p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") |
| pmid:22040696 | p(HGNC:CHRNA7) association p(HGNC:BDNF) |
| pmid:22040696 | tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript)) |
| pmid:22040696 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:22040696 | p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") |
| pmid:22040696 | p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") |
| pmid:22040696 | p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") |
| pmid:28901280 | p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") |
| pmid:28901280 | p(HGNC:CHRNA7) regulates path(MESH:Inflammation) |
| pmid:28901280 | p(HGNC:CHRNA7) association path(MESH:Neoplasms) |
| pmid:28901280 | p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") |
| pmid:28901280 | p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") |
| pmid:29191965 | p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement") |
| pmid:29191965 | p(HGNC:CHRNA7) regulates act(a(GO:synapse)) |
| pmid:29191965 | p(HGNC:CHRNA7) association path(MESH:Tauopathies) |
| pmid:26813123 | p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | p(HGNC:CHRNA9) increases path(MESH:Neoplasms) |
| pmid:26813123 | p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") |
| pmid:17009926 | act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") |
| pmid:26813123 | p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) |
| pmid:19721446 | p(HGNC:CHRNB2) association p(HGNC:DNM1) |
| pmid:19721446 | p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") |
| pmid:19721446 | p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) |
| pmid:26813123 | p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19126755 | p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") |
| pmid:26813123 | p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNB4) association act(a(CHEBI:nicotine)) |
| pmid:19721446 | p(HGNC:CHRNB4) association path(MESH:Craving) |
| pmid:19721446 | p(HGNC:CHRNB4) association path(MESH:Recurrence) |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | act(p(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") |
| pmid:19126755 | act(p(HBP:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:19126755 | act(p(HBP:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) |
| pmid:26472524 | act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") |
| pmid:19126755 | p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") |
| pmid:19126755 | p(HBP:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") |
| pmid:26472524 | p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") |
| pmid:19126755 | bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) |
| pmid:19126755 | a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:Neurons) decreases r(HGNC:CHRNA3) |
| pmid:19126755 | a(MESH:Neurons) increases r(HGNC:CHRNA4) |
| pmid:19126755 | a(MESH:Neurons) association p(HGNC:CHRNA7) |
| pmid:19126755 | a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") |
| pmid:21482353 | a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:21482353 | a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:28901280 | a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") |
| pmid:24027553 | act(a(MESH:Neurons)) negativeCorrelation p(HGNC:MAPT) |
| pmid:29238289 | act(a(MESH:Neurons)) increases sec(p(HGNC:MAPT)) |
| pmid:29238289 | act(a(MESH:Neurons)) increases sec(p(HGNC:MAPT)) |
| pmid:27671637 | act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27796283 | act(a(MESH:Neurons)) increases p(HGNC:CAMKV) |
| pmid:27087442 | act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1) |
| pmid:27087442 | act(a(MESH:Neurons)) positiveCorrelation act(p(HBP:RAC1b)) |
| pmid:27087442 | act(a(MESH:Neurons)) negativeCorrelation p(MGI:Cdk5) |
| pmid:19126755 | complex(a(MESH:"alpha-cobratoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) |
| pmid:21787755 | a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) |
| pmid:19126755 | act(p(HBP:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19126755 | complex(a(HBP:"kappa-Bungarotoxin"), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) |
| pmid:19126755 | a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) |
| pmid:19126755 | a(MESH:Conotoxins) decreases act(a(MESH:"Voltage-Gated Sodium Channels")) |
| pmid:19721446 | a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:19721446 | a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pmid:19721446 | a(MESH:Conotoxins) decreases path(MESH:Pain) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) |
| pmid:19126755 | a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") |
| pmid:19126755 | complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(TAXONOMY:92736) increases a(CHEBI:epibatidine) |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange bp(GO:memory) |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") |
| pmid:28132910 | a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pmid:19126755 | complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) |
| pmid:19293145 | a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(MESH:methyllycaconitine) decreases path(HBP:neurotoxicity) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) |
| pmid:19721446 | a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) |
| pmid:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) |
| pmid:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) |
| pmid:19126755 | r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") |
| pmid:19126755 | r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") |
| pmid:21787755 | r(HGNC:CHRNB4) association r(HGNC:CHRNA4) |
| pmid:21787755 | r(HGNC:CHRNA4) association r(HGNC:CHRNB4) |
| pmid:21787755 | r(HGNC:CHRNA6) association path(MESH:Reward) |
| pmid:21787755 | r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") |
| pmid:21787755 | r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) |
| pmid:19126755 | a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) |
| pmid:19126755 | path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) |
| pmid:24561250 | path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") |
| pmid:24561250 | path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") |
| pmid:19126755 | a(MESH:Adult) decreases r(HGNC:CHRNA3) |
| pmid:19126755 | a(MESH:Adult) increases r(HGNC:CHRNA4) |
| pmid:19126755 | r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly") |
| pmid:19126755 | act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4) |
| pmid:18494933 | p(HGNC:JUN) partOf p(FPLX:AP1) |
| pmid:19126755 | act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) |
| pmid:19126755 | p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) |
| pmid:19126755 | p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) |
| pmid:19126755 | complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) |
| pmid:19126755 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) |
| pmid:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR") |
| pmid:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR")) |
| pmid:19126755 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) |
| pmid:19126755 | a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNA1) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNB1) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRND) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNG) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) |
| pmid:23038257 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) |
| pmid:26813123 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) |
| pmid:19126755 | act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") |
| pmid:26813123 | p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) |
| pmid:19126755 | bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) |
| pmid:19126755 | bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:17009926 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") |
| pmid:26472524 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") |
| pmid:19126755 | r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
| pmid:19126755 | composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)), p(HGNC:CHRNB1)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | a(MESH:Oocytes) association composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pmid:19126755 | composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) |
| pmid:19126755 | a(MESH:Hippocampus) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(MESH:Hippocampus) increases p(HGNC:CHRNA7) |
| pmid:19721446 | a(MESH:Hippocampus) association p(HGNC:CHRNA7) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:cognition) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:learning) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:learning) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:memory) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:memory) |
| pmid:19721446 | a(MESH:Hippocampus) association bp(GO:memory) |
| pmid:24511233 | a(MESH:Hippocampus) association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM1) |
| pmid:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM2) |
| pmid:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM3) |
| pmid:26390242 | a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate) |
| pmid:19126755 | a(MESH:Ganglia) increases p(HBP:"alpha-3 beta-2 nAChR") |
| pmid:19126755 | a(MESH:Ganglia) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) |
| pmid:19126755 | g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") |
| pmid:19126755 | a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19126755 | composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:25514383 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19126755 | p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pmid:19126755 | a(MESH:"Endoplasmic Reticulum") regulates bp(HBP:"nAChR assembly") |
| pmid:19126755 | a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pmid:19126755 | bp(HBP:"nAChR assembly") increases p(HBP:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) |
| pmid:19126755 | bp(HBP:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) |
| pmid:19126755 | a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pmid:29626319 | a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) |
| pmid:29626319 | a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) |
| pmid:21787755 | a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19126755 | composite(a(CHEBI:nicotine), g(HGNC:CHRNA4), g(HGNC:CHRNA6), g(HGNC:CHRNB2), g(HGNC:CHRNB3)) increases composite(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pmid:19126755 | act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) |
| pmid:19293145 | a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") |
| pmid:25514383 | act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") |
| pmid:25514383 | act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction") |
| pmid:25514383 | act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") |
| pmid:21482353 | a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") |
| pmid:21482353 | a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") |
| pmid:19126755 | sec(a(CHEBI:"gamma-aminobutyric acid")) increases bp(GO:"hyperpolarization of postsynaptic membrane") |
| pmid:21482353 | a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) |
| pmid:21482353 | a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) |
| pmid:21482353 | a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:19126755 | bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) |
| pmid:19126755 | bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) |
| pmid:26813123 | bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26813123 | bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) |
| pmid:28901280 | bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") |
| pmid:19126755 | act(p(FPLX:CREB), ma(tscript)) regulates bp(GO:"gene expression") |
| pmid:19126755 | act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") |
| pmid:27550730 | act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) |
| pmid:19126755 | act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") |
| pmid:19126755 | act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(tscript)) |
| pmid:19126755 | complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) |
| pmid:19126755 | p(HBP:"alpha-4-containing nAChR") increases sec(a(CHEBI:dopamine)) |
| pmid:19126755 | p(HBP:"alpha-6-containing nAChR") increases sec(a(CHEBI:dopamine)) |
| pmid:19126755 | bp(GO:"neuronal action potential") increases sec(a(CHEBI:dopamine)) |
| pmid:28445721 | bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) |
| pmid:19126755 | a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") |
| pmid:19293145 | act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity) |
| pmid:17009926 | sec(a(CHEBI:"glutamate(2-)")) increases bp(GO:"long-term synaptic potentiation") |
| pmid:16273023 | a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") |
| pmid:16273023 | a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) |
| pmid:19126755 | a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:28901280 | a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) |
| pmid:19126755 | a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:28901280 | a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") |
| pmid:24027553 | a(MESH:"Endothelial Cells") increases sec(a(CHEBI:Thrombin)) |
| pmid:24027553 | a(MESH:"Endothelial Cells") increases a(CHEBI:Thrombin) |
| pmid:19126755 | a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:26813123 | a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) |
| pmid:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) |
| pmid:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:18986241 | a(CHEBI:physostigmine) decreases path(MESH:D000544) |
| pmid:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) |
| pmid:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:noradrenaline)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:serotonin)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) |
| pmid:19126755 | a(HBP:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) |
| pmid:19126755 | a(HBP:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) |
| pmid:19126755 | a(HBP:"FK1 antibody") decreases a(CHEBI:codeine) |
| pmid:19126755 | a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) |
| pmid:19126755 | a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) |
| pmid:19126755 | path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pmid:19126755 | path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pmid:19126755 | path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") |
| pmid:23383175 | a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) |
| pmid:23383175 | a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") |
| pmid:28803412 | a(MESH:Astrocytes) increases deg(a(HBP:HBP00093)) |
| pmid:30108137 | act(a(MESH:Astrocytes)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26195256 | a(MESH:Astrocytes) increases sec(p(MESH:Endopeptidases)) |
| pmid:26195256 | a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) |
| pmid:26195256 | a(MESH:Astrocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | act(a(MESH:Astrocytes)) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(a(MESH:Astrocytes)) increases a(MESH:Cytokines) |
| pmid:18562203 | act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:27314526 | a(MESH:Astrocytes) increases p(HGNC:NLRP3) |
| pmid:27314526 | a(MESH:Astrocytes) increases p(HGNC:TLR4) |
| pmid:27314526 | a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) |
| pmid:19126755 | a(CHEBI:"L-kynurenine") increases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") |
| pmid:19126755 | act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine") |
| pmid:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") |
| pmid:19165623 | a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid") |
| pmid:19623258 | a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP2CA) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP1CA) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") directlyIncreases act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:WISP1) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) |
| pmid:19126755 | act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) |
| pmid:19126755 | p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) |
| pmid:19293145 | p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:25514383 | p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") |
| pmid:25881725 | act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") |
| pmid:25514383 | p(MGI:Chrna7) decreases p(MGI:Syp) |
| pmid:25514383 | p(MGI:Chrna7) decreases p(MGI:Map2) |
| pmid:25514383 | p(MGI:Chrna7) increases p(MGI:Map2) |
| pmid:25514383 | p(MGI:Chrna7) increases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | p(MGI:Chrna7) decreases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | p(MGI:Chrna7) increases bp(GO:cognition) |
| pmid:25514383 | p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") |
| pmid:25514383 | p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") |
| pmid:27522251 | p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") |
| pmid:27522251 | p(MGI:Chrna7) association bp(GO:aging) |
| pmid:27522251 | p(MGI:Chrna7) increases a(HBP:HBP00022) |
| pmid:25881725 | act(p(MGI:Chrna7)) increases bp(GO:learning) |
| pmid:25881725 | p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28901280 | p(MGI:Chrna7) association act(a(MESH:Epithelium)) |
| pmid:21482353 | a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) |
| pmid:19126755 | bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) |
| pmid:24760868 | bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) |
| pmid:28420982 | bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) |
| pmid:28420982 | bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates") |
| pmid:19126755 | a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) |
| pmid:19126755 | a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNC:CNR1) |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNC:CNR2) |
| pmid:19126755 | a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") |
| pmid:19126755 | a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") |
| pmid:19126755 | a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:anandamide) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") |
| pmid:19126755 | p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19293145 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) |
| pmid:17009926 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") |
| pmid:19126755 | p(HGNC:CNR1) association a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNC:CNR2) association a(CHEBI:anandamide) |
| pmid:19126755 | a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) |
| pmid:19126755 | a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) |
| pmid:19126755 | a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") |
| pmid:28391535 | a(CHEBI:bupropion) increases act(a(MESH:"Central Nervous System")) |
| pmid:28391535 | a(CHEBI:bupropion) decreases path(MESH:Depression) |
| pmid:28391535 | a(CHEBI:bupropion) decreases act(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR")) |
| pmid:19126755 | path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:"Irritable Mood") |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Anger) |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:"Stress, Psychological") |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Anxiety) |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:"Sleep Wake Disorders") |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Depression) |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Craving) |
| pmid:28391535 | path(MESH:"Smoking Cessation") decreases bp(GO:cognition) |
| pmid:28391535 | path(MESH:"Smoking Cessation") decreases path(MESH:Attention) |
| pmid:28391535 | path(MESH:"Smoking Cessation") increases path(MESH:Appetite) |
| pmid:26813123 | p(FPLX:PKA) increases p(FPLX:CHRN, pmod(Ph)) |
| pmid:24653673 | p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(Ph, Ser)) |
| pmid:24653673 | p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(Ph, Ser)) |
| pmid:12428809 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26195256 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22908190 | act(p(FPLX:PKA)) increases p(HGNC:UCHL1) |
| pmid:30116051 | act(p(FPLX:PKA), ma(kin)) increases p(HGNC:PSMC5, pmod(Ph, Ser, 120)) |
| pmid:25331948 | p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25331948 | p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25331948 | act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(Ph)) |
| pmid:26631930 | p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23001711 | act(p(FPLX:PKA), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:17493042 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:17078951 | p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17078951 | p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) |
| pmid:17078951 | p(FPLX:PKA) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) |
| pmid:26692334 | act(p(FPLX:PKA)) positiveCorrelation a(CHEBI:rolipram) |
| pmid:26692334 | act(p(FPLX:PKA)) positiveCorrelation act(complex(GO:"proteasome complex")) |
| pmid:19721446 | act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) |
| pmid:23001711 | p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:19126755 | act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") |
| pmid:19293145 | act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") |
| pmid:28784767 | act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:28784767 | act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:25001178 | act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6)) |
| pmid:25001178 | act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin)) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:28445721 | path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21787755 | path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) |
| pmid:21787755 | path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") |
| pmid:21787755 | path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") |
| pmid:28901280 | path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730) |
| pmid:19126755 | bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:Skin) association act(a(CHEBI:nicotine)) |
| pmid:29626319 | a(MESH:Skin) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19126755 | path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") |
| pmid:19126755 | path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") |
| pmid:19126755 | path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") |
| pmid:28901280 | path(MESH:Neoplasms) association p(HGNC:CHRNA7) |
| pmid:22020111 | path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) |
| pmid:22020111 | path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) |
| pmid:23454242 | path(MESH:Neoplasms) association p(FPLX:PPP2) |
| pmid:23454242 | path(MESH:Neoplasms) negativeCorrelation act(p(FPLX:PPP2)) |
| pmid:22299660 | path(MESH:Neoplasms) association p(FPLX:PPP2) |
| pmid:25784053 | path(MESH:Neoplasms) association act(p(HGNC:HSF1)) |
| pmid:18930136 | path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process") |
| pmid:24563850 | path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") |
| pmid:24563850 | path(MESH:Neoplasms) association bp(GO:"protein oxidation") |
| pmid:29311797 | path(MESH:Neoplasms) association p(HGNC:STUB1) |
| pmid:22807490 | path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking) |
| pmid:23746257 | bp(GO:"cell cycle") association p(FPLX:HSP90) |
| pmid:30126037 | bp(GO:"cell cycle") association bp(GO:"cellular senescence") |
| pmid:19126755 | path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") |
| pmid:19126755 | path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") |
| pmid:21718217 | path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) |
| pmid:19126755 | path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ac)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:CAPN2) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HBP:"Tau C3") |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ub)) |
| pmid:19126755 | path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration) |
| pmid:25514383 | p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) |
| pmid:25514383 | p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") |
| pmid:25514383 | p(MGI:Chrnb2) increases path(MESH:Attention) |
| pmid:25514383 | p(MGI:Chrnb2) increases bp(GO:cognition) |
| pmid:27522251 | p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:Chrnb2) increases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) |
| pmid:19126755 | a(HBP:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") isA a(CHEBI:"amyloid-beta") |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") directlyIncreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) |
| pmid:26813123 | a(HBP:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) |
| pmid:30145931 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:23528736 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT) |
| pmid:30145931 | a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| pmid:30145931 | a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:17403556 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:GRIA1) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:FYN) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.S404A"), loc(MESH:"Dendritic Spines")) |
| pmid:23528736 | a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) |
| pmid:22156579 | act(a(HBP:"amyloid-beta oligomers")) positiveCorrelation p(INTERPRO:"Kinase associated domain 1 (KA1)") |
| pmid:19126755 | act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") |
| pmid:19126755 | a(CHEBI:"NS-398") decreases p(HGNC:CHRNA4) |
| pmid:19126755 | path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:19126755 | path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:19126755 | path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:17009926 | path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) |
| pmid:19721446 | path(MESH:Craving) association p(HGNC:CHRNA3) |
| pmid:19721446 | path(MESH:Craving) association p(HGNC:CHRNB4) |
| pmid:19126755 | a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine) |
| pmid:19126755 | a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) |
| pmid:19126755 | path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) |
| pmid:19126755 | path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR") |
| pmid:19126755 | a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") |
| pmid:11230871 | a(HBP:"alpha-4-containing nAChR") negativeCorrelation bp(GO:aging) |
| pmid:11230871 | a(HBP:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:Death) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) |
| pmid:27574109 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pmid:22299660 | a(MESH:"Neurofibrillary Tangles") association p(FPLX:PPP2C, pmod(Ph)) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26195256 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:27574109 | a(MESH:"Neurofibrillary Tangles") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain") |
| pmid:23528736 | a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1") |
| pmid:19293145 | a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") |
| pmid:16273023 | a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") |
| pmid:16273023 | a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) |
| pmid:21882945 | a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) |
| pmid:19293145 | composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:19293145 | a(HBP:"amyloid-beta fibrils") isA a(CHEBI:"amyloid-beta") |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:19293145 | a(HBP:"Abeta*56") decreases path(MESH:"Maze Learning") |
| pmid:19293145 | p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) |
| pmid:18986241 | act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine)) |
| pmid:18986241 | p(HGNC:BCHE) association a(MESH:D016874) |
| pmid:18986241 | p(HGNC:BCHE) association path(MESH:D058225) |
| pmid:18986241 | p(HGNC:BCHE) association path(MESH:D003071) |
| pmid:19293145 | g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases bp(MESH:Neuroprotection) |
| pmid:17009926 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2)) |
| pmid:17009926 | a(CHEBI:"dihydro-beta-erythroidine") decreases bp(GO:memory) |
| pmid:19293145 | a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) |
| pmid:28391535 | a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) |
| pmid:17009926 | a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") |
| pmid:17009926 | a(CHEBI:Mecamylamine) decreases path(MESH:Attention) |
| pmid:26813123 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) |
| pmid:11230871 | a(CHEBI:Mecamylamine) decreases bp(GO:cognition) |
| pmid:19721446 | a(CHEBI:Mecamylamine) decreases bp(GO:cognition) |
| pmid:28391535 | a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension) |
| pmid:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Tremor) |
| pmid:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Confusion) |
| pmid:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Seizures) |
| pmid:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:"Bipolar Disorder") |
| pmid:28391535 | a(CHEBI:Mecamylamine) increases path(MESH:Depression) |
| pmid:28391535 | a(CHEBI:Mecamylamine) decreases path(MESH:Smoking) |
| pmid:28391535 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:28391535 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:23038257 | bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) |
| pmid:19293145 | a(MESH:Bungarotoxins) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23038257 | a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") |
| pmid:23038257 | a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) |
| pmid:23038257 | a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) |
| pmid:25514383 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19293145 | composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity) |
| pmid:19293145 | a(MESH:Serum) decreases bp(GO:"cell death") |
| pmid:30985105 | a(CHEBI:glucose) positiveCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:24183963 | a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24183963 | a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:16630055 | a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting) |
| pmid:19293145 | a(CHEBI:thapsigargin) increases bp(GO:"cell death") |
| pmid:19293145 | a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") |
| pmid:29024336 | a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") |
| pmid:19293145 | act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity) |
| pmid:26813123 | bp(HBP:Neurodegeneration) negativeCorrelation bp(GO:memory) |
| pmid:26813123 | bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") |
| pmid:26813123 | bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:18986241 | bp(HBP:Neurodegeneration) association path(MESH:D060825) |
| pmid:19293145 | act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") |
| pmid:23702978 | act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) |
| pmid:19293145 | bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) |
| pmid:19293145 | p(FPLX:SRC) increases act(a(CHEBI:nicotine)) |
| pmid:17009926 | act(p(FPLX:SRC), ma(kin)) increases p(HGNC:CHRNA7, pmod(Ph)) |
| pmid:22040696 | act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) |
| pmid:22040696 | act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) |
| pmid:19293145 | a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:18680553 | p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | p(HGNC:FYN) increases bp(GO:cognition) |
| pmid:19293145 | p(HGNC:FYN) increases act(p(FPLX:PI3K)) |
| pmid:19293145 | p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph)) |
| pmid:19293145 | p(HGNC:FYN) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | p(HGNC:FYN) association bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:FYN) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) |
| pmid:19293145 | p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) |
| pmid:19293145 | p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) |
| pmid:24760868 | p(HGNC:FYN) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:30640040 | p(HGNC:FYN) association a(PUBCHEM:4878) |
| pmid:29191965 | p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:26751493 | p(HGNC:FYN) association p(HBP:"projection domain") |
| pmid:26631930 | p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:17493042 | p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26631930 | p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph)) |
| pmid:18680553 | p(HGNC:FYN) association p(HGNC:MAPT) |
| pmid:18680553 | p(HGNC:FYN) association p(HGNC:MAPT, frag("223_226")) |
| pmid:18680553 | p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:26751493 | p(HGNC:FYN) association a(HBP:"projection domain") |
| pmid:19293145 | complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) |
| pmid:19293145 | p(MGI:Fyn) decreases bp(MESH:Neuroprotection) |
| pmid:18096814 | p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") |
| pmid:18096814 | p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:25125464 | p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") |
| pmid:25125464 | act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) |
| pmid:25125464 | act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8") |
| pmid:19293145 | p(HGNC:JAK2) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:JAK2) association bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:JAK2) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | p(HGNC:JAK2) association act(p(HGNC:STAT3)) |
| pmid:19293145 | p(HGNC:JAK2) increases act(p(HGNC:FYN)) |
| pmid:19293145 | complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(HBP:Excitotoxicity) |
| pmid:18680553 | complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) |
| pmid:19293145 | p(HGNC:MAPT, pmod(Ph, Tyr)) association p(HGNC:PTK2, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Tyr)) increases a(HBP:"Tau aggregates") |
| pmid:19293145 | p(HGNC:PTK2, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:19293145 | p(HGNC:PTK2, pmod(Ph)) decreases act(p(HGNC:PTK2)) |
| pmid:19293145 | p(HGNC:CHRNA7, pmod(Ph)) decreases act(a(CHEBI:acetylcholine)) |
| pmid:23038257 | p(HGNC:CHRNA7, pmod(Ph)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) |
| pmid:17009926 | p(HGNC:CHRNA7, pmod(Ph)) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:estradiol) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | a(CHEBI:estradiol) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) |
| pmid:19293145 | composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) |
| pmid:19293145 | act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:INS) increases a(CHEBI:"amyloid-beta") |
| pmid:19293145 | g(HGNC:NIN) association g(HGNC:GSK3B) |
| pmid:19293145 | g(HGNC:GSK3B) association g(HGNC:NIN) |
| pmid:19293145 | act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") |
| pmid:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) |
| pmid:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(Ph)) |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(Ph)) |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(Ph)) |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(Ph)) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) |
| pmid:18494933 | p(HGNC:MAPK8, pmod(Ph)) increases act(p(HGNC:MAPK8)) |
| pmid:23528736 | p(HGNC:MAPK8) increases bp(GO:autophagy) |
| pmid:23528736 | p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph)) |
| pmid:23528736 | p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(Ph)) |
| pmid:18494933 | act(p(HGNC:MAPK8)) increases p(HGNC:JUN) |
| pmid:11943212 | p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:19293145 | a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph)) |
| pmid:19293145 | a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941")) |
| pmid:19293145 | act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph)) |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases sec(a(CHEBI:dopamine)) |
| pmid:19293145 | composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(FPLX:RAS)) increases p(HGNC:STAT3) |
| pmid:18986241 | p(FPLX:RAS) association bp(GO:"GO:0014065") |
| pmid:18986241 | p(FPLX:RAS) association bp(GO:"GO:0043491") |
| pmid:19293145 | composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:23746257 | bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90) |
| pmid:25514383 | bp(GO:"calcium ion transport") negativeCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:25514383 | bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19293145 | a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) |
| pmid:19721446 | a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pmid:19293145 | a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") |
| pmid:19293145 | composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(Ph)) |
| pmid:19293145 | bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2))) increases bp(GO:"cellular calcium ion homeostasis") |
| pmid:19293145 | composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:19293145 | g(HGNC:APOE) increases p(HGNC:APOE) |
| pmid:19293145 | g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) |
| pmid:19293145 | g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) |
| pmid:19293145 | g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19293145 | bp(GO:"lipid metabolic process") association p(HGNC:APOE) |
| pmid:19293145 | bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) |
| pmid:19293145 | p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol) |
| pmid:24590577 | a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) |
| pmid:26751493 | a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain") |
| pmid:26751493 | a(CHEBI:phosphatidylinositol) association a(HBP:"projection domain") |
| pmid:19293145 | p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) |
| pmid:26195256 | p(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HBP:"APOE e4") regulates bp(GO:"establishment of blood-brain barrier") |
| pmid:26195256 | p(HBP:"APOE e4") increases act(p(HGNC:PPIA)) |
| pmid:26195256 | p(HBP:"APOE e4") negativeCorrelation bp(HBP:"perivascular drainage pathways") |
| pmid:26195256 | p(HBP:"APOE e4") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Cdk5) |
| pmid:27087442 | p(HBP:"APOE e4") increases p(HBP:"CDK5R1 p25") |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Cdk5r1) |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Capn1) |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Capn2) |
| pmid:27087442 | p(HBP:"APOE e4") causesNoChange p(MGI:Gsk3b) |
| pmid:28720530 | p(HBP:"APOE e4") directlyDecreases p(HGNC:PPP2R5E) |
| pmid:28720530 | p(HBP:"APOE e4") negativeCorrelation complex(GO:"protein phosphatase type 2A complex") |
| pmid:19293145 | a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) |
| pmid:30145931 | a(CHEBI:wortmannin) decreases bp(GO:autophagy) |
| pmid:30145931 | a(CHEBI:wortmannin) increases p(HGNC:MAPT) |
| pmid:30145931 | a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| pmid:30145931 | a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:19293145 | composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) |
| pmid:22040696 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity) |
| pmid:19293145 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) |
| pmid:18986241 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) |
| pmid:18986241 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases bp(GO:"GO:0007271") |
| pmid:22040696 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") |
| pmid:19293145 | composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) |
| pmid:19293145 | composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") |
| pmid:19293145 | bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) |
| pmid:24653673 | bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) |
| pmid:29191965 | bp(GO:"insulin receptor signaling pathway") association a(CHEBI:ethosuximide) |
| pmid:19293145 | bp(GO:"choline transport") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) |
| pmid:25514383 | a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) |
| pmid:19293145 | p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pmid:21482353 | p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:18986241 | r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071) |
| pmid:18986241 | r(HGNC:CHRNA7) regulates act(a(MESH:D059329)) |
| pmid:18986241 | r(HGNC:CHRNA7) increases path(MESH:D009410) |
| pmid:11230871 | r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7) |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) |
| pmid:23038257 | a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) |
| pmid:23038257 | a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) |
| pmid:23038257 | a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) |
| pmid:23038257 | a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26813123 | a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) |
| pmid:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") |
| pmid:26813123 | a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) |
| pmid:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19721446 | a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin)) |
| pmid:23038257 | a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(HBP:"cell population proliferation") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) association a(HBP:neurotransmitters) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) association a(HBP:neurotransmitters) |
| pmid:23038257 | p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) |
| pmid:23038257 | a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) |
| pmid:19721446 | a(CHEBI:"zinc(2+)") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:2833519 | a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) |
| pmid:23038257 | a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) |
| pmid:23038257 | a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) |
| pmid:23038257 | p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) |
| pmid:23038257 | a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:23038257 | a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") |
| pmid:19721446 | a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:23038257 | p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(Ph, Tyr)) |
| pmid:23038257 | p(HGNC:RAPSN, pmod(Ph, Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) |
| pmid:22040696 | p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") |
| pmid:23038257 | p(MESH:"Receptors, Nicotinic", pmod(Ph)) increases act(p(MESH:Agrin)) |
| pmid:23038257 | p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) |
| pmid:24511233 | p(HGNC:CHRM1) association bp(GO:cognition) |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pmid:24511233 | p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) |
| pmid:24511233 | p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") |
| pmid:24511233 | p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:24511233 | p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases deg(a(HBP:"sAPP-alpha")) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") |
| pmid:26813123 | act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") |
| pmid:26813123 | act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) |
| pmid:26813123 | act(p(HGNC:CHRM1)) association act(a(CHEBI:"amyloid-beta")) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:26813123 | act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26813123 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:26813123 | act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:Hippocampus) |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:Thalamus) |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:learning) |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:memory) |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:"neuron differentiation") |
| pmid:24590577 | p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:24590577 | act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) |
| pmid:24590577 | p(HGNC:CHRM1) regulates p(HGNC:BACE1) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") |
| pmid:18986241 | p(HGNC:CHRM1) association path(MESH:D060825) |
| pmid:18986241 | p(HGNC:CHRM1) association path(MESH:D024801) |
| pmid:18986241 | p(HGNC:CHRM1) association path(MESH:D000686) |
| pmid:26813123 | p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | p(HGNC:CHRM2) association a(MESH:Hippocampus) |
| pmid:24590577 | p(HGNC:CHRM2) association a(MESH:Neocortex) |
| pmid:24590577 | p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) |
| pmid:24590577 | p(HGNC:CHRM3) association a(MESH:Hypothalamus) |
| pmid:24590577 | p(HGNC:CHRM3) association a(MESH:Hippocampus) |
| pmid:24511233 | p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") |
| pmid:24511233 | p(HGNC:CHRM4) association a(MESH:Hippocampus) |
| pmid:24511233 | p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") |
| pmid:24590577 | p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") |
| pmid:24511233 | p(HGNC:CHRM4) association a(MESH:Neocortex) |
| pmid:24511233 | p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pmid:24511233 | act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:24590577 | p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") |
| pmid:24590577 | p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") |
| pmid:24590577 | p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) |
| pmid:24590577 | p(HGNC:CHRM5) association a(MESH:"Pars Compacta") |
| pmid:24590577 | p(HGNC:CHRM5) increases bp(GO:"response to drug") |
| pmid:24590577 | p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) |
| pmid:24590577 | p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) |
| pmid:24511233 | complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pmid:24511233 | complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pmid:26088141 | p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pmid:24511233 | complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pmid:24511233 | complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pmid:24511233 | complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pmid:24511233 | complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pmid:24511233 | complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26088141 | p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) |
| pmid:24511233 | complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:17009926 | path(MESH:Depression) association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:Depression) association p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21482353 | path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:19721446 | path(MESH:Depression) increases a(CHEBI:choline) |
| pmid:28901280 | path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") |
| pmid:27314526 | bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) |
| pmid:24511233 | a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) |
| pmid:24511233 | a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) |
| pmid:24511233 | path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") |
| pmid:24511233 | a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:24590577 | a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:24511233 | a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:24511233 | a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) |
| pmid:24590577 | a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:29626319 | a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24511233 | path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Attention) association path(MESH:Schizophrenia) |
| pmid:17009926 | path(MESH:Attention) association p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:25514383 | path(MESH:Attention) association a(HP:"cholinergic neuron") |
| pmid:24511233 | path(MESH:"Executive Function") association path(MESH:Schizophrenia) |
| pmid:24511233 | a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) |
| pmid:24511233 | a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) |
| pmid:24511233 | bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) |
| pmid:24511233 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pmid:24590577 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pmid:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) |
| pmid:26813123 | a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) |
| pmid:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Delusions) |
| pmid:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) |
| pmid:24511233 | a(CHEBI:xanomeline) increases bp(GO:learning) |
| pmid:24511233 | a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") |
| pmid:24511233 | a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") |
| pmid:26813123 | a(CHEBI:xanomeline) increases bp(GO:memory) |
| pmid:24590577 | a(CHEBI:xanomeline) increases bp(GO:memory) |
| pmid:26813123 | a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") |
| pmid:26813123 | a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") |
| pmid:24590577 | a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") |
| pmid:24590577 | a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) |
| pmid:24511233 | p(MGI:Chrm1) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:24590577 | p(MGI:Chrm1) increases bp(GO:cognition) |
| pmid:24590577 | p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") |
| pmid:24590577 | act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing") |
| pmid:24590577 | act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") |
| pmid:18986241 | act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) |
| pmid:24511233 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) |
| pmid:24590577 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") |
| pmid:24511233 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) |
| pmid:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) |
| pmid:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pmid:24511233 | act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") |
| pmid:24511233 | a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) |
| pmid:24511233 | a(MESH:VU0357017) increases bp(GO:"behavioral fear response") |
| pmid:24590577 | a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") |
| pmid:24590577 | a(MESH:VU0357017) increases bp(GO:learning) |
| pmid:24511233 | complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) |
| pmid:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) |
| pmid:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing") |
| pmid:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:cognition) |
| pmid:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:learning) |
| pmid:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:memory) |
| pmid:24511233 | a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(HBP:VU0456940) increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) |
| pmid:24511233 | a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") |
| pmid:24511233 | act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") |
| pmid:24511233 | act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") |
| pmid:24511233 | path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) |
| pmid:24511233 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) |
| pmid:24762290 | a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24511233 | a(MESH:Neocortex) association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:Neocortex) association p(HGNC:CHRM2) |
| pmid:24511233 | a(HBP:VU10010) increases act(a(CHEBI:acetylcholine)) |
| pmid:24511233 | a(HBP:VU10010) increases act(p(HGNC:CHRM4)) |
| pmid:24511233 | a(HBP:VU0152099) decreases act(a(CHEBI:amphetamine)) |
| pmid:24511233 | a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) |
| pmid:28445721 | bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) |
| pmid:21787755 | bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") |
| pmid:17009926 | bp(GO:"developmental process") association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) |
| pmid:21482353 | path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) |
| pmid:21787755 | path(MESH:Epilepsy) association a(HBP:AβOs) |
| pmid:28901280 | path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") |
| pmid:17009926 | path(MESH:"Autistic Disorder") association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) |
| pmid:30106381 | path(MESH:"Autistic Disorder") association p(HGNC:ADNP) |
| pmid:30106381 | path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404) |
| pmid:26472524 | tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) |
| pmid:17009926 | composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | composite(a(CHEBI:"5-hydroxyindole"), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) |
| pmid:28132910 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) |
| pmid:28132910 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:noradrenaline)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:serotonin)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) |
| pmid:19323834 | a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) |
| pmid:17009926 | a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:17009926 | bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) |
| pmid:17009926 | act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) |
| pmid:17009926 | bp(GO:"action potential") increases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | bp(GO:"response to pain") association p(FPLX:CHRN) |
| pmid:17009926 | a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | a(PUBCHEM:5311278) decreases bp(GO:memory) |
| pmid:25514383 | a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:26813123 | p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") |
| pmid:26813123 | p(FPLX:CHRM) regulates a(MESH:"Ion Channels") |
| pmid:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) |
| pmid:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) |
| pmid:26813123 | act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:25514383 | p(FPLX:CHRM) regulates bp(GO:cognition) |
| pmid:17009926 | p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) |
| pmid:17009926 | g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:17009926 | path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) |
| pmid:17009926 | path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) |
| pmid:17009926 | g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:28445721 | path(MESH:Arousal) association p(FPLX:CHRN) |
| pmid:28901280 | path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") |
| pmid:23702978 | a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") |
| pmid:23702978 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:23702978 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) |
| pmid:23702978 | a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B)) |
| pmid:24561250 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) |
| pmid:26472524 | act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") |
| pmid:26751493 | p(MESH:"Receptors, N-Methyl-D-Aspartate") association a(HBP:"projection domain") |
| pmid:16820021 | a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) |
| pmid:16820021 | a(MESH:antalarmin) increases p(RGD:Drd2) |
| pmid:16820021 | a(MESH:antalarmin) decreases p(RGD:Drd2) |
| pmid:16820021 | a(MESH:antalarmin) increases p(RGD:Drd3) |
| pmid:16820021 | a(MESH:antalarmin) decreases p(RGD:Drd3) |
| pmid:16820021 | a(MESH:antalarmin) decreases path(HBP:"isolation rearing") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) |
| pmid:16820021 | a(MESH:antalarmin) decreases r(RGD:Ntrk2) |
| pmid:16820021 | a(MESH:antalarmin) increases r(RGD:Ntrk2) |
| pmid:29807032 | a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") |
| pmid:29807032 | a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) |
| pmid:29807032 | a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") |
| pmid:23211705 | a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") |
| pmid:23211705 | a(MESH:antalarmin) increases a(MESH:Morula) |
| pmid:23211705 | a(MESH:antalarmin) increases a(MESH:Blastocyst) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) regulates p(MGI:Crh) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd2) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd2) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd3) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd3) |
| pmid:16820021 | path(HBP:"isolation rearing") decreases r(RGD:Bdnf) |
| pmid:16820021 | path(HBP:"isolation rearing") increases r(RGD:Bdnf) |
| pmid:16820021 | path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) |
| pmid:16820021 | path(HBP:"isolation rearing") increases r(RGD:Ntrk2) |
| pmid:11230871 | a(CHEBI:neurotransmitter) association bp(GO:cognition) |
| pmid:14556719 | sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub)) |
| pmid:26813123 | bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) |
| pmid:24563850 | bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") |
| pmid:24563850 | bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(Ph)) |
| pmid:24563850 | bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) |
| pmid:24563850 | bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(tscript)) |
| pmid:26813123 | bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pmid:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pmid:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) |
| pmid:26813123 | p(HGNC:CHAT, pmod(Ph)) regulates act(p(HGNC:CHAT)) |
| pmid:26813123 | a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) |
| pmid:26813123 | a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pmid:26813123 | p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") |
| pmid:26813123 | p(MGI:Slc18a3) increases bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) |
| pmid:26813123 | a(CHEBI:antidote) increases act(p(HGNC:ACHE)) |
| pmid:26813123 | a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) |
| pmid:26813123 | a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) |
| pmid:26813123 | p(MGI:Slc5a7) decreases path(MESH:Death) |
| pmid:26813123 | complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") |
| pmid:26813123 | a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | p(FPLX:CHRN, pmod(Ph)) regulates act(p(FPLX:CHRN)) |
| pmid:26813123 | a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(Ph)) |
| pmid:26813123 | complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:22020111 | a(CHEBI:cystine) increases a(CHEBI:glutathione) |
| pmid:26813123 | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:11230871 | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) |
| pmid:29626319 | a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) |
| pmid:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) |
| pmid:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) |
| pmid:26088141 | act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) |
| pmid:26088141 | act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") |
| pmid:26813123 | complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) |
| pmid:25514383 | a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) |
| pmid:26813123 | path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:24590577 | p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) |
| pmid:24590577 | p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") |
| pmid:24590577 | p(MGI:Chrm4) decreases act(p(MGI:Drd1)) |
| pmid:26813123 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:22020111 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates") |
| pmid:12428809 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(MESH:"Intermediate Filaments") |
| pmid:29758300 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) |
| pmid:29758300 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) |
| pmid:22908190 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) |
| pmid:22908190 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) |
| pmid:25784053 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) |
| pmid:25784053 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Frontotemporal Dementia") |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) |
| pmid:29980653 | path(MESH:"Amyotrophic Lateral Sclerosis") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29980653 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP) |
| pmid:26813123 | path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:29758300 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) |
| pmid:29311797 | path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) |
| pmid:29191965 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr")) |
| pmid:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) |
| pmid:28420982 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:26751493 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") |
| pmid:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") |
| pmid:26631930 | path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation g(HGNC:MIR132) |
| pmid:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) |
| pmid:26631930 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)") |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) |
| pmid:11089576 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:22057784 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:17050703 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:29281045 | path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) |
| pmid:29281045 | path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89") |
| pmid:26813123 | path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | act(a(GO:"cholinergic synapse")) association a(HBP:"amyloid-beta oligomers") |
| pmid:26813123 | complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(HBP:"amyloid-beta fibrils") |
| pmid:26813123 | p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26813123 | p(MGI:App, var("?")) decreases p(FPLX:CHRM) |
| pmid:26813123 | p(MGI:App, var("?")) decreases p(FPLX:CHRN) |
| pmid:22419736 | p(MGI:App, var("?")) increases p(MGI:Ak1) |
| pmid:26813123 | a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) |
| pmid:26813123 | a(PUBCHEM:10013505) increases bp(GO:cognition) |
| pmid:26813123 | a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:26813123 | a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) |
| pmid:26813123 | a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") |
| pmid:24653673 | p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) |
| pmid:22299660 | p(HGNC:MAPT, var("?")) association path(MESH:"Frontotemporal Dementia") |
| pmid:30116051 | p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | p(HGNC:MAPT, var("?")) decreases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:30116051 | p(HGNC:MAPT, var("?")) decreases deg(a(HBP:"Tau oligomers")) |
| pmid:30116051 | p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29215007 | p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29988016 | act(p(HGNC:MAPT, var("?"))) increases a(HBP:"Tau aggregates") |
| pmid:29988016 | act(p(HGNC:MAPT, var("?"))) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:26631930 | p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse)) |
| pmid:26813123 | a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) |
| pmid:26813123 | a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26813123 | a(PUBCHEM:9867750) increases bp(GO:cognition) |
| pmid:26813123 | a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") |
| pmid:26813123 | a(PUBCHEM:1476756) increases bp(GO:memory) |
| pmid:25899010 | a(HBP:Excitotoxicity) positiveCorrelation p(HGNC:DAPK1) |
| pmid:26813123 | a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | a(MESH:"Nerve Growth Factor") increases bp(GO:memory) |
| pmid:11230871 | a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:16273023 | path(MESH:D000544) association path(MESH:D016874) |
| pmid:18986241 | path(MESH:D000544) increases path(MESH:D016874) |
| pmid:16273023 | path(MESH:D000544) association path(MESH:D058225) |
| pmid:16273023 | path(MESH:D000544) association bp(GO:"GO:0070997") |
| pmid:16273023 | path(MESH:D000544) decreases bp(MESH:D009435) |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0007271") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0035249") |
| pmid:16273023 | path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(cat)) |
| pmid:18986241 | path(MESH:D000544) decreases p(HGNC:CHAT) |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0015871") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0008292") |
| pmid:16273023 | path(MESH:D000544) causesNoChange p(MESH:D011950) |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0051935") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0014047") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0014047") |
| pmid:16273023 | path(MESH:D000544) decreases bp(MESH:D017774) |
| pmid:16273023 | path(MESH:D000544) decreases bp(MESH:D017774) |
| pmid:16273023 | path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D019636) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D008568) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D003071) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D001526) |
| pmid:18986241 | path(MESH:D000544) association path(HBP:aMCI) |
| pmid:18986241 | path(MESH:D000544) decreases a(MESH:D059329) |
| pmid:18986241 | path(MESH:D000544) association a(MESH:D059329) |
| pmid:18986241 | path(MESH:D000544) decreases a(MESH:D059329) |
| pmid:18986241 | path(MESH:D000544) association a(MESH:D016874) |
| pmid:18986241 | path(MESH:D000544) decreases p(HGNC:ACHE) |
| pmid:18986241 | path(MESH:D000544) causesNoChange act(p(HGNC:ACHE)) |
| pmid:18986241 | path(MESH:D000544) decreases act(p(HGNC:ACHE)) |
| pmid:18986241 | path(MESH:D000544) decreases act(p(HGNC:ACHE)) |
| pmid:18986241 | path(MESH:D000544) increases act(p(HGNC:BCHE)) |
| pmid:18986241 | path(MESH:D000544) causesNoChange p(HGNC:SLC18A3) |
| pmid:18986241 | path(MESH:D000544) increases path(MESH:D001284) |
| pmid:18986241 | path(MESH:D000544) decreases p(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D000544) increases p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D000544) association p(HGNC:SORT1) |
| pmid:18986241 | path(MESH:D000544) decreases bp(GO:"GO:0032455") |
| pmid:18986241 | path(MESH:D000544) increases act(p(HGNC:MMP9)) |
| pmid:18986241 | path(MESH:D000544) decreases g(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D000544) decreases g(HGNC:NTRK2) |
| pmid:18986241 | path(MESH:D000544) decreases g(HGNC:NTRK3) |
| pmid:18986241 | path(MESH:D000544) increases g(HGNC:NGFR) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:CHAT) |
| pmid:18986241 | path(MESH:D000544) increases r(HGNC:CHRNA7) |
| pmid:18986241 | path(MESH:D000544) increases r(HGNC:CHRNA7) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:CHRM1) |
| pmid:18986241 | path(MESH:D000544) decreases r(HGNC:SYP) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:VAMP1) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:SNAP29) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:APP) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:NOTCH1) |
| pmid:18986241 | path(MESH:D000544) increases r(HGNC:CTSD) |
| pmid:18986241 | path(MESH:D000544) decreases r(HGNC:PPP1CA) |
| pmid:18986241 | path(MESH:D000544) decreases r(HGNC:PPP1CC) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:MAPT) |
| pmid:18986241 | path(MESH:D000544) decreases a(HBP:"3R tau") |
| pmid:16273023 | path(MESH:D016874) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D016874) association bp(HBP:hyperphosphorylation) |
| pmid:16273023 | path(MESH:D058225) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D058225) association p(HGNC:BCHE) |
| pmid:18986241 | path(MESH:D058225) association p(HGNC:ACHE) |
| pmid:16273023 | bp(GO:"GO:0070997") association path(MESH:D000544) |
| pmid:16273023 | bp(GO:"GO:0070997") association act(p(MESH:D017470)) |
| pmid:16273023 | bp(GO:"GO:0007271") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0007271") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0007271") association a(MESH:D002800) |
| pmid:16273023 | bp(GO:"GO:0035249") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0035249") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") |
| pmid:16273023 | bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0035249") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0035249") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0007271") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0007271") |
| pmid:18986241 | path(MESH:D003071) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D003071) association p(HGNC:BCHE) |
| pmid:18986241 | path(MESH:D003071) association g(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D003071) association g(HGNC:NTRK2) |
| pmid:18986241 | path(MESH:D003071) association g(HGNC:NTRK3) |
| pmid:18986241 | path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7) |
| pmid:18986241 | path(MESH:D003071) association act(p(HGNC:GAL)) |
| pmid:16273023 | bp(GO:"GO:0008292") association path(MESH:D003704) |
| pmid:16273023 | path(MESH:D003704) association bp(GO:"GO:0008292") |
| pmid:18986241 | path(MESH:D003704) association path(HBP:aMCI) |
| pmid:18986241 | path(MESH:D003704) association a(MESH:D059329) |
| pmid:18986241 | path(MESH:D003704) decreases p(HGNC:ACHE) |
| pmid:16273023 | path(MESH:D013850) association a(MESH:D006624) |
| pmid:16273023 | path(MESH:D013850) association a(MESH:D019579) |
| pmid:16273023 | path(MESH:D013850) association a(CHEBI:"glutamate(1-)") |
| pmid:16273023 | a(MESH:D006624) association path(MESH:D013850) |
| pmid:16273023 | a(MESH:D006624) association path(MESH:D008568) |
| pmid:16273023 | a(MESH:D019579) association path(MESH:D013850) |
| pmid:16273023 | a(MESH:D019579) association path(MESH:D008568) |
| pmid:16273023 | path(MESH:D008568) association a(MESH:D006624) |
| pmid:16273023 | path(MESH:D008568) association a(MESH:D019579) |
| pmid:16273023 | path(MESH:D008568) association a(CHEBI:"glutamate(1-)") |
| pmid:16273023 | path(MESH:D008568) association bp(MESH:D017774) |
| pmid:18986241 | path(MESH:D008568) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D008568) association a(MESH:D059329) |
| pmid:16273023 | act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") |
| pmid:16273023 | bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") |
| pmid:16273023 | bp(GO:"GO:0014047") increases bp(MESH:D017774) |
| pmid:16273023 | bp(GO:"GO:0051935") increases a(CHEBI:glutamine) |
| pmid:16273023 | a(CHEBI:glutamine) increases bp(GO:"GO:0006868") |
| pmid:16273023 | act(p(MESH:D017470)) association bp(GO:"GO:0070997") |
| pmid:16273023 | bp(MESH:D017774) association path(MESH:D008568) |
| pmid:16273023 | bp(MESH:D017774) association path(MESH:D007858) |
| pmid:16273023 | path(MESH:D007858) association bp(MESH:D017774) |
| pmid:16273023 | a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) |
| pmid:16273023 | composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) |
| pmid:16273023 | a(MESH:D002800) increases bp(GO:"GO:0014047") |
| pmid:16273023 | a(MESH:D002800) increases bp(GO:"GO:0014047") |
| pmid:16273023 | a(MESH:D002800) increases a(CHEBI:acetylcholine) |
| pmid:16273023 | a(MESH:D002800) association bp(GO:"GO:0007271") |
| pmid:18986241 | a(MESH:D002800) decreases path(MESH:D000544) |
| pmid:18986241 | a(MESH:D002800) decreases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | a(MESH:D002800) increases bp(MESH:D000066829) |
| pmid:18986241 | a(MESH:D002800) association bp(GO:"GO:0050435") |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D007319) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D003967) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D009325) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D005221) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D000855) |
| pmid:16273023 | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) |
| pmid:16273023 | a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:12428809 | bp(GO:"axonal transport") association p(HGNC:MAPT) |
| pmid:12428809 | bp(GO:"axonal transport") association p(HGNC:APP) |
| pmid:12428809 | bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:12428809 | bp(GO:"axonal transport") association a(CHEBI:"amyloid-beta") |
| pmid:12428809 | bp(GO:"axonal transport") association p(HGNC:GSK3B) |
| pmid:26631930 | bp(GO:"axonal transport") decreases path(HBP:Neurodegeneration) |
| pmid:21734277 | bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:PPP1CA)) |
| pmid:24590577 | complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pmid:24590577 | complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pmid:24590577 | complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pmid:24590577 | complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pmid:24590577 | complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pmid:24590577 | complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pmid:24590577 | complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") |
| pmid:24590577 | complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:24590577 | complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") |
| pmid:24590577 | complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:24590577 | path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:24590577 | a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:29626319 | a(MESH:Kidney) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24590577 | a(MESH:Thalamus) association p(HGNC:CHRM1) |
| pmid:24762290 | a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24762290 | a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24590577 | p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") |
| pmid:24590577 | a(MESH:Hypothalamus) association p(HGNC:CHRM3) |
| pmid:24590577 | p(MGI:Chrm3) regulates bp(GO:"response to food") |
| pmid:24590577 | p(MGI:Chrm3) increases bp(GO:"pituitary gland development") |
| pmid:24590577 | p(MGI:Chrm3) increases p(MGI:Prl) |
| pmid:24590577 | p(MGI:Chrm3) increases p(MGI:Gh) |
| pmid:24590577 | p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") |
| pmid:24590577 | a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") |
| pmid:24590577 | a(MESH:"Pars Compacta") association p(HGNC:CHRM5) |
| pmid:22020111 | a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24401760 | p(MGI:Bace1) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:24590577 | complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) |
| pmid:29686391 | bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:24590577 | bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity) |
| pmid:23454242 | bp(GO:"Wnt signaling pathway") association p(FPLX:PPP2) |
| pmid:18494933 | bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24590577 | a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases a(HBP:"Tau aggregates") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:MAPT, frag("?")) |
| pmid:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) |
| pmid:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) |
| pmid:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") |
| pmid:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") |
| pmid:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") |
| pmid:24590577 | a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24590577 | a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") |
| pmid:24590577 | a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(CHEBI:cevimeline) causesNoChange a(HBP:"sAPP-alpha") |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:Confusion) |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:Diarrhea) |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:Asthenia) |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha") |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) |
| pmid:24590577 | a(MESH:"WAY 132983") increases bp(GO:cognition) |
| pmid:24590577 | a(MESH:"WAY 132983") increases path(MESH:Salivation) |
| pmid:24590577 | a(MESH:"WAY 132983") increases path(MESH:Hypothermia) |
| pmid:24590577 | a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pmid:24590577 | a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pmid:24590577 | a(HBP:VU0184670) increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(HBP:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pmid:26088141 | p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) |
| pmid:26088141 | p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) |
| pmid:26088141 | p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) |
| pmid:26088141 | composite(p(HBP:"alpha-Bungarotoxin"), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins")) |
| pmid:21958873 | p(HBP:"alpha-Bungarotoxin") causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:21958873 | p(HBP:"alpha-Bungarotoxin") decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26088141 | p(HBP:"GPBC, alpha-7 nAChR") orthologous p(HBP:"GPBC, Glycine Receptor 1") |
| pmid:26088141 | p(HBP:"GPBC, Glycine Receptor 1") orthologous p(HBP:"GPBC, alpha-7 nAChR") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases bp(HBP:"nAChR assembly") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") |
| pmid:26088141 | a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) |
| pmid:26088141 | a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) |
| pmid:26088141 | a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) |
| pmid:26088141 | a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) |
| pmid:26088141 | a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:25514383 | a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") |
| pmid:24762290 | a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:25514383 | a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HP:"cholinergic neuron") association bp(GO:cognition) |
| pmid:25514383 | a(HP:"cholinergic neuron") increases bp(GO:cognition) |
| pmid:25514383 | a(HP:"cholinergic neuron") association path(MESH:Attention) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") |
| pmid:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") |
| pmid:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"intracellular signal transduction") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(Ph)) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") |
| pmid:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") |
| pmid:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) |
| pmid:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) |
| pmid:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) |
| pmid:28132910 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(HBP:"B-973") |
| pmid:30664622 | a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404)) |
| pmid:30664622 | a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP)) |
| pmid:25514383 | a(HBP:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:"amyloid-beta")) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(HBP:"amyloid-beta aggregates") |
| pmid:25514383 | p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") |
| pmid:27522251 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") |
| pmid:25514383 | a(PUBCHEM:637026) increases act(a(HBP:"beta-2-containing nAChR")) |
| pmid:25514383 | a(HBP:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:28420982 | bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) |
| pmid:25514383 | a(HBP:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") |
| pmid:22419736 | a(HBP:"amyloid-beta 42 oligomers") association path(MESH:Tauopathies) |
| pmid:22419736 | a(HBP:"amyloid-beta 42 oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:28901280 | bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) |
| pmid:30126037 | bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") |
| pmid:24563850 | bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") |
| pmid:30126037 | bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) |
| pmid:28420982 | bp(HP:Neurodegeneration) decreases sec(p(HGNC:MAPT)) |
| pmid:25514383 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") |
| pmid:28901280 | path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases bp(GO:memory) |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(HBP:"S 24795") decreases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | a(HBP:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25514383 | a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") |
| pmid:25514383 | a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:25514383 | a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") |
| pmid:25514383 | a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") |
| pmid:25514383 | a(CHEBI:simvastatin) increases bp(GO:cognition) |
| pmid:25514383 | a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") |
| pmid:29626319 | a(CHEBI:simvastatin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:29626319 | a(CHEBI:simvastatin) increases sec(p(HGNC:MME)) |
| pmid:21718217 | bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) |
| pmid:25514383 | composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) |
| pmid:25881725 | p(MGI:App, frag("25_35")) decreases bp(GO:learning) |
| pmid:25881725 | p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") |
| pmid:25881725 | p(MGI:App, frag("25_35")) increases a(HBP:"amyloid-beta oligomers", loc(GO:"extracellular region")) |
| pmid:25881725 | p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") |
| pmid:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HBP:"PTI-125") decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) |
| pmid:25514383 | a(HBP:"PTI-125") decreases complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) |
| pmid:25514383 | a(HBP:"PTI-125") increases act(a(CHEBI:"amyloid-beta")) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022) |
| pmid:27522251 | complex(a(CHEBI:"amyloid-beta"), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(HBP:HBP00022) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Pons) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:Memory) |
| pmid:24762290 | a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24762290 | a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24762290 | a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:21718217 | a(HBP:HBP00089) association bp(GO:"microglial cell activation") |
| pmid:21718217 | a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation") |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:IFNG)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:TNF)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:IL1B)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:IL6)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) |
| pmid:22807490 | p(HGNC:IFNG) increases p(HGNC:NOS2) |
| pmid:23702978 | p(HGNC:IFNG) increases act(p(HGNC:NOS2)) |
| pmid:22807490 | p(HGNC:IFNG) increases p(HGNC:PTGS2) |
| pmid:23702978 | p(HGNC:IFNG) increases p(HGNC:AIM2) |
| pmid:23702978 | p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) |
| pmid:23702978 | p(HGNC:IFNG) increases p(HGNC:CARD17) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") |
| pmid:21718217 | act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") |
| pmid:21718217 | act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") |
| pmid:21718217 | p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") |
| pmid:21718217 | p(HGNC:PPARG) association bp(GO:"response to insulin") |
| pmid:21718217 | p(HGNC:PPARG) association bp(GO:"lipid storage") |
| pmid:21718217 | p(HGNC:PPARG) increases p(HGNC:APOE) |
| pmid:21718217 | p(HGNC:PPARG) increases p(HGNC:ABCA1) |
| pmid:21718217 | p(HGNC:PPARG) increases p(HGNC:NR1H3) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases p(HGNC:ARG1) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases p(HGNC:IL4) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") |
| pmid:21718217 | act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") |
| pmid:21718217 | p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") |
| pmid:21718217 | p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") |
| pmid:21718217 | p(HGNC:NR1H3) increases p(HGNC:APOE) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) |
| pmid:21718217 | p(HGNC:NR1H3) increases p(HGNC:ABCA1) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases bp(GO:memory) |
| pmid:21718217 | act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") |
| pmid:21718217 | p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(FPLX:PPAR) association bp(GO:"fat cell differentiation") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") |
| pmid:21718217 | p(FPLX:PPAR) association bp(GO:"response to insulin") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") |
| pmid:21718217 | p(FPLX:PPAR) association bp(GO:"response to tumor cell") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") |
| pmid:21718217 | p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") |
| pmid:21718217 | act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") |
| pmid:21718217 | act(p(FPLX:RXR)) increases p(HGNC:APOE) |
| pmid:21718217 | act(p(FPLX:RXR)) increases p(HGNC:ABCA1) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) |
| pmid:25784053 | bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) |
| pmid:21718217 | bp(GO:"fat cell differentiation") association p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to insulin") association p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to insulin") association p(HGNC:PPARG) |
| pmid:21718217 | bp(GO:"response to tumor cell") association p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"lipid storage") association p(HGNC:PPARG) |
| pmid:21718217 | p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") |
| pmid:21718217 | act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") |
| pmid:21718217 | act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") |
| pmid:21718217 | act(p(HGNC:PPARD)) increases p(HGNC:ARG1) |
| pmid:21718217 | act(p(HGNC:PPARD)) increases p(HGNC:IL4) |
| pmid:21718217 | bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) |
| pmid:21718217 | a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) |
| pmid:21718217 | a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) |
| pmid:21718217 | bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) |
| pmid:21718217 | a(HBP:HBP00030) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21718217 | a(HBP:HBP00030) increases a(HBP:HBP00018) |
| pmid:21718217 | p(HGNC:ABCA1) increases p(HGNC:APOE) |
| pmid:21718217 | p(HGNC:ABCA1) decreases a(HBP:HBP00018) |
| pmid:21718217 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) |
| pmid:26195256 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:26195256 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:28019679 | p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | p(HGNC:IDE) increases deg(p(HGNC:IAPP)) |
| pmid:30116051 | p(HGNC:IDE) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30116051 | p(HGNC:IDE) decreases a(HBP:"amyloid-beta aggregates") |
| pmid:30116051 | p(HGNC:IDE) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | p(HGNC:IDE) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:IDE) decreases a(HBP:"alpha-synuclein fibrils") |
| pmid:30116051 | p(HGNC:IDE) increases deg(a(HBP:"alpha-synuclein fibrils")) |
| pmid:26195256 | p(HGNC:IDE) increases deg(p(HGNC:INS)) |
| pmid:29626319 | p(HGNC:IDE) negativeCorrelation bp(GO:aging) |
| pmid:29626319 | p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") |
| pmid:28019679 | p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") |
| pmid:21718217 | a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases p(HGNC:APOE) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) |
| pmid:21718217 | a(CHEBI:"GW 3965") decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases bp(GO:memory) |
| pmid:21718217 | a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038)) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) |
| pmid:21718217 | p(MGI:Abca1) decreases a(CHEBI:"amyloid-beta") |
| pmid:21718217 | p(MGI:Abca1) decreases a(HBP:HBP00038) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21718217 | a(CHEBI:pioglitazone) increases bp(GO:behavior) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases p(MGI:Abca1) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases p(MGI:Apoe) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases bp(GO:memory) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases bp(GO:cognition) |
| pmid:29626319 | a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta") |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pmid:29626319 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:behavior) |
| pmid:21718217 | a(CHEBI:rosiglitazone) causesNoChange a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:rosiglitazone) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases p(MGI:Abca1) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:memory) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:cognition) |
| pmid:29626319 | a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) |
| pmid:19732809 | path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation a(HBP:"O-GlcNAcylation") |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:APOA1) |
| pmid:21718217 | a(CHEBI:"GW 501516") decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:MME) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:IDE) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing") |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin)) |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:21718217 | a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) |
| pmid:21718217 | a(CHEBI:bexarotene) increases p(HGNC:APOE) |
| pmid:21718217 | a(CHEBI:bexarotene) increases p(HGNC:ABCA1) |
| pmid:21718217 | a(CHEBI:bexarotene) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:bexarotene) increases bp(GO:behavior) |
| pmid:21718217 | a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) |
| pmid:21718217 | a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) |
| pmid:21718217 | a(CHEBI:Honokiol) increases p(HGNC:APOE) |
| pmid:21718217 | a(CHEBI:Honokiol) increases p(HGNC:ABCA1) |
| pmid:21718217 | r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) |
| pmid:21718217 | p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") |
| pmid:21718217 | p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") |
| pmid:21718217 | a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) |
| pmid:19721446 | a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:29758300 | a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:29758300 | a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex")) |
| pmid:22908190 | a(CHEBI:cholesterol) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis) |
| pmid:22908190 | a(CHEBI:cholesterol) increases a(GO:endosome) |
| pmid:21718217 | p(HBP:HBP00030) association path(MESH:"Alzheimer Disease") |
| pmid:21718217 | p(HGNC:IL10) decreases a(MESH:Macrophages) |
| pmid:21718217 | a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) |
| pmid:28445721 | path(MESH:Motivation) association p(FPLX:CHRN) |
| pmid:30985105 | bp(GO:"dopamine secretion") association p(HGNC:SNCA) |
| pmid:28445721 | bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) |
| pmid:22040696 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) |
| pmid:28445721 | p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:22040696 | p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:22040696 | p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pmid:22040696 | p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:22040696 | p(HGNC:RIC3) increases p(HGNC:CHRNA9) |
| pmid:22040696 | p(HGNC:RIC3) increases p(HGNC:CHRNA7) |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder") |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders") |
| pmid:28445721 | p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) regulates surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(HBP:HBP00174)) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(HBP:HBP00174)) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(HBP:HBP00174) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta2") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta4") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28445721 | p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:28445721 | p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:28445721 | p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") |
| pmid:28445721 | act(p(MGI:Tmem35a), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | p(MGI:Tmem35a) association p(MGI:Canx) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00180)) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) |
| pmid:28445721 | p(MGI:Tmem35a) increases a(HBP:HBP00180) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(GO:membrane), a(MESH:Bungarotoxins)) |
| pmid:28445721 | p(MGI:Tmem35a) increases p(FPLX:CHRN) |
| pmid:28445721 | p(MGI:Tmem35a) regulates p(FPLX:CHRN) |
| pmid:28445721 | p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") |
| pmid:28445721 | p(MGI:Tmem35a) decreases bp(GO:locomotion) |
| pmid:28445721 | p(MGI:Tmem35a) decreases bp(GO:locomotion) |
| pmid:28445721 | p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") |
| pmid:28445721 | p(MGI:Tmem35a) increases bp(GO:learning) |
| pmid:28445721 | p(MGI:Tmem35a) increases bp(GO:memory) |
| pmid:28445721 | p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") |
| pmid:28445721 | p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") |
| pmid:11230871 | complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) |
| pmid:11230871 | complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) |
| pmid:28445721 | p(MGI:Canx) association p(MGI:Tmem35a) |
| pmid:18174175 | complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:21787755 | a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:28445721 | a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:21787755 | a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:28445721 | bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) |
| pmid:21482353 | a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:27671637 | a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:21482353 | p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) |
| pmid:21482353 | p(HGNC:CHRNA4, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:21482353 | p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) |
| pmid:21482353 | p(HGNC:CHRNB2, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) |
| pmid:19721446 | p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association surf(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") |
| pmid:21482353 | p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") |
| pmid:21482353 | p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") |
| pmid:21482353 | p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") |
| pmid:28901280 | p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:28901280 | p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) |
| pmid:21482353 | composite(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) |
| pmid:21482353 | complex(a(HBP:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-7-containing nAChR")) |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") negativeCorrelation bp(GO:aging) |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") regulates act(a(CHEBI:"amyloid-beta")) |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures) |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death") |
| pmid:21482353 | p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(GO:learning) |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(GO:memory) |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | p(MGI:Lynx1) increases a(MESH:Neurons) |
| pmid:21482353 | act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:22299660 | a(MESH:Brain) association p(HGNC:PPP2R2A) |
| pmid:21482353 | p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) |
| pmid:21482353 | p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) |
| pmid:21482353 | p(HGNC:PSCA) decreases bp(GO:"programmed cell death") |
| pmid:21482353 | bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) |
| pmid:21482353 | bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) |
| pmid:21482353 | bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) |
| pmid:21482353 | bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) |
| pmid:21482353 | path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") |
| pmid:21482353 | a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") |
| pmid:21482353 | act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) |
| pmid:21482353 | a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) |
| pmid:24563850 | act(p(FPLX:NOS)) increases a(CHEBI:radical) |
| pmid:24563850 | act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species") |
| pmid:24563850 | act(p(FPLX:NOS)) increases a(CHEBI:"reactive nitrogen species") |
| pmid:21482353 | a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) |
| pmid:21482353 | g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) |
| pmid:21482353 | g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) |
| pmid:21482353 | a(HBP:"GTS-21") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | a(HBP:"GTS-21") increases path(MESH:Attention) |
| pmid:21482353 | a(HBP:"GTS-21") increases bp(GO:"sensory processing") |
| pmid:21482353 | a(HBP:"GTS-21") decreases path(MESH:Anhedonia) |
| pmid:21482353 | a(HBP:"GTS-21") decreases path(MESH:Aphasia) |
| pmid:21482353 | p(HGNC:SLC12A5) decreases a(CHEBI:chloride) |
| pmid:21482353 | p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:21482353 | p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) |
| pmid:21482353 | a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) |
| pmid:21482353 | p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") |
| pmid:21482353 | p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) |
| pmid:21482353 | path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) |
| pmid:21482353 | bp(GO:"macrophage activation") association a(HBP:"alpha-7-containing nAChR") |
| pmid:21482353 | bp(GO:"response to cytokine") association a(HBP:"alpha-7-containing nAChR") |
| pmid:21482353 | bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) |
| pmid:23746257 | bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") |
| pmid:25784053 | bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) |
| pmid:21482353 | path(MESH:Fear) increases a(CHEBI:dopamine) |
| pmid:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) |
| pmid:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) |
| pmid:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") |
| pmid:18986241 | path(MESH:D019636) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D001526) association path(MESH:D000544) |
| pmid:18986241 | path(HBP:aMCI) association path(MESH:D008569) |
| pmid:18986241 | path(HBP:aMCI) association path(MESH:D003704) |
| pmid:18986241 | path(HBP:aMCI) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D008569) association path(HBP:aMCI) |
| pmid:18986241 | path(HBP:mdMCI) association path(MESH:D060825) |
| pmid:18986241 | path(MESH:D060825) association path(HBP:mdMCI) |
| pmid:18986241 | path(MESH:D060825) association path(MESH:D062706) |
| pmid:18986241 | path(MESH:D060825) association bp(HBP:Neurodegeneration) |
| pmid:18986241 | path(MESH:D060825) causesNoChange act(p(HGNC:CHAT)) |
| pmid:18986241 | path(MESH:D060825) increases act(p(HGNC:CHAT)) |
| pmid:18986241 | path(MESH:D060825) increases act(p(HGNC:CHAT)) |
| pmid:18986241 | path(MESH:D060825) decreases a(MESH:D013569) |
| pmid:18986241 | path(MESH:D060825) increases act(p(HGNC:MMP9)) |
| pmid:18986241 | path(MESH:D060825) causesNoChange r(HGNC:CHAT) |
| pmid:18986241 | path(MESH:D060825) association p(HGNC:CHRM1) |
| pmid:18986241 | path(MESH:D060825) decreases a(HBP:"3R tau") |
| pmid:18986241 | path(MESH:D062706) association path(MESH:D060825) |
| pmid:18986241 | a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384") |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D008568) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D001288) |
| pmid:18986241 | a(MESH:D059329) association a(MESH:D016874) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D000544) |
| pmid:18986241 | a(MESH:D059329) association a(MESH:D009479) |
| pmid:18986241 | a(MESH:D059329) association a(MESH:D059330) |
| pmid:18986241 | a(MESH:D059329) association p(RGD:Gal) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D008570) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D003704) |
| pmid:18986241 | bp(GO:"GO:0060384") association p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D001288) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D016874) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D016874) association path(MESH:D000544) |
| pmid:18986241 | a(MESH:D016874) association p(HGNC:BCHE) |
| pmid:18986241 | a(MESH:D009479) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D059330) association a(MESH:D059329) |
| pmid:18986241 | p(RGD:Gal) association a(MESH:D059329) |
| pmid:18986241 | path(MESH:D008570) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D005625) positiveCorrelation path(MESH:D011597) |
| pmid:18986241 | path(MESH:D011597) positiveCorrelation a(MESH:D005625) |
| pmid:18986241 | p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) |
| pmid:18986241 | complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0038180") |
| pmid:18986241 | complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") |
| pmid:18986241 | p(HGNC:NTRK1) negativeCorrelation path(MESH:D003072) |
| pmid:18986241 | p(HGNC:NTRK1) biomarkerFor path(MESH:D000544) |
| pmid:18986241 | p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) |
| pmid:18986241 | bp(GO:"GO:0038180") increases bp(GO:"GO:1990089") |
| pmid:18986241 | complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) |
| pmid:18986241 | bp(GO:"GO:1901214") association p(HGNC:NGFR) |
| pmid:18986241 | path(MESH:D003072) negativeCorrelation p(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D003072) positiveCorrelation act(p(HGNC:MMP9)) |
| pmid:18986241 | bp(MESH:D000375) increases p(HGNC:NGFR) |
| pmid:18986241 | p(HGNC:SORT1) association path(MESH:D000544) |
| pmid:18986241 | act(p(HGNC:MMP9)) positiveCorrelation path(MESH:D003072) |
| pmid:27594586 | p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) |
| pmid:27594586 | act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") |
| pmid:27594586 | act(p(HGNC:MMP9)) increases bp(GO:"neuron death") |
| pmid:27594586 | p(HGNC:MMP9) increases bp(GO:"neuron death") |
| pmid:27594586 | act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) |
| pmid:26195256 | p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:29626319 | act(p(HGNC:MMP9)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:18986241 | g(HGNC:NTRK1) association path(MESH:D003071) |
| pmid:18986241 | g(HGNC:NTRK2) association path(MESH:D003071) |
| pmid:18986241 | g(HGNC:NTRK3) association path(MESH:D003071) |
| pmid:18986241 | bp(GO:"GO:0000165") association bp(GO:"GO:0006915") |
| pmid:18986241 | bp(GO:"GO:0000165") association bp(GO:"GO:0030182") |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:RAS)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:RAF)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:MEK)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2)) |
| pmid:18986241 | bp(GO:"GO:0006915") association bp(GO:"GO:0000165") |
| pmid:18986241 | bp(GO:"GO:0030182") association bp(GO:"GO:0000165") |
| pmid:18986241 | act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph)) |
| pmid:18986241 | act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph)) |
| pmid:18986241 | bp(GO:"GO:0014065") regulates bp(MESH:D002470) |
| pmid:18986241 | bp(GO:"GO:0014065") association p(FPLX:RAS) |
| pmid:18986241 | bp(GO:"GO:0014065") association p(HGNC:IRS1) |
| pmid:18986241 | bp(GO:"GO:0014065") association p(HGNC:GAB1) |
| pmid:18986241 | bp(GO:"GO:0043491") regulates bp(MESH:D002470) |
| pmid:18986241 | bp(GO:"GO:0043491") association p(FPLX:RAS) |
| pmid:18986241 | bp(GO:"GO:0043491") association p(HGNC:IRS1) |
| pmid:18986241 | bp(GO:"GO:0043491") association p(HGNC:GAB1) |
| pmid:18986241 | p(HGNC:IRS1) association bp(GO:"GO:0014065") |
| pmid:18986241 | p(HGNC:IRS1) association bp(GO:"GO:0043491") |
| pmid:18986241 | p(HGNC:GAB1) association bp(GO:"GO:0014065") |
| pmid:18986241 | p(HGNC:GAB1) association bp(GO:"GO:0043491") |
| pmid:18986241 | act(p(HGNC:PLCG1)) association bp(MESH:D018384) |
| pmid:18467332 | p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pmid:18986241 | bp(MESH:D018384) association act(p(HGNC:PLCG1)) |
| pmid:18986241 | bp(MESH:D018384) association path(MESH:D000375) |
| pmid:18986241 | bp(MESH:D018384) association path(MESH:D009410) |
| pmid:18986241 | path(MESH:D000375) association bp(MESH:D018384) |
| pmid:18986241 | path(MESH:D009410) association bp(MESH:D018384) |
| pmid:18986241 | bp(GO:"GO:0006665") association act(p(HGNC:NGFR)) |
| pmid:18986241 | p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491") |
| pmid:18986241 | p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165") |
| pmid:18986241 | path(MESH:D024801) association p(HGNC:CHRM1) |
| pmid:18986241 | path(MESH:D000686) association p(HGNC:CHRM1) |
| pmid:26751493 | r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:18986241 | bp(HBP:hyperphosphorylation) association path(MESH:D016874) |
| pmid:17493042 | p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau") |
| pmid:17493042 | p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau") |
| pmid:17493042 | p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform D (383 aa)") isA p(HBP:"4R tau") |
| pmid:17493042 | p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform E (412 aa)") isA p(HBP:"4R tau") |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion") |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion") |
| pmid:25374103 | p(HBP:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death") |
| pmid:25374103 | p(HBP:"Tau isoform F (441 aa)") increases act(p(HGNC:CASP3)) |
| pmid:25374103 | p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform F (441 aa)") isA p(HBP:"4R tau") |
| pmid:30145931 | r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:18986241 | act(p(HGNC:GAL)) association path(MESH:D003071) |
| pmid:18986241 | act(p(HGNC:GAL)) association bp(MESH:D009473) |
| pmid:18986241 | act(p(HGNC:GAL)) increases bp(GO:"GO:0060384") |
| pmid:18986241 | act(p(HGNC:GAL)) regulates act(a(MESH:D059329)) |
| pmid:18986241 | act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | act(p(HGNC:GAL)) increases r(HGNC:CHAT) |
| pmid:18986241 | act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423") |
| pmid:18986241 | act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) |
| pmid:18986241 | act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) |
| pmid:18986241 | bp(MESH:D009473) association act(p(HGNC:GAL)) |
| pmid:18986241 | a(HBP:"Tau C3") biomarkerFor path(MESH:D059329) |
| pmid:18986241 | p(RGD:Ngf) increases r(RGD:Gal) |
| pmid:18986241 | p(RGD:Ngf) decreases path(MESH:D060825) |
| pmid:18986241 | bp(GO:"GO:0050435") association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D007319) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D003967) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D009325) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D005221) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D000855) association a(MESH:D002800) |
| pmid:18986241 | bp(GO:"GO:0007269") association p(HGNC:NGF) |
| pmid:18986241 | bp(GO:"GO:0048485") association p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D002100) association p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D006930) association p(HGNC:NGF) |
| pmid:18986241 | g(HGNC:NGF) directlyIncreases p(HGNC:NGF) |
| pmid:11230871 | a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) |
| pmid:11230871 | a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:11230871 | a(PUBCHEM:132228) increases p(FPLX:CHRN) |
| pmid:11230871 | a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) |
| pmid:11230871 | a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") |
| pmid:11230871 | a(PUBCHEM:119380) increases bp(GO:memory) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(CHEBI:acetylcholine)) |
| pmid:28132910 | a(HBP:"B-973") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) |
| pmid:28132910 | a(HBP:"B-973") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pmid:28132910 | a(HBP:"B-973") increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) |
| pmid:28132910 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28391535 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28391535 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28391535 | a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) |
| pmid:28391535 | a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) |
| pmid:17640819 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:"amyloid-beta") |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) |
| pmid:19721446 | a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) |
| pmid:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) |
| pmid:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) |
| pmid:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) |
| pmid:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) |
| pmid:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) |
| pmid:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) |
| pmid:19721446 | p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) |
| pmid:19721446 | p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) |
| pmid:19721446 | p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) |
| pmid:19721446 | p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) |
| pmid:19721446 | a(MESH:"AR-R 17779") increases bp(GO:learning) |
| pmid:19721446 | a(MESH:"AR-R 17779") increases bp(GO:memory) |
| pmid:19721446 | a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) |
| pmid:19721446 | a(DRUGBANK:Facinicline) increases bp(GO:cognition) |
| pmid:19721446 | a(DRUGBANK:Facinicline) increases bp(GO:memory) |
| pmid:19721446 | a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") |
| pmid:19721446 | a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(HBP:neurotoxicity) |
| pmid:19721446 | a(MESH:"Entorhinal Cortex") association bp(GO:memory) |
| pmid:19721446 | path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") |
| pmid:19721446 | path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) |
| pmid:19721446 | a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pmid:19721446 | bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pmid:19721446 | bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) |
| pmid:19721446 | a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:19721446 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:28901280 | a(MESH:"Dihydro-beta-Erythroidine") decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:Nicotine)) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2")) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), p(HGNC:CHRNB2)) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha4beta2")) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28391535 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19721446 | a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") |
| pmid:19721446 | a(CHEBI:varenicline) increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19721446 | a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) |
| pmid:28391535 | a(CHEBI:varenicline) increases act(a(MESH:"nicotinic receptor alpha4beta2")) |
| pmid:28391535 | a(CHEBI:varenicline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19721446 | complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19721446 | complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19721446 | g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") |
| pmid:19721446 | g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") |
| pmid:19721446 | g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") |
| pmid:19721446 | path(MESH:Recurrence) association p(HGNC:CHRNA3) |
| pmid:19721446 | path(MESH:Recurrence) association p(HGNC:CHRNB4) |
| pmid:19721446 | a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:sertraline) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pmid:19721446 | a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19721446 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) |
| pmid:19721446 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) |
| pmid:28901280 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") |
| pmid:22040696 | p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) |
| pmid:22040696 | p(FPLX:"p14_3_3") increases p(FPLX:CHRN) |
| pmid:22040696 | p(HGNC:HSPA5) increases p(FPLX:CHRN) |
| pmid:22040696 | p(HGNC:CANX) increases p(FPLX:CHRN) |
| pmid:22040696 | complex(GO:"proteasome complex") regulates p(FPLX:CHRN) |
| pmid:22040696 | complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") |
| pmid:22040696 | complex(GO:"proteasome complex") regulates p(HGNC:RIC3) |
| pmid:29758300 | complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:29758300 | complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA)) |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) |
| pmid:14556719 | complex(GO:"proteasome complex") increases a(CHEBI:peptide) |
| pmid:14556719 | complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:14556719 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) |
| pmid:18930136 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) |
| pmid:22908190 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(Ub))) |
| pmid:22908190 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(UbK48))) |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"paired helical filaments") |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:22908190 | complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(Ub))) |
| pmid:22908190 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) |
| pmid:22908190 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) |
| pmid:22908190 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) |
| pmid:26751493 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) |
| pmid:17954934 | act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) |
| pmid:24457024 | complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:18930136 | act(complex(GO:"proteasome complex")) decreases path(HBP:Neurodegeneration) |
| pmid:18930136 | act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1) |
| pmid:18930136 | act(complex(GO:"proteasome complex")) decreases r(HGNC:SQSTM1) |
| pmid:30116051 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:30116051 | complex(GO:"proteasome complex") increases deg(a(HBP:"Tau oligomers")) |
| pmid:17954934 | act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") |
| pmid:17954934 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) |
| pmid:19732809 | act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"O-GlcNAcylation") |
| pmid:19732809 | act(complex(GO:"proteasome complex")) positiveCorrelation g(HGNC:OGT) |
| pmid:26041011 | act(complex(GO:"proteasome complex")) decreases a(HBP:"Tau aggregates") |
| pmid:26692334 | act(complex(GO:"proteasome complex")) positiveCorrelation act(p(FPLX:PKA)) |
| pmid:22040696 | composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases surf(p(HGNC:HTR3A)) |
| pmid:22040696 | p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) |
| pmid:22040696 | p(FPLX:CHRN, pmod(Ph, Tyr)) decreases act(p(FPLX:CHRN)) |
| pmid:22040696 | complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") |
| pmid:22040696 | complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") |
| pmid:22040696 | complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) |
| pmid:22040696 | complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) |
| pmid:22040696 | p(HGNC:CHRNA7, pmod(Ph, Tyr)) decreases act(p(HGNC:CHRNA7)) |
| pmid:21787755 | bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR") |
| pmid:22040696 | act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) |
| pmid:22040696 | act(a(MESH:"SNARE Proteins")) causesNoChange surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:22040696 | r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") |
| pmid:22040696 | path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) |
| pmid:22040696 | path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) |
| pmid:22040696 | bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") |
| pmid:18174175 | complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:26837465 | p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") |
| pmid:26837465 | p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") |
| pmid:26837465 | p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:21787755 | bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR") |
| pmid:21787755 | a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") |
| pmid:21787755 | a(HBP:AβOs) association path(MESH:"Alzheimer Disease") |
| pmid:21787755 | a(HBP:AβOs) association path(MESH:Epilepsy) |
| pmid:22908190 | a(HBP:AβOs) decreases act(a(GO:synapse)) |
| pmid:22908190 | a(HBP:AβOs) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:22908190 | a(HBP:AβOs) decreases bp(GO:learning) |
| pmid:22908190 | a(HBP:AβOs) decreases bp(GO:memory) |
| pmid:22908190 | a(HBP:AβOs) increases bp(GO:"long-term synaptic depression") |
| pmid:22908190 | a(HBP:AβOs) decreases bp(GO:"L-glutamate import") |
| pmid:22908190 | a(HBP:AβOs) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22908190 | a(HBP:AβOs) increases deg(a(MESH:Neurites)) |
| pmid:22908190 | a(HBP:AβOs) decreases act(complex(GO:"proteasome complex")) |
| pmid:28528849 | a(HBP:AβOs) decreases a(MESH:"Dendritic Spines") |
| pmid:21787755 | a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") |
| pmid:21787755 | path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") |
| pmid:21787755 | path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") |
| pmid:21787755 | path(MESH:Reward) association r(HGNC:CHRNA6) |
| pmid:21787755 | path(MESH:Reward) association p(HGNC:CHRNA6) |
| pmid:28901280 | path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") |
| pmid:21787755 | path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") |
| pmid:21787755 | a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) |
| pmid:21787755 | a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) |
| pmid:21787755 | bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) |
| pmid:21787755 | bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(HBP:"cell population proliferation") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell adhesion") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(GO:"secretion by cell") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:Apoptosis) |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(HBP:"juxtacrine signaling") |
| pmid:28901280 | a(MESH:Acetylcholine) decreases path(MESH:Inflammation) |
| pmid:28901280 | a(MESH:Acetylcholine) increases path(MESH:Neoplasms) |
| pmid:28901280 | a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pmid:28901280 | a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) |
| pmid:28901280 | complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) |
| pmid:28901280 | a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:28901280 | a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:28901280 | a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:28901280 | a(MESH:Nicotine) decreases a(MESH:Neurons) |
| pmid:28901280 | a(MESH:Nicotine) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") |
| pmid:28901280 | a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Glutamates) |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Glutamates) |
| pmid:28901280 | a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") |
| pmid:28901280 | a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") |
| pmid:28901280 | a(MESH:Nicotine) increases bp(GO:"action potential initiation") |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Dopamine) |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Dopamine) |
| pmid:28901280 | a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) |
| pmid:28901280 | a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) |
| pmid:28901280 | a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:28901280 | a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") |
| pmid:28901280 | act(a(MESH:Nicotine)) association g(DNSNP:rs16969968) |
| pmid:28901280 | a(MESH:Nicotine) increases path(MESH:Neoplasms) |
| pmid:28901280 | a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pmid:28901280 | a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) |
| pmid:28901280 | complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) |
| pmid:28901280 | bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(HBP:"cell population proliferation") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(HBP:"cell population proliferation") association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(GO:"secretion by cell") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(MESH:Apoptosis) association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(HBP:"juxtacrine signaling") association a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") |
| pmid:29626319 | a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:28901280 | a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") |
| pmid:28901280 | path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) |
| pmid:28901280 | bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(HBP:cytisine) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(HBP:cytisine) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(MESH:Carbachol) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Carbachol) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(MESH:Varenicline) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Varenicline) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(MESH:Mecamylamine) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Mecamylamine) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) |
| pmid:28901280 | a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) |
| pmid:28901280 | a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") |
| pmid:28901280 | a(MESH:Glutamates) increases bp(GO:"action potential initiation") |
| pmid:27796283 | bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) |
| pmid:27041503 | bp(MESH:"Long-Term Potentiation") negativeCorrelation bp(GO:"actin filament polymerization") |
| pmid:27041503 | bp(MESH:"Long-Term Potentiation") negativeCorrelation p(HGNC:WWC1) |
| pmid:27041503 | bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:memory) |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA3, loc(MESH:"Central Nervous System")) |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNB4, loc(MESH:"Central Nervous System")) |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System")) |
| pmid:28901280 | g(DNSNP:rs16969968) association act(a(MESH:Nicotine)) |
| pmid:28901280 | p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) |
| pmid:28901280 | p(MGI:Chrna5) increases a(MESH:Nicotine) |
| pmid:28901280 | p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | p(MGI:Chrna2) increases a(MESH:Nicotine) |
| pmid:28901280 | a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") |
| pmid:28901280 | a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") |
| pmid:28901280 | a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) |
| pmid:28901280 | p(HBP:"LY6 family") regulates p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms") |
| pmid:28901280 | g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") |
| pmid:28901280 | bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) |
| pmid:28901280 | a(MESH:Epithelium) regulates a(MESH:Acetylcholine) |
| pmid:28901280 | act(a(MESH:Epithelium)) association p(MGI:Chrna7) |
| pmid:28901280 | a(MESH:Choline) increases act(p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) |
| pmid:28901280 | a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) |
| pmid:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) |
| pmid:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) |
| pmid:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:FPR3) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TUBB1) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates act(p(HGNC:LIPA)) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:HIST1H3B) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates p(HGNC:HIST1H3B) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:ABCF3) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:BMP4) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:CDH17) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KDM5D) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KLF1) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:PER1) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AKT1) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Vestibular Diseases") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation bp(MESH:"Body Height") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation path(MESH:"Weight Gain") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Motor Activity") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Motor Activity") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(MESH:"Hand Strength") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange bp(MESH:"Hand Strength") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Recognition (Psychology)") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder") |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell) |
| pmid:30106381 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:memory) |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Motor Skills Disorders") |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Brain Injuries") |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(MESH:"Nerve Fibers, Myelinated") |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7) |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) |
| pmid:30664622 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:SLC17A7) |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP) |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking") |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:saccharin), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TFAP2B) |
| pmid:30008470 | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:TFAP2B) |
| pmid:30106381 | p(HGNC:DLG4) regulates act(p(HGNC:ADNP)) |
| pmid:30664622 | p(HGNC:DLG4) association act(p(HGNC:ADNP)) |
| pmid:30106381 | p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404)) |
| pmid:30664622 | p(HGNC:DLG4) association act(a(PUBCHEM:9832404)) |
| pmid:30106381 | p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity") |
| pmid:24760868 | p(HGNC:DLG4) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:26751493 | p(HGNC:DLG4) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:DLG4) association a(HBP:"projection domain") |
| pmid:30106381 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine") |
| pmid:30664622 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) |
| pmid:30664622 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) |
| pmid:30008470 | composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") |
| pmid:30106381 | bp(GO:"nervous system development") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"nervous system development") association a(PUBCHEM:9832404) |
| pmid:30106381 | bp(GO:"AMPA glutamate receptor clustering") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"AMPA glutamate receptor clustering") association a(PUBCHEM:9832404) |
| pmid:30106381 | bp(GO:"social behavior") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"social behavior") association a(PUBCHEM:9832404) |
| pmid:30106381 | bp(GO:"vocalization behavior") association p(HGNC:ADNP) |
| pmid:30106381 | bp(GO:"vocalization behavior") association a(PUBCHEM:9832404) |
| pmid:21882945 | p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pmid:21882945 | p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) |
| pmid:21367866 | act(p(HGNC:AKT1), ma(kin)) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pmid:30106381 | p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome") |
| pmid:30106381 | g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"calcium-mediated signaling") |
| pmid:30106381 | g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"action potential") |
| pmid:30106381 | g(HGNC:"IQCJ-SCHIP1") increases bp(MESH:"Neuronal Outgrowth") |
| pmid:30106381 | g(HGNC:"IQCJ-SCHIP1") association p(HGNC:ADNP) |
| pmid:30106381 | g(HGNC:"IQCJ-SCHIP1") association a(PUBCHEM:9832404) |
| pmid:30106381 | p(HGNC:LIPA) increases bp(GO:"lipid metabolic process") |
| pmid:22142809 | p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b) |
| pmid:30106381 | p(HGNC:NLGN2) association a(PUBCHEM:9832404) |
| pmid:30106381 | p(HGNC:NLGN2) association p(HGNC:ADNP) |
| pmid:30106381 | p(HGNC:PAX6) association a(PUBCHEM:9832404) |
| pmid:30106381 | p(HGNC:WFS1) association path(HBP:Neurodegeneration) |
| pmid:30106381 | p(HGNC:WFS1) regulates bp(GO:"cellular calcium ion homeostasis") |
| pmid:30106381 | p(HGNC:WFS1) association p(HGNC:ADNP) |
| pmid:30106381 | path(MESH:Intelligence) association p(HGNC:ADNP) |
| pmid:26010758 | p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation") |
| pmid:30106381 | bp(GO:translation) association p(HGNC:MTOR) |
| pmid:30106381 | bp(MESH:"Body Height") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) |
| pmid:30106381 | path(MESH:"Weight Gain") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) |
| pmid:28391535 | path(MESH:"Motor Activity") negativeCorrelation a(CHEBI:nicotine) |
| pmid:30664622 | path(MESH:Smell) regulates bp(GO:"social behavior") |
| pmid:30664622 | a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pmid:30664622 | a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body")) |
| pmid:30664622 | a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pmid:30664622 | a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") |
| pmid:30664622 | a(CHEBI:chlorobutanol) increases bp(GO:"social behavior") |
| pmid:30664622 | a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) |
| pmid:30664622 | a(CHEBI:chlorobutanol) decreases path(MESH:Smell) |
| pmid:30664622 | a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pmid:30664622 | a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery")) |
| pmid:30664622 | a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) |
| pmid:26195256 | a(MESH:"Blood-Brain Barrier") decreases a(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) |
| pmid:30664622 | composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory) |
| pmid:30664622 | composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior") |
| pmid:30664622 | composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated") |
| pmid:30664622 | composite(a(PUBCHEM:59557), a(PUBCHEM:9832404)) decreases bp(GO:"social behavior") |
| pmid:30664622 | composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) |
| pmid:30664622 | composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) |
| pmid:30664622 | p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis") |
| pmid:30664622 | p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import") |
| pmid:30985105 | bp(GO:"motor behavior") negativeCorrelation deg(a(HBP:"Dopaminergic cell groups")) |
| pmid:30985105 | bp(GO:"motor behavior") decreases path(MESH:Hypokinesia) |
| pmid:30985105 | bp(GO:"motor behavior") decreases path(MESH:"Muscle Rigidity") |
| pmid:30985105 | bp(GO:"motor behavior") decreases path(HP:"Postural instability") |
| pmid:29724491 | p(HGNC:ADNP, frag("1_719")) decreases bp(GO:"walking behavior") |
| pmid:28167836 | path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Arg205del") |
| pmid:28167836 | path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Glu239del") |
| pmid:30008470 | path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP) |
| pmid:30008470 | path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B) |
| pmid:30008470 | g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking") |
| pmid:22807490 | path(MESH:"Hashimoto Disease") association path(MESH:Smoking) |
| pmid:22807490 | p(HGNC:TPO) negativeCorrelation path(MESH:Smoking) |
| pmid:22807490 | path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2) |
| pmid:22807490 | a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:21958873 | a(PUBCHEM:71311633) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:21958873 | a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:21958873 | a(PUBCHEM:56972222) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:21958873 | a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:21958873 | a(PUBCHEM:11957537) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:21958873 | a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:23178521 | a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) |
| pmid:23178521 | a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) |
| pmid:23383175 | p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations") |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | p(MGI:Stat3) regulates bp(GO:"cytokine production") |
| pmid:23383175 | path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Il1b) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Ifng) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Tnf) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases a(MESH:Microglia) |
| pmid:23383175 | path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") |
| pmid:23383175 | p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | p(MGI:Rela) regulates bp(GO:"cytokine production") |
| pmid:23383175 | path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") |
| pmid:23383175 | bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath") |
| pmid:23383175 | a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis) |
| pmid:12428809 | p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) association path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29191965 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau oligomers") |
| pmid:22486774 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(HBP:"Tau oligomers") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(RGD:Mapt, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) |
| pmid:25331948 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo a(HBP:"Tau epitope, CP13") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:19459590 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo p(HBP:"Tau epitope, CP13") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:24406748 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:23294633 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:22253473 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(GO:"neurofibrillary tangle") |
| pmid:16464864 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(CHEBI:"okadaic acid") |
| pmid:16464864 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17403556 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22253473 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) |
| pmid:24653673 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) |
| pmid:10391244 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) association p(HGNC:PIN1, frag("5_39")) |
| pmid:10391244 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA) |
| pmid:23948915 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo a(HBP:"Tau epitope, AT180") |
| pmid:19623258 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo p(HBP:"Tau epitope, AT180") |
| pmid:22926167 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(HBP:"Tau aggregates") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:pretangles) |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(GO:"Pick body") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) |
| pmid:29686391 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25887395 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:28528849 | a(HBP:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation") |
| pmid:28528849 | a(HBP:"Tau oligomers") decreases bp(GO:memory) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:memory) |
| pmid:29191965 | a(HBP:"Tau oligomers") decreases a(MESH:Neurons) |
| pmid:29686391 | a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) |
| pmid:29686391 | a(HBP:"Tau oligomers") positiveCorrelation tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:30985105 | a(HBP:"Tau oligomers") increases a(GO:"neurofibrillary tangle") |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:Disease) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases a(GO:synapse) |
| pmid:22486774 | a(HBP:"Tau oligomers") partOf a(GO:synapse) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") |
| pmid:28420982 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26631930 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:cognition) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") |
| pmid:28420982 | a(HBP:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases a(HBP:"Tau annular protofibrils") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(MESH:"Cell Survival") |
| pmid:28420982 | a(HBP:"Tau oligomers") association p(HGNC:PRNP) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases act(a(GO:microtubule)) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") |
| pmid:28420982 | a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9)) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS)) |
| pmid:27373205 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:22817713 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26631930 | a(HBP:"Tau oligomers") increases path(HBP:Neurodegeneration) |
| pmid:26631930 | a(HBP:"Tau oligomers") decreases a(MESH:"Dendritic Spines") |
| pmid:22817713 | a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates") |
| pmid:22817713 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22817713 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:29238289 | a(HBP:"Tau oligomers") decreases path(MESH:Memory) |
| pmid:29238289 | a(HBP:"Tau oligomers") decreases bp(MESH:"Long-Term Potentiation") |
| pmid:26671985 | act(a(HBP:"Tau oligomers")) increases a(HBP:neurotoxicity) |
| pmid:26671985 | act(a(HBP:"Tau oligomers")) decreases act(complex(GO:axon)) |
| pmid:26671985 | act(a(HBP:"Tau oligomers")) positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:27716675 | a(HBP:"Tau oligomers") positiveCorrelation a(HBP:neuroinflammation) |
| pmid:27716675 | a(HBP:"Tau oligomers") increases a(HBP:"Pathological Tau Spreading") |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22611162 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) association p(HGNC:MAPT, var("p.Val277Met")) |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(RGD:Mapt, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:23948915 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:28176663 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:29844403 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation act(p(HGNC:GSK3B)) |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22611162 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) association p(HGNC:MAPT, var("p.Val277Met")) |
| pmid:24760868 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, AD2") |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| DOI:10.4172/2168-975X.1000126 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) |
| pmid:25331948 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) |
| pmid:22419736 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) |
| pmid:24183963 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:29121589 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:29844403 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) |
| pmid:21734277 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) |
| pmid:25331948 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) negativeCorrelation act(p(HGNC:SYK)) |
| DOI:10.4172/2168-975X.1000126 | p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) |
| pmid:23454242 | p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) |
| pmid:29121589 | p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) |
| pmid:29121589 | p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") |
| pmid:28391535 | sec(a(CHEBI:adrenaline)) increases sec(a(CHEBI:glucose)) |
| pmid:28391535 | sec(a(CHEBI:adrenaline)) increases path(MESH:"Blood Pressure") |
| pmid:28391535 | sec(a(CHEBI:adrenaline)) increases bp(GO:"cellular respiration") |
| pmid:28391535 | sec(a(CHEBI:adrenaline)) increases bp(MESH:"Heart Rate") |
| pmid:22908190 | a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR) |
| pmid:28391535 | a(CHEBI:"(S)-nicotine") increases path(MESH:Death) |
| pmid:28391535 | a(CHEBI:"(R)-nicotine") increases path(MESH:Death) |
| pmid:28391535 | a(MESH:Liver) increases bp(GO:"nicotine metabolic process") |
| pmid:29626319 | a(MESH:Liver) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:28391535 | bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine") |
| pmid:28391535 | bp(GO:"nicotine metabolic process") increases a(CHEBI:nornicotine) |
| pmid:28391535 | a(MESH:Lung) increases bp(GO:"nicotine metabolic process") |
| pmid:26195256 | path(MESH:Hypertension) increases path(MESH:"Alzheimer Disease") |
| pmid:28391535 | a(CHEBI:Hexamethonium) negativeCorrelation act(a(CHEBI:nicotine)) |
| pmid:28391535 | a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2")) |
| pmid:28391535 | a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine)) |
| pmid:28391535 | a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:methamphetamine)) |
| pmid:19165623 | complex(a(CHEBI:"1-methylpyrrolinium"), a(CHEBI:"nicotinic acid")) increases a(CHEBI:nicotine) |
| pmid:19165623 | a(CHEBI:arginine) increases a(CHEBI:"1-methylpyrrolinium") |
| pmid:19165623 | a(CHEBI:ornithine) increases a(CHEBI:"1-methylpyrrolinium") |
| pmid:19165623 | a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) |
| pmid:19165623 | a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) |
| pmid:19165623 | a(UNIPROT:Q9SEH4) increases rxn(reactants(a(CHEBI:arginine), a(CHEBI:ornithine)), products(a(CHEBI:"1-methylpyrrolinium"))) |
| pmid:19165623 | a(UNIPROT:Q9SEH4) decreases a(CHEBI:Anatabine) |
| pmid:19165623 | p(HGNC:QPRT) increases rxn(reactants(a(CHEBI:"quinolinic acid")), products(a(CHEBI:"nicotinic acid"))) |
| pmid:19165623 | p(HGNC:QPRT) regulates rxn(reactants(a(CHEBI:"nicotinic acid")), products(a(CHEBI:Anatabine))) |
| pmid:19165623 | p(HGNC:QPRT) increases a(CHEBI:Anatabine) |
| pmid:19165623 | p(HGNC:QPRT) increases a(CHEBI:nicotine) |
| pmid:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") |
| pmid:22020111 | act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pmid:24563850 | p(HGNC:NFE2L2) increases bp(HBP:Proteostasis) |
| pmid:29121589 | p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) |
| pmid:24355211 | p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18") |
| pmid:22020111 | a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NFE2L2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SIRT1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SLC7A11) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:AKR1B10) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PTGR1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:HMOX1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:HMOX1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:HMOX1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:AIFM2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:OSGIN1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:GPX3) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SQSTM1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:HSPB8) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:TNFSF9) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CTNNB1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:DHFR) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:DHFR) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:EDN1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:ITGB3) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MKI67) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MMP11) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MMP14) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MMP2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PDE7A) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PDE7B) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PLAU) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:SCARB1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NR3C1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NR3C1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PPARA) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PPARA) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:EGR1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PTGS2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PTGS2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SOAT1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:ACLY) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:ACLY) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:ANTXR1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:C20orf27) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CCNA2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CHAF1A) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:EFCAB11) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:FEN1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:GINS2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MCM10) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MCM4) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:RNASEH2A) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:SLIT2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:SPC25) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TFRC) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TK1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TMEM97) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TRIP13) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TUBB) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TUBB) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TYMS) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TYMS) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:UBA1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:UNG) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:UNG) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:VRK1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:ABCD3) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:GLRX2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:GLRX2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:MICB) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NQO1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NQO1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NQO1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:AGRN) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:ANP32A) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:BAX) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:BCHE) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:BGN) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:BRCA1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CADPS2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CAPN1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CCNB1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CDK1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CDK2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:CXCR4) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:FOLH1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:HOMER1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:HRH1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:IGF2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:LDLR) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:MAOA) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:NEFH) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:NPDC1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:NRGN) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PREP) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PROS1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TAGLN) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:TGFB1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:VKORC1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:CANX) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:GCNT2) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:IDE) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:MMP1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SLC6A6) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SYVN1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:TSHZ1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:TXN) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:ATAD2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:BECN1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:DHCR24) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:FGF2) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:HTRA1) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PRKCE) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:PRKDC) |
| pmid:22020111 | a(PUBCHEM:135316034) decreases p(HGNC:SCD) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:ATP1A1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:CTSD) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:GLRX) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:GLRX) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:IL6R) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:NPTX1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PHF1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:PRKCD) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:RANBP9) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SOD1) |
| pmid:22020111 | a(PUBCHEM:135316034) increases p(HGNC:SOD1) |
| pmid:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") |
| pmid:22020111 | a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") |
| pmid:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) |
| pmid:22020111 | a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:ERK)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:p38)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") negativeCorrelation p(HGNC:DPYSL2, pmod(Ph)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases a(HBP:Astrogliosis) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases a(HBP:Microgliosis) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") |
| pmid:22020111 | p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") |
| pmid:22020111 | p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:22020111 | p(HGNC:AKR1B10) increases bp(GO:detoxification) |
| pmid:22020111 | p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) |
| pmid:22020111 | p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) |
| pmid:22020111 | p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) |
| pmid:22020111 | p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) |
| pmid:22020111 | p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) |
| pmid:22020111 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pmid:22908190 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:SQSTM1) regulates bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:SQSTM1) increases bp(GO:autophagy) |
| pmid:22020111 | p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") |
| pmid:29758300 | p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT)) |
| pmid:29758300 | p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:29758300 | p(HGNC:SQSTM1) increases p(HGNC:SYP) |
| pmid:29758300 | p(HGNC:SQSTM1) regulates bp(GO:"short-term memory") |
| pmid:22908190 | p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process") |
| pmid:18930136 | p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | p(HGNC:SQSTM1) regulates a(GO:aggresome) |
| pmid:18930136 | p(HGNC:SQSTM1) association a(GO:"Lewy body") |
| pmid:18930136 | p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle") |
| pmid:18930136 | p(HGNC:SQSTM1) association a(MESH:"Huntingtin Protein") |
| pmid:18930136 | p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?")) |
| pmid:18930136 | p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(Ub))) |
| pmid:18930136 | p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") |
| pmid:30116051 | p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:22020111 | p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pmid:27491084 | p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates") |
| pmid:24563850 | p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:24563850 | p(HGNC:HSPB8) association p(HGNC:EIF2A) |
| pmid:22020111 | complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) |
| pmid:22020111 | complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates")) |
| pmid:23746257 | p(HGNC:BAG3) increases bp(GO:macroautophagy) |
| pmid:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pmid:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) |
| pmid:25036637 | p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) |
| pmid:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) |
| pmid:25036637 | p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) |
| pmid:29626319 | p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) |
| pmid:22020111 | p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) |
| pmid:22020111 | p(HGNC:TNFSF9) increases bp(GO:"T cell activation") |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:DHFR) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:EDN1) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:ITGB3) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:MKI67) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:MMP11) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:MMP14) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:MMP2) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:PDE7A) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:PDE7B) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:PLAU) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:PTGS1) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:SCARB1) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:TUBB3) |
| pmid:22020111 | path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1) |
| pmid:22020111 | path(MESH:Atherosclerosis) decreases p(HGNC:PPARA) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:EGR1) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:PTGS2) |
| pmid:22020111 | path(MESH:Atherosclerosis) increases p(HGNC:SOAT1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1) |
| pmid:22020111 | path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") |
| pmid:25036637 | p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") |
| pmid:25036637 | p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") |
| pmid:14556719 | act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:18930136 | p(HGNC:UBA1) increases bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") |
| pmid:29626319 | p(HGNC:UBA1) increases deg(a(MESH:Proteins)) |
| pmid:25673844 | p(HGNC:VRK1) isA p(HBP:"CK1 superfamily") |
| pmid:22020111 | p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") |
| pmid:22020111 | p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") |
| pmid:22020111 | p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) |
| pmid:24653673 | p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) |
| pmid:24653673 | p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:ANP32A) decreases act(p(FPLX:PPP2)) |
| pmid:30116051 | p(HGNC:CAPN1) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) |
| pmid:10391244 | act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:10391244 | p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") |
| pmid:12428809 | p(HGNC:CDK2) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:22072628 | act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22072628 | p(HGNC:CDK2) increases a(HBP:"Tau epitope, AT180") |
| pmid:22072628 | act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:22072628 | act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 217)) |
| pmid:26195256 | p(HGNC:FOLH1) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNC:HTRA1) association bp(HBP:"APP processing") |
| pmid:24027553 | p(HGNC:HTRA1) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) regulates act(a(MESH:Microtubules)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils")) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates")) |
| pmid:22020111 | p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23702978 | act(p(HGNC:PRKCD), ma(kin)) increases p(HGNC:NLRC4, pmod(Ph, Ser)) |
| pmid:22020111 | p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") |
| pmid:24563850 | p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) |
| pmid:22020111 | path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) |
| pmid:22020111 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) |
| pmid:22020111 | path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) |
| pmid:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell division") |
| pmid:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell growth") |
| pmid:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell development") |
| pmid:23454242 | bp(GO:phosphorylation) increases bp(GO:"negative regulation of apoptotic process") |
| pmid:23454242 | bp(GO:phosphorylation) regulates bp(GO:"cell population proliferation") |
| pmid:23454242 | bp(GO:phosphorylation) regulates bp(GO:"apoptotic process") |
| pmid:21882945 | bp(GO:phosphorylation) regulates a(HBP:"Hsp27 oligomers") |
| pmid:25784053 | bp(GO:"cell division") association p(FPLX:"CCT_complex") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"glycolytic process") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"lipid metabolic process") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"catecholamine biosynthetic process") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell cycle") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"DNA replication") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"transcription, DNA-templated") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:translation) |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"signal transduction") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization") |
| pmid:23454242 | p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"cell motility") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"apoptotic process") |
| pmid:23454242 | p(FPLX:PPP2) regulates bp(GO:"apoptotic process") |
| pmid:23454242 | p(FPLX:PPP2) association path(MESH:"Cell Transformation, Neoplastic") |
| pmid:23454242 | p(FPLX:PPP2) association path(MESH:Neoplasms) |
| pmid:23454242 | p(FPLX:PPP2) decreases path(MESH:Neoplasms) |
| pmid:23454242 | act(p(FPLX:PPP2)) negativeCorrelation path(MESH:Neoplasms) |
| pmid:22299660 | p(FPLX:PPP2) association path(MESH:Neoplasms) |
| pmid:23454242 | p(FPLX:PPP2) decreases p(HGNC:VIM, pmod(Ph)) |
| pmid:23454242 | act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22299660 | act(p(FPLX:PPP2)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:23454242 | act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Me)) |
| pmid:23454242 | act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Ph)) |
| pmid:23454242 | p(FPLX:PPP2) decreases p(FPLX:AKT, pmod(Ph, Thr, 308)) |
| pmid:23454242 | p(FPLX:PPP2) association bp(GO:"Wnt signaling pathway") |
| pmid:23454242 | p(FPLX:PPP2) decreases p(HGNC:CTNNB1, pmod(Ph)) |
| pmid:23454242 | p(FPLX:PPP2) increases deg(p(HGNC:CTNNB1)) |
| pmid:23454242 | p(FPLX:PPP2) decreases p(HGNC:BAD, pmod(Ph)) |
| pmid:23454242 | p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(Ph)) |
| pmid:12428809 | p(FPLX:PPP2) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22299660 | p(FPLX:PPP2) association a(MESH:Cytosol) |
| pmid:22299660 | p(FPLX:PPP2) association a(MESH:"Cell Nucleus") |
| pmid:22299660 | p(FPLX:PPP2) association a(MESH:Mitochondria) |
| pmid:22299660 | p(FPLX:PPP2) association a(MESH:Cytoskeleton) |
| pmid:22299660 | p(FPLX:PPP2) association a(MESH:"Cell Membrane") |
| pmid:22299660 | p(FPLX:PPP2) association path(MESH:"Frontotemporal Dementia") |
| pmid:22299660 | act(p(FPLX:PPP2)) negativeCorrelation a(HBP:"paired helical filaments") |
| pmid:22299660 | act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:22299660 | act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 42)) |
| pmid:22299660 | act(p(FPLX:PPP2)) decreases act(p(HGNC:CDK5)) |
| pmid:22299660 | act(p(FPLX:PPP2)) decreases act(p(HGNC:TPK1)) |
| pmid:22299660 | act(p(FPLX:PPP2)) decreases act(p(HGNC:GSK3B)) |
| pmid:22299660 | act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:23943618 | act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) |
| pmid:27068745 | act(p(FPLX:PPP2), ma(kin)) positiveCorrelation p(HGNC:UNC5B) |
| pmid:27068745 | act(p(FPLX:PPP2), ma(kin)) increases act(p(HGNC:DAPK1)) |
| pmid:23454242 | path(MESH:"Cell Transformation, Neoplastic") association p(FPLX:PPP2) |
| pmid:22299660 | p(FPLX:PPP2C) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23454242 | p(HGNC:PPP2CA) association a(MESH:"Cell Membrane") |
| pmid:19277525 | p(HGNC:PPP2CA) increases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pmid:19277525 | p(HGNC:PPP2CA) increases complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?")) |
| pmid:24653673 | p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29062069 | act(p(HGNC:PPP2CA)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:29626319 | p(HGNC:PPP2CA) increases bp(GO:autophagy) |
| pmid:10464280 | p(HGNC:PPP2CA) association complex(GO:microtubule) |
| pmid:10464280 | p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) |
| pmid:29228318 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:19401603 | act(p(HGNC:PPP2CA)) positiveCorrelation act(p(HGNC:PIN1)) |
| pmid:19401603 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:19401603 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:23454242 | p(HGNC:PPP2CB) association a(MESH:Cytosol) |
| pmid:23454242 | p(HGNC:PPP2CB) association a(MESH:"Cell Nucleus") |
| pmid:24653673 | p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?")) |
| pmid:24653673 | p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23454242 | a(MESH:"Cell Membrane") association p(HGNC:PPP2CA) |
| pmid:22299660 | a(MESH:"Cell Membrane") association p(FPLX:PPP2) |
| pmid:21339331 | a(MESH:"Cell Membrane") association p(HGNC:ANXA2) |
| pmid:21339331 | a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2CB) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R2A) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R2B) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5A) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5B) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5E) |
| pmid:23454242 | a(MESH:Cytosol) association p(HGNC:PPP2R5D) |
| pmid:22299660 | a(MESH:Cytosol) association p(FPLX:PPP2) |
| pmid:23454242 | a(MESH:"Cell Nucleus") association p(HGNC:PPP2CB) |
| pmid:23454242 | a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5C) |
| pmid:23454242 | a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5D) |
| pmid:22299660 | a(MESH:"Cell Nucleus") association p(FPLX:PPP2) |
| pmid:19277525 | p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pmid:19277525 | act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) |
| pmid:23454242 | p(HGNC:PPP2R2A) association a(MESH:Cytosol) |
| pmid:23454242 | p(HGNC:PPP2R2A) increases bp(GO:cytokinesis) |
| pmid:23454242 | p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization") |
| pmid:24653673 | p(HGNC:PPP2R2A) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2R2A) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | p(HGNC:PPP2R2A) increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) |
| pmid:24653673 | p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:PPP2R2A) association a(MESH:Brain) |
| pmid:23454242 | p(HGNC:PPP2R2B) association a(MESH:Cytosol) |
| pmid:23454242 | p(HGNC:PPP2R2B) increases bp(GO:cytokinesis) |
| pmid:23454242 | p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization") |
| pmid:23454242 | p(HGNC:PPP2R2C) association a(MESH:Cytoskeleton) |
| pmid:23454242 | p(HGNC:PPP2R2C) increases bp(GO:cytokinesis) |
| pmid:23454242 | p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization") |
| pmid:19277525 | p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pmid:19277525 | p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pmid:19277525 | p(HGNC:PPP2R3A) association p(INTERPRO:"EF-hand domain") |
| pmid:19277525 | p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pmid:19277525 | p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pmid:19277525 | p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:19277525 | p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) |
| pmid:19277525 | p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) |
| pmid:23454242 | p(HGNC:PPP2R5A) association a(MESH:Cytosol) |
| pmid:23454242 | p(HGNC:PPP2R5B) association a(MESH:Cytosol) |
| pmid:21882945 | p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23454242 | p(HGNC:PPP2R5C) association a(MESH:"Cell Nucleus") |
| pmid:23454242 | p(HGNC:PPP2R5D) association a(MESH:Cytosol) |
| pmid:23454242 | p(HGNC:PPP2R5D) association a(MESH:"Cell Nucleus") |
| pmid:24653673 | p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23454242 | p(HGNC:PPP2R5E) association a(MESH:Cytosol) |
| pmid:28720530 | p(HGNC:PPP2R5E) partOf complex(GO:"protein phosphatase type 2A complex") |
| pmid:23454242 | a(MESH:Cytoskeleton) association p(HGNC:PPP2R2C) |
| pmid:22299660 | a(MESH:Cytoskeleton) association p(FPLX:PPP2) |
| pmid:23454242 | composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A)) |
| pmid:24027553 | composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:23454242 | complex(p(FPLX:PPP2), p(HGNC:SGO1)) decreases p(FPLX:Cohesin, pmod(Ph)) |
| pmid:23454242 | p(FPLX:Cohesin, pmod(Ph)) increases bp(GO:"spindle disassembly") |
| pmid:23454242 | p(HGNC:SET) decreases act(p(FPLX:PPP2)) |
| pmid:22299660 | p(HGNC:SET) decreases act(p(FPLX:PPP2)) |
| pmid:24653673 | p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) |
| pmid:24653673 | p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) |
| pmid:24653673 | p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23454242 | a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) |
| pmid:23454242 | a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2C)) |
| pmid:19277525 | a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:19277525 | a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) |
| pmid:19277525 | a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1)) |
| pmid:24653673 | a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) |
| pmid:24653673 | a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) |
| pmid:24653673 | a(CHEBI:"okadaic acid") decreases bp(GO:cognition) |
| pmid:24653673 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | a(CHEBI:"okadaic acid") increases bp(HBP:amyloidogenesis) |
| pmid:24653673 | a(CHEBI:"okadaic acid") decreases a(GO:synapse) |
| pmid:24653673 | a(CHEBI:"okadaic acid") increases path(HBP:Neurodegeneration) |
| pmid:22299660 | a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:16464864 | a(CHEBI:"okadaic acid") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22299660 | a(CHEBI:"okadaic acid") decreases bp(GO:learning) |
| pmid:22299660 | a(CHEBI:"okadaic acid") decreases bp(GO:memory) |
| pmid:16464864 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:23454242 | a(PUBCHEM:5311365) decreases act(p(FPLX:PPP2)) |
| pmid:24653673 | a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) |
| pmid:24653673 | a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) |
| pmid:23454242 | a(CHEBI:microcystin) decreases act(p(FPLX:PPP2)) |
| pmid:23454242 | a(CHEBI:cantharidin) decreases act(p(FPLX:PPP2)) |
| pmid:23454242 | a(PUBCHEM:4162) decreases act(p(FPLX:PPP2)) |
| pmid:23454242 | a(PUBCHEM:6913994) decreases act(p(FPLX:PPP2)) |
| pmid:24653673 | a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) |
| pmid:24653673 | a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) |
| pmid:23454242 | a(CHEBI:Tautomycin) decreases act(p(FPLX:PPP2)) |
| pmid:23454242 | a(PUBCHEM:71361092) increases path(MESH:Neoplasms) |
| pmid:23454242 | a(PUBCHEM:71361092) decreases act(p(FPLX:PPP2)) |
| pmid:23454242 | p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C)) |
| pmid:23454242 | a(CHEBI:bortezomib) decreases p(HGNC:CIP2A) |
| pmid:23454242 | a(CHEBI:bortezomib) increases act(p(FPLX:PPP2C)) |
| pmid:23454242 | p(FPLX:PPP2, pmod(Me)) association act(p(FPLX:PPP2)) |
| pmid:19277525 | p(FPLX:PPP2, pmod(Me)) regulates bp(GO:"cell cycle") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) association bp(GO:"one-carbon metabolic process") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) negativeCorrelation a(CHEBI:homocysteine) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:APP, pmod(Ph)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) regulates bp(HBP:"APP processing") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) regulates bp(MESH:"Neuronal Outgrowth") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me)) regulates p(HGNC:MAPT) |
| pmid:23454242 | p(FPLX:PPP2, pmod(Ph)) association act(p(FPLX:PPP2)) |
| pmid:23454242 | p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(p(FPLX:PPP2)) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Ph, Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:23454242 | p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me, Leu, 309)) |
| pmid:19277525 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:23943618 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:29281045 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1)) |
| pmid:19277525 | p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) |
| pmid:24653673 | p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains")) |
| pmid:24653673 | p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me)) |
| pmid:23454242 | p(FPLX:PPP2, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) |
| pmid:23454242 | p(FPLX:AKT, pmod(Ph, Thr, 308)) increases act(p(FPLX:AKT)) |
| pmid:23454242 | p(HGNC:CTNNB1, pmod(Ph)) increases bp(GO:"Wnt signaling pathway") |
| pmid:23454242 | p(HGNC:BAD, pmod(Ph)) decreases bp(GO:"apoptotic process") |
| pmid:23454242 | p(HGNC:BCL2, pmod(Ph)) decreases bp(GO:"apoptotic process") |
| pmid:23528736 | p(HGNC:BCL2, pmod(Ph)) increases bp(GO:autophagy) |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle") |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation") |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death") |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton)) |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility") |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction") |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA) |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation") |
| pmid:19277525 | complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:19277525 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) |
| pmid:24653673 | complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B)) |
| pmid:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5)) |
| pmid:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate")) |
| pmid:24653673 | complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?")) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(Ph, Tyr, 307)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death") |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK)) |
| pmid:24653673 | act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK)) |
| pmid:10464280 | act(complex(GO:"protein phosphatase type 2A complex")) association p(HBP:"microtubule-binding region") |
| pmid:10464280 | act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pmid:28720530 | complex(GO:"protein phosphatase type 2A complex") negativeCorrelation p(HBP:"APOE e4") |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat") |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:24653673 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pmid:24653673 | p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome)) |
| pmid:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19277525 | p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pmid:19277525 | p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pmid:19277525 | p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pmid:19277525 | p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(HGNC:PPP2CA)) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) |
| pmid:23943618 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Me)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:29228318 | p(HGNC:PPP2CA, pmod(Me)) increases act(p(HGNC:PPP2CA)) |
| pmid:24653673 | complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:19277525 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:24653673 | act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1)) |
| pmid:19277525 | p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) |
| pmid:19277525 | p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) |
| pmid:19277525 | p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) |
| pmid:24653673 | p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) |
| pmid:22299660 | p(HGNC:PPME1) decreases p(FPLX:PPP2C, pmod(Me)) |
| pmid:19277525 | p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) |
| pmid:19277525 | p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") |
| pmid:19277525 | p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) |
| pmid:19277525 | p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pmid:19277525 | p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) |
| pmid:19277525 | a(CHEBI:"microcystin-LR") decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:19277525 | a(CHEBI:"microcystin-LR") decreases act(p(HGNC:PPME1)) |
| pmid:29228318 | a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle") |
| pmid:19277525 | p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") |
| pmid:19277525 | p(INTERPRO:"EF-hand domain") association p(HGNC:PPP2R3A) |
| pmid:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19277525 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) |
| pmid:19277525 | complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) |
| pmid:19277525 | complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:19277525 | composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) |
| pmid:24653673 | a(CHEBI:"S-adenosyl-L-methionine") increases act(p(HGNC:LCMT1)) |
| pmid:24653673 | a(CHEBI:"S-adenosyl-L-homocysteine") decreases act(p(HGNC:LCMT1)) |
| pmid:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Me)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(Ub)) increases deg(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2CA, pmod(HBP:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2R5A, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2R5D, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) |
| pmid:24653673 | p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) |
| pmid:24653673 | p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:29758300 | a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:21882945 | a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:24653673 | complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) |
| pmid:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) |
| pmid:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:24653673 | path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) |
| pmid:29758300 | path(MESH:Tauopathies) association p(HGNC:MAPT) |
| pmid:29980653 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT) |
| pmid:29758300 | path(MESH:Tauopathies) association path(MESH:Dementia) |
| pmid:29758300 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1) |
| pmid:30145931 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:29024336 | path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") |
| pmid:24027553 | path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:24027553 | path(MESH:Tauopathies) association p(HGNC:NPEPPS) |
| pmid:27574109 | path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:29686391 | path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:21734277 | path(MESH:Tauopathies) association p(HBP:"AT8 tau", pmod(Ph)) |
| pmid:30108137 | path(MESH:Tauopathies) association act(p(MGI:Tfeb)) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Tfeb) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Tfeb) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Lamp1) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Ctsd) |
| pmid:21882945 | path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") |
| pmid:28420982 | path(MESH:Tauopathies) association bp(GO:"neuron death") |
| pmid:21882945 | path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) |
| pmid:30126037 | path(MESH:Tauopathies) association bp(GO:"cellular senescence") |
| pmid:30126037 | path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:22419736 | path(MESH:Tauopathies) association a(HBP:"amyloid-beta 42 oligomers") |
| pmid:29191965 | path(MESH:Tauopathies) association p(HGNC:WNT2) |
| pmid:29191965 | path(MESH:Tauopathies) association p(HGNC:TTBK2) |
| pmid:29191965 | path(MESH:Tauopathies) association p(HGNC:GSK3B) |
| pmid:29191965 | path(MESH:Tauopathies) association p(HGNC:TAOK1) |
| pmid:29191965 | path(MESH:Tauopathies) association p(HGNC:CTSE) |
| pmid:29191965 | path(MESH:Tauopathies) association p(HGNC:CHRNA7) |
| pmid:28420982 | path(MESH:Tauopathies) association a(HBP:"Tau annular protofibrils") |
| pmid:26631930 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:26631930 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:26631930 | path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:26631930 | path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) |
| pmid:29980653 | path(MESH:Tauopathies) isA path(MESH:"Neurodegenerative Diseases") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me, Tyr, 307)) association a(GO:"neurofibrillary tangle") |
| pmid:24653673 | p(FPLX:PPP2, pmod(Me, Tyr, 307)) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:24653673 | p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:24653673 | p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?")) |
| pmid:22908190 | p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) |
| pmid:24653673 | p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex") |
| pmid:24653673 | p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA)) |
| pmid:24653673 | p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB)) |
| pmid:24653673 | p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) |
| pmid:24653673 | bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B)) |
| pmid:24653673 | bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5)) |
| pmid:24653673 | bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK)) |
| pmid:30985105 | complex(a(GO:microtubule), p(HGNC:MAPT)) increases act(p(HGNC:MAPT)) |
| pmid:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation") |
| pmid:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") |
| pmid:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(HBP:"Tau aggregates") |
| pmid:26631930 | complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates") |
| pmid:24653673 | bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis) |
| pmid:24653673 | bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668)) |
| pmid:24653673 | bp(GO:"one-carbon metabolic process") increases bp(GO:cognition) |
| pmid:24653673 | bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:24653673 | a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | a(CHEBI:folates) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | a(CHEBI:folates) increases p(HGNC:APP, pmod(Ph)) |
| pmid:24653673 | path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(Ph)) |
| pmid:24653673 | a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(Me)) |
| pmid:24653673 | a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:24653673 | a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(Ph)) |
| pmid:28632203 | a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:26323690 | bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) |
| pmid:12428809 | p(HGNC:MAPK9) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12428809 | p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21311567 | act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22952452 | act(p(HGNC:MARK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21311567 | act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") |
| pmid:22952452 | p(HGNC:MARK1) negativeCorrelation p(HGNC:TRAK1) |
| pmid:22952452 | p(HGNC:MARK1) negativeCorrelation p(HGNC:RHOT1) |
| pmid:12428809 | p(HGNC:CAMK2B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27796283 | p(HGNC:CAMK2B) increases p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) |
| pmid:12428809 | p(FPLX:CK2) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12428809 | p(FPLX:PPP1) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12428809 | p(FPLX:PPP3) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12428809 | p(HBP:"4R tau") increases path(MESH:"Wallerian Degeneration") |
| pmid:12428809 | p(HBP:"4R tau") increases path(MESH:"Muscular Atrophy") |
| pmid:12428809 | p(HBP:"4R tau") increases path(HP:Neurodegeneration) |
| pmid:12428809 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:12428809 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:26631930 | p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26631930 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26631930 | p(HBP:"4R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"4R tau")) |
| pmid:23407988 | p(HBP:"4R tau") isA p(HGNC:MAPT) |
| pmid:23407988 | p(HBP:"4R tau") partOf a(HBP:pretangles) |
| pmid:23407988 | p(HBP:"4R tau") partOf complex(GO:"neurofibrillary tangle") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36") |
| pmid:23407988 | p(HBP:"4R tau") partOf complex(GO:"neuronal cell body") |
| pmid:23407988 | p(HBP:"4R tau") partOf complex(GO:dendrite) |
| pmid:23407988 | p(HBP:"4R tau") partOf a(MESH:Neuropil) |
| pmid:28775333 | p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) |
| pmid:21427723 | p(HBP:"4R tau") partOf path(HBP:"4R tauopathy") |
| pmid:27574109 | p(HBP:"4R tau") positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:12428809 | a(MESH:"Intermediate Filaments") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:12428809 | a(MESH:"Intermediate Filaments") negativeCorrelation a(MESH:Axons) |
| pmid:12428809 | a(MESH:Axons) negativeCorrelation a(MESH:"Intermediate Filaments") |
| pmid:27671637 | a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:12428809 | p(HBP:"3R tau") increases a(HBP:"straight filaments") |
| pmid:26751493 | p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:26631930 | p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:26631930 | p(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HBP:"3R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"3R tau")) |
| pmid:23407988 | p(HBP:"3R tau") isA p(HGNC:MAPT) |
| pmid:23407988 | p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"ghost tangles") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf complex(GO:dendrite) |
| pmid:23407988 | p(HBP:"3R tau") partOf a(MESH:Neuropil) |
| pmid:23407988 | p(HBP:"3R tau") partOf complex(GO:"neuronal cell body") |
| pmid:26655600 | p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") |
| pmid:28775333 | p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:28775333 | p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") |
| pmid:12428809 | a(HBP:"straight filaments") association path(MESH:"Alzheimer Disease") |
| pmid:29238289 | a(MESH:Microtubules) association p(HGNC:MAPT) |
| pmid:25374103 | bp(GO:"anterograde axonal transport") decreases a(MESH:Mitochondria) |
| pmid:25374103 | bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2)) |
| pmid:12428809 | p(HGNC:APPL) increases bp(GO:"anterograde axonal transport") |
| pmid:22299660 | a(MESH:Mitochondria) association p(FPLX:PPP2) |
| pmid:30126037 | act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") |
| pmid:22299660 | a(HBP:"paired helical filaments") negativeCorrelation act(p(FPLX:PPP2)) |
| pmid:14556719 | a(HBP:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) |
| pmid:22908190 | a(HBP:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:22908190 | a(HBP:"paired helical filaments") association a(GO:"neurofibrillary tangle") |
| pmid:22908190 | a(HBP:"paired helical filaments") association a(HBP:"dystrophic neurite") |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HGNC:MAPT) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HGNC:MAPT) |
| pmid:22908190 | a(HBP:"paired helical filaments") association a(MESH:Ubiquitin) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) |
| pmid:22908190 | a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) |
| pmid:26631930 | a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26631930 | a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:7667312 | a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S") |
| pmid:7667312 | a(HBP:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") |
| pmid:8391280 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254)) |
| pmid:8391280 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257)) |
| pmid:8391280 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311)) |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) isA p(RGD:Mapt, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA) |
| pmid:25331948 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:19459590 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29191965 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau aggregates") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau antibody, TNT1") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases p(HGNC:MAPT, frag("?")) |
| pmid:26671985 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:26671985 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction") |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA) |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(GO:"neurofibrillary tangle") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(MESH:"Neuropil Threads") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf path(MESH:"Plaque, Amyloid") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau epitope, AP422") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:23294633 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport") |
| pmid:22299660 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) increases bp(GO:autophagy) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) |
| pmid:25374103 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:CDC37) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MARK4, pmod(Ph)) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"granulovacuolar degeneration") |
| pmid:22692785 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(GO:"neurofibrillary tangle") |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(HBP:"Tau epitope, 12E8") |
| pmid:23948915 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:22952452 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:Neurodegeneration) |
| pmid:22299660 | p(FPLX:PPP2C, pmod(Me)) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) |
| pmid:22299660 | p(HGNC:ICMT) increases p(FPLX:PPP2C, pmod(Me)) |
| pmid:22299660 | p(HGNC:ICMT) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) decreases act(p(FPLX:PPP2)) |
| pmid:22299660 | p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(FPLX:PPP2C, pmod(Me, Leu, 309)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22299660 | p(FPLX:PPP2C, pmod(Me, Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) |
| pmid:22299660 | p(FPLX:PPP2C, pmod(Ph)) association a(MESH:"Neurofibrillary Tangles") |
| pmid:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:28083634 | p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) |
| pmid:28083634 | p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) |
| pmid:28083634 | p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:OTUB1) negativeCorrelation a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:OTUB1) regulates p(HGNC:MAPT) |
| pmid:28083634 | p(HGNC:OTUB1) increases p(HGNC:MAPT) |
| pmid:28083634 | p(HGNC:OTUB1) decreases deg(p(HGNC:MAPT)) |
| pmid:28083634 | p(HGNC:OTUB1) regulates deg(p(HGNC:MAPT)) |
| pmid:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(HGNC:OTUB1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(HGNC:OTUB1) increases a(HBP:"Tau oligomers") |
| pmid:28083634 | p(HGNC:OTUB1) increases a(HBP:"Tau oligomers") |
| pmid:28083634 | p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(UbK48)) |
| pmid:28083634 | p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(UbK63)) |
| pmid:22908190 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ub)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:UBE2D2) |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) |
| pmid:25378699 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation deg(p(HGNC:MAPT)) |
| pmid:24905733 | p(HGNC:MAPT, pmod(Ub)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:28083634 | complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28083634 | complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:USP5) decreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:28083634 | p(HGNC:USP5) increases complex(p(HGNC:MAPT), p(HGNC:USP5)) |
| pmid:28083634 | p(HGNC:USP5) causesNoChange a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:USP9X) decreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:28083634 | p(HGNC:USP9X) increases complex(p(HGNC:MAPT), p(HGNC:USP9X)) |
| pmid:28083634 | p(HGNC:USP9X) causesNoChange a(HBP:"Tau aggregates") |
| pmid:28083634 | p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(UbK48)) |
| pmid:28083634 | p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT)) |
| pmid:28083634 | p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(HGNC:OTUB1, frag("?")) decreases p(HGNC:MAPT, pmod(UbK48)) |
| pmid:28083634 | p(HGNC:OTUB1, frag("?")) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(MGI:Otub1) increases p(MGI:Mapt) |
| pmid:28083634 | p(MGI:Otub1) increases a(HBP:"Tau oligomers") |
| pmid:28083634 | p(MGI:Otub1) increases a(HBP:"Tau oligomers") |
| pmid:28083634 | p(MGI:Otub1) increases a(HBP:"Tau oligomers") |
| pmid:28083634 | p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:28083634 | p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(HBP:"Tau oligomers") |
| pmid:28083634 | p(MGI:Otub1, frag("?")) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:25437566 | act(p(FPLX:HSP90)) association a(CHEBI:ATP) |
| pmid:25437566 | p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(FPLX:HSP90) increases bp(GO:"protein folding") |
| pmid:23746257 | act(p(FPLX:HSP90)) increases bp(GO:"protein folding") |
| pmid:25784053 | p(FPLX:HSP90) regulates bp(GO:"protein folding") |
| pmid:27491084 | p(FPLX:HSP90) association bp(HBP:Proteostasis) |
| pmid:29311797 | p(FPLX:HSP90) association bp(HBP:Proteostasis) |
| pmid:23746257 | act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding") |
| pmid:23746257 | act(p(FPLX:HSP90)) association bp(GO:"protein refolding") |
| pmid:23746257 | p(FPLX:HSP90) association bp(GO:"cell cycle") |
| pmid:23746257 | p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway") |
| pmid:23746257 | p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling") |
| pmid:23746257 | p(FPLX:HSP90) association bp(GO:"protein transport") |
| pmid:23746257 | p(FPLX:HSP90) association bp(GO:"protein secretion") |
| pmid:23746257 | p(FPLX:HSP90) association bp(GO:"immune response") |
| pmid:23746257 | p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") |
| pmid:25784053 | p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(FPLX:HSP90) regulates bp(MESH:Proteolysis) |
| pmid:25784053 | act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) |
| pmid:24563850 | p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") |
| pmid:21882945 | act(p(FPLX:HSP90)) association a(CHEBI:celastrol) |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:autophagy) |
| pmid:21882945 | p(FPLX:HSP90) increases act(p(HGNC:STUB1)) |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:"protein catabolic process") |
| pmid:21882945 | p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:19363271 | p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) |
| pmid:21882945 | p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) |
| pmid:29311797 | p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) |
| pmid:25374103 | p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:29311797 | p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25374103 | p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) |
| pmid:29311797 | p(FPLX:HSP90) regulates a(HBP:"Tau aggregates") |
| pmid:29311797 | p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) |
| pmid:29311797 | p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") |
| pmid:29311797 | act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) |
| pmid:19363271 | p(FPLX:HSP90) association p(HBP:"VQIVYK motif") |
| pmid:19363271 | p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pmid:19363271 | p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:20133804 | p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386")) |
| pmid:21367866 | act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37) |
| pmid:21367866 | act(p(FPLX:HSP90)) negativeCorrelation deg(p(HGNC:MAPT)) |
| pmid:25437566 | act(p(FPLX:HSPA)) association a(CHEBI:ATP) |
| pmid:27491084 | p(FPLX:HSPA) association bp(HBP:Proteostasis) |
| pmid:27491084 | p(FPLX:HSPA) decreases p(HBP:"huntingtin aggregates") |
| pmid:27491084 | p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:24563850 | p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:27491084 | p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") |
| pmid:23746257 | act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") |
| pmid:23746257 | act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") |
| pmid:24563850 | p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") |
| pmid:27491084 | p(FPLX:HSPA) decreases bp(HBP:misfolding) |
| pmid:24563850 | p(FPLX:HSPA) decreases bp(HBP:misfolding) |
| pmid:27491084 | p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") |
| pmid:27491084 | p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") |
| pmid:27491084 | p(FPLX:HSPA) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(FPLX:HSPA) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:23746257 | p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) |
| pmid:14556719 | p(FPLX:HSPA) decreases a(HBP:"protein aggregates") |
| pmid:14556719 | p(FPLX:HSPA) decreases bp(GO:"cell death") |
| pmid:23746257 | act(p(FPLX:HSPA)) association bp(GO:"protein refolding") |
| pmid:23746257 | act(p(FPLX:HSPA)) association bp(GO:"protein refolding") |
| pmid:23746257 | act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport") |
| pmid:23746257 | act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process") |
| pmid:23746257 | p(FPLX:HSPA) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(FPLX:HSPA) regulates bp(GO:"protein folding") |
| pmid:24563850 | p(FPLX:HSPA) increases bp(GO:"protein folding") |
| pmid:25784053 | p(FPLX:HSPA) regulates bp(MESH:Proteolysis) |
| pmid:25784053 | p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:29626319 | p(FPLX:HSPA) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:25437566 | act(p(HGNC:HSPD1)) association a(CHEBI:ATP) |
| pmid:27491084 | p(HGNC:HSPD1) association bp(HBP:Proteostasis) |
| pmid:25784053 | p(HGNC:HSPD1) increases bp(HBP:Proteostasis) |
| pmid:23746257 | p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates") |
| pmid:25784053 | p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") |
| pmid:27491084 | p(HGNC:TPR) association bp(HBP:Proteostasis) |
| pmid:27491084 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(HBP:Proteostasis) |
| pmid:27491084 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity")) |
| pmid:23746257 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA)) |
| pmid:23746257 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"huntingtin aggregates") |
| pmid:23746257 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:25784053 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") |
| pmid:27491084 | p(FPLX:HSPB) association bp(HBP:Proteostasis) |
| pmid:27491084 | p(FPLX:HSPB) association bp(HBP:misfolding) |
| pmid:23746257 | act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates") |
| pmid:25784053 | p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") |
| pmid:25437566 | p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(HGNC:HSPA8) increases bp(GO:"protein folding") |
| pmid:25437566 | p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates") |
| pmid:29758300 | p(HGNC:HSPA8) increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | act(p(HGNC:HSPA8)) increases deg(p(HGNC:MAPT)) |
| pmid:18930136 | p(HGNC:HSPA8) association bp(GO:"chaperone-mediated autophagy") |
| pmid:18930136 | p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) |
| pmid:24706768 | p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") |
| pmid:24706768 | p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") |
| pmid:24706768 | p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly") |
| pmid:21882945 | p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:18500754 | p(HGNC:HSPA8) association p(HBP:"microtubule-binding region") |
| pmid:18500754 | act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) |
| pmid:25437566 | p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates") |
| pmid:23746257 | p(FPLX:"CCT_complex") decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") |
| pmid:25784053 | p(FPLX:"CCT_complex") association bp(GO:"cell division") |
| pmid:25784053 | p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") |
| pmid:25784053 | p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) |
| pmid:25437566 | p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(HGNC:DNAJA1) increases bp(GO:"protein folding") |
| pmid:25437566 | p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:23746257 | p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:25036637 | p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:29311797 | p(HGNC:STIP1) decreases p(HGNC:MAPT) |
| pmid:29311797 | p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") |
| pmid:25784053 | bp(GO:"protein folding") association bp(HBP:Proteostasis) |
| pmid:29311797 | bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") |
| pmid:25437566 | p(HGNC:TTC1) increases bp(GO:"protein folding") |
| pmid:25437566 | p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates") |
| pmid:25036637 | p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"embryo development") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"cell maturation") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"signal transduction") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") |
| pmid:27491084 | a(MESH:"Molecular Chaperones") decreases path(HBP:proteotoxicity) |
| pmid:23746257 | a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates") |
| pmid:25784053 | a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:21882945 | a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:29311797 | a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") |
| pmid:29311797 | a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) |
| pmid:29311797 | a(MESH:"Molecular Chaperones") association deg(p(MESH:Proteins, pmod(HBP:misfolded))) |
| pmid:27491084 | bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:27491084 | bp(HBP:Proteostasis) association p(HGNC:HSPD1) |
| pmid:27491084 | bp(HBP:Proteostasis) association p(FPLX:HSPA) |
| pmid:27491084 | bp(HBP:Proteostasis) association p(HGNC:TPR) |
| pmid:27491084 | bp(HBP:Proteostasis) association p(FPLX:HSPB) |
| pmid:27491084 | bp(HBP:Proteostasis) association p(FPLX:HSP90) |
| pmid:29311797 | bp(HBP:Proteostasis) association p(FPLX:HSP90) |
| pmid:27491084 | bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases") |
| pmid:23746257 | bp(HBP:Proteostasis) association bp(GO:"inflammatory response") |
| pmid:23746257 | bp(HBP:Proteostasis) association bp(GO:"response to oxidative stress") |
| pmid:23746257 | bp(HBP:Proteostasis) association bp(GO:"behavioral response to starvation") |
| pmid:23746257 | bp(HBP:Proteostasis) negativeCorrelation bp(GO:"cell death") |
| pmid:25784053 | bp(HBP:Proteostasis) association bp(MESH:"Protein Biosynthesis") |
| pmid:25784053 | bp(HBP:Proteostasis) association bp(GO:"protein folding") |
| pmid:25784053 | bp(HBP:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | bp(HBP:Proteostasis) association bp(MESH:Proteolysis) |
| pmid:25784053 | bp(HBP:Proteostasis) decreases bp(MESH:Aging) |
| pmid:21882945 | bp(HBP:Proteostasis) regulates p(HGNC:MAPT) |
| pmid:21882945 | bp(HBP:Proteostasis) regulates a(MESH:Proteins) |
| pmid:27491084 | p(HGNCGENEFAMILY:"AAA ATPases") association bp(HBP:Proteostasis) |
| pmid:27491084 | p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) |
| pmid:27491084 | p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) |
| pmid:27491084 | p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration) |
| pmid:23528736 | p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") |
| pmid:14556719 | p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) |
| pmid:27491084 | p(HGNC:AR, var("?")) association path(HP:Neurodegeneration) |
| pmid:30640040 | p(HGNC:AR) association a(PUBCHEM:5833) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") association bp(HBP:Proteostasis) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) |
| pmid:24706768 | path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8)) |
| pmid:24706768 | path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") |
| pmid:27491084 | p(HGNC:STUB1) decreases path(HP:Neurodegeneration) |
| pmid:22908190 | p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) |
| pmid:25036637 | p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(HGNC:STUB1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pmid:25036637 | p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") |
| pmid:24027553 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48)) |
| pmid:26631930 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48)) |
| pmid:24027553 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK63)) |
| pmid:23528736 | p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") |
| pmid:23528736 | p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") |
| pmid:21882945 | act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") |
| pmid:21882945 | act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") |
| pmid:25374103 | p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:25374103 | p(HGNC:STUB1) regulates act(p(HGNC:CASP3)) |
| pmid:25374103 | p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) |
| pmid:25374103 | p(HGNC:STUB1) decreases p(HBP:"Tau C3") |
| pmid:25374103 | p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) |
| pmid:25374103 | p(HGNC:STUB1) causesNoChange bp(GO:"cell death") |
| pmid:25374103 | p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(Ub)), p(HGNC:STUB1)) |
| pmid:25374103 | p(HGNC:STUB1) increases deg(p(HBP:"4R tau", var("p.Lys280del"))) |
| pmid:25374103 | p(HGNC:STUB1) decreases act(p(FPLX:Caspase)) |
| pmid:25374103 | p(HGNC:STUB1) increases deg(p(FPLX:Caspase)) |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Huntington Disease") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Parkinson Disease") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:Neoplasms) |
| pmid:14612456 | p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pmid:17954934 | p(HGNC:STUB1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:25031639 | act(p(HGNC:STUB1)) negativeCorrelation a(HBP:"Tau epitope, 12E8") |
| pmid:25031639 | act(p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) |
| pmid:27325702 | p(HGNC:STUB1) association p(HBP:"APP, ACR") |
| pmid:27325702 | p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") |
| pmid:27491084 | p(UNIPROT:P15705) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(UNIPROT:P32589) regulates act(p(FPLX:HSPA)) |
| pmid:27491084 | p(UNIPROT:P32589) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:27491084 | p(HGNC:HSPB7) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates") |
| pmid:27491084 | p(UNIPROT:Q9XXG5) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates") |
| pmid:27491084 | p(UNIPROT:P12612) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates") |
| pmid:27491084 | p(UNIPROT:P02829) decreases path(HBP:proteotoxicity) |
| pmid:27491084 | p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates") |
| pmid:23746257 | bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins)) |
| pmid:23746257 | bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) |
| pmid:23746257 | bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) |
| pmid:23746257 | bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90)) |
| pmid:27491084 | bp(HBP:misfolding) association p(FPLX:HSPB) |
| pmid:24563850 | bp(HBP:misfolding) increases path(MESH:"Protein Aggregation, Pathological") |
| pmid:27491084 | p(HGNC:HSPB1) association a(HBP:"amyloid-beta aggregates") |
| pmid:21882945 | p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:21882945 | p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | p(HGNC:HSPB1) increases bp(GO:autophagy) |
| pmid:21882945 | p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:21882945 | p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) |
| pmid:21882945 | p(HGNC:HSPB1) increases p(HGNC:MAPT) |
| pmid:21882945 | p(HGNC:HSPB1) decreases p(HGNC:MAPT) |
| pmid:14963027 | p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT) |
| pmid:21882945 | p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) |
| pmid:21882945 | p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:14963027 | p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:14963027 | p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") |
| pmid:27491084 | p(HGNC:CRYAB) association a(HBP:"amyloid-beta aggregates") |
| pmid:27491084 | p(HGNC:HSPB6) association a(HBP:"amyloid-beta aggregates") |
| pmid:27491084 | p(HGNC:HSF1) increases bp(HBP:Proteostasis) |
| pmid:21882945 | p(HGNC:HSF1) increases bp(HBP:Proteostasis) |
| pmid:23746257 | p(HGNC:HSF1) regulates bp(GO:"cellular response to stress") |
| pmid:23746257 | p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones") |
| pmid:25784053 | act(p(HGNC:HSF1), ma(tscript)) increases a(MESH:"Molecular Chaperones") |
| pmid:23746257 | p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates") |
| pmid:25784053 | act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:25784053 | act(p(HGNC:HSF1)) association path(MESH:Neoplasms) |
| pmid:24563850 | p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") |
| pmid:21882945 | p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") |
| pmid:30116051 | act(p(HGNC:HSF1), ma(tscript)) increases act(p(FPLX:HSPA)) |
| pmid:27491084 | a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A)) |
| pmid:27491084 | a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B)) |
| pmid:25784053 | p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:22817713 | p(HGNC:HSPA1A) decreases a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:HSPA1A) increases deg(a(HBP:"Tau aggregates")) |
| pmid:25784053 | p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25784053 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) |
| pmid:29758300 | bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) |
| pmid:29758300 | bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29758300 | bp(GO:macroautophagy) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29758300 | bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") |
| pmid:29758300 | bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) |
| pmid:29758300 | bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) |
| pmid:29758300 | bp(GO:macroautophagy) association p(HGNC:BECN1) |
| pmid:29758300 | bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid") |
| pmid:29758300 | bp(GO:macroautophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:29758300 | bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride)) |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:29758300 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary") |
| pmid:22908190 | bp(GO:macroautophagy) increases a(GO:autophagosome) |
| pmid:22908190 | bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) |
| pmid:18930136 | bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") |
| pmid:18930136 | bp(GO:macroautophagy) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29024336 | bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) |
| pmid:26751493 | bp(GO:macroautophagy) decreases p(HGNC:MAPT) |
| pmid:22908190 | a(HBP:"dystrophic neurite") association a(HBP:"paired helical filaments") |
| pmid:22908190 | a(HBP:"dystrophic neurite") association a(MESH:Ubiquitin) |
| pmid:22908190 | a(HBP:"dystrophic neurite") association a(GO:autophagosome) |
| pmid:22908190 | a(HBP:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:18930136 | a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:18930136 | a(GO:autolysosome) decreases path(HBP:Neurodegeneration) |
| pmid:29758300 | bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome) |
| pmid:29758300 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A)) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport") |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(Ub)) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides")) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:"amyloid-beta") |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning) |
| pmid:22908190 | bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory) |
| pmid:29758300 | p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle") |
| pmid:30116051 | p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) |
| pmid:29758300 | bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1) |
| pmid:22908190 | a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(Ub))) |
| pmid:22908190 | a(GO:lysosome) increases deg(p(HGNC:MAPT)) |
| pmid:22908190 | a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | a(GO:lysosome) increases a(GO:organelle) |
| pmid:18930136 | a(GO:lysosome) negativeCorrelation p(HGNC:CTSD) |
| pmid:18930136 | act(a(GO:lysosome)) decreases path(HBP:Neurodegeneration) |
| pmid:18930136 | act(a(GO:lysosome)) increases a(GO:autophagosome) |
| pmid:18930136 | act(a(GO:lysosome)) increases a(GO:lysosome) |
| pmid:18930136 | act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses") |
| pmid:29024336 | a(GO:lysosome) increases deg(a(HBP:HBP00053)) |
| pmid:29590627 | a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:29590627 | a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(GO:lysosome) association a(HBP:"Tau aggregates") |
| pmid:29590627 | a(GO:lysosome) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:24561250 | a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:29758300 | p(MESH:Proteins, pmod(HBP:misfolding)) decreases bp(GO:"neuron cellular homeostasis") |
| pmid:29758300 | p(MESH:Proteins, pmod(HBP:misfolding)) decreases a(MESH:Neurons) |
| pmid:14556719 | p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein") |
| pmid:24457024 | p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation") |
| pmid:18930136 | p(MESH:Proteins, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") |
| pmid:18930136 | p(MESH:Proteins, pmod(HBP:misfolding)) increases p(HGNC:SQSTM1) |
| pmid:18930136 | p(MESH:Proteins, pmod(HBP:misfolding)) increases r(HGNC:SQSTM1) |
| pmid:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) |
| pmid:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies) |
| pmid:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") |
| pmid:29758300 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HGNC:PRNP, loc(MESH:Cytoplasm)) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(HBP:"protein aggregates") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) |
| pmid:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(Ub))) |
| pmid:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity") |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") |
| pmid:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning) |
| pmid:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory) |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) |
| pmid:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC)) |
| pmid:22908190 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory") |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis") |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide))) |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling") |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy) |
| pmid:18930136 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(p(HGNC:MAPT)) |
| pmid:25374103 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association path(HP:Neurodegeneration) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HBP:"Tau oligomers", pmod(HBP:hyperphosphorylation)) |
| pmid:29758300 | bp(GO:proteolysis) decreases bp(GO:"neuron death") |
| pmid:14556719 | bp(GO:proteolysis) association p(HGNC:UBA3) |
| pmid:24027553 | bp(GO:proteolysis) increases bp(GO:autophagy) |
| pmid:24027553 | bp(GO:proteolysis) decreases a(MESH:Autophagosomes) |
| pmid:29626319 | bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29758300 | bp(GO:"chaperone-mediated autophagy") decreases a(HBP:"protein aggregates") |
| pmid:29758300 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pmid:22908190 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pmid:29758300 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA) |
| pmid:29758300 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:18930136 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:18930136 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:18930136 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:29758300 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?")) |
| pmid:22908190 | bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) |
| pmid:18930136 | bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) |
| pmid:18930136 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:HSPA8) |
| pmid:24563850 | bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, frag("?"))) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") |
| pmid:25374103 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) |
| pmid:29311797 | bp(GO:"chaperone-mediated autophagy") negativeCorrelation path(MESH:"Neurodegenerative Diseases") |
| pmid:29311797 | bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) |
| pmid:29311797 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) |
| pmid:29758300 | p(MESH:"Amyloid beta-Peptides", pmod(HBP:misfolding)) increases path(MESH:"Alzheimer Disease") |
| pmid:29758300 | act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29626319 | complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") |
| pmid:29758300 | bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | bp(GO:endocytosis) association p(HGNC:BECN1) |
| pmid:22908190 | bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome)) |
| pmid:22908190 | bp(GO:endocytosis) increases act(a(MESH:Neurons)) |
| pmid:22908190 | bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity") |
| pmid:22908190 | bp(GO:endocytosis) increases bp(GO:memory) |
| pmid:22908190 | bp(GO:endocytosis) increases bp(GO:learning) |
| pmid:22908190 | bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation p(HGNC:APP) |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation g(HBP:"APOE e4") |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol) |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins) |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid) |
| pmid:22908190 | bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse)) |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pmid:18930136 | bp(GO:endocytosis) increases a(GO:lysosome) |
| pmid:29590627 | bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:28420982 | bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) |
| pmid:29686391 | bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") |
| pmid:29758300 | p(HGNC:ATG7) increases bp(GO:macroautophagy) |
| pmid:18930136 | p(HGNC:ATG7) decreases path(HBP:Neurodegeneration) |
| pmid:29758300 | path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT) |
| pmid:22908190 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"UBB+1") |
| pmid:26751493 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") |
| pmid:26631930 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") |
| pmid:26751493 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) |
| pmid:26631930 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:29758300 | p(FPLX:MAPK) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62)) |
| pmid:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67)) |
| pmid:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) |
| pmid:29758300 | composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pmid:18930136 | p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) |
| pmid:30116051 | p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:30116051 | p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) |
| pmid:29758300 | p(HGNC:NBR1) association p(HGNC:MAPT) |
| pmid:29758300 | p(HGNC:SNCA, pmod(HBP:misfolding)) increases a(HBP:"alpha-synuclein oligomers") |
| pmid:29758300 | a(HBP:"alpha-synuclein oligomers") increases path(HBP:neuroinflammation) |
| pmid:29758300 | a(HBP:"alpha-synuclein oligomers") increases bp(GO:"cell death") |
| pmid:30985105 | a(HBP:"alpha-synuclein oligomers") negativeCorrelation a(HBP:"alpha-synuclein aggregates") |
| pmid:29758300 | complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:29758300 | complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") |
| pmid:29758300 | p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:29758300 | p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:29758300 | a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") |
| pmid:29758300 | a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") |
| pmid:29758300 | a(CHEBI:lipid) regulates bp(GO:macroautophagy) |
| pmid:29758300 | a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process") |
| pmid:29758300 | a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy) |
| pmid:22908190 | a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A)) |
| pmid:22908190 | a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis) |
| pmid:29758300 | path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"))) |
| pmid:29758300 | path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pmid:29758300 | path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) |
| pmid:18930136 | path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pmid:29238289 | path(MESH:Starvation) increases sec(p(HGNC:MAPT)) |
| pmid:24561250 | a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) |
| pmid:29758300 | rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex")) |
| pmid:29758300 | complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") |
| pmid:29758300 | complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(HBP:"Tau aggregates") |
| pmid:29758300 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:23528736 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:30116051 | p(FPLX:AMPK) increases bp(GO:macroautophagy) |
| pmid:30116051 | act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) |
| pmid:30116051 | act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:AMPK) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 317)) |
| pmid:30116051 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 777)) |
| pmid:30116051 | p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(Ph)) |
| pmid:30116051 | p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") |
| pmid:30116051 | act(p(FPLX:AMPK)) increases bp(GO:autophagy) |
| pmid:23528736 | p(FPLX:AMPK) increases bp(GO:autophagy) |
| pmid:30116051 | act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) |
| pmid:23528736 | p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) |
| pmid:22419736 | act(p(FPLX:AMPK)) association p(MESH:"Acetyl-CoA Carboxylase") |
| pmid:22419736 | act(p(FPLX:AMPK)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | p(FPLX:AMPK) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | p(FPLX:AMPK) negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:29758300 | composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR)) |
| pmid:29758300 | p(HGNC:TFEB) regulates a(GO:lysosome) |
| pmid:29626319 | p(HGNC:TFEB) increases act(a(GO:lysosome)) |
| pmid:29626319 | p(HGNC:TFEB) increases act(a(GO:lysosome)) |
| pmid:29758300 | p(HGNC:TFEB) regulates bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pmid:29626319 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29626319 | p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29758300 | p(HGNC:TFEB) increases act(p(HGNC:PTEN)) |
| pmid:28803412 | p(HGNC:TFEB) decreases a(HBP:HBP00093) |
| pmid:30116051 | p(HGNC:TFEB) increases bp(GO:macroautophagy) |
| pmid:30116051 | tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pmid:29626319 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pmid:30108137 | act(p(HGNC:TFEB, loc(GO:nucleus))) decreases act(a(MESH:Lysosomes)) |
| pmid:30108137 | act(p(HGNC:TFEB, loc(GO:nucleus))) increases a(HBP:"protein aggregates") |
| pmid:29626319 | p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) |
| pmid:29758300 | p(HGNC:TFEB, pmod(Ph)) decreases act(p(HGNC:TFEB)) |
| pmid:29758300 | complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy) |
| pmid:29758300 | complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome) |
| pmid:29758300 | bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) |
| pmid:29758300 | bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) |
| pmid:18930136 | bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1) |
| pmid:18930136 | bp(GO:"cellular response to stress") increases r(HGNC:SQSTM1) |
| pmid:21882945 | bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") |
| pmid:21882945 | bp(GO:"cellular response to stress") increases a(HBP:"Hsp27 oligomers") |
| pmid:29758300 | p(HGNC:PTEN) increases bp(GO:macroautophagy) |
| pmid:29758300 | composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy) |
| pmid:29758300 | p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:PICALM) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29758300 | p(HGNC:PICALM) increases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:PICALM) decreases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid") |
| pmid:29758300 | p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis") |
| pmid:29758300 | p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pmid:29758300 | p(HGNC:PICALM) regulates bp(GO:macroautophagy) |
| pmid:29758300 | p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) |
| pmid:29626319 | p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27260836 | p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27260836 | p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:27260836 | p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:27260836 | p(HGNC:PICALM) partOf a(HBP:"granulovacuolar degeneration") |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"Pick body") |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"Cajal body") |
| pmid:27260836 | p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) |
| pmid:27260836 | p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) |
| pmid:29758300 | tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(HBP:"Tau aggregates")) |
| pmid:29758300 | p(HGNC:BIN1) increases bp(GO:endocytosis) |
| pmid:29758300 | p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process") |
| pmid:29758300 | p(HGNC:BIN1) increases bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:BIN1) decreases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies) |
| pmid:29758300 | p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT) |
| pmid:29758300 | p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:29758300 | p(HGNC:TREM2) increases bp(GO:macroautophagy) |
| pmid:29758300 | p(HGNC:TREM2) increases bp(GO:"metabolic process") |
| pmid:29758300 | p(HGNC:TREM2) increases bp(GO:"metabolic process") |
| pmid:29758300 | p(HGNC:TREM2) increases act(complex(GO:"TOR complex")) |
| pmid:29626319 | p(HGNC:TREM2) association bp(GO:phagocytosis) |
| pmid:29626319 | act(p(HGNC:TREM2)) increases bp(GO:phagocytosis) |
| pmid:29626319 | act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:29758300 | p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:TREM2, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) |
| pmid:29758300 | p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) |
| pmid:29758300 | p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy) |
| pmid:29758300 | p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion)) |
| pmid:29758300 | p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:29758300 | p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:29758300 | a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") |
| pmid:27671637 | a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP) |
| pmid:23528736 | act(a(GO:mitochondrion)) increases a(CHEBI:"reactive oxygen species") |
| pmid:25987199 | act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) |
| pmid:22952452 | act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:TRAK1) |
| pmid:22952452 | act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:RHOT1) |
| pmid:18930136 | bp(GO:mitophagy) isA bp(GO:macroautophagy) |
| pmid:30116051 | bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:29758300 | p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy) |
| pmid:29758300 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) |
| pmid:29758300 | p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome)) |
| pmid:29758300 | p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:29758300 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29758300 | p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:HBP00045) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044) |
| pmid:29024336 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29191965 | p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:"Tau oligomers") |
| pmid:29758300 | composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death") |
| pmid:27594586 | composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") |
| pmid:29758300 | path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy) |
| pmid:14556719 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:18930136 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy) |
| pmid:29758300 | path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy) |
| pmid:29758300 | a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29626319 | a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases a(HBP:"huntingtin aggregates") |
| pmid:30116051 | a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) |
| pmid:29626319 | a(CHEBI:Temsirolimus) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:Temsirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:29758300 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) |
| pmid:18930136 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:30145931 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:18930136 | a(CHEBI:"alpha,alpha-trehalose") decreases path(HBP:Neurodegeneration) |
| pmid:30145931 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) |
| pmid:30145931 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) |
| pmid:30145931 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") |
| pmid:23528736 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"huntingtin aggregates") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"amyloid-beta aggregates") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) |
| pmid:23528736 | a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) |
| pmid:18930136 | p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) |
| pmid:18930136 | p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) |
| pmid:27260836 | p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) |
| pmid:29758300 | a(CHEBI:paclitaxel) increases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:paclitaxel) increases a(GO:microtubule) |
| pmid:29758300 | a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons)) |
| pmid:22941973 | a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain")) |
| pmid:22941973 | a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:29758300 | a(CHEBI:epothilone) decreases path(MESH:Tauopathies) |
| pmid:29758300 | a(CHEBI:epothilone) increases bp(GO:cognition) |
| pmid:14556719 | composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:22908190 | composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:14556719 | act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) |
| pmid:22908190 | a(MESH:Ubiquitin) association a(HBP:"paired helical filaments") |
| pmid:22908190 | a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle") |
| pmid:22908190 | a(MESH:Ubiquitin) association a(HBP:"dystrophic neurite") |
| pmid:22908190 | a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") |
| pmid:22908190 | a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") |
| pmid:22908190 | a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads") |
| pmid:22908190 | a(MESH:Ubiquitin) association a(GO:"Lewy body") |
| pmid:22908190 | a(MESH:Ubiquitin) association a(GO:"Lewy body") |
| pmid:22908190 | a(MESH:Ubiquitin) association a(GO:"Pick body") |
| pmid:22908190 | act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:22908190 | a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:signaling) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:endocytosis) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") |
| pmid:24457024 | act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) |
| pmid:14556719 | p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:14556719 | p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) |
| pmid:14556719 | act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:UBA2) increases p(HGNC:HTT, pmod(Ub)) |
| pmid:24457024 | p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(HGNC:UBA3) association bp(GO:proteolysis) |
| pmid:22908190 | p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) |
| pmid:24457024 | p(HGNC:UBA3) increases act(p(HGNC:UBA2)) |
| pmid:24457024 | p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") |
| pmid:24457024 | p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:14556719 | p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:14556719 | p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:24457024 | p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) |
| pmid:22908190 | a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A)) |
| pmid:22908190 | a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis) |
| pmid:24457024 | tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) |
| pmid:18930136 | tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins)) |
| pmid:14556719 | bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") |
| pmid:14556719 | bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") |
| pmid:14556719 | bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | bp(GO:"protein ubiquitination") regulates bp(GO:autophagy) |
| pmid:14556719 | bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) |
| pmid:22908190 | bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") |
| pmid:18930136 | bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) |
| pmid:18930136 | bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) |
| pmid:18930136 | bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) |
| pmid:14556719 | p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") |
| pmid:22908190 | p(HBP:"20 S Proteasome") increases deg(p(HGNC:MAPT)) |
| pmid:22908190 | p(HBP:"20 S Proteasome") increases complex(a(HBP:"Tau aggregates"), p(HBP:"20 S Proteasome")) |
| pmid:16816118 | act(p(HBP:"20 S Proteasome")) negativeCorrelation p(RGD:Mapt, pmod(HBP:nitration)) |
| pmid:16816118 | act(p(HBP:"20 S Proteasome")) negativeCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:14556719 | complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") |
| pmid:14556719 | p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) |
| pmid:14556719 | p(HGNC:PSMD4) association p(HGNC:PRKN) |
| pmid:24457024 | p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) |
| pmid:14556719 | p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) |
| pmid:14556719 | deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) |
| pmid:14556719 | deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) |
| pmid:14556719 | complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") |
| pmid:25036637 | bp(GO:"gene silencing") association p(HGNC:DCP1A) |
| pmid:25036637 | bp(GO:"gene silencing") association p(HGNC:EDC3) |
| pmid:25036637 | bp(GO:"gene silencing") association p(HGNC:DDX6) |
| pmid:14556719 | bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23746257 | bp(GO:"protein catabolic process") association act(p(FPLX:HSPA)) |
| pmid:14556719 | path(MESH:Cachexia) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | path(MESH:Sepsis) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | path(MESH:Acidosis) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | a(MESH:Denervation) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(Sumo)) |
| pmid:27716675 | p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23229893 | p(HGNC:SUMO1) partOf a(GO:lysosome) |
| pmid:19323834 | p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) |
| pmid:18675254 | p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) |
| pmid:18675254 | p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) |
| pmid:16464864 | p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:16464864 | p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(Sumo)) |
| pmid:14556719 | p(HGNC:NFKBIA, pmod(Sumo)) decreases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pmid:22908190 | p(MESH:Proteins, pmod(Ub)) increases deg(p(MESH:Proteins, pmod(Ub))) |
| pmid:22908190 | p(MESH:Proteins, pmod(Ub)) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) |
| pmid:14556719 | p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) |
| pmid:14556719 | a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") |
| pmid:14556719 | a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(MESH:"Lewy Bodies") association a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") |
| pmid:14556719 | a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") |
| pmid:14556719 | p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:PSMD4) |
| pmid:14556719 | p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") |
| pmid:14556719 | p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:GPR37) |
| pmid:14556719 | p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") |
| pmid:14556719 | p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) |
| pmid:14556719 | p(HGNC:PRKN) regulates p(HGNC:SNCA) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:SNCA, pmod(OGlyco)) |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) |
| pmid:14556719 | p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:CCNE1) |
| pmid:14556719 | p(HGNC:PRKN) decreases p(HGNC:CCNE1) |
| pmid:14556719 | p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") |
| pmid:14556719 | p(HGNC:PRKN) decreases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) association a(GO:"actin filament") |
| pmid:14556719 | p(HGNC:PRKN) regulates act(a(MESH:Actins)) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:SNCA, pmod(Glyco)) |
| pmid:22908190 | p(HGNC:PRKN) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:PRKN) association path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:PRKN) increases bp(GO:mitophagy) |
| pmid:22908190 | p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:23528736 | p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") |
| pmid:14556719 | p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) |
| pmid:14556719 | p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) |
| pmid:14556719 | p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) |
| pmid:28803412 | p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") |
| pmid:30116051 | p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") positiveCorrelation a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) |
| pmid:30126037 | path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:14556719 | p(HGNC:PRKN, var("p.Arg42")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) |
| pmid:14556719 | p(HGNC:PRKN, var("p.Arg42")) increases path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(Ub)) |
| pmid:29121589 | p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) |
| pmid:14556719 | p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) |
| pmid:14556719 | complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) |
| pmid:14556719 | p(HGNC:SEPT5) decreases sec(a(CHEBI:"growth hormone")) |
| pmid:14556719 | p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter)) |
| pmid:14556719 | p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) |
| pmid:14556719 | complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) |
| pmid:29191965 | a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT)) |
| pmid:14556719 | p(HGNC:GPR37) association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding)) |
| pmid:14556719 | p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | bp(GO:"response to unfolded protein") increases bp(GO:"cell death") |
| pmid:14556719 | bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") |
| pmid:14556719 | bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") |
| pmid:14556719 | bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") |
| pmid:23746257 | bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis) |
| pmid:24563850 | bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5)) |
| pmid:24563850 | bp(GO:"response to endoplasmic reticulum stress") decreases bp(HBP:misfolding) |
| pmid:24563850 | bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death") |
| pmid:24563850 | bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death") |
| pmid:24563850 | bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process") |
| pmid:23702978 | bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:14556719 | p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") |
| pmid:14556719 | composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) |
| pmid:14556719 | a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") |
| pmid:14556719 | bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") |
| pmid:14556719 | bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") |
| pmid:14556719 | bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") |
| pmid:23746257 | bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") |
| pmid:23746257 | bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) |
| pmid:23746257 | bp(MESH:"Heat-Shock Response") regulates bp(HBP:Proteostasis) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pmid:14556719 | p(HGNC:SNCA, pmod(OGlyco)) association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:SNCAIP) association p(HGNC:SNCA) |
| pmid:14556719 | composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") |
| pmid:14556719 | p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) |
| pmid:14556719 | p(HGNC:CCNE1) association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") |
| pmid:14556719 | composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) |
| pmid:14556719 | p(HGNC:AIMP2) increases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(Ub)) |
| pmid:14556719 | p(HGNC:SYT11, pmod(Ub)) association bp(GO:"synaptic vesicle transport") |
| pmid:14556719 | p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter)) |
| pmid:14556719 | a(GO:"actin filament") association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) |
| pmid:14556719 | act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") |
| pmid:22908190 | p(HGNC:UBE3A) increases deg(p(HGNC:ARC)) |
| pmid:14556719 | p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23528736 | p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") |
| pmid:23528736 | p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") |
| pmid:14556719 | complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") |
| pmid:22908190 | p(HGNC:SNCA, pmod(Ub)) positiveCorrelation p(HGNC:SNCA) |
| pmid:22908190 | p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:22908190 | p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia) |
| pmid:14556719 | p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") |
| pmid:14556719 | p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") |
| pmid:14556719 | p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") |
| pmid:14556719 | a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) |
| pmid:14556719 | a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) |
| pmid:14556719 | a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) |
| pmid:14556719 | a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) |
| pmid:14556719 | bp(HBP:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) |
| pmid:14556719 | bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils") |
| pmid:14556719 | a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | p(HGNC:SNCA, pmod(Glyco)) association p(HGNC:PRKN) |
| pmid:14556719 | complex(a(HBP:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) |
| pmid:29191965 | p(HGNC:TH) regulates a(CHEBI:dopamine) |
| pmid:29191965 | p(HGNC:TH) regulates a(CHEBI:serotonin) |
| pmid:29191965 | p(HGNC:TH) regulates act(p(HGNC:DDC)) |
| pmid:14556719 | g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7)) |
| pmid:14556719 | complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(Sumo)) |
| pmid:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) |
| pmid:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) |
| pmid:14556719 | p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") |
| pmid:14556719 | deg(p(HGNC:CFTR)) increases path(MESH:"Cystic Fibrosis") |
| pmid:29311797 | path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) |
| pmid:29311797 | path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) |
| pmid:14556719 | bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) |
| pmid:14556719 | bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding))) |
| pmid:24457024 | bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:14556719 | p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) |
| pmid:14556719 | g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pmid:29311797 | path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) |
| pmid:27260836 | path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") |
| pmid:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29)) |
| pmid:14556719 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") |
| pmid:14556719 | a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | a(CHEBI:lactacystin) increases bp(GO:"cell death") |
| pmid:22908190 | a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") |
| pmid:30145931 | a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) |
| pmid:24027553 | a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:lactacystin) increases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:lactacystin) decreases act(p(HBP:"20 S Proteasome")) |
| pmid:24027553 | a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L")) |
| pmid:24027553 | a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:14556719 | a(MESH:Prions) increases path(MESH:"Prion Diseases") |
| pmid:14556719 | a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Dementia) |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Death) |
| pmid:14556719 | path(MESH:"Prion Diseases") increases bp(GO:"neuron death") |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Gliosis) |
| pmid:14556719 | path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates") |
| pmid:14556719 | path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29980653 | path(MESH:"Prion Diseases") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29980653 | path(MESH:"Prion Diseases") positiveCorrelation p(HGNC:PRNP, var("?")) |
| pmid:14556719 | complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30985105 | p(HGNC:SOD1, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) |
| pmid:18930136 | p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1) |
| pmid:14556719 | p(HGNC:SOD1, pmod(HBP:misfolding)) increases a(HBP:"protein aggregates") |
| pmid:14556719 | p(HGNC:RNF19A) decreases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:14556719 | composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") |
| pmid:26631930 | p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(Ac, Lys)) |
| pmid:14556719 | p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") |
| pmid:14556719 | p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") |
| pmid:24457024 | p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) |
| pmid:14556719 | p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(HBP:"protein aggregates") |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(HBP:"protein aggregates") |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") |
| pmid:14556719 | a(CHEBI:"Congo Red") decreases a(HBP:"huntingtin aggregates") |
| pmid:14556719 | a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) |
| pmid:22908190 | p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) |
| pmid:25374103 | p(FPLX:Caspase) increases path(MESH:Tauopathies) |
| pmid:26631930 | p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230")) |
| pmid:22908190 | bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy) |
| pmid:22908190 | bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins) |
| pmid:22908190 | bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1) |
| pmid:24027553 | bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pmid:26631930 | bp(GO:"proteasomal protein catabolic process") decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) |
| pmid:26631930 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(Ub))) |
| pmid:26631930 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(UbK63))) |
| pmid:22908190 | composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) |
| pmid:22908190 | act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") |
| pmid:22908190 | act(p(HGNC:VCP)) regulates a(GO:autophagosome) |
| pmid:24457024 | p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:24457024 | p(HGNC:VCP) increases bp(GO:"protein ubiquitination") |
| pmid:22908190 | path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) |
| pmid:22908190 | path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) |
| pmid:22908190 | a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin) |
| pmid:26195256 | a(MESH:"Neuropil Threads") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22817713 | a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") |
| pmid:18239272 | a(MESH:"Neuropil Threads") association p(HBP:"Tau epitope, AT8") |
| pmid:22908190 | bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic") |
| pmid:22908190 | bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) association a(HBP:"paired helical filaments") |
| pmid:22908190 | p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) association a(HBP:"paired helical filaments") |
| pmid:26751493 | p(HBP:"Tau aggregates") association a(CHEBI:heparin) |
| pmid:26751493 | p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:26751493 | p(HBP:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:19517062 | p(HBP:"Tau aggregates") increases bp(GO:"apoptotic process") |
| pmid:19517062 | p(HBP:"Tau aggregates") increases bp(GO:"necrotic cell death") |
| pmid:26751493 | p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274)) |
| pmid:28760828 | p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:28500862 | p(HBP:"Tau aggregates") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:22908190 | a(GO:"Pick body") association p(HGNC:MAPT) |
| pmid:27574109 | a(GO:"Pick body") association p(HGNC:MAPT) |
| pmid:22908190 | a(GO:"Pick body") association a(MESH:Ubiquitin) |
| pmid:27574109 | a(GO:"Pick body") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(GO:"Pick body") association a(HBP:"phosphatase-activating domain") |
| pmid:22908190 | p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:22908190 | p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:22908190 | p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") |
| pmid:22908190 | complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(Ub)) |
| pmid:24457024 | complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") |
| pmid:22908190 | p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination") |
| pmid:22908190 | complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(HBP:"20 S Proteasome")) |
| pmid:22908190 | complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:22908190 | complex(a(GO:"proteasome regulatory particle"), a(HBP:"paired helical filaments")) decreases act(complex(GO:"proteasome complex")) |
| pmid:22908190 | p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation)) increases p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation), pmod(Ub)) |
| pmid:22908190 | p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HBP:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:22908190 | p(HBP:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:22908190 | p(HBP:"UBB+1") decreases bp(GO:memory) |
| pmid:23528736 | p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles") |
| pmid:22908190 | p(HBP:"UBB+1", pmod(UbPoly)) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:22908190 | p(HBP:"UBB+1", pmod(UbPoly)) decreases deg(p(HBP:"UBB+1", pmod(UbPoly))) |
| pmid:22908190 | p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:22908190 | p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1)) |
| pmid:22908190 | p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(Ub))) |
| pmid:22908190 | p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1)) |
| pmid:22908190 | p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | deg(p(FPLX:PKA, pmod(Ub))) increases act(p(FPLX:PKA)) |
| pmid:22908190 | p(HGNC:ARC) regulates bp(GO:"synapse maturation") |
| pmid:22908190 | act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?")) |
| pmid:28877763 | a(MESH:Neurites) positiveCorrelation act(p(MGI:Syk)) |
| pmid:22908190 | complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:22908190 | complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination") |
| pmid:22908190 | a(GO:caveola) increases bp(GO:"plasma membrane invagination") |
| pmid:22908190 | bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination") |
| pmid:29590627 | bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") |
| pmid:29590627 | bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") |
| pmid:22908190 | p(HGNC:RAB7A) increases a(GO:endosome) |
| pmid:22908190 | p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) |
| pmid:22908190 | p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") |
| pmid:18930136 | p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") |
| pmid:29238289 | p(HGNC:RAB7A) association sec(p(HGNC:MAPT)) |
| pmid:22908190 | act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway") |
| pmid:22908190 | act(a(GO:endosome)) decreases path(HBP:Neurodegeneration) |
| pmid:22908190 | complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) |
| pmid:22908190 | p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) |
| pmid:22908190 | a(MESH:Cathepsins) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:22908190 | sec(a(MESH:Cathepsins)) increases bp(GO:"apoptotic process") |
| pmid:22908190 | p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) |
| pmid:22908190 | bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) |
| pmid:22908190 | bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) |
| pmid:18930136 | bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates") |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) |
| pmid:22908190 | complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | a(GO:"late endosome") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29590627 | a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:29590627 | a(GO:"late endosome") association a(HBP:"Tau aggregates") |
| pmid:22908190 | complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome) |
| pmid:29590627 | a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:29590627 | a(GO:"early endosome") association a(HBP:"Tau aggregates") |
| pmid:18930136 | a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome)) |
| pmid:22908190 | bp(GO:"response to nutrient") regulates p(HGNC:MTOR) |
| pmid:22908190 | bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") |
| pmid:22908190 | bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II") |
| pmid:22908190 | bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:22908190 | bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) |
| pmid:22908190 | bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) |
| pmid:22908190 | bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) |
| pmid:22908190 | a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size") |
| pmid:27574109 | a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Braak_Stage II") association p(HGNC:MAPT) |
| pmid:28176663 | a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:22908190 | p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) |
| pmid:22908190 | p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") |
| pmid:22908190 | act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins) |
| pmid:22908190 | act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid) |
| pmid:22908190 | act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process") |
| pmid:22908190 | act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death") |
| pmid:22908190 | act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) |
| pmid:22908190 | act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) |
| pmid:22908190 | act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis) |
| pmid:22908190 | act(p(HGNC:RAB5A)) increases a(CHEBI:"amyloid-beta") |
| pmid:22908190 | act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:22908190 | act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") |
| pmid:30116051 | act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) |
| pmid:27607061 | act(p(HGNC:RAB5A)) negativeCorrelation surf(p(HGNC:GRIK2)) |
| pmid:27607061 | act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") |
| pmid:22908190 | p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22908190 | p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) |
| pmid:22908190 | p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") |
| pmid:22908190 | p(HGNC:ATP6V0A1, pmod(NGlyco)) increases bp(GO:"pH reduction") |
| pmid:22908190 | complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1)) increases act(p(HGNC:RAB5A)) |
| pmid:22908190 | a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| pmid:22908190 | a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) |
| pmid:22908190 | bp(GO:"response to acidic pH") increases a(HBP:"amyloid-beta oligomers") |
| pmid:30116051 | p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:26631930 | p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, frag("?")) increases path(HBP:Neurodegeneration) |
| pmid:29626319 | p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) |
| pmid:22908190 | p(HGNC:RIN1) increases act(p(HGNC:RAB5A)) |
| pmid:22908190 | p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:22908190 | p(HGNC:RIN1) decreases bp(GO:"fear response") |
| pmid:22908190 | p(HGNC:RIN1) decreases bp(GO:memory) |
| pmid:22908190 | p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA") |
| pmid:22908190 | sec(a(MESH:Hydrolases)) increases path(MESH:Necrosis) |
| pmid:22908190 | p(HGNC:CST3) decreases act(a(GO:synapse)) |
| pmid:24563850 | a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") |
| pmid:21882945 | a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) |
| pmid:23746257 | act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding") |
| pmid:23746257 | act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding") |
| pmid:23746257 | bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins)) |
| pmid:23746257 | bp(GO:"protein refolding") association act(p(FPLX:HSPA)) |
| pmid:23746257 | bp(GO:"protein refolding") association act(p(FPLX:HSPA)) |
| pmid:23746257 | bp(GO:"protein refolding") association act(p(FPLX:HSP90)) |
| pmid:23746257 | complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding") |
| pmid:23746257 | bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90) |
| pmid:23746257 | bp(GO:"protein secretion") association p(FPLX:HSP90) |
| pmid:23746257 | bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA)) |
| pmid:23746257 | p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA)) |
| pmid:23746257 | composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates") |
| pmid:21882945 | p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23746257 | complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding") |
| pmid:23746257 | complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) |
| pmid:23746257 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90)) |
| pmid:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(MESH:Proteolysis) |
| pmid:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein folding") |
| pmid:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein modification process") |
| pmid:23746257 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pmid:25784053 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pmid:29311797 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pmid:25784053 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) |
| pmid:23746257 | p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:21882945 | p(HGNC:CDC37) regulates act(p(FPLX:HSP90)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) |
| pmid:21882945 | p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) |
| pmid:29311797 | p(HGNC:CDC37) increases p(HGNC:MAPT) |
| pmid:21367866 | p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) |
| pmid:21367866 | p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation act(p(HGNC:CDK5)) |
| pmid:21367866 | p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) |
| pmid:21367866 | p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) |
| pmid:23746257 | p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:21882945 | p(HGNC:AHSA1) regulates act(p(FPLX:HSP90)) |
| pmid:29311797 | p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:21882945 | p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) |
| pmid:21882945 | p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) |
| pmid:29311797 | p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29311797 | p(HGNC:AHSA1) increases a(HBP:"Tau aggregates") |
| pmid:29311797 | p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") |
| pmid:23746257 | bp(GO:"behavioral response to starvation") association bp(HBP:Proteostasis) |
| pmid:23746257 | p(FPLX:Proteasome) increases bp(GO:"protein catabolic process") |
| pmid:26195256 | act(p(FPLX:Proteasome)) increases bp(GO:"protein catabolic process") |
| pmid:23746257 | p(FPLX:Proteasome) increases bp(GO:"protein unfolding") |
| pmid:25784053 | p(FPLX:Proteasome) increases bp(MESH:Proteolysis) |
| pmid:25784053 | p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30145931 | act(p(FPLX:Proteasome)) decreases path(HBP:neurotoxicity) |
| pmid:30145931 | act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT) |
| pmid:30145931 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, loc(MESH:Dendrites))) |
| pmid:26195256 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pmid:30145931 | act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) |
| pmid:29311797 | act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Neurodegenerative Diseases") |
| pmid:26195256 | act(p(FPLX:Proteasome)) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) |
| pmid:23746257 | composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") |
| pmid:23746257 | p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:25036637 | p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) |
| pmid:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) |
| pmid:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) |
| pmid:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) |
| pmid:21882945 | p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pmid:17954934 | p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) |
| pmid:17954934 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pmid:17954934 | p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:17954934 | p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:17954934 | p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:23746257 | a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2)) |
| pmid:23746257 | a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B)) |
| pmid:23746257 | a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(Ph)) |
| pmid:23746257 | p(FPLX:EIF2B, pmod(Ph)) decreases act(p(FPLX:EIF2B)) |
| pmid:23746257 | a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1)) |
| pmid:25784053 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30116051 | a(CHEBI:geldanamycin) decreases a(HBP:"alpha-synuclein oligomers") |
| pmid:24027553 | a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:21882945 | a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) |
| pmid:23746257 | composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates") |
| pmid:23746257 | composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(HBP:"huntingtin aggregates") |
| pmid:24457024 | complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:24457024 | complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:24457024 | p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) |
| pmid:24457024 | p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) |
| pmid:24457024 | path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(HBP:misfolding))) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway") |
| pmid:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") |
| pmid:25784053 | p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) |
| pmid:25784053 | p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) |
| pmid:25784053 | p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) |
| pmid:26041011 | act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) |
| pmid:24457024 | act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) |
| pmid:24457024 | p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) |
| pmid:24457024 | p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) |
| pmid:24457024 | complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) |
| pmid:25784053 | bp(MESH:"Protein Biosynthesis") association bp(HBP:Proteostasis) |
| pmid:25784053 | bp(MESH:Proteolysis) association bp(HBP:Proteostasis) |
| pmid:29311797 | bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") |
| pmid:25784053 | bp(MESH:"Growth and Development") regulates bp(HBP:Proteostasis) |
| pmid:25784053 | complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:25036637 | p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25784053 | a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") |
| pmid:25784053 | bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") |
| pmid:25784053 | a(MESH:Lysosomes) increases bp(MESH:Proteolysis) |
| pmid:25784053 | a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:24027553 | a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29238289 | act(a(MESH:Lysosomes)) decreases sec(p(HGNC:MAPT)) |
| pmid:25784053 | bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) |
| pmid:25784053 | bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin)) |
| pmid:25784053 | p(HGNC:HSF1, pmod(Ac)) decreases act(p(HGNC:HSF1)) |
| pmid:25784053 | complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) |
| pmid:25784053 | act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph)) |
| pmid:25784053 | act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) |
| pmid:25784053 | p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) |
| pmid:25784053 | act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein") |
| pmid:25784053 | bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) |
| pmid:25784053 | bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:EIF2AK3), ma(kin)) |
| pmid:25784053 | p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:25784053 | p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") |
| pmid:25784053 | p(HGNC:PRSS1) decreases p(HGNC:ATF6) |
| pmid:25784053 | p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6") |
| pmid:25784053 | p(HGNC:PRSS2) decreases p(HGNC:ATF6) |
| pmid:25784053 | p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6") |
| pmid:25784053 | tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) |
| pmid:25784053 | act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") |
| pmid:25784053 | act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph)) |
| pmid:25784053 | p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript)) |
| pmid:23702978 | p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation) |
| pmid:25784053 | act(p(HGNC:EIF2S1), ma(tscript)) increases p(HGNC:ATF4) |
| pmid:25784053 | p(HGNC:ATF4) increases p(HGNC:DDIT3) |
| pmid:25784053 | p(HGNC:DDIT3) increases bp(GO:"apoptotic process") |
| pmid:23702978 | p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") |
| pmid:23702978 | p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:25784053 | p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) |
| pmid:25784053 | p(MGI:Atg5) decreases bp(HP:Neurodegeneration) |
| pmid:25784053 | p(MGI:Atg7) decreases bp(HP:Neurodegeneration) |
| pmid:24027553 | p(MGI:Atg7) decreases path(HBP:Neurodegeneration) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:25784053 | p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") |
| pmid:29238289 | p(HGNC:RAB1A) association sec(p(HGNC:MAPT)) |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine") |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:chloroquine) decreases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine") |
| pmid:25784053 | a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) |
| pmid:25784053 | a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) |
| pmid:24027553 | a(CHEBI:chloroquine) increases p(HGNC:MAPT) |
| pmid:24027553 | a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) |
| pmid:25784053 | a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pmid:25784053 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:tanespimycin) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:21367866 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:tanespimycin) increases bp(GO:memory) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases a(HBP:"alpha-synuclein oligomers") |
| pmid:21882945 | a(CHEBI:tanespimycin) directlyIncreases complex(a(CHEBI:tanespimycin), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pmid:21882945 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:21882945 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:29311797 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:25784053 | a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) |
| pmid:25784053 | a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) |
| pmid:30116051 | p(FPLX:mTORC1) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:mTORC1) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(Ph, Ser, 757)) |
| pmid:30116051 | p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) |
| pmid:30116051 | act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) |
| pmid:30116051 | act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") |
| pmid:23528736 | p(FPLX:mTORC1) decreases bp(GO:autophagy) |
| pmid:23528736 | act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:23528736 | act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) |
| pmid:30108137 | act(p(FPLX:mTORC1)) increases p(MGI:Tfeb, pmod(Ph)) |
| pmid:25784053 | a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) |
| pmid:25784053 | a(PUBCHEM:10521421) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:fluphenazine) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) |
| pmid:25784053 | a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) |
| pmid:25784053 | a(PUBCHEM:799645) increases bp(GO:autophagy) |
| pmid:25784053 | a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:799645) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | a(PUBCHEM:877863) increases bp(GO:autophagy) |
| pmid:25784053 | a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | a(PUBCHEM:1560402) increases bp(GO:autophagy) |
| pmid:25784053 | a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:1560402) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:675434) decreases p(HGNC:MAPT) |
| pmid:23528736 | a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) |
| pmid:25784053 | a(PUBCHEM:675434) decreases p(HGNC:TARDBP) |
| pmid:25784053 | a(PUBCHEM:675434) decreases p(HGNC:ATXN3) |
| pmid:25784053 | a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) |
| pmid:23528736 | a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) |
| pmid:25784053 | a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) |
| pmid:23528736 | a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) |
| pmid:18930136 | deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid") |
| pmid:18930136 | bp(GO:"antigen processing and presentation") association bp(GO:autophagy) |
| pmid:18930136 | bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") |
| pmid:18930136 | bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) |
| pmid:18930136 | bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy) |
| pmid:18930136 | bp(GO:pexophagy) isA bp(GO:macroautophagy) |
| pmid:18930136 | bp(GO:reticulophagy) isA bp(GO:macroautophagy) |
| pmid:18930136 | bp(GO:xenophagy) isA bp(GO:macroautophagy) |
| pmid:18930136 | bp(GO:ribophagy) isA bp(GO:macroautophagy) |
| pmid:18930136 | bp(GO:aggrephagy) isA bp(GO:macroautophagy) |
| pmid:18930136 | complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:18930136 | complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases complex(a(MESH:Proteins), p(HGNC:HSPA8), p(HGNC:LAMP2)) |
| pmid:18930136 | a(GO:phagophore) increases a(GO:autophagosome) |
| pmid:18930136 | composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5)) |
| pmid:18930136 | composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore) |
| pmid:18930136 | complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) |
| pmid:18930136 | complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation")) |
| pmid:18930136 | p(HGNC:ATG5) decreases path(HBP:Neurodegeneration) |
| pmid:18930136 | complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore) |
| pmid:18930136 | p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2)) |
| pmid:18930136 | p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?")) |
| pmid:18930136 | p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7)) |
| pmid:18930136 | composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?"))) |
| pmid:18930136 | complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome) |
| pmid:18930136 | complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome) |
| pmid:18930136 | p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP)) |
| pmid:18930136 | complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) |
| pmid:18930136 | complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome) |
| pmid:18930136 | path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome) |
| pmid:18930136 | path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome)) |
| pmid:18930136 | p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses") |
| pmid:18930136 | p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:18930136 | p(HGNC:ATP13A2, var("?")) increases path(HBP:Neurodegeneration) |
| pmid:18930136 | p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") |
| pmid:18930136 | a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") |
| pmid:26631930 | act(a(MESH:Dyneins)) association p(HGNC:MAPT) |
| pmid:18930136 | p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome) |
| pmid:8391280 | p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") |
| pmid:8391280 | p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:8391280 | p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") |
| pmid:18930136 | bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis) |
| pmid:18930136 | a(GO:aggresome) negativeCorrelation bp(GO:"cell death") |
| pmid:18930136 | composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process") |
| pmid:18930136 | composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(Ub)) |
| pmid:18930136 | p(HGNC:HDAC6) regulates bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:HDAC6) increases bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | p(HGNC:HDAC6) regulates a(GO:aggresome) |
| pmid:18930136 | p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) |
| pmid:18930136 | p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation") |
| pmid:18930136 | p(HGNC:HDAC6) regulates complex(GO:"chaperone complex") |
| pmid:18930136 | p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pmid:28803412 | p(HGNC:HDAC6) decreases a(HBP:HBP00093) |
| pmid:30640040 | p(HGNC:HDAC6) association a(PUBCHEM:53340666) |
| pmid:29311797 | p(HGNC:HDAC6) increases act(p(HGNC:AIP)) |
| pmid:29311797 | p(HGNC:HDAC6) association a(HBP:"Tau aggregates") |
| pmid:26751493 | p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") |
| pmid:26631930 | p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(Ac, Lys)) |
| pmid:26751493 | p(HGNC:HDAC6) association a(HBP:"microtubule-binding region") |
| pmid:25031639 | act(p(HGNC:HDAC6)) positiveCorrelation a(HBP:"Tau epitope, 12E8") |
| pmid:24844691 | act(p(HGNC:HDAC6)) negativeCorrelation p(FPLX:Tubulin, pmod(Ac)) |
| pmid:25546293 | act(p(HGNC:HDAC6)) negativeCorrelation p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:23487739 | act(p(HGNC:HDAC6)) negativeCorrelation a(GO:microtubule) |
| pmid:23487739 | act(p(HGNC:HDAC6)) decreases p(INTERPRO:"Tubulin/FtsZ, GTPase domain", pmod(Ac)) |
| pmid:28760828 | p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT) |
| pmid:28760828 | p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:29844403 | act(p(HGNC:HDAC6)) positiveCorrelation act(p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:18930136 | p(HGNC:WDFY3) regulates bp(GO:autophagy) |
| pmid:18930136 | p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | p(HGNC:WDFY3) regulates a(GO:aggresome) |
| pmid:18930136 | tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination") |
| pmid:18930136 | p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process") |
| pmid:18930136 | bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1)) |
| pmid:18930136 | a(MESH:"Huntingtin Protein") association p(HGNC:SQSTM1) |
| pmid:24563850 | a(CHEBI:radical) association bp(GO:"detection of redox state") |
| pmid:24563850 | a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") |
| pmid:24563850 | a(CHEBI:radical) regulates bp(MESH:Metabolism) |
| pmid:24563850 | a(CHEBI:radical) decreases a(MESH:Antioxidants) |
| pmid:24563850 | a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") |
| pmid:24563850 | a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification") |
| pmid:24563850 | a(CHEBI:radical) increases bp(HBP:misfolding) |
| pmid:24563850 | a(CHEBI:radical) increases bp(GO:"protein oxidation") |
| pmid:24563850 | a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") |
| pmid:24563850 | act(p(HGNC:XDH)) increases a(CHEBI:radical) |
| pmid:24563850 | act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species") |
| pmid:24563850 | act(p(HGNC:XDH)) increases a(CHEBI:"reactive nitrogen species") |
| pmid:24563850 | act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) |
| pmid:24563850 | act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species") |
| pmid:24563850 | act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive nitrogen species") |
| pmid:24563850 | act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) |
| pmid:24563850 | act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive oxygen species") |
| pmid:24563850 | act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive nitrogen species") |
| pmid:24563850 | bp(GO:"response to radiation") increases a(CHEBI:radical) |
| pmid:24563850 | a(MESH:"Air Pollution") increases a(CHEBI:radical) |
| pmid:24563850 | bp(GO:"detection of redox state") association a(CHEBI:radical) |
| pmid:24563850 | bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) |
| pmid:24563850 | bp(HBP:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) |
| pmid:24563850 | bp(HBP:"non-enzymatic protein modification") increases bp(HBP:misfolding) |
| pmid:24563850 | p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:24563850 | bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") |
| pmid:24563850 | p(HGNC:EIF2A) association p(HGNC:HSPB8) |
| pmid:24563850 | bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space")) |
| pmid:24563850 | p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water))) |
| pmid:29626319 | tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:"amyloid-beta") |
| pmid:24563850 | p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water))) |
| pmid:24563850 | act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:KEAP1) isA p(ECCODE:"2.3.2.27") |
| pmid:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1) |
| pmid:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1) |
| pmid:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC) |
| pmid:24563850 | complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST) |
| pmid:24563850 | bp(GO:"protein oxidation") association bp(GO:aging) |
| pmid:24563850 | bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") |
| pmid:24563850 | bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) |
| pmid:24563850 | bp(GO:"protein oxidation") association path(MESH:Neoplasms) |
| pmid:29024336 | bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) |
| pmid:24563850 | path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") |
| pmid:26195256 | path(MESH:"Cardiovascular Diseases") increases path(MESH:"Alzheimer Disease") |
| pmid:24563850 | bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates") |
| pmid:24563850 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") |
| pmid:24563850 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(HBP:misfolding) |
| pmid:24563850 | p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates") |
| pmid:24563850 | act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates") |
| pmid:25036637 | p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | act(p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pmid:18500754 | p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) |
| pmid:25036637 | p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") |
| pmid:29844403 | act(p(INTERPRO:"Heat shock protein Hsp90 family")) positiveCorrelation act(p(HGNC:HDAC6)) |
| pmid:25036637 | p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) |
| pmid:25036637 | p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) |
| pmid:25036637 | complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) |
| pmid:25036637 | p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:CDC37) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:EGLN1) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:PDCD2) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:ANKMY2) |
| pmid:25036637 | p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) |
| pmid:25036637 | p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") |
| pmid:21882945 | p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) |
| pmid:21882945 | p(HGNC:FKBP5) increases p(HGNC:MAPT) |
| pmid:20071522 | p(HGNC:FKBP5) increases p(HGNC:MAPT) |
| pmid:21882945 | p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | p(HGNC:FKBP5) isA a(MESH:Immunophilins) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:20071522 | p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) |
| pmid:20071522 | p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") |
| pmid:29686391 | p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26631930 | p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:25036637 | p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") |
| pmid:25036637 | p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") |
| pmid:25036637 | bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) |
| pmid:25036637 | bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) |
| pmid:25036637 | p(HGNC:EGLN1) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:PDCD2) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") |
| pmid:25036637 | p(HGNC:ANKMY2) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") |
| pmid:25036637 | p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") |
| pmid:25036637 | p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) |
| pmid:23702978 | bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) |
| pmid:25036637 | p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) |
| pmid:25036637 | p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") |
| pmid:29311797 | p(HGNC:FKBP8) isA a(MESH:Immunophilins) |
| pmid:25036637 | p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") |
| pmid:25036637 | p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") |
| pmid:25036637 | bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) |
| pmid:25036637 | p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) |
| pmid:25036637 | p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) |
| pmid:29311797 | p(HGNC:FKBP6) isA a(MESH:Immunophilins) |
| pmid:25036637 | a(HBP:"OSW-1") decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) |
| pmid:25036637 | p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:25036637 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) |
| pmid:21882945 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") |
| pmid:25036637 | p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) |
| pmid:25036637 | p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) |
| pmid:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) |
| pmid:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) |
| pmid:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) |
| pmid:25036637 | p(HGNC:BAG4) negativeCorrelation complex(GO:"P-body") |
| pmid:25036637 | p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) |
| pmid:25036637 | p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) |
| pmid:25036637 | p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") |
| pmid:25036637 | p(HGNC:DCP1A) association bp(GO:"gene silencing") |
| pmid:25036637 | p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") |
| pmid:25036637 | p(HGNC:EDC3) association bp(GO:"gene silencing") |
| pmid:25036637 | p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") |
| pmid:25036637 | p(HGNC:DDX6) association bp(GO:"gene silencing") |
| pmid:25036637 | complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4) |
| pmid:25036637 | complex(GO:"P-body") association p(HGNC:BAG4, var("p.Asp424Ala")) |
| pmid:25036637 | complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) |
| pmid:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:"P-body") |
| pmid:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:"P-body") |
| pmid:25036637 | a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) |
| pmid:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) |
| pmid:25036637 | p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) |
| pmid:29311797 | p(HGNC:FKBP4) isA a(MESH:Immunophilins) |
| pmid:26631930 | p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") |
| pmid:26903089 | act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif") |
| pmid:21882945 | p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:21882945 | p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) |
| pmid:21882945 | p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") |
| pmid:21882945 | p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) |
| pmid:25036637 | p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) |
| pmid:25036637 | p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) |
| pmid:25036637 | p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) |
| pmid:25036637 | p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) |
| pmid:25036637 | p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) |
| pmid:25374103 | complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) |
| pmid:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) |
| pmid:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) |
| pmid:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) |
| pmid:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) |
| pmid:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) |
| pmid:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) |
| pmid:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) |
| pmid:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) |
| pmid:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) |
| pmid:25036637 | p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) |
| pmid:25036637 | p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) |
| pmid:25036637 | p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) |
| pmid:25036637 | p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) |
| pmid:25036637 | a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) |
| pmid:25036637 | a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) |
| pmid:21882945 | p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) |
| pmid:29311797 | p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | p(HGNC:PTGES3) increases p(HGNC:MAPT) |
| pmid:29311797 | p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") |
| pmid:25036637 | p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") |
| pmid:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) |
| pmid:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) |
| pmid:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) |
| pmid:25036637 | p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) |
| pmid:25036637 | p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) |
| pmid:25036637 | a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") |
| pmid:24706768 | a(HBP:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) |
| pmid:24706768 | a(HBP:"polyQ aggregates") decreases bp(GO:endocytosis) |
| pmid:24706768 | a(HBP:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis") |
| pmid:24706768 | p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") |
| pmid:24706768 | complex(a(HBP:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00016) increases path(MESH:"Parkinson Disease") |
| pmid:27075649 | a(HBP:HBP00016) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:27075649 | a(HBP:HBP00016) positiveCorrelation path(MESH:"Multiple System Atrophy") |
| pmid:27075649 | a(HBP:HBP00016) positiveCorrelation path(MESH:"Lewy Body Disease") |
| pmid:28803412 | a(HBP:HBP00093) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00093) biomarkerFor path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00093) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00093) increases a(HBP:HBP00092) |
| pmid:27075649 | a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"apoptotic process") |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"apoptotic process") |
| pmid:27075649 | a(HBP:HBP00093) increases bp(GO:"apoptotic process") |
| pmid:28803412 | a(HBP:HBP00093) decreases a(MESH:Mitochondria) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(HBP:HBP00037) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(MESH:"Endoplasmic Reticulum Stress") |
| pmid:28803412 | a(HBP:HBP00093) decreases act(complex(GO:"proteasome complex")) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"microglial cell activation") |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"inflammatory response") |
| pmid:28803412 | a(HBP:HBP00093) increases act(p(HGNC:TLR2)) |
| pmid:28803412 | a(HBP:HBP00093) increases a(CHEBI:"reactive oxygen species") |
| pmid:28803412 | a(HBP:HBP00093) decreases a(MESH:"Cell Membrane") |
| pmid:28803412 | a(HBP:HBP00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pmid:27075649 | a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)") |
| pmid:28803412 | a(HBP:HBP00093) decreases bp(GO:"synaptic vesicle transport") |
| pmid:28803412 | a(HBP:HBP00093) decreases bp(GO:"axonal transport") |
| pmid:28803412 | a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pmid:28803412 | a(HBP:HBP00093) decreases a(MESH:"Golgi Apparatus") |
| pmid:28803412 | a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process") |
| pmid:27075649 | a(HBP:HBP00092) increases bp(GO:"apoptotic process") |
| pmid:28803412 | a(HBP:HBP00092) increases bp(GO:"inflammatory response") |
| pmid:28803412 | a(HBP:HBP00092) increases bp(GO:"microglial cell activation") |
| pmid:27075649 | a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)") |
| pmid:27075649 | a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093) |
| pmid:27075649 | a(HBP:HBP00092) increases a(HBP:HBP00016) |
| pmid:28803412 | a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") |
| pmid:28803412 | a(CHEBI:salubrinal) decreases a(HBP:HBP00093) |
| pmid:28803412 | complex(a(HBP:HBP00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") |
| pmid:26631930 | act(a(MESH:Kinesin)) association p(HGNC:MAPT) |
| pmid:28803412 | p(HGNC:USP19) increases sec(p(HGNC:SNCA)) |
| pmid:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) |
| pmid:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) |
| pmid:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017) |
| pmid:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2) |
| pmid:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1) |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) |
| pmid:28803412 | a(HBP:HBP00094) decreases a(HBP:HBP00016) |
| pmid:28803412 | a(HBP:HBP00094) decreases bp(GO:"apoptotic process") |
| pmid:27075649 | path(MESH:"Multiple System Atrophy") positiveCorrelation a(HBP:HBP00016) |
| pmid:27075649 | a(HBP:HBP00095) increases bp(GO:"neuron death") |
| pmid:27075649 | a(HBP:HBP00095) decreases bp(GO:"ion homeostasis") |
| pmid:27075649 | a(HBP:HBP00095) increases a(HBP:HBP00016) |
| pmid:27075649 | a(CHEBI:glutaraldehyde) increases a(HBP:HBP00093) |
| pmid:29807032 | act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") |
| pmid:29807032 | p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) |
| pmid:29807032 | path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein") |
| pmid:23211705 | p(MGI:Crh) decreases a(MESH:Estradiol) |
| pmid:23211705 | p(MGI:Crh) regulates p(HGNC:CGB3) |
| pmid:23211705 | p(MGI:Crh) decreases p(HGNC:CGB3) |
| pmid:23211705 | p(MGI:Crh) causesNoChange a(MESH:Progesterone) |
| pmid:23211705 | p(MGI:Crh) decreases a(MESH:Progesterone) |
| pmid:23211705 | p(MGI:Crh) decreases a(MESH:Progesterone) |
| pmid:25125464 | p(MGI:Crh) increases p(HBP:"Tau epitope, AT8") |
| pmid:25125464 | p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1") |
| pmid:25125464 | p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262)) |
| pmid:25125464 | p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422)) |
| pmid:8940412 | act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") |
| pmid:8940412 | act(p(RGD:Crh)) regulates sec(p(RGD:Pomc)) |
| pmid:8940412 | act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) |
| pmid:8940412 | a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) |
| pmid:8940412 | a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) |
| pmid:8940412 | a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") |
| pmid:8940412 | a(CHEBI:antalarmin) decreases sec(p(RGD:Pomc)) |
| pmid:30145931 | a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy) |
| pmid:30145931 | a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) |
| pmid:30145931 | a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| pmid:30145931 | a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:24027553 | a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) |
| pmid:24027553 | a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:epoxomicin) increases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) |
| pmid:30145931 | composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) increases bp(GO:"protein ubiquitination") |
| pmid:30145931 | composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") |
| pmid:30145931 | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers") |
| pmid:30145931 | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:wortmannin) |
| pmid:30145931 | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) |
| pmid:30145931 | a(CHEBI:rolipram) increases act(p(FPLX:Proteasome)) |
| pmid:30145931 | a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pmid:29626319 | a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26692334 | a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) |
| pmid:26692334 | a(CHEBI:rolipram) positiveCorrelation act(p(FPLX:PKA)) |
| pmid:26692334 | a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) |
| pmid:26692334 | a(CHEBI:rolipram) decreases a(HBP:"Tau aggregates") |
| pmid:30145931 | composite(a(CHEBI:wortmannin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") |
| pmid:30145931 | a(CHEBI:cycloheximide) decreases bp(GO:translation) |
| pmid:30145931 | a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pmid:23702978 | a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") |
| pmid:30145931 | a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation) |
| pmid:30145931 | a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) |
| pmid:22072628 | p(HGNC:MAPT, pmod(Ph, Ser, 235)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:26996941 | p(HGNC:MAPT, pmod(Ph, Ser, 235)) association act(p(HGNC:PIN1)) |
| pmid:8282104 | a(HBP:HBP00172) directlyIncreases p(HBP:HBP00053, pmod(Ph)) |
| pmid:8282104 | complex(a(HBP:HBP00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | a(HBP:HBP00006) association p(HGNC:CDK5) |
| pmid:8282104 | a(HBP:HBP00006) association p(HGNC:PRKACA) |
| pmid:8282104 | a(HBP:HBP00006) association p(FPLX:ERK) |
| pmid:8282104 | a(HBP:HBP00006) association p(FPLX:GSK3) |
| pmid:27594586 | g(DBSNP:rs63751011) increases p(HGNC:MAP2) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") |
| pmid:27594586 | g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | g(DBSNP:rs63751011) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP9) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP9) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP2) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP2) |
| pmid:27594586 | g(DBSNP:rs63751011) increases bp(GO:"neuron death") |
| pmid:27594586 | g(DBSNP:rs63751011) increases a(HBP:HBP00045) |
| pmid:27594586 | g(DBSNP:rs63751011) decreases a(HBP:HBP00044) |
| pmid:27594586 | path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) |
| pmid:27594586 | a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") |
| pmid:8726973 | a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) |
| pmid:23666762 | a(CHEBI:staurosporine) decreases act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) |
| pmid:23001711 | a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(kin)) |
| pmid:23001711 | a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:27594586 | a(CHEBI:rotenone) increases bp(HBP:HBP00037) |
| pmid:27594586 | composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") |
| pmid:27594586 | composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) |
| pmid:27594586 | p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) |
| pmid:30116051 | composite(a(CHEBI:"NAD(+)"), p(HGNC:SIRT1)) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:ULK1, pmod(Ph, Ser, 317)) increases act(p(HGNC:ULK1)) |
| pmid:30116051 | p(HGNC:ULK1, pmod(Ph, Ser, 777)) increases act(p(HGNC:ULK1)) |
| pmid:30116051 | p(FPLX:mTORC1, pmod(Ph)) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | p(HGNC:ULK1, pmod(Ph, Ser, 757)) decreases act(p(HGNC:ULK1)) |
| pmid:30116051 | p(HGNC:FOXO1) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:FOXO3) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:AMBRA1, pmod(Ph)) increases act(p(HGNC:AMBRA1)) |
| pmid:30116051 | act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) |
| pmid:30116051 | act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:30116051 | p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") |
| pmid:30116051 | p(HGNC:GBA, var("?")) decreases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:GBA, var("?")) increases p(HGNC:SNCA) |
| pmid:30116051 | p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") |
| pmid:30116051 | p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pmid:30116051 | p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pmid:30116051 | p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:clonidine) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) |
| pmid:30116051 | a(CHEBI:Rilmenidine) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) |
| pmid:30116051 | p(HGNC:CAPN2) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) |
| pmid:24027553 | p(HGNC:CAPN2) association path(MESH:"Neurofibrillary Tangles") |
| pmid:30116051 | p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) |
| pmid:30116051 | p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) |
| pmid:30116051 | p(HGNC:CAST) increases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:SOD1)) |
| pmid:30116051 | a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) |
| pmid:30116051 | a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) |
| pmid:30116051 | a(CHEBI:Calpeptin) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) |
| pmid:22419736 | a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) |
| pmid:22419736 | a(CHEBI:"AICA ribonucleotide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:30116051 | a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | a(PUBCHEM:54708532) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30116051 | a(CHEBI:selenomethionine) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") |
| pmid:30116051 | composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:22419736 | p(FPLX:AMPK, pmod(Ph, Thr, 172)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22419736 | p(FPLX:AMPK, pmod(Ph, Thr, 172)) negativeCorrelation p(HGNC:AK1) |
| pmid:30116051 | a(CHEBI:metformin) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:metformin) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:metformin) increases bp(MESH:Longevity) |
| pmid:30116051 | a(CHEBI:metformin) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30116051 | a(CHEBI:metformin) decreases bp(GO:"neuron death") |
| pmid:30116051 | a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:calcitriol) increases bp(GO:macroautophagy) |
| pmid:29626319 | a(CHEBI:calcitriol) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | a(CHEBI:calcitriol) decreases p(HGNC:AGER) |
| pmid:29626319 | a(CHEBI:calcitriol) increases p(HGNC:LRP1) |
| pmid:30116051 | complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) |
| pmid:26631930 | p(HGNC:FUS) decreases p(HBP:"4R tau") |
| pmid:26631930 | p(HGNC:FUS) decreases p(HBP:"Tau isoform F (441 aa)") |
| pmid:26631930 | p(HGNC:FUS) decreases p(HBP:"Tau isoform C (410 aa)") |
| pmid:26631930 | p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") |
| pmid:30116051 | a(CHEBI:fisetin) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) |
| pmid:30116051 | a(CHEBI:fisetin) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | p(HGNC:ABL1) decreases bp(GO:macroautophagy) |
| pmid:29191965 | p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:26631930 | p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:17493042 | p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:23687953 | act(p(HGNC:ABL1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 363)) |
| pmid:30116051 | a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) |
| pmid:30116051 | a(CHEBI:nilotinib) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | a(CHEBI:cilostazol) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:BECN1)) |
| pmid:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:ATG5)) |
| pmid:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:MAP1LC3A)) |
| pmid:30116051 | a(CHEBI:cilostazol) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(HGNC:CTSB) |
| pmid:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172)) |
| pmid:30116051 | composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) increases bp(GO:cognition) |
| pmid:30116051 | composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30116051 | a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(Ac)) |
| pmid:30116051 | a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(Ac)) |
| pmid:30116051 | a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) |
| pmid:30116051 | a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) |
| pmid:30116051 | a(CHEBI:Isorhynchophylline) increases act(p(HGNC:BECN1)) |
| pmid:30116051 | a(CHEBI:Isorhynchophylline) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | a(CHEBI:Isorhynchophylline) increases bp(GO:macroautophagy) |
| pmid:30116051 | complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) |
| pmid:30116051 | a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) |
| pmid:30116051 | a(PUBCHEM:16240819) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) |
| pmid:30116051 | a(CHEBI:"epothilone A") increases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:"epothilone D") increases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:"epothilone D") increases bp(GO:cognition) |
| pmid:30116051 | a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | a(PUBCHEM:129688311) decreases p(HGNC:SNCA) |
| pmid:30116051 | a(PUBCHEM:129688311) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) |
| pmid:30116051 | act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) |
| pmid:30116051 | act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | act(p(HGNC:MCOLN1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(HBP:"amyloid-beta aggregates") |
| pmid:30116051 | a(CHEBI:ambroxol) increases p(HGNC:GBA) |
| pmid:30116051 | a(CHEBI:ambroxol) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | a(CHEBI:ambroxol) decreases p(HGNC:SNCA) |
| pmid:30116051 | a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") |
| pmid:30116051 | a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(tscript)) |
| pmid:30116051 | a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(PUBCHEM:46216556) decreases a(HBP:"huntingtin aggregates") |
| pmid:30116051 | a(PUBCHEM:46216556) increases path(MESH:"Motor Activity") |
| pmid:30116051 | a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(kin)) |
| pmid:30116051 | p(HGNC:PSMC5, pmod(Ph, Ser, 120)) increases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) |
| pmid:23702978 | p(HGNC:BIRC2) decreases complex(GO:ripoptosome) |
| pmid:30116051 | p(HGNC:SESN2) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | p(HGNC:SESN2) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:SESN2) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:SESN2) increases act(p(FPLX:mTORC1)) |
| pmid:30116051 | p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | p(HGNC:PLG) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30116051 | p(HGNC:PLG) increases deg(p(HGNC:SNCA)) |
| pmid:26195256 | p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:30116051 | p(HGNC:KLK6) increases p(HGNC:SNCA, frag("?")) |
| pmid:30985105 | p(HGNC:SNCA, frag("?")) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:IDE)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:MME)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) |
| pmid:30116051 | a(CHEBI:somatostatin) increases p(HGNC:IDE) |
| pmid:30116051 | a(CHEBI:somatostatin) increases sec(p(HGNC:IDE)) |
| pmid:30116051 | a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:somatostatin) increases p(HGNC:IDE) |
| pmid:30116051 | a(CHEBI:somatostatin) increases p(HGNC:MME) |
| pmid:30116051 | a(CHEBI:somatostatin) increases sec(p(HGNC:MME)) |
| pmid:30116051 | a(CHEBI:somatostatin) increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:somatostatin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:GRN) increases act(p(HGNC:MME)) |
| pmid:30116051 | p(HGNC:GRN) decreases path(MESH:"Plaque, Amyloid") |
| pmid:30116051 | a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) |
| pmid:30116051 | a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) |
| pmid:30116051 | act(p(HGNC:AQP4)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:AQP4) association deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(HGNC:AQP4)) increases act(a(HBP:"Glymphatic System")) |
| pmid:29626319 | p(HGNC:AQP4) increases a(HP:"glymphatic system") |
| pmid:29626319 | p(HGNC:AQP4) increases a(HP:"glymphatic system") |
| pmid:23484434 | a(CHEBI:6872) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:8028) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:44932) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:3647) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:87637) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:22580) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:1457) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:10642) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:4806) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:4806) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:74460) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(HBP:HBP00021) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(HBP:HBP00019) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:90) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:18152) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:3441) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:3441) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:6710) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:6710) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:112284) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(HBP:HBP00020) decreases a(HBP:HBP00006) |
| pmid:29024336 | path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00006) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00100) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(HBP:HBP00009) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pmid:29024336 | complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") |
| pmid:28019679 | a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | a(CHEBI:paraquat) increases p(HGNC:CASP1) |
| pmid:28019679 | a(CHEBI:paraquat) increases p(HGNC:IL1B) |
| pmid:29024336 | composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:paraquat), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") |
| pmid:23528736 | a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) |
| pmid:29024336 | a(HBP:HBP00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | a(HBP:HBP00057) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | a(HBP:HBP00055) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | a(HBP:HBP00055) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | a(HBP:HBP00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases a(HBP:HBP00006) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29215007 | a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169) |
| pmid:29215007 | composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") |
| pmid:24760868 | complex(GO:"filamentous actin") association p(HGNC:MAPT) |
| pmid:24760868 | complex(GO:"filamentous actin") increases p(HGNC:MAPT) |
| pmid:24760868 | complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:17187063 | complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) |
| pmid:29215007 | a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) |
| pmid:29215007 | complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) |
| pmid:29215007 | a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) |
| pmid:29215007 | p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) |
| pmid:29215007 | p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") |
| pmid:29215007 | p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") |
| pmid:29215007 | p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:22072628 | bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:22072628 | bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) |
| pmid:29215007 | p(HGNC:MAPT, frag("277_280")) increases a(HBP:HBP00170) |
| pmid:29215007 | p(HGNC:MAPT, frag("261_265")) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) |
| pmid:29215007 | p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("315_318")) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | act(p(HGNC:MARK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21311567 | act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23001711 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:29215007 | act(p(HGNC:MARK2), ma(kin)) increases p(HBP:HBP00098, pmod(Ph)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 293)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 293)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 305)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 305)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 416)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 416)) |
| pmid:21882945 | act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21311567 | act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 352)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 413)) |
| pmid:25031639 | p(HGNC:MARK2) increases a(HBP:"Tau epitope, 12E8") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:24251416 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:24251416 | p(HGNC:MAPT, pmod(Ph, Ser, 305)) partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HBP:"Tau aggregates") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HGNC:HDAC6) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:CDC37) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) partOf a(HBP:"Tau epitope, 12E8") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ac)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:29540553 | p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(MGI:Sirt3) |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac)) decreases p(HGNC:WWC1) |
| pmid:20869593 | p(HGNC:MAPT, pmod(Ac)) negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:20869593 | p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:24027553 | p(HGNC:MAPT, pmod(HBP:nitration)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(GO:coagulation) |
| pmid:24027553 | a(CHEBI:Thrombin) increases path(HBP:"neurite retraction") |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") |
| pmid:24027553 | a(CHEBI:Thrombin) increases a(HBP:"Tau aggregates") |
| pmid:24027553 | a(CHEBI:Thrombin, loc(MESH:Neurons)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | a(CHEBI:Thrombin, loc(MESH:Astrocytes)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) association path(HBP:Excitotoxicity) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration) |
| pmid:30985105 | p(HGNCGENEFAMILY:Calpains) increases p(HGNC:SNCA, frag("?")) |
| pmid:30985105 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:SNCA, frag("?")) |
| pmid:30985105 | p(HGNCGENEFAMILY:Calpains) increases p(HBP:"alpha-synuclein fibrils", frag("?")) |
| pmid:30985105 | act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") |
| pmid:30985105 | act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") |
| pmid:30985105 | p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72))) |
| pmid:30985105 | p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Ser, 87))) |
| pmid:30985105 | p(HGNCGENEFAMILY:Calpains) increases deg(p(HGNC:SNCA)) |
| pmid:24027553 | p(HGNC:NPEPPS) increases act(p(HGNCGENEFAMILY:Aminopeptidases)) |
| pmid:24027553 | p(HGNC:NPEPPS) association path(MESH:Tauopathies) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) |
| pmid:24027553 | p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.P301L")) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L")) |
| pmid:24027553 | p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:24027553 | p(HGNC:NPEPPS) decreases p(HGNC:MAPT) |
| pmid:24027553 | p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNC:NPEPPS) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Paralysis) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Gliosis) |
| pmid:24027553 | p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | p(HGNC:NPEPPS) increases bp(GO:autophagy) |
| pmid:24027553 | p(HGNC:NPEPPS) increases bp(GO:"autophagosome assembly") |
| pmid:24027553 | p(HGNC:MAPT, var("p.P301L")) association path(MESH:"Frontotemporal Dementia") |
| pmid:24027553 | p(MGI:Mapt, var("p.P301L")) increases path(HBP:Neurodegeneration) |
| pmid:24027553 | p(MGI:Mapt, var("p.P301L")) positiveCorrelation p(HGNC:NPEPPS) |
| pmid:24027553 | p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.P301L"))) |
| pmid:26751493 | p(HGNC:PIN1) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:PIN1) association a(HBP:"projection domain") |
| pmid:25899010 | p(HGNC:PIN1) decreases a(HBP:Excitotoxicity) |
| pmid:25899010 | p(HGNC:PIN1) negativeCorrelation p(HGNC:DAPK1) |
| pmid:24964035 | p(HGNC:PIN1) increases deg(p(HGNC:SMAD2)) |
| pmid:24964035 | p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:SMAD2)) |
| pmid:23157676 | act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau") |
| pmid:26996941 | act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:22926167 | act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:19401603 | act(p(HGNC:PIN1)) positiveCorrelation act(p(HGNC:PPP2CA)) |
| pmid:19401603 | act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:24027553 | deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HGNC:MAPT, frag("561_685")) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HBP:"cis p-tau") decreases deg(p(HBP:"cis p-tau")) |
| pmid:24027553 | p(HBP:"cis p-tau") decreases act(p(HGNC:PIN1)) |
| pmid:23157676 | p(HBP:"cis p-tau") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23157676 | p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates") |
| pmid:23157676 | p(HBP:"cis p-tau") partOf a(HBP:"dystrophic neurite") |
| pmid:28528849 | a(HBP:"Tau fibrils") causesNoChange a(MESH:"Dendritic Spines") |
| pmid:30108137 | a(HBP:"Tau fibrils", loc(GO:lysosome)) increases deg(p(MGI:Tfeb)) |
| pmid:29988016 | a(HBP:"Tau fibrils") increases a(HBP:"Tau aggregates") |
| pmid:29686391 | a(HBP:"Tau fibrils") causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28420982 | a(HBP:"Tau fibrils") increases a(GO:"neurofibrillary tangle") |
| pmid:24027553 | p(HGNC:MAPT, frag("?", "17kD")) increases path(HBP:"neurite retraction") |
| pmid:24027553 | p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(HBP:neurotoxicity) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*")) |
| pmid:24027553 | act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3") |
| pmid:24027553 | p(HBP:"Tau C3") increases bp(GO:"apoptotic process") |
| pmid:24027553 | p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition) |
| pmid:24027553 | p(HBP:"Tau C3") association path(MESH:"Neurofibrillary Tangles") |
| pmid:25374103 | p(HBP:"Tau C3") causesNoChange bp(GO:"cell death") |
| pmid:25374103 | p(HBP:"Tau C3") increases act(p(HGNC:CASP3)) |
| pmid:25374103 | p(HBP:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | p(HBP:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") |
| pmid:24027553 | p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process") |
| pmid:24027553 | composite(a(MESH:"Amyloid beta-Peptides"), p(HGNC:CASP3)) increases p(HBP:"Tau C3") |
| pmid:24027553 | a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ub))) |
| pmid:24027553 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(Ub))) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers")) |
| pmid:24027553 | act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") increases p(HGNC:MAPT) |
| pmid:24027553 | a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor")) |
| pmid:24027553 | act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) |
| pmid:21882945 | a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) |
| pmid:24027553 | a(MESH:Autophagosomes) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:24027553 | a(MESH:Autophagosomes) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) |
| pmid:24027553 | bp(GO:"vacuolar acidification") increases bp(GO:autophagy) |
| pmid:24027553 | bp(GO:"vacuolar acidification") decreases a(MESH:Autophagosomes) |
| pmid:24027553 | composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) |
| pmid:24027553 | composite(p(HGNC:CTSD), p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) |
| pmid:24027553 | a(MESH:"3-methyladenine") decreases bp(GO:"autophagosome assembly") |
| pmid:24027553 | a(MESH:"3-methyladenine") increases p(HGNC:MAPT) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.P301L")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases a(HBP:"Tau aggregates") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) |
| pmid:24027553 | bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HBP:"Tau C3")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HBP:"Tau C3") |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HBP:"Tau epitope, AT8") |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HBP:"Tau epitope, PHF1") |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HBP:"Tau epitope, 12E8") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers")) |
| pmid:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:Trehalose) decreases a(HBP:"Tau aggregates") |
| pmid:24027553 | a(MESH:Trehalose) decreases p(HGNC:MAPT) |
| pmid:24027553 | composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:16176937 | p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) |
| pmid:16176937 | p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) |
| pmid:20133804 | act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") |
| pmid:20133804 | act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") |
| pmid:28784767 | p(HBP:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) |
| pmid:28784767 | p(HBP:"Tau epitope, AT8") increases a(HBP:"Tau aggregates") |
| pmid:18239272 | p(HBP:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") |
| pmid:18239272 | p(HBP:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") |
| pmid:18239272 | p(HBP:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") |
| pmid:28784767 | p(HBP:"Tau epitope, AT8") increases bp(HBP:"Tau aggregates") |
| pmid:27087442 | p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25") |
| pmid:25125464 | p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1) |
| pmid:19459590 | p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:19459590 | p(HBP:"Tau epitope, AT8") decreases act(p(HGNC:MAPT)) |
| pmid:22833681 | p(HBP:"Tau epitope, AT8") increases complex(p(HGNC:FYN), p(MGI:Mapt)) |
| pmid:22253473 | p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) |
| pmid:20869593 | p(HBP:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(Ac)) |
| pmid:20869593 | p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:19623258 | p(HBP:"Tau epitope, AT8") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pmid:24033439 | p(HBP:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:24033439 | p(HBP:"Tau epitope, PHF1") increases a(GO:"neurofibrillary tangle") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"Tau isoform F (441 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:29686391 | a(HBP:"Tau isoform F (441 aa)") positiveCorrelation tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau isoform F (441 aa)") |
| pmid:29686391 | a(HBP:"Tau isoform F (441 aa)") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(CHEBI:heparin) |
| pmid:29686391 | tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(HBP:"6-O-sulfated heparin") |
| pmid:27574109 | bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:pretangles) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(GO:"Pick body") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:29191965 | p(HBP:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion) |
| pmid:17493042 | p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | a(HBP:"Tau isoform B (381 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform E (412 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:pretangles) association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:pretangles) association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:pretangles) association p(HGNC:MAPT) |
| pmid:23407988 | a(HBP:pretangles) increases complex(GO:"dendritic tree") |
| pmid:18239272 | a(HBP:pretangles) association p(HGNC:TTBK1) |
| pmid:18239272 | a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:18239272 | a(HBP:pretangles) isA a(GO:"neurofibrillary tangle") |
| pmid:27574109 | a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Braak_Stage I") association p(HGNC:MAPT) |
| pmid:28176663 | a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pmid:27574109 | composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(Ph)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26195256 | deg(a(HBP:"amyloid-beta derived diffusible ligands")) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(GO:"extracellular region"), toLoc(MESH:"Intracellular Space")) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:"Extracellular Fluid")) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Cardiovascular System")) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymphatic System")) decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:18096814 | a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:18096814 | a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:30985105 | p(RGD:Mapt, pmod(Ph)) negativeCorrelation p(RGD:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:20133804 | p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) association a(MESH:Exosomes) |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) partOf p(HBP:"Tau epitope, AT270") |
| pmid:28176663 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") |
| pmid:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(CHEBI:LY294002) decreases bp(GO:"signal transduction") |
| pmid:17403556 | a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) |
| pmid:27671637 | a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:27671637 | a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(HBP:Neurodegeneration) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory) |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau fibrils") |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau oligomers") |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(HBP:"Tau oligomers", var("p.Lys280del")) |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species") |
| pmid:28528849 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:27671637 | a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) |
| pmid:27671637 | p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) |
| pmid:27671637 | a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:22156579 | a(HBP:"Tau epitope, 12E8") positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:25031639 | a(HBP:"Tau epitope, 12E8") positiveCorrelation act(p(HGNC:HDAC6)) |
| pmid:25031639 | a(HBP:"Tau epitope, 12E8") partOf p(HBP:"KXGS motif") |
| pmid:25031639 | a(HBP:"Tau epitope, 12E8") negativeCorrelation act(p(HGNC:STUB1)) |
| pmid:27671637 | a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:22764226 | a(HBP:"Tau epitope, PHF1") negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation a(HBP:"Tau epitope, 12E8") |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:25125464 | a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1) |
| pmid:19459590 | a(HBP:"Tau epitope, PHF1") decreases act(p(HGNC:MAPT)) |
| pmid:25031639 | a(HBP:"Tau epitope, PHF1") positiveCorrelation deg(p(HGNC:MAPT)) |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:27671637 | a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:22833681 | a(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:27671637 | a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:27671637 | composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process") |
| pmid:27671637 | p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) |
| pmid:27671637 | p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") |
| pmid:27671637 | p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") |
| pmid:27671637 | a(CHEBI:adenosine) increases act(p(MGI:Adora1)) |
| pmid:27671637 | a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) |
| pmid:27671637 | a(CHEBI:adenosine) decreases act(a(GO:presynapse)) |
| pmid:27671637 | a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:21882945 | a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:27671637 | act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) |
| pmid:27671637 | act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) |
| pmid:27671637 | act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:27671637 | a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) |
| pmid:27671637 | a(PUBCHEM:64627) increases act(a(MESH:Neurons)) |
| pmid:27671637 | a(PUBCHEM:64627) increases act(a(GO:presynapse)) |
| pmid:27671637 | a(PUBCHEM:64627) increases a(GO:"dendritic spine") |
| pmid:27671637 | a(PUBCHEM:64627) decreases a(MESH:Axons) |
| pmid:27671637 | a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates") |
| pmid:27671637 | a(MESH:"BSc 3094") increases act(a(GO:presynapse)) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons)) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:24760868 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) |
| pmid:29191965 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau oligomers") |
| pmid:22486774 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(HBP:"Tau oligomers") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA) |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:24406748 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:23294633 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:22253473 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(GO:"neurofibrillary tangle") |
| pmid:28784767 | p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates") |
| pmid:28784767 | p(HGNC:MAPT, var("pGly207Val")) increases bp(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") |
| pmid:28784767 | p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn") |
| pmid:28784767 | act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) |
| pmid:25673844 | p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) equivalentTo p(HBP:"Tau epitope, AT8") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) |
| pmid:29590627 | a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) |
| pmid:28420982 | a(CHEBI:dextran) association a(HBP:"Tau aggregates") |
| pmid:29590627 | a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:heparin) causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:25887395 | a(CHEBI:heparin) decreases a(HBP:"Tau aggregates") |
| pmid:29988016 | a(CHEBI:heparin) negativeCorrelation a(HBP:"Tau aggregates") |
| pmid:30108137 | a(CHEBI:heparin) decreases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:25887395 | a(CHEBI:heparin) decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) |
| pmid:29988016 | a(CHEBI:heparin) increases act(p(HGNC:MAPT, var("?"))) |
| pmid:29686391 | a(CHEBI:heparin) association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:heparin) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26751493 | a(CHEBI:heparin) association p(HBP:"Tau aggregates") |
| pmid:27601475 | a(CHEBI:heparin) increases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:29590627 | a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29686391 | a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") |
| pmid:29590627 | a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") |
| pmid:29590627 | a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") |
| pmid:29590627 | bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) |
| pmid:29590627 | bp(GO:"actin filament polymerization") increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:24760868 | bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") |
| pmid:27041503 | bp(GO:"actin filament polymerization") negativeCorrelation bp(MESH:"Long-Term Potentiation") |
| pmid:29590627 | bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") |
| pmid:29590627 | bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") |
| pmid:30108137 | bp(GO:macropinocytosis) increases act(a(MESH:Astrocytes)) |
| pmid:30108137 | bp(GO:macropinocytosis) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26751493 | bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:26751493 | bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:26751493 | bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:29590627 | composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) increases path(HBP:neurotoxicity) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases p(HBP:"4R tau") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases p(HBP:"3R tau") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases bp(GO:memory) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition) |
| pmid:11606569 | p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) |
| pmid:11606569 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif") |
| pmid:11606569 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(HBP:"Tau aggregates") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(HBP:"Tau aggregates") |
| pmid:22611162 | p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Val277Met")) increases path(HBP:neurotoxicity) |
| pmid:22611162 | p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development") |
| pmid:22611162 | a(PUBCHEM:25096749) increases bp(GO:locomotion) |
| pmid:22611162 | a(PUBCHEM:25096749) decreases a(HBP:"Tau aggregates") |
| pmid:22611162 | a(HBP:bb14) increases bp(GO:locomotion) |
| pmid:22611162 | a(HBP:cmp16) decreases a(HBP:"Tau fibrils") |
| pmid:22611162 | a(HBP:cmp16) increases bp(GO:locomotion) |
| pmid:22611162 | a(HBP:cmp16) decreases path(HP:Neurodegeneration) |
| pmid:24760868 | p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:17187063 | complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration) |
| pmid:24760868 | a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") |
| pmid:24760868 | a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") |
| pmid:24760868 | a(MESH:jasplakinolide) increases p(HGNC:MAPT) |
| pmid:24760868 | a(MESH:jasplakinolide) increases p(HGNC:GRIA1) |
| pmid:24760868 | a(MESH:jasplakinolide) decreases p(HGNC:FYN) |
| pmid:24760868 | a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") |
| pmid:24760868 | a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") |
| pmid:24760868 | a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(MGI:Wnt3) |
| pmid:21734277 | p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau") increases act(p(MESH:"Protein Phosphatase 1")) |
| pmid:21734277 | p(HBP:"6D tau") increases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pmid:21734277 | act(p(HBP:"6D tau")) association p(HBP:"6D tau", frag("2_18")) |
| pmid:21734277 | p(HBP:"6P tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6P tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) association act(p(HBP:"6D tau")) |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) association bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) decreases p(HBP:"endogenous axoplasmic phosphatases") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) association p(HBP:TNT1) |
| pmid:21734277 | act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") |
| pmid:21734277 | act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") |
| pmid:21734277 | a(HBP:"I-2") increases act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | a(HBP:"ING-135") increases act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | p(HBP:"AT8 tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"AT8 tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:"AT8 tau") causesNoChange act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | p(HBP:"AT8 tau", pmod(Ph)) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:21734277 | p(HBP:"AT8 tau", pmod(Ph)) association path(MESH:Tauopathies) |
| pmid:21734277 | p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:TNT1) association p(HBP:"6D tau", frag("2_18")) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HBP:"Tau fibrils", var("p.Lys280del")) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases sec(p(HGNC:CYCS)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) |
| pmid:28528849 | p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse) |
| pmid:29238289 | p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT)) |
| pmid:23702978 | tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) |
| pmid:23702978 | tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) |
| pmid:28528849 | p(HGNC:DBN1) increases bp(GO:"synapse assembly") |
| pmid:28528849 | act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") |
| pmid:23528736 | p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HBP:"UBB+1", pmod(Ub)) decreases bp(GO:"protein deubiquitination") |
| pmid:23528736 | p(HBP:"UBB+1", pmod(Ub)) decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | p(HBP:"UBB+1", pmod(Ub)) regulates path(HP:Neurodegeneration) |
| pmid:23528736 | p(HBP:"UBB+1", pmod(Ub)) increases bp(MESH:"Stress, Physiological") |
| pmid:23528736 | p(HBP:"UBB+1", pmod(Ub)) increases act(p(HGNC:TP53)) |
| pmid:23528736 | p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") |
| pmid:23528736 | p(HGNC:RNF182) association path(MESH:"Alzheimer Disease") |
| pmid:23528736 | complex(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) |
| pmid:14612456 | p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:14612456 | p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pmid:23528736 | p(HGNC:BCL2L11, pmod(Ph)) increases bp(GO:autophagy) |
| pmid:23528736 | path(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | p(HGNC:DCTN4) decreases a(HBP:"Tau aggregates") |
| pmid:23528736 | a(CHEBI:"lithium atom") increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:"lithium atom") decreases path(HP:"Neurofibrillary tangles") |
| pmid:30108137 | r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:30108137 | r(HGNC:TFEB) increases path(MESH:Dementia) |
| pmid:30108137 | r(HGNC:TFEB) decreases bp(GO:cognition) |
| pmid:30108137 | act(p(MGI:Tfeb)) association path(MESH:Tauopathies) |
| pmid:30108137 | p(MGI:Tfeb) decreases path(MESH:Tauopathies) |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Lamp1) |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Ctsa) |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Ctsb) |
| pmid:30108137 | p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) |
| pmid:30108137 | p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) |
| pmid:30108137 | p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:30108137 | p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:30108137 | p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:30108137 | p(MGI:Tfeb) increases a(HBP:"Tau fibrils", loc(GO:lysosome)) |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Tfeb, loc(GO:nucleus)) |
| pmid:30108137 | p(MGI:Tfeb, loc(GO:nucleus)) increases act(p(MGI:Tfeb)) |
| pmid:30108137 | p(MGI:Tfeb) increases bp(MESH:Phagocytosis) |
| pmid:30108137 | p(MGI:Tfeb) increases r(MGI:Lamp1) |
| pmid:30108137 | p(MGI:Tfeb) increases bp(MESH:Proteolysis) |
| pmid:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 199), pmod(Ph, Ser, 202), pmod(Ph, Ser, 208)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:30108137 | p(MGI:Tfeb) decreases path(MESH:Gliosis) |
| pmid:30108137 | p(MGI:Tfeb) decreases a(GO:"neurofibrillary tangle") |
| pmid:30108137 | a(CHEBI:"torin 1") decreases act(p(FPLX:mTORC1)) |
| pmid:30108137 | composite(a(CHEBI:"torin 1"), p(MGI:Tfeb)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 202)) association p(HGNC:SYK, pmod(Ph)) |
| pmid:29221819 | p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk) |
| pmid:25887395 | p(HGNC:MAPT, frag("243_375")) increases a(HBP:"Tau fibrils") |
| pmid:25887395 | complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25887395 | complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(HBP:"Tau aggregates") |
| pmid:29980653 | p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29980653 | p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29980653 | p(HGNCGENEFAMILY:Syndecans) association a(MESH:Glycosaminoglycans) |
| pmid:29980653 | p(HGNCGENEFAMILY:Syndecans) increases tloc(a(HBP:"alpha-synuclein fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:25887395 | a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) |
| pmid:25887395 | a(CHEBI:"sodium chlorate") decreases p(HGNCGENEFAMILY:Syndecans, pmod(Sulf)) |
| pmid:25887395 | a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates") |
| pmid:29980653 | p(HGNCGENEFAMILY:Syndecans, pmod(Sulf)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange a(HBP:"Tau aggregates") |
| pmid:22817713 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") |
| pmid:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25887395 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") |
| pmid:29988016 | complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") |
| pmid:25887395 | complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases a(HBP:"Tau aggregates") |
| pmid:25887395 | complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:29988016 | p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")), p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala"))) |
| pmid:29988016 | a(PUBCHEM:100984821) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) |
| pmid:21882945 | a(CHEBI:rhodanine) decreases a(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates") |
| pmid:21882945 | a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") |
| pmid:29191965 | a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") |
| pmid:29191965 | a(HBP:"Phenylthiazolyl-hydrazide") increases bp(GO:locomotion) |
| pmid:21882945 | a(PUBCHEM:53789478) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:anthraquinone) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:benzothiazoles) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:phenothiazines) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:polyphenol) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) |
| pmid:21882945 | a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) |
| pmid:21882945 | a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) |
| pmid:21882945 | a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) |
| pmid:21882945 | p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90)) |
| pmid:21882945 | a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pmid:21882945 | a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) |
| pmid:21882945 | a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) |
| pmid:21882945 | a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:celastrol) association act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:celastrol) decreases act(p(HGNC:CDC37)) |
| pmid:29311797 | a(CHEBI:celastrol) decreases p(HGNC:MAPT) |
| pmid:21882945 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:21882945 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pmid:21882945 | complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pmid:20071522 | complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau oligomers") |
| pmid:21882945 | complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") |
| pmid:21882945 | complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) |
| pmid:21882945 | complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) |
| pmid:21882945 | complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(GO:"cell cycle") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") |
| pmid:30126037 | bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") |
| pmid:30126037 | bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") |
| pmid:30126037 | bp(GO:"cellular senescence") association p(MGI:Cdkn2a) |
| pmid:30126037 | bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"neuron death") |
| pmid:30126037 | bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") |
| pmid:30126037 | bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) |
| pmid:30126037 | bp(GO:"cellular senescence") association path(MESH:Tauopathies) |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") |
| pmid:30126037 | bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins)) |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") |
| pmid:30126037 | bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) |
| pmid:30126037 | bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(GO:"inflammatory response") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(HBP:HBP00037) |
| pmid:29221819 | bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:30126037 | p(MGI:Cdkn2a) association bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") |
| pmid:30126037 | p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") |
| pmid:30126037 | path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) |
| pmid:30126037 | path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") |
| pmid:30126037 | p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Glb1) positiveCorrelation a(HP:brain) |
| pmid:30126037 | a(HP:brain) positiveCorrelation p(MGI:Glb1) |
| pmid:30126037 | bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") |
| pmid:30126037 | path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) |
| pmid:30126037 | path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases a(GO:"neurofibrillary tangle") |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases path(MESH:"Plaque, Amyloid") |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases a(GO:"neurofibrillary tangle") |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases path(MESH:"Plaque, Amyloid") |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases a(MESH:"Neuropil Threads") |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau46") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau46") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:25995053 | p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") |
| pmid:25125464 | p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh) |
| pmid:26095350 | p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25331948 | a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(MESH:Brain), toLoc(MESH:Plasma)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(Ph)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC)) |
| pmid:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) |
| pmid:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) |
| pmid:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK)) |
| pmid:25331948 | a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK)) |
| pmid:25331948 | composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF)) |
| pmid:25331948 | composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | p(HGNC:SYK) increases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | act(p(HGNC:SYK)) increases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | act(p(HGNC:SYK)) decreases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) |
| pmid:25331948 | act(p(HGNC:SYK)) increases sec(p(HBP:"sAPP-beta")) |
| pmid:28877763 | p(HGNC:SYK) regulates p(HBP:"sAPP-beta") |
| pmid:25331948 | act(p(HGNC:SYK)) increases r(HGNC:BACE1) |
| pmid:25331948 | act(p(HGNC:SYK)) increases p(HGNC:BACE1) |
| pmid:28877763 | p(HGNC:SYK) regulates p(HGNC:BACE1) |
| pmid:25331948 | act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(Ph)) |
| pmid:25331948 | p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | act(p(HGNC:SYK), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26631930 | p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:25331948 | act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B)) |
| pmid:28877763 | p(HGNC:SYK) increases act(p(HGNC:GSK3B)) |
| pmid:25331948 | act(p(HGNC:SYK)) positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:25331948 | p(HGNC:SYK) decreases act(p(FPLX:PKA)) |
| pmid:25331948 | p(HGNC:SYK) decreases act(p(FPLX:PKA)) |
| pmid:25331948 | p(HGNC:SYK) increases p(FPLX:PKA, pmod(Ph, Tyr, 330)) |
| pmid:29191965 | p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:28877763 | act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:28877763 | act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:28877763 | act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(HBP:misfolded)) |
| pmid:28877763 | act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:misfolded)) |
| pmid:28877763 | p(HGNC:SYK) increases p(HGNC:MAPT) |
| pmid:28877763 | p(HGNC:SYK) regulates deg(p(HGNC:MAPT)) |
| pmid:28877763 | p(HGNC:SYK) causesNoChange r(HGNC:MAPT) |
| pmid:28877763 | act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:26501932 | p(HGNC:SYK) partOf a(HBP:pretangles) |
| pmid:26501932 | p(HGNC:SYK) partOf a(HBP:"GVD bodies") |
| pmid:25331948 | act(p(HGNC:SYK)) negativeCorrelation p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:23702978 | act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) |
| pmid:25331948 | act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | a(PUBCHEM:71656932) decreases act(p(HGNC:BTK)) |
| pmid:25331948 | a(PUBCHEM:71656932) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases sec(p(HBP:"sAPP-beta")) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38")) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(Ph, Tyr, 231)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(Ph, Tyr, 231)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(Ph, Ser, 473)) |
| pmid:25331948 | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(Ph)) |
| pmid:28877763 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) |
| pmid:28877763 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) |
| pmid:28877763 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK)) |
| pmid:28877763 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation act(p(HGNC:SYK)) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) association a(HBP:"paired helical filaments") |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(FPLX:PKA, pmod(Ph, Tyr, 330)) decreases act(p(FPLX:PKA)) |
| pmid:22419736 | p(HGNC:AK1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22419736 | p(HGNC:AK1) increases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:22419736 | p(HGNC:AK1) increases p(HBP:"Tau aggregates") |
| pmid:22419736 | p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | p(HGNC:AK1) negativeCorrelation p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:22419736 | p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) |
| pmid:22419736 | p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) |
| pmid:22419736 | p(HGNC:AK1) regulates act(p(FPLX:AMPK)) |
| pmid:22419736 | p(HGNC:AK1) increases act(p(HGNC:MAPT)) |
| pmid:22419736 | p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") |
| pmid:22419736 | p(HGNC:AK1) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22419736 | p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(MGI:Ak1) |
| pmid:22419736 | p(MGI:Ak1) positiveCorrelation p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) |
| pmid:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 231)) |
| pmid:22419736 | p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Thr, 235)) |
| pmid:22419736 | p(MESH:"Acetyl-CoA Carboxylase") association act(p(FPLX:AMPK)) |
| pmid:22419736 | p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:22419736 | p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | a(CHEBI:dorsomorphin) decreases act(p(FPLX:AMPK)) |
| pmid:22419736 | a(CHEBI:dorsomorphin) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | composite(p(HGNC:AK1), p(HGNC:MAPT)) increases path(MESH:"Retinal Degeneration") |
| pmid:22419736 | path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:30640040 | act(p(HGNC:FLT1)) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | act(p(HGNC:KDR)) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | p(HGNC:KDR) association a(PUBCHEM:11154925) |
| pmid:30640040 | p(HGNC:KDR) association a(PUBCHEM:11234052) |
| pmid:30640040 | act(p(FPLX:TGFB)) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | act(p(FPLX:HDAC)) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | p(FPLX:HDAC) association a(PUBCHEM:9865515) |
| pmid:21427723 | act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac)) |
| pmid:30640040 | a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC)) |
| pmid:30640040 | a(PUBCHEM:9804992) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:9865515) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:9865515) association p(FPLX:HDAC) |
| pmid:30640040 | a(PUBCHEM:4261) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:4261) association p(HGNC:HDAC1) |
| pmid:30640040 | a(PUBCHEM:4261) association p(HGNC:HDAC3) |
| pmid:30640040 | a(PUBCHEM:24756910) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:24756910) association p(FPLX:"HDAC_I") |
| pmid:30640040 | a(PUBCHEM:24756910) association p(FPLX:"HDAC_II") |
| pmid:30640040 | a(PUBCHEM:24756910) association p(HGNC:EGFR) |
| pmid:30640040 | a(PUBCHEM:24756910) association p(HGNC:ERBB2) |
| pmid:30640040 | a(PUBCHEM:448537) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:448537) association p(FPLX:ESR) |
| pmid:30640040 | a(PUBCHEM:5318517) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:5318517) association p(FPLX:NFkappaB) |
| pmid:30640040 | a(PUBCHEM:5318517) association p(FPLX:Actin) |
| pmid:30640040 | a(PUBCHEM:71295844) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:71295844) association p(HGNC:GSK3A) |
| pmid:30640040 | a(PUBCHEM:71295844) association p(HGNC:GSK3B) |
| pmid:30640040 | a(PUBCHEM:42640) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:42640) association p(HGNC:MDM4) |
| pmid:30640040 | a(PUBCHEM:2746) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:2746) association p(FPLX:"HDAC_I") |
| pmid:30640040 | a(PUBCHEM:71729974) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases") |
| pmid:30640040 | a(PUBCHEM:53340666) increases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:53340666) association p(HGNC:HDAC6) |
| pmid:30640040 | a(PUBCHEM:11154925) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:11154925) association p(HGNC:KDR) |
| pmid:30640040 | a(PUBCHEM:4521392) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:4521392) association p(HGNC:TGFBR1) |
| pmid:30640040 | a(PUBCHEM:11234052) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:11234052) association p(HGNC:KDR) |
| pmid:30640040 | a(PUBCHEM:46209426) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:46209426) association p(FPLX:ROCK) |
| pmid:30640040 | a(PUBCHEM:6321424) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory")) |
| pmid:30640040 | a(PUBCHEM:11570805) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:11570805) association p(HGNC:MAPK14) |
| pmid:30640040 | a(PUBCHEM:156422) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:156422) association p(HGNC:MAPK14) |
| pmid:30640040 | a(PUBCHEM:9880) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:9880) decreases act(p(HGNC:AR)) |
| pmid:30640040 | a(PUBCHEM:3033825) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:3033825) association p(HGNC:TNC) |
| pmid:30640040 | a(PUBCHEM:5311272) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase")) |
| pmid:30640040 | a(PUBCHEM:49806720) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:49806720) decreases act(p(HGNC:ALK)) |
| pmid:30640040 | a(PUBCHEM:9839311) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:9839311) association p(HGNC:SELE) |
| pmid:30640040 | a(PUBCHEM:9839311) association p(HGNC:ICAM1) |
| pmid:30640040 | a(PUBCHEM:447966) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:447966) association p(HGNC:TGFBR1) |
| pmid:30640040 | a(PUBCHEM:11655119) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:11655119) association p(HGNC:TGFBR1) |
| pmid:30640040 | a(PUBCHEM:11655119) association p(HGNC:TGFBR2) |
| pmid:30640040 | a(PUBCHEM:10435235) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase")) |
| pmid:30640040 | a(PUBCHEM:5833) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:5833) association p(HGNC:AR) |
| pmid:30640040 | a(PUBCHEM:10341154) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:10341154) association p(HGNC:MAPK14) |
| pmid:30640040 | a(PUBCHEM:4878) decreases a(HBP:"Tau aggregates") |
| pmid:30640040 | a(PUBCHEM:4878) association p(HGNC:LCK) |
| pmid:30640040 | a(PUBCHEM:4878) association p(HGNC:FYN) |
| pmid:30640040 | p(HGNC:HDAC1) association a(PUBCHEM:4261) |
| pmid:30640040 | p(HGNC:HDAC3) association a(PUBCHEM:4261) |
| pmid:28771976 | p(HGNC:HDAC3) increases act(a(CL:0000129)) |
| pmid:28771976 | p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") |
| pmid:28771976 | p(HGNC:HDAC3) decreases a(GO:"dendritic spine") |
| pmid:30640040 | p(FPLX:"HDAC_I") association a(PUBCHEM:24756910) |
| pmid:30640040 | p(FPLX:"HDAC_I") association a(PUBCHEM:2746) |
| pmid:30640040 | p(FPLX:"HDAC_II") association a(PUBCHEM:24756910) |
| pmid:30640040 | p(HGNC:ERBB2) association a(PUBCHEM:24756910) |
| pmid:30640040 | p(FPLX:ESR) association a(PUBCHEM:448537) |
| pmid:30640040 | p(FPLX:Actin) association a(PUBCHEM:5318517) |
| pmid:22033876 | act(p(FPLX:Actin)) association a(HBP:"proline-rich domain") |
| pmid:30640040 | p(HGNC:MDM4) association a(PUBCHEM:42640) |
| pmid:30640040 | p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974) |
| pmid:30640040 | p(HGNC:TGFBR1) association a(PUBCHEM:4521392) |
| pmid:30640040 | p(HGNC:TGFBR1) association a(PUBCHEM:447966) |
| pmid:30640040 | p(HGNC:TGFBR1) association a(PUBCHEM:11655119) |
| pmid:30640040 | p(FPLX:ROCK) association a(PUBCHEM:46209426) |
| pmid:30640040 | p(HGNC:TNC) association a(PUBCHEM:3033825) |
| pmid:30640040 | p(HGNC:SELE) association a(PUBCHEM:9839311) |
| pmid:30640040 | p(HGNC:ICAM1) association a(PUBCHEM:9839311) |
| pmid:30640040 | p(HGNC:TGFBR2) association a(PUBCHEM:11655119) |
| pmid:29191965 | composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis) |
| pmid:29191965 | bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") |
| pmid:29191965 | composite(p(HGNC:MAPT), p(HGNC:SPTB)) increases a(GO:"microtubule cytoskeleton") |
| pmid:29191965 | composite(p(HGNC:KLC3), p(HGNC:MAPT)) increases complex(p(HGNC:KLC3), p(HGNC:MAPT)) |
| pmid:29191965 | complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle") |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(HBP:Neurodegeneration) |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion) |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival) |
| pmid:29191965 | p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(HBP:Neurodegeneration) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death") |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Thr, 205)) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 262)) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 400)) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 404)) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 409)) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 422)) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule) |
| pmid:29191965 | p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death") |
| pmid:29191965 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases bp(GO:locomotion) |
| pmid:29191965 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases a(MESH:"Motor Neurons") |
| pmid:29191965 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis) |
| pmid:29191965 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") |
| pmid:29191965 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons") |
| pmid:29191965 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse) |
| pmid:29191965 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion") |
| pmid:25374103 | p(HBP:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death") |
| pmid:25374103 | p(HBP:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | p(HBP:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) association bp(GO:"cell aging") |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) |
| pmid:29191965 | p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") |
| pmid:29191965 | bp(GO:"cell aging") association p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) |
| pmid:29191965 | complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle")) |
| pmid:29191965 | complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion) |
| pmid:29191965 | p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling") |
| pmid:29191965 | a(GO:"cell body") association p(HGNC:MAPT) |
| pmid:29191965 | p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | composite(p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")), p(HGNC:CDK5)) decreases a(MESH:Neurons) |
| pmid:29191965 | a(PUBCHEM:6475963) decreases a(HBP:"Tau aggregates") |
| pmid:29191965 | a(PUBCHEM:6475963) increases bp(GO:locomotion) |
| pmid:29191965 | a(PUBCHEM:66766582) decreases path(HBP:Neurodegeneration) |
| pmid:29191965 | a(CHEBI:azaperone) increases bp(GO:locomotion) |
| pmid:29191965 | a(CHEBI:azaperone) decreases p(HGNC:MAPT) |
| pmid:29191965 | a(CHEBI:azaperone) decreases path(HBP:Neurodegeneration) |
| pmid:29191965 | a(CHEBI:ethosuximide) increases bp(MESH:Longevity) |
| pmid:29191965 | a(CHEBI:ethosuximide) increases bp(GO:locomotion) |
| pmid:29191965 | a(CHEBI:ethosuximide) association bp(GO:"insulin receptor signaling pathway") |
| pmid:29191965 | p(HGNC:WNT2) association path(MESH:Tauopathies) |
| pmid:29191965 | p(HGNC:TTBK2) association path(MESH:Tauopathies) |
| pmid:17620722 | p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) |
| pmid:17620722 | p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 210)) |
| pmid:25673844 | p(HGNC:TTBK2) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:25473830 | p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) |
| pmid:25473830 | p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pmid:27607061 | p(HGNC:TTBK2) decreases surf(p(HGNC:GRIK2)) |
| pmid:26323690 | p(HGNC:TTBK2) increases p(HGNC:KIF2A, pmod(Ph)) |
| pmid:26323690 | p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) |
| pmid:26323690 | p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) |
| pmid:26323690 | p(HGNC:TTBK2) association p(HGNC:CEP164) |
| pmid:26323690 | act(p(HGNC:TTBK2)) positiveCorrelation p(HGNC:CEP164) |
| pmid:26323690 | p(HGNC:TTBK2) association p(HGNC:MAPRE1) |
| pmid:26323690 | act(p(HGNC:TTBK2)) decreases p(HGNC:CCP110) |
| pmid:26323690 | act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph)) |
| pmid:26323690 | act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph)) |
| pmid:29191965 | p(HGNC:TAOK1) association path(MESH:Tauopathies) |
| pmid:25974414 | act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) |
| pmid:29191965 | p(HGNC:CTSE) association path(MESH:Tauopathies) |
| pmid:29191965 | p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH)) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies) |
| pmid:29191965 | p(HGNC:ZC3H14) decreases bp(GO:locomotion) |
| pmid:29191965 | p(HGNC:ZC3H14) increases path(HBP:Neurodegeneration) |
| pmid:29191965 | p(HGNC:ZC3H14) increases p(HGNC:MAPT) |
| pmid:29191965 | p(HGNC:ZC3H14) increases path(MESH:Tauopathies) |
| pmid:29191965 | p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") |
| pmid:29191965 | bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases") |
| pmid:29191965 | bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(HBP:misfolding)) |
| pmid:29191965 | p(HGNC:DDC) increases a(CHEBI:dopamine) |
| pmid:29191965 | p(HGNC:DDC) increases a(CHEBI:serotonin) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(HBP:Neurodegeneration) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies) |
| pmid:29191965 | p(HGNC:GCH1) regulates a(CHEBI:dopamine) |
| pmid:29191965 | p(HGNC:GCH1) regulates a(CHEBI:serotonin) |
| pmid:29191965 | p(HGNC:GCH1) regulates act(p(HGNC:DDC)) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies) |
| pmid:29191965 | p(HGNC:TPH1) regulates a(CHEBI:dopamine) |
| pmid:29191965 | p(HGNC:TPH1) regulates a(CHEBI:serotonin) |
| pmid:29191965 | p(HGNC:TPH1) regulates act(p(HGNC:DDC)) |
| pmid:29191965 | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies) |
| pmid:29686391 | a(HBP:"sonicated tau fibrils") positiveCorrelation tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"sonicated tau fibrils") |
| pmid:29686391 | g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") |
| pmid:29686391 | g(HGNC:TP53) decreases bp(GO:"cell proliferation") |
| pmid:29686391 | bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) |
| pmid:29686391 | bp(GO:"mitotic G1 phase") regulates tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:CDK6) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:palbociclib) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) |
| pmid:29686391 | a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) |
| pmid:29686391 | p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") |
| pmid:29686391 | p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) |
| pmid:29686391 | bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) |
| pmid:29686391 | p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") |
| pmid:29686391 | p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:HS6ST1) increases a(HBP:"6-O-sulfated heparin") |
| pmid:29686391 | p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29980653 | a(HBP:"6-O-sulfated heparin") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(MESH:"Heparitin Sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin") |
| pmid:29686391 | a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:"chondroitin sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:"chondroitin sulfate") causesNoChange tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF1) decreases a(HBP:"6-O-sulfated heparin") |
| pmid:29686391 | p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF2) decreases a(HBP:"6-O-sulfated heparin") |
| pmid:30985105 | p(HGNC:OGT) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | p(HGNC:OGT) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | p(HGNC:OGT) association bp(GO:"brain development") |
| pmid:30985105 | act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30985105 | act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30985105 | act(p(HGNC:OGT)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30985105 | act(p(HGNC:OGT)) increases p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | act(p(HGNC:OGT)) decreases a(HBP:"Tau aggregates") |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"cellular glucose homeostasis") |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation a(CHEBI:glucose) |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation act(p(HGNC:OGA)) |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"protein phosphorylation") |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"protein phosphorylation") |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"glucose metabolic process") |
| pmid:30985105 | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation deg(a(GO:"neurofibrillary tangle")) |
| pmid:30985105 | p(HGNC:OGA) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | act(p(HGNC:OGA)) negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | act(p(HGNC:OGA)) decreases p(HGNC:MTOR, pmod(Ph)) |
| pmid:30985105 | act(p(HGNC:OGA)) decreases p(FPLX:AKT, pmod(Ph)) |
| pmid:30985105 | act(p(HGNC:OGA)) decreases bp(GO:autophagy) |
| pmid:30985105 | act(p(HGNC:OGA)) decreases p(HGNC:HTT, var("?")) |
| pmid:30985105 | bp(GO:"cellular glucose homeostasis") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | path(MESH:Hyperglycemia) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) |
| pmid:30985105 | a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) |
| pmid:30985105 | a(PUBCHEM:9576811) decreases act(a(MESH:Hexosaminidases)) |
| pmid:30985105 | a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(PUBCHEM:9576811) increases sec(p(HBP:"sAPP-alpha")) |
| pmid:30985105 | a(PUBCHEM:9576811) decreases sec(a(CHEBI:"amyloid-beta polypeptide 40")) |
| pmid:30985105 | a(PUBCHEM:9576811) increases tloc(p(HGNC:APP), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"plasma membrane")) |
| pmid:30985105 | a(PUBCHEM:9576811) decreases tloc(p(HGNC:APP), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:30985105 | a(PUBCHEM:9576811) increases bp(HBP:"APP processing") |
| pmid:30985105 | a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) |
| pmid:30985105 | a(PUBCHEM:135566354) increases p(HGNC:SNCA) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates") |
| pmid:30985105 | a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates") |
| pmid:30985105 | a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates") |
| pmid:30985105 | a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates", loc(MESH:Brain)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(Ph, Thr, 231)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(Ph, Ser, 396)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(Ph, Ser, 422)) |
| pmid:30985105 | a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases bp(GO:"neuron death") |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Ser, 205)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 626)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 356)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:30985105 | a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 400)) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) |
| pmid:30985105 | a(PUBCHEM:135566354) increases bp(GO:cognition) |
| pmid:30985105 | a(PUBCHEM:135566354) decreases a(CHEBI:"amyloid-beta") |
| pmid:30985105 | a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(Ph)) |
| pmid:30985105 | bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | deg(a(HBP:"Dopaminergic cell groups")) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:30985105 | deg(a(HBP:"Dopaminergic cell groups")) negativeCorrelation bp(GO:"motor behavior") |
| pmid:30985105 | complex(p(HGNC:SNCA), p(HGNC:SNCA)) association path(MESH:"Parkinson Disease") |
| pmid:30985105 | complex(a(CHEBI:phospholipid), p(HGNC:SNCA)) increases bp(GO:"SNARE complex assembly") |
| pmid:30985105 | complex(p(HGNC:SNCA), p(HGNC:VAMP2)) increases bp(GO:"SNARE complex assembly") |
| pmid:30985105 | p(HGNC:SNCA, frag("?_*")) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HBP:"alpha-synuclein fibrils", frag("?")) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:SNCA, pmod(Ph)) increases path(MESH:"Parkinson Disease") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation")) increases a(HBP:"alpha-synuclein oligomers") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) decreases complex(p(HGNC:SNCA), p(HGNC:SNCA)) |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) decreases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Ser, 87)) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 75)) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 81)) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Ser, 87), pmod(HBP:"O-GlcNAcylation", Thr, 75), pmod(HBP:"O-GlcNAcylation", Thr, 81)) causesNoChange a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:SNCA, frag("68_77")) increases a(HBP:"alpha-synuclein aggregates") |
| pmid:30985105 | p(HGNC:MTOR, pmod(Ph)) decreases bp(GO:autophagy) |
| pmid:30985105 | act(p(MGI:Oga)) decreases bp(GO:autophagy) |
| pmid:30985105 | act(p(RGD:Oga)) decreases bp(GO:autophagy) |
| pmid:30985105 | p(RGD:Mapt, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(RGD:Mapt, pmod(Ph)) |
| pmid:30985105 | p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:30985105 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:28877763 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases act(p(MGI:Syk)) |
| pmid:28877763 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") |
| pmid:26458742 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25143394 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) |
| pmid:25143394 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) |
| pmid:25143394 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) |
| pmid:23134599 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(RGD:Ppp2ca) |
| pmid:30985105 | bp(GO:"glucose metabolic process") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:16630055 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau oligomers") |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau oligomers") |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau aggregates") |
| pmid:19732809 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:30985105 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau oligomers") |
| pmid:30985105 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation", Ser, 400)) association a(HBP:"Tau aggregates") |
| pmid:30985105 | p(HBP:"VQIVYK motif", pmod(HBP:"O-GlcNAcylation")) decreases complex(p(HBP:"VQIVYK motif"), p(HBP:"VQIVYK motif")) |
| pmid:30985105 | p(HBP:"VQIVYK motif", pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau fibrils") |
| pmid:26631930 | p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HBP:"VQIVYK motif") increases a(HBP:"Tau fibrils") |
| pmid:17493042 | p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") |
| pmid:23531502 | p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") |
| pmid:17493042 | p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:23531502 | p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:19363271 | p(HBP:"VQIVYK motif") association p(FPLX:HSP90) |
| pmid:19363271 | p(HBP:"VQIVYK motif") isA p(HBP:"tubulin-binding repeat 4") |
| pmid:19363271 | p(HBP:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pmid:23531502 | p(HBP:"VQIVYK motif") positiveCorrelation p(HBP:"KXGS motif") |
| pmid:28002468 | p(HBP:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) |
| pmid:11606569 | p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:11606569 | p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:11606569 | p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates") |
| pmid:26903089 | p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4)) |
| pmid:30985105 | p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases act(p(HGNC:OGA)) |
| pmid:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases a(CHEBI:"amyloid-beta") |
| pmid:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases path(MESH:Gliosis) |
| pmid:30985105 | a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") increases p(MGI:Sod1, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | a(CHEBI:"prostaglandin J2") regulates path(MESH:Inflammation) |
| pmid:30985105 | a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, frag("?")) |
| pmid:30985105 | a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) |
| pmid:30985105 | bp(GO:"vesicle transport along microtubule") association p(HGNC:HTT) |
| pmid:30985105 | p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) increases a(HBP:"huntingtin aggregates") |
| pmid:30985105 | p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) decreases deg(a(HBP:"huntingtin aggregates")) |
| pmid:30985105 | p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) decreases act(a(GO:autophagosome)) |
| pmid:30985105 | p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) decreases bp(GO:autophagy) |
| pmid:30985105 | p(MGI:Sod1, var("?")) decreases p(MGI:Sod1, pmod(HBP:"O-GlcNAcylation")) |
| pmid:28877763 | p(HGNC:MAPT, pmod(HBP:misfolded)) positiveCorrelation act(p(HGNC:SYK)) |
| pmid:29311797 | p(HGNC:MAPT, pmod(HBP:misfolded)) increases bp(GO:"cell death in response to oxidative stress") |
| pmid:25374103 | composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport") |
| pmid:25374103 | p(MGI:Stub1) decreases act(p(MGI:Casp3)) |
| pmid:25374103 | p(MGI:Stub1) decreases p(HBP:"Tau C3") |
| pmid:29311797 | p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(Ph))) |
| pmid:29311797 | p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(HBP:misfolded))) |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau isoform F (441 aa)") |
| pmid:25374103 | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) |
| pmid:25374103 | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases complex(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) |
| pmid:25374103 | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") |
| pmid:25374103 | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) |
| pmid:25374103 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) |
| pmid:25374103 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:25374103 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") |
| pmid:25374103 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") |
| pmid:25374103 | composite(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pmid:25374103 | composite(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) |
| pmid:25374103 | complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) |
| pmid:25374103 | composite(p(HBP:"4R tau"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins") |
| pmid:25374103 | p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1)) |
| pmid:25374103 | complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"Tau isoform F (441 aa)") |
| pmid:25374103 | complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"4R tau", var("p.Lys280del")) |
| pmid:28877763 | act(p(MGI:Syk)) positiveCorrelation bp(GO:"microglial cell activation") |
| pmid:28877763 | act(p(MGI:Syk)) positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:28877763 | act(p(MGI:Syk)) positiveCorrelation a(MESH:Neurites) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 301)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:28877763 | p(MGI:Syk, pmod(Ph)) positiveCorrelation bp(GO:"microglial cell activation") |
| pmid:28877763 | p(MGI:Syk, pmod(Ph)) positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:28877763 | p(MGI:Syk, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:28877763 | p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite") |
| pmid:28877763 | p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:28877763 | p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:28877763 | p(MGI:Mapt, var("p.Pro301Ser")) increases a(HBP:"Tau aggregates") |
| pmid:28877763 | p(MGI:Syk, pmod(Ph, Tyr, 525)) association a(HBP:"Tau aggregates") |
| pmid:28877763 | p(MGI:Syk, pmod(Ph, Tyr, 526)) association a(HBP:"Tau aggregates") |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) association a(HBP:"Tau aggregates") |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) association p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:28420982 | a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") |
| pmid:28420982 | bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) |
| pmid:28420982 | a(MESH:Exosomes) association sec(p(HGNC:MAPT)) |
| pmid:29238289 | act(a(MESH:Exosomes)) association p(HGNC:MAPT) |
| pmid:28420982 | a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") |
| pmid:28420982 | a(MESH:Exosomes) association p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:28420982 | a(GO:microvesicle) association sec(p(HGNC:MAPT)) |
| pmid:28420982 | a(GO:microvesicle) regulates sec(p(HGNC:MAPT)) |
| pmid:28420982 | complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases sec(p(HGNC:MAPT)) |
| pmid:28420982 | complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pmid:28420982 | complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(HBP:"Tau aggregates") |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association a(HBP:"dense core plaques") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"Tau fibrils") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"amyloid-beta fibrils") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pmid:28420982 | a(HBP:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pmid:28420982 | a(HBP:"Tau annular protofibrils") association path(MESH:Tauopathies) |
| pmid:28420982 | complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) |
| pmid:28420982 | p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") |
| pmid:26631930 | p(HGNC:MAPT, frag("1_421")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle") |
| pmid:28420982 | p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") |
| pmid:28420982 | complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) |
| pmid:23702978 | complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") |
| pmid:29311797 | path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) |
| pmid:29276758 | path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:29311797 | p(HGNC:HSP90AA1) association bp(GO:growth) |
| pmid:29311797 | p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") |
| pmid:29311797 | p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) |
| pmid:29311797 | p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") |
| pmid:29311797 | bp(GO:growth) association p(HGNC:HSP90AA1) |
| pmid:29311797 | bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) |
| pmid:29311797 | bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) |
| pmid:29311797 | path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) |
| pmid:29311797 | bp(GO:"embryo development") association p(HGNC:HSP90AB1) |
| pmid:29311797 | bp(GO:"cell maturation") association p(HGNC:HSP90AB1) |
| pmid:29311797 | bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) |
| pmid:29311797 | p(HGNC:PPID) isA a(MESH:Immunophilins) |
| pmid:29311797 | p(HGNC:PPID) decreases a(HBP:"Tau fibrils") |
| pmid:29311797 | p(HGNC:PPID) decreases a(HBP:"Tau aggregates") |
| pmid:29311797 | p(HGNC:PPID) increases bp(GO:memory) |
| pmid:29311797 | p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") |
| pmid:29311797 | p(HGNC:FKBPL) isA a(MESH:Immunophilins) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") |
| pmid:29311797 | complex(p(HGNC:FKBP4), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") |
| pmid:29311797 | bp(GO:"glucocorticoid receptor signaling pathway") association a(HBP:"Tau aggregates") |
| pmid:29311797 | p(HGNC:TOMM34) decreases path(MESH:Tauopathies) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) |
| pmid:21367866 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(kin)) |
| pmid:29311797 | act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:29311797 | p(MGI:Ahsa1) increases a(HBP:"Tau oligomers") |
| pmid:29311797 | p(MGI:Ahsa1) increases bp(GO:"neuron apoptotic process") |
| pmid:29311797 | p(HGNC:S100A1) increases p(HGNC:MAPT) |
| pmid:29311797 | p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) |
| pmid:29311797 | p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(Ac)) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(NO)) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(GO:"protein oxidation")) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(HBP:EC102) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:29311797 | a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | a(PUBCHEM:14719853) decreases p(MGI:Mapt) |
| pmid:29311797 | a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:"withaferin A") decreases act(p(HGNC:CDC37)) |
| pmid:29311797 | a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) |
| pmid:29311797 | a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pmid:29311797 | a(PUBCHEM:162859) causesNoChange act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") |
| pmid:29311797 | a(HBP:"KU-177") decreases act(p(HGNC:AHSA1)) |
| pmid:29311797 | a(HBP:"KU-177") decreases p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:26751493 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Pro301Leu")) increases bp(GO:memory) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Astrogliosis) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Microgliosis) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:"Tau epitope, AT100") |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11606569 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif") |
| pmid:11606569 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif") |
| pmid:27716675 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:neuroinflammation) |
| pmid:26751493 | r(MGI:Mapt) partOf a(CL:0000127) |
| pmid:26751493 | r(MGI:Mapt) partOf a(CL:0000128) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28176663 | p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:8226987 | p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT)) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Tyr, 394)) association a(HBP:"paired helical filaments") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) |
| pmid:26751493 | p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:10464280 | p(HBP:"microtubule-binding region") isA p(HGNC:MAPT) |
| pmid:10464280 | p(HBP:"microtubule-binding region") association act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:10464280 | p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) |
| pmid:18500754 | p(HBP:"microtubule-binding region") association p(HGNC:HSPA8) |
| pmid:18500754 | p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") |
| pmid:8391280 | p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin) |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 1") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("244_274")) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"4R tau") |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau") |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") association p(HBP:"APOE e3") |
| pmid:26751493 | g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:LCK) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:FGR) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:SRC) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:GRB2) |
| pmid:26751493 | p(HBP:"projection domain") association p(FPLX:PLC) |
| pmid:26751493 | p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) |
| pmid:26751493 | p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:PIN1) |
| pmid:26751493 | p(HBP:"projection domain") partOf p(HGNC:MAPT) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:FYN) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:DLG4) |
| pmid:26751493 | p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26751493 | p(HGNC:FGR) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:FGR) association a(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:GRB2) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:GRB2) association a(HBP:"projection domain") |
| pmid:26751493 | a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain") |
| pmid:26751493 | a(CHEBI:"phosphatidylinositol bisphosphate") association a(HBP:"projection domain") |
| pmid:26751493 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") |
| pmid:26631930 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") |
| pmid:22057784 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:17050703 | path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:21427723 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:21427723 | path(HBP:"Corticobasal Degeneration") isA path(HBP:"4R tauopathy") |
| pmid:26751493 | path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Val337Met")) increases a(HBP:"Tau aggregates") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) decreases p(HBP:"4R tau") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Gly272Val")) increases p(HBP:"3R tau") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg406Trp")) increases a(HBP:"Tau aggregates") |
| pmid:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:26751493 | g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") |
| pmid:26751493 | g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:22002427 | p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) |
| pmid:22002427 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22002427 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) |
| pmid:26751493 | p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:26751493 | p(HBP:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") |
| pmid:26751493 | p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:26751493 | p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:26751493 | complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) |
| pmid:26751493 | complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) |
| pmid:26751493 | bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(HGNC:PPME1)) |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:cognition) |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:"motor behavior") |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(ECCODE:"3.1.1.89")) |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") positiveCorrelation act(complex(GO:"respiratory chain complex I")) |
| pmid:26751493 | p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26751493 | a(CHEBI:"azure A") increases bp(GO:"protein catabolic process") |
| pmid:26751493 | a(CHEBI:"azure A") association bp(GO:"response to oxidative stress") |
| pmid:26751493 | a(CHEBI:"azure A") decreases act(p(HGNC:CASP1)) |
| pmid:26751493 | a(CHEBI:"azure A") decreases act(p(HGNC:CASP3)) |
| pmid:26751493 | a(CHEBI:"azure B") increases bp(GO:"protein catabolic process") |
| pmid:26751493 | a(CHEBI:"azure B") association bp(GO:"response to oxidative stress") |
| pmid:26751493 | a(CHEBI:"azure B") decreases act(p(HGNC:CASP1)) |
| pmid:26751493 | a(CHEBI:"azure B") decreases act(p(HGNC:CASP3)) |
| pmid:28019679 | p(HGNC:CASP1) increases act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases sec(p(HGNC:IL18)) |
| pmid:24561250 | p(HGNC:CASP1) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:CASP1) increases p(HGNC:IL18) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:27314526 | sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:28019679 | p(HGNC:CASP1) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases sec(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:24561250 | p(HGNC:CASP1) increases p(HGNC:IL1B) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:27314526 | sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:28019679 | act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") |
| pmid:28019679 | act(p(HGNC:CASP1)) increases sec(p(HGNC:TNF)) |
| pmid:28019679 | act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) |
| pmid:24561250 | p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) increases p(HBP:"Tau aggregates") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates") |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases p(HGNC:WWC1) |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:"actin filament polymerization") |
| pmid:26751493 | a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:emodin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates") |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Thr, 205)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 262)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 400)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 404)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 409)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pmid:26458742 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) |
| pmid:26195256 | act(a(HBP:"Glymphatic System")) decreases a(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) |
| pmid:26195256 | act(a(HBP:"Glymphatic System")) decreases a(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) |
| pmid:26195256 | act(a(HBP:"Glymphatic System")) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:CLU, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Craniocerebral Trauma") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | bp(MESH:Exercise) decreases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:Thinking) decreases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:Atrophy) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(MESH:"Cerebral Ventricles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Cerebral Amyloid Angiopathy") association a(HBP:"amyloid-beta aggregates") |
| pmid:26195256 | path(MESH:"Cerebral Amyloid Angiopathy") negativeCorrelation bp(HBP:"perivascular drainage pathways") |
| pmid:26195256 | p(MESH:Endopeptidases) increases bp(GO:"protein catabolic process") |
| pmid:26195256 | p(MESH:Endopeptidases) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) |
| pmid:26195256 | act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) increases bp(GO:"protein catabolic process") |
| pmid:26195256 | act(p(MESH:"Amyloid Precursor Protein Secretases")) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"), a(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) |
| pmid:26195256 | a(HBP:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(MESH:Cathepsins)) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) |
| pmid:26195256 | p(HGNC:MMP3) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:29626319 | act(p(HGNC:MMP3)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:29626319 | p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:ECE2) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:26195256 | p(HGNC:PLAT) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:26195256 | p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) |
| pmid:29626319 | p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) |
| pmid:29626319 | p(HGNC:ACE) regulates a(MESH:"Body Fluids") |
| pmid:29626319 | p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") |
| pmid:29626319 | p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") |
| pmid:29626319 | act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(MESH:"Muscle, Smooth, Vascular") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(MESH:Neprilysin) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) |
| pmid:29626319 | p(HGNC:ABCB1) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:ABCB1) increases act(p(HGNC:APOE)) |
| pmid:26195256 | p(HGNC:ABCB1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:A2M) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:LRP2) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(MESH:"ATP-Binding Cassette Transporters") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) |
| pmid:26195256 | act(p(HGNC:PPIA)) decreases bp(GO:"establishment of blood-brain barrier") |
| pmid:26195256 | bp(HBP:"perivascular drainage pathways") decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | bp(HBP:"perivascular drainage pathways") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | bp(HBP:"perivascular drainage pathways") negativeCorrelation path(MESH:"Cerebral Amyloid Angiopathy") |
| pmid:26195256 | bp(HBP:"perivascular drainage pathways") negativeCorrelation p(HBP:"APOE e4") |
| pmid:26195256 | path(HBP:"high-fat prenatal maternal diet") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) |
| pmid:26195256 | path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow") |
| pmid:26195256 | path(MESH:Sleep) increases p(HGNC:LRP1) |
| pmid:26195256 | a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:Aging) |
| pmid:26195256 | a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | act(p(HGNC:AQP1)) negativeCorrelation path(MESH:Aging) |
| pmid:26195256 | act(p(HGNC:AQP1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | act(p(HGNC:AQP1)) increases a(MESH:"Cerebrospinal Fluid") |
| pmid:26195256 | act(p(HGNC:AQP1)) increases sec(a(CHEBI:water)) |
| pmid:29626319 | p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) |
| pmid:29626319 | p(HGNC:AQP1) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | path(MESH:"Calcification, Physiologic") decreases a(MESH:"Cerebrospinal Fluid") |
| pmid:26195256 | path(MESH:Fibrosis) decreases a(MESH:"Cerebrospinal Fluid") |
| pmid:26195256 | act(p(MESH:Lysosomes)) increases deg(p(HGNC:MAPT)) |
| pmid:26195256 | act(p(MESH:Calpain)) increases deg(p(HGNC:MAPT)) |
| pmid:26195256 | p(HBP:"tau aggregates") association path(MESH:"Brain Injuries, Traumatic") |
| pmid:26195256 | p(HBP:"tau aggregates") increases path(MESH:"Neurodegenerative Diseases") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau aggregates") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau dimers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau dimers") |
| pmid:27373205 | a(HBP:"Tau antibody, TNT1") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26631930 | g(HGNC:MIR219A1) increases complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) |
| pmid:26631930 | complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) decreases p(HGNC:MAPT) |
| pmid:26631930 | p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule") |
| pmid:26631930 | complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT) |
| pmid:26631930 | p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule") |
| pmid:26631930 | a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) |
| pmid:26631930 | complex(GO:"mitochondrial respiratory chain complex I") decreases p(HGNC:SRSF2) |
| pmid:26631930 | p(HGNC:SRSF2) increases p(HBP:"4R tau") |
| pmid:29226865 | act(p(HGNC:SRSF2)) increases p(HBP:"4R tau") |
| pmid:26631930 | p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:29226865 | act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52)) |
| pmid:26631930 | complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(HBP:Neurodegeneration) |
| pmid:24561250 | a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) |
| pmid:26631930 | complex(a(GO:microtubule), p(HBP:"4R tau")) increases bp(GO:"microtubule polymerization") |
| pmid:26631930 | complex(a(GO:microtubule), p(HBP:"3R tau")) increases bp(GO:"microtubule polymerization") |
| pmid:26631930 | p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ph, Ser, 214), pmod(Ph, Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") |
| pmid:26631930 | complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") |
| pmid:26631930 | complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases bp(GO:"axonal transport") |
| pmid:26631930 | complex(GO:"kinesin complex") regulates bp(GO:"axonal transport") |
| pmid:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) |
| pmid:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) |
| pmid:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") |
| pmid:26631930 | p(HGNC:EP300) increases p(HGNC:MAPT, pmod(Ac, Lys)) |
| pmid:11691934 | p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(Ac)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 280))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29276758 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21427723 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:29276758 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases a(MESH:Neurons) |
| pmid:29276758 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:"Tau aggregates") |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf p(HBP:"VQIINK motif") |
| pmid:26940749 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26940749 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:Neurodegeneration) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf a(HBP:"microtubule-binding region") |
| pmid:21427723 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 163))) |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 163)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 163)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 281))) |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates") |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) partOf p(HBP:"VQIINK motif") |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:WWC1) |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:"actin filament polymerization") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf a(HBP:"microtubule-binding region") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 259))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases a(HBP:"Tau aggregates") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf a(HBP:"microtubule-binding region") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 290)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 290))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 321))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases a(HBP:"Tau aggregates") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf a(HBP:"microtubule-binding region") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HBP:"Tau aggregates") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 353)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 353))) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT)) |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration) |
| pmid:29540553 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(NGlyco)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(NGlyco)) regulates a(HBP:"paired helical filaments") |
| pmid:26631930 | p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:19517062 | p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product") |
| pmid:19517062 | p(HGNC:MAPT, pmod(HBP:glycation)) partOf p(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:deamidation)) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:18562203 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(MESH:Astrocytes)) |
| pmid:18562203 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies) |
| pmid:26631930 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26631930 | p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441"))) |
| pmid:26631930 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1)) |
| pmid:8391280 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") |
| pmid:8391280 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) |
| pmid:26631930 | complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pmid:26631930 | complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)")) |
| pmid:26631930 | complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") |
| pmid:26631930 | complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Asn279Lys")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:26631930 | p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Leu266Val")) decreases p(HBP:"4R tau") |
| pmid:26631930 | p(HGNC:MAPT, var("p.Leu266Val")) increases p(HBP:"3R tau") |
| pmid:26631930 | p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") |
| pmid:17493042 | p(HBP:"VQIINK motif") partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:17493042 | p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:28002468 | p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) |
| pmid:28002468 | p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) |
| pmid:11606569 | p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:11606569 | p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:11606569 | p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates") |
| pmid:26631930 | a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") |
| pmid:26631930 | a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:YWHAZ) increases a(HBP:"Tau aggregates") |
| pmid:12551948 | p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pmid:12551948 | p(HGNC:YWHAZ) association p(HGNC:MAPT) |
| pmid:12551948 | p(HGNC:YWHAZ) association p(HGNC:GSK3B) |
| pmid:12551948 | p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) |
| pmid:26631930 | p(HGNC:MAPT, frag("151_391")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, frag("1_368")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:MAPT, frag("1_368")) increases path(HBP:Neurodegeneration) |
| pmid:26631930 | p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization") |
| pmid:26631930 | p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) |
| pmid:26631930 | p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates") |
| pmid:26631930 | p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) |
| pmid:26631930 | tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:"amyloid-beta")) |
| pmid:26631930 | p(HGNC:SPAST) increases bp(GO:"microtubule severing") |
| pmid:26631930 | complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse")) |
| pmid:26631930 | complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta")) |
| pmid:26631930 | p(HGNC:GRIN2B, pmod(Ph)) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) |
| pmid:21548880 | p(HGNC:GRIN2B) negativeCorrelation p(HGNC:TTBK1) |
| pmid:22817713 | complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) |
| pmid:22817713 | a(CHEBI:"arachidonic acid") increases a(HBP:"Tau oligomers") |
| pmid:22817713 | a(CHEBI:"arachidonic acid") increases a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) |
| pmid:26142647 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph)) |
| pmid:21734277 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:21734277 | act(p(HGNC:PPP1CA)) increases act(p(HGNC:GSK3B)) |
| pmid:21734277 | act(p(HGNC:PPP1CA)) negativeCorrelation bp(GO:"axonal transport") |
| pmid:25001178 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22817713 | p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:26671985 | p(HGNC:MAPT, frag("2_18")) equivalentTo p(HBP:"phosphatase-activating domain") |
| pmid:26671985 | p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) |
| pmid:22817713 | composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:29626319 | p(FPLX:UBE2) increases deg(a(MESH:Proteins)) |
| pmid:29626319 | a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) |
| pmid:29626319 | p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) |
| pmid:29626319 | a(HBP:"20 S Proteasome") increases bp(GO:"proteasomal ubiquitin-independent protein catabolic process") |
| pmid:29626319 | a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(HP:"glymphatic system") decreases p(HGNC:MAPT) |
| pmid:29626319 | p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) |
| pmid:29626319 | p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(FPLX:MMP) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:CMKLR1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(FPLX:TLR) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:23702978 | act(p(FPLX:TLR)) increases p(HGNC:NLRP3) |
| pmid:23702978 | act(p(FPLX:TLR)) increases p(HGNC:IL1B) |
| pmid:29626319 | p(HGNC:FPR2) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ABCA7) association bp(GO:phagocytosis) |
| pmid:29626319 | p(HGNC:ABCA7) regulates bp(GO:phagocytosis) |
| pmid:29626319 | p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:ABCA7) decreases p(HGNC:BACE1) |
| pmid:29626319 | p(HGNC:CD33) association bp(GO:phagocytosis) |
| pmid:29626319 | p(HGNC:CD33) decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) |
| pmid:29626319 | p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:SLC2A1) increases p(HGNC:LRP1) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") |
| pmid:29626319 | a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") |
| pmid:29626319 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:TTR)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:"Lymph Nodes") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | composite(a(CHEBI:"amyloid-beta"), a(MESH:"Serum Albumin")) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:tenuigenin) increases p(HGNC:PSMD7) |
| pmid:29626319 | bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) |
| pmid:29626319 | a(CHEBI:wogonin) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:wogonin) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29626319 | p(HGNC:NPAS4) increases bp(GO:autophagy) |
| pmid:29626319 | p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29626319 | a(CHEBI:statin) increases sec(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:statin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) |
| pmid:29626319 | a(CHEBI:atorvastatin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:atorvastatin) increases sec(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:nobiletin) increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:nobiletin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) |
| pmid:29626319 | a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) |
| pmid:29626319 | a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) |
| pmid:29626319 | p(HGNC:ANXA1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ANXA1) increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:minocycline) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:oleocanthal) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:oleocanthal) increases p(HGNC:LRP1) |
| pmid:29626319 | a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) |
| pmid:29238289 | complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) |
| pmid:29238289 | complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases bp(GO:"apoptotic process") |
| pmid:29238289 | rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) increases sec(p(HGNC:MAPT)) |
| pmid:29238289 | complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) regulates sec(p(HGNC:MAPT)) |
| pmid:29238289 | p(HGNC:SNAP23) increases sec(p(HGNC:MAPT)) |
| pmid:29238289 | p(HGNC:SNAP23) isA p(MESH:"SNARE Proteins") |
| pmid:29238289 | p(MESH:"SNARE Proteins") increases bp(GO:exocytosis) |
| pmid:29238289 | p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) |
| pmid:29238289 | p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") |
| pmid:29238289 | a(MESH:"Transport Vesicles") association sec(p(HGNC:MAPT)) |
| pmid:29980653 | p(HGNC:PRNP, var("?")) positiveCorrelation path(MESH:"Prion Diseases") |
| pmid:29980653 | complex(a(HBP:"protein aggregates"), p(HGNCGENEFAMILY:Syndecans)) increases path(HBP:Neurodegeneration) |
| pmid:29980653 | a(MESH:Glycosaminoglycans) association p(HGNCGENEFAMILY:Syndecans) |
| pmid:29980653 | complex(a(HBP:"Tau aggregates"), a(MESH:Glycosaminoglycans)) increases a(HBP:"Tau fibrils") |
| pmid:29980653 | complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau aggregates")) increases a(HBP:"Tau fibrils") |
| pmid:29980653 | complex(a(HBP:"Tau aggregates"), p(HGNCGENEFAMILY:Syndecans, pmod(Sulf))) increases a(HBP:"Tau fibrils") |
| pmid:17493042 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:23531502 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:10537045 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:26751493 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:17493042 | a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) |
| pmid:17493042 | a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:21757739 | a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain") |
| pmid:21757739 | a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) |
| pmid:1918161 | a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) |
| pmid:10537045 | a(HBP:"microtubule-binding region") association act(p(HGNC:TGM2)) |
| pmid:26751493 | a(HBP:"microtubule-binding region") association p(HGNC:HDAC6) |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 2") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("275_305")) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"4R tau") |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau") |
| pmid:2123288 | p(HBP:"tubulin-binding repeat 2") association p(FPLX:CALM) |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") |
| pmid:23531502 | p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 3") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("306_336")) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"4R tau") |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau") |
| pmid:23832849 | p(HBP:"tubulin-binding repeat 3") increases a(HBP:"Tau aggregates") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 4") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("337_367")) |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 4") partOf p(HBP:"4R tau") |
| pmid:17493042 | a(HBP:"projection domain") partOf p(HGNC:MAPT) |
| pmid:26751493 | a(HBP:"projection domain") partOf p(HGNC:MAPT) |
| pmid:17493042 | a(HBP:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") |
| pmid:17493042 | a(HBP:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:LCK) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:FGR) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:SRC) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:GRB2) |
| pmid:26751493 | a(HBP:"projection domain") association p(FPLX:PLC) |
| pmid:26751493 | a(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) |
| pmid:26751493 | a(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:PIN1) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:FYN) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:DLG4) |
| pmid:26751493 | a(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:17493042 | p(INTERPRO:"MAP2/Tau projection") equivalentTo a(HBP:"projection domain") |
| pmid:8391280 | p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) |
| pmid:8391280 | p(INTERPRO:"MAP2/Tau projection") partOf p(HGNC:MAPT) |
| pmid:12551948 | p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT) |
| pmid:12551948 | p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") |
| pmid:12551948 | p(INTERPRO:"MAP2/Tau projection") negativeCorrelation act(complex(GO:"plasma membrane")) |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(HBP:"tubulin-binding repeat 1") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(HBP:"tubulin-binding repeat 2") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(HBP:"tubulin-binding repeat 3") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("337_367")) equivalentTo p(HBP:"tubulin-binding repeat 4") |
| pmid:17493042 | p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HGNC:MAPT, frag("1_198")) equivalentTo a(HBP:"projection domain") |
| pmid:17493042 | p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:17493042 | bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:21757739 | a(HBP:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) |
| pmid:21757739 | p(HGNC:MAPT, frag("199_441")) equivalentTo a(HBP:"assembly domain") |
| pmid:21757739 | p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region") |
| pmid:21757739 | p(HGNC:MAPT, frag("370_441")) partOf a(HBP:"assembly domain") |
| pmid:21757739 | a(HBP:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) |
| pmid:21757739 | a(HBP:"proline-rich region 2") partOf a(HBP:"assembly domain") |
| pmid:21757739 | a(HBP:"proline-rich region 2") partOf a(HBP:"proline-rich domain") |
| pmid:21757739 | p(HGNC:MAPT, frag("199_244")) equivalentTo a(HBP:"proline-rich region 2") |
| pmid:21757739 | a(HBP:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") |
| pmid:22033876 | a(HBP:"proline-rich domain") association act(p(FPLX:Actin)) |
| pmid:22033876 | a(HBP:"proline-rich domain") association p(INTERPRO:"SH3 domain") |
| pmid:21757739 | p(INTERPRO:"PSP, proline-rich") equivalentTo a(HBP:"proline-rich domain") |
| pmid:21757739 | a(HBP:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("151_198")) |
| pmid:21757739 | a(HBP:"proline-rich region 1") partOf a(HBP:"proline-rich domain") |
| pmid:21757739 | a(HBP:"proline-rich region 1") partOf a(HBP:"projection domain") |
| pmid:21757739 | p(HGNC:MAPT, frag("151_198")) equivalentTo a(HBP:"proline-rich region 1") |
| pmid:21757739 | p(HGNC:MAPT, frag("1_151")) partOf a(HBP:"projection domain") |
| pmid:27260836 | complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pmid:27260836 | p(HGNC:AP2M1) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2B1) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2A1) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2A2) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2S1) partOf p(HBP:"AP-2 complex") |
| pmid:11943212 | a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MARK4, pmod(Ph)) |
| pmid:11943212 | a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:27260836 | complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:26655600 | complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") |
| pmid:24368848 | p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") |
| pmid:23407988 | a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree") |
| pmid:23407988 | a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") |
| pmid:22253473 | a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:23407988 | complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) |
| pmid:22142809 | p(HBP:RAC1b) association p(HGNC:NGFR) |
| pmid:22142809 | p(HBP:RAC1b) isA p(HGNC:RAC1) |
| pmid:22142809 | p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) |
| pmid:22142809 | p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) |
| pmid:22142809 | p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) |
| pmid:22142809 | p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex") |
| pmid:27087442 | act(p(HBP:RAC1b)) negativeCorrelation p(MGI:Cdk5) |
| pmid:27087442 | act(p(HBP:RAC1b)) positiveCorrelation act(a(MESH:Neurons)) |
| pmid:27796283 | act(p(HGNC:RAC1)) increases bp(GO:"dendritic spine development") |
| pmid:22142809 | p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) |
| pmid:22142809 | p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b) |
| pmid:22142809 | a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b) |
| pmid:6543144 | complex(GO:microtubule) association p(HGNC:MAPT) |
| pmid:10464280 | complex(GO:microtubule) association p(HGNC:MAPT) |
| pmid:19491104 | complex(GO:microtubule) association p(HGNC:KIF5B) |
| pmid:10464280 | act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region") |
| pmid:10464280 | complex(GO:microtubule) association p(HGNC:PPP2CA) |
| pmid:10464280 | act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex")) |
| pmid:18500754 | act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) |
| pmid:18500754 | complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") |
| pmid:20133804 | complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") |
| pmid:1918161 | p(HGNC:MAPT, frag("237_367")) directlyIncreases complex(GO:microtubule) |
| pmid:1918161 | p(HGNC:MAPT, frag("237_367")) partOf p(HGNC:MAPT) |
| pmid:1918161 | p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region") |
| pmid:1918161 | complex(GO:axon) positiveCorrelation p(HGNC:MAPT) |
| pmid:26671985 | act(complex(GO:axon)) negativeCorrelation a(HBP:neurotoxicity) |
| pmid:1918161 | complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) |
| pmid:17187063 | p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration) |
| pmid:17187063 | a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:19251756 | a(HBP:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:22952452 | a(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:6543144 | complex(GO:neurofilament) association p(HGNC:MAPT) |
| pmid:2446784 | complex(GO:"polysomal ribosome") association p(HGNC:MAPT) |
| pmid:11812770 | p(HGNC:MAPT, frag("1_244")) partOf p(HGNC:MAPT) |
| pmid:11812770 | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) |
| pmid:11812770 | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) |
| pmid:18680553 | p(HGNC:MAPT, frag("223_226")) association p(HGNC:FYN) |
| pmid:18680553 | p(HGNC:MAPT, frag("223_226")) partOf p(HGNC:MAPT) |
| pmid:18680553 | bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:18680553 | bp(GO:myelination) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:SRC, frag("84_145")) partOf p(HGNC:SRC) |
| pmid:18467332 | p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") |
| pmid:18467332 | p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) |
| pmid:18467332 | p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) |
| pmid:22033876 | p(INTERPRO:"SH3 domain") association a(HBP:"proline-rich domain") |
| pmid:18467332 | p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:PLCG1, frag("790_851")) partOf p(HGNC:PLCG1) |
| pmid:18467332 | p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) partOf p(HGNC:GRB2) |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") |
| pmid:18467332 | complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) |
| pmid:18467332 | p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) |
| pmid:18467332 | p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) |
| pmid:18467332 | p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:PIK3R1, frag("3_79")) partOf p(HGNC:PIK3R1) |
| pmid:18467332 | p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") |
| pmid:18467332 | p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pmid:19491104 | bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) |
| pmid:19491104 | p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(Ph)) |
| pmid:19491104 | act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) |
| pmid:19491104 | act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) |
| pmid:10464280 | rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:18500754 | p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region") |
| pmid:19363271 | a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:14612456 | complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:8391280 | p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region") |
| pmid:8391280 | p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:8391280 | act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) |
| pmid:8391280 | complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) |
| pmid:8391280 | g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:8391280 | g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:16176937 | p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) |
| pmid:16176937 | p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") |
| pmid:16176937 | p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) |
| pmid:16176937 | p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") |
| pmid:16176937 | p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) |
| pmid:16176937 | p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) |
| pmid:16176937 | p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") |
| pmid:16176937 | p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) |
| pmid:10391244 | p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:10391244 | act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pmid:10391244 | complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) |
| pmid:10391244 | complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") |
| pmid:10391244 | complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT)) |
| pmid:10391244 | p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) |
| pmid:20133804 | p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) |
| pmid:20133804 | p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) |
| pmid:20133804 | p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) |
| pmid:20133804 | p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") |
| pmid:20133804 | p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90) |
| pmid:20133804 | p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) |
| pmid:20133804 | p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4)) |
| pmid:20071522 | complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) |
| pmid:2123288 | p(FPLX:CALM) association p(HBP:"tubulin-binding repeat 2") |
| pmid:2123288 | act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) |
| pmid:2123288 | act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") |
| pmid:27133022 | act(p(FPLX:CALM)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") |
| pmid:27133022 | act(p(FPLX:CALM)) increases act(p(HGNC:DAPK2)) |
| pmid:2123288 | complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:2833519 | p(HGNC:S100B) association p(HGNC:MAPT) |
| pmid:2833519 | p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) |
| pmid:2833519 | act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) |
| pmid:18494933 | p(HGNC:S100B) increases act(p(HGNC:AGER)) |
| pmid:18494933 | p(HGNC:S100B) directlyIncreases act(p(HGNC:AGER)) |
| pmid:18494933 | p(HGNC:S100B) increases p(FPLX:JNK) |
| pmid:18494933 | p(HGNC:S100B) increases p(FPLX:JNK, pmod(Ph)) |
| pmid:18494933 | p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") |
| pmid:18494933 | p(HGNC:S100B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:2833519 | complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) |
| pmid:2833519 | act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12714745 | g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") |
| pmid:12714745 | g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") |
| pmid:12714745 | complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) |
| pmid:12714745 | composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"neurofibrillary tangle") |
| pmid:12714745 | composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"Lewy body") |
| pmid:12551948 | act(complex(GO:"plasma membrane")) negativeCorrelation p(INTERPRO:"MAP2/Tau projection") |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) |
| pmid:22072628 | p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:21339331 | p(HGNC:ANXA2) association p(HGNC:MAPT) |
| pmid:21339331 | p(HGNC:ANXA2) association a(MESH:"Cell Membrane") |
| pmid:21339331 | p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:18096814 | a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm)) |
| pmid:18096814 | a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt) |
| pmid:18096814 | a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn) |
| pmid:18096814 | p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:21131359 | bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pmid:21131359 | bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pmid:21131359 | bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) |
| pmid:21131359 | bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") |
| pmid:8226987 | bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:19732809 | bp(MESH:"Hot Temperature") association a(HBP:"O-GlcNAcylation") |
| pmid:21131359 | a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) |
| pmid:21131359 | a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pmid:8985176 | a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph)) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) |
| pmid:28173111 | act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | complex(GO:mitochondrion) positiveCorrelation p(MGI:Nrf1) |
| pmid:28173111 | complex(GO:mitochondrion) positiveCorrelation p(MGI:Nfe2l2) |
| pmid:28173111 | complex(GO:mitochondrion) positiveCorrelation p(MGI:Ppargc1a) |
| pmid:28173111 | bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syp) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Dlg4) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn1) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn2) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Synpo2) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Nrgn) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Gap43) |
| pmid:28173111 | r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Syp) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Dlg4) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Syn1) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Syn2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Syn2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Synpo2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Synpo2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Nrgn) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Gap43) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Fis1) positiveCorrelation bp(GO:"mitochondrial fission") |
| pmid:28173111 | bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Fis1) |
| pmid:28173111 | bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Dnm1l) positiveCorrelation bp(GO:"mitochondrial fission") |
| pmid:28173111 | r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppid) positiveCorrelation complex(GO:"mitochondrial matrix") |
| pmid:28173111 | complex(GO:"mitochondrial matrix") positiveCorrelation p(MGI:Ppid) |
| pmid:28173111 | r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn1) positiveCorrelation bp(GO:"mitochondrial fusion") |
| pmid:28173111 | r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn2) positiveCorrelation bp(GO:"mitochondrial fusion") |
| pmid:28173111 | r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Opa1) positiveCorrelation bp(GO:"mitochondrial fusion") |
| pmid:28173111 | bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn1) |
| pmid:28173111 | bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn2) |
| pmid:28173111 | bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Opa1) |
| pmid:28173111 | r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nrf1) positiveCorrelation complex(GO:mitochondrion) |
| pmid:28173111 | r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nfe2l2) positiveCorrelation complex(GO:mitochondrion) |
| pmid:28173111 | r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppargc1a) positiveCorrelation complex(GO:mitochondrion) |
| pmid:25987199 | act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) |
| pmid:28173111 | r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26671985 | p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:26671985 | p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation p(HBP:neurotoxicity) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, pmod(HBP:polyamination, Gln, 6)) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) |
| pmid:24844691 | p(FPLX:Tubulin, pmod(Ac)) negativeCorrelation act(p(HGNC:HDAC6)) |
| pmid:25974414 | act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) |
| pmid:25974414 | act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) |
| pmid:25974414 | act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) |
| pmid:25974414 | act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) |
| pmid:25974414 | p(HGNC:MAPT, pmod(Ph, Thr, 17)) isA p(HGNC:MAPT) |
| pmid:25974414 | act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:26671985 | a(HBP:neurotoxicity) negativeCorrelation act(complex(GO:axon)) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") positiveCorrelation act(a(HBP:"Tau oligomers")) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") decreases act(complex(GO:axon)) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport") |
| pmid:27260838 | p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT1") |
| pmid:27260838 | p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT2") |
| pmid:27260838 | p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:pretangles) |
| pmid:27574109 | p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"4R tau") |
| pmid:27373205 | p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:21734277 | p(HBP:"phosphatase-activating domain") directlyIncreases act(p(HGNC:PPP1CA)) |
| pmid:26671985 | p(HBP:neurotoxicity) positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me2, Lys, 311)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 259)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 290)) partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 353)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 163)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 163)) partOf a(HBP:"proline-rich domain") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 174)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 174)) partOf a(HBP:"proline-rich domain") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 180)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 180)) partOf a(HBP:"proline-rich domain") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 254)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 254)) partOf p(HBP:"tubulin-binding repeat 1") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Ub, Lys, 254)) association p(HGNC:MAPT) |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 267)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 267)) partOf p(HBP:"tubulin-binding repeat 1") |
| pmid:23943618 | complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) |
| pmid:23943618 | complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1") |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) |
| pmid:22764226 | a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) |
| pmid:22764226 | a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) |
| pmid:22764226 | p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:25143394 | p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:25681682 | bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) |
| pmid:24183963 | p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24183963 | p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25987199 | act(p(HGNC:GLP1R)) decreases bp(MESH:"Oxidative Stress") |
| pmid:25987199 | act(p(HGNC:GLP1R)) increases act(a(GO:mitochondrion)) |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) decreases p(HBP:"KXGS motif") |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) causesNoChange bp(GO:"microtubule polymerization") |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) decreases act(a(CHEBI:"hydrogen peroxide")) |
| pmid:23531502 | p(HBP:"KXGS motif") positiveCorrelation p(HBP:"VQIVYK motif") |
| pmid:25031639 | p(HBP:"KXGS motif") increases a(GO:"neurofibrillary tangle") |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") decreases p(HBP:"KXGS motif") |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") increases complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) |
| pmid:23531502 | complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) decreases act(a(CHEBI:acrolein)) |
| pmid:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:17082178 | a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") |
| pmid:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:23531502 | act(a(CHEBI:acrolein)) decreases a(MESH:Neurons) |
| pmid:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26655600 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) |
| pmid:26655600 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) |
| pmid:26655600 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) decreases bp(GO:"canonical glycolysis") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases a(HBP:"GA-AGE") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) decreases p(HGNC:APP, frag("672_713")) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) |
| pmid:19251756 | bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26304819 | r(HGNC:GAPDH) association bp(GO:"apoptotic process") |
| pmid:26304819 | a(HBP:"GA-AGE") isA a(CHEBI:"advanced glycation end-product") |
| pmid:26095350 | a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product") |
| pmid:26095350 | a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214)) |
| pmid:26095350 | a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:26095350 | a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:28176663 | a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:28176663 | a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:28176663 | a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 287)) |
| pmid:26095350 | a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 306)) |
| pmid:19517062 | a(CHEBI:"D-ribose") increases p(HBP:"Tau aggregates") |
| pmid:19517062 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation)) |
| pmid:28176663 | a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product") |
| pmid:26095350 | p(MGI:Mapt, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:26095350 | p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:26095350 | p(MGI:Camk2b, pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b)) |
| pmid:26095350 | p(MGI:Camk2b, pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(HGNC:AGER) |
| pmid:19251756 | a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:17082178 | a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:"D-glyceraldehyde 3-phosphate"))) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") |
| pmid:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(HBP:Neurodegeneration) |
| pmid:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) association p(HGNC:MAPT) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| pmid:19251756 | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19251756 | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) partOf a(GO:"neurofibrillary tangle") |
| pmid:16630055 | path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:16630055 | path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph)) |
| pmid:16630055 | path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose) |
| pmid:12578227 | p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:12578227 | p(HGNC:TGM1) isA p(ECCODE:"2.3.2.13") |
| pmid:12578227 | r(HBP:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) |
| pmid:12578227 | p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:9099822 | act(p(HGNC:TGM2)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:12578227 | p(HGNC:TGM2) isA p(ECCODE:"2.3.2.13") |
| pmid:10537045 | p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) |
| pmid:10537045 | p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pmid:10537045 | act(p(HGNC:TGM2)) association a(HBP:"microtubule-binding region") |
| pmid:11089576 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:11089576 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:11738469 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:8985134 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:11738469 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:8985134 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:10537045 | complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") |
| pmid:10537045 | a(HBP:maitotoxin) increases a(CHEBI:"calcium(2+)") |
| pmid:10537045 | a(HBP:maitotoxin) increases act(p(HGNC:TGM2)) |
| pmid:22057784 | p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:17768677 | p(MGI:Mapt, pmod(HBP:nitration, Tyr, 488)) causesNoChange act(p(MGI:Mapt)) |
| pmid:17768677 | p(MGI:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain) |
| pmid:16816118 | a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) |
| pmid:16816118 | a(CHEBI:linsidomine) decreases act(p(HBP:"20 S Proteasome")) |
| pmid:16816118 | p(RGD:Mapt, pmod(HBP:nitration)) negativeCorrelation act(p(HBP:"20 S Proteasome")) |
| pmid:27796283 | act(p(HGNC:RHOA)) decreases bp(GO:"dendritic spine development") |
| pmid:27796283 | act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") |
| pmid:27796283 | act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) |
| pmid:27796283 | bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") |
| pmid:27796283 | p(HGNC:TIAM1, pmod(Ph)) increases act(p(HGNC:RAC1)) |
| pmid:27796283 | p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) increases act(p(HBP:"Kalirin 7")) |
| pmid:27796283 | act(p(HBP:"Kalirin 7")) increases act(p(HGNC:RAC1)) |
| pmid:27796283 | p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) |
| pmid:27796283 | p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) increases act(p(HGNC:ARHGEF7)) |
| pmid:27796283 | act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) |
| pmid:27796283 | complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) |
| pmid:27796283 | act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") |
| pmid:27796283 | act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) |
| pmid:27796283 | act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) |
| pmid:27796283 | p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pmid:27796283 | p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") |
| pmid:27796283 | complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) |
| pmid:27796283 | p(HGNC:CAMKV, pmod(Ph, Thr, 345)) decreases act(p(HGNC:CAMKV)) |
| pmid:29121589 | complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) increases p(HGNC:NFE2L2, pmod(UbPoly)) |
| pmid:29121589 | p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:NFE2L2, pmod(UbPoly)) increases deg(p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:NFE2L2, pmod(Ph)) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) |
| pmid:29121589 | p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) |
| pmid:29121589 | p(HGNC:BTRC) isA p(ECCODE:"2.3.2.27") |
| pmid:29121589 | complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases p(HGNC:NFE2L2, pmod(UbPoly)) |
| pmid:29121589 | p(HGNC:DPYSL2, pmod(Ph)) negativeCorrelation a(CHEBI:"dimethyl fumarate") |
| pmid:24401760 | a(HBP:Astrogliosis) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:29121589 | r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") |
| pmid:29121589 | r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") |
| pmid:27807169 | p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) |
| pmid:27807169 | p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") |
| pmid:27807169 | p(RGD:Cdk5r2) positiveCorrelation a(GO:synapse) |
| pmid:21489990 | act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396)) |
| pmid:21489990 | act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:21489990 | act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca)) |
| pmid:7514173 | a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) |
| pmid:22072628 | p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:9089387 | p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph))) |
| pmid:9089387 | act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph)) |
| pmid:22102280 | a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:22102280 | a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:22102280 | a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph)) |
| pmid:11013232 | a(HBP:indirubin) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:10998059 | act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph)) |
| pmid:26400044 | act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Wasf1, pmod(Ph)) |
| pmid:26400044 | act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Dpysl2, pmod(Ph)) |
| pmid:24808823 | p(MGI:Cdk5) negativeCorrelation bp(GO:learning) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation act(p(HBP:RAC1b)) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation path(MESH:Cognition) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation act(a(MESH:Neurons)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 175)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 176)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 178)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 195)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 217)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 220)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 239)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 400)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 403)) |
| pmid:8702879 | p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) |
| pmid:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551)) |
| pmid:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62)) |
| pmid:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67)) |
| pmid:8702879 | p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) |
| pmid:8702879 | p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) |
| pmid:26400044 | p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:26400044 | p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:26400044 | complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") |
| pmid:8726973 | a(HBP:isopentanyladenine) decreases act(p(HGNC:CDK5)) |
| pmid:8726973 | a(HBP:olomoucine) decreases act(p(HGNC:CDK5)) |
| pmid:18239272 | p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:25673844 | p(HGNC:CSNK1D) isA p(FPLX:CSNK1) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:18239272 | p(HGNC:TTBK1) association a(HBP:pretangles) |
| pmid:20096481 | p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) |
| pmid:20096481 | p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:21548880 | p(HGNC:TTBK1) increases p(HGNC:CDK5R1) |
| pmid:21548880 | p(HGNC:TTBK1) positiveCorrelation act(p(ECCODE:"3.4.22.52")) |
| pmid:21548880 | p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2B) |
| pmid:21548880 | p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2D) |
| pmid:25673844 | p(HGNC:TTBK1) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:25473830 | p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) |
| pmid:25473830 | p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pmid:23687953 | act(p(HGNC:TTBK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 197)) |
| pmid:20096481 | g(DBSNP:rs2651206) association path(MESH:"Alzheimer Disease") |
| pmid:21548880 | g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:20096481 | g(DBSNP:rs2651206) association g(HGNC:TTBK1) |
| pmid:21548880 | g(DBSNP:rs2651206) isA g(HGNC:TTBK1) |
| pmid:20096481 | g(DBSNP:rs10807287) association path(MESH:"Alzheimer Disease") |
| pmid:20096481 | g(DBSNP:rs10807287) association g(HGNC:TTBK1) |
| pmid:20096481 | g(DBSNP:rs7764257) association path(MESH:"Alzheimer Disease") |
| pmid:20096481 | g(DBSNP:rs7764257) association g(HGNC:TTBK1) |
| pmid:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs2651206) |
| pmid:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs10807287) |
| pmid:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs7764257) |
| pmid:2820993 | act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(kin)) |
| pmid:21548880 | path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) |
| pmid:21548880 | path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) |
| pmid:21548880 | path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(kin)) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(kin)) |
| pmid:21548880 | act(p(ECCODE:"3.4.22.52")) positiveCorrelation p(HGNC:TTBK1) |
| pmid:21548880 | p(HGNC:GRIN2D) negativeCorrelation p(HGNC:TTBK1) |
| pmid:25673844 | p(HGNC:VRK2) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:VRK3) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1E) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1) |
| pmid:25673844 | p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:27607061 | surf(p(HGNC:GRIK2)) negativeCorrelation act(p(HGNC:RAB5A)) |
| pmid:26323690 | p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") |
| pmid:26323690 | act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") |
| pmid:26323690 | bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) |
| pmid:26323690 | p(HGNC:CEP164) association p(HGNC:TTBK2) |
| pmid:26323690 | p(HGNC:CEP164) positiveCorrelation act(p(HGNC:TTBK2)) |
| pmid:26323690 | p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pmid:26323690 | p(HGNC:MAPRE1) association p(HGNC:TTBK2) |
| pmid:26323690 | p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pmid:26323690 | complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph)) |
| pmid:26323690 | p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pmid:24808823 | p(MGI:Ttbk1) negativeCorrelation bp(GO:learning) |
| pmid:24808823 | p(MGI:Ttbk1) increases a(HBP:pretangles) |
| pmid:24808823 | p(MGI:Ttbk1) increases bp(GO:"neuron death") |
| pmid:24808823 | surf(p(MGI:Grin2b)) positiveCorrelation bp(GO:learning) |
| pmid:11943212 | p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:11943212 | p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Thr, 396)) partOf p(HBP:"Tau epitope, AD2") |
| pmid:26751493 | p(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") |
| pmid:26751493 | p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:29281045 | p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:26751493 | act(complex(GO:"respiratory chain complex I")) positiveCorrelation a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") |
| pmid:11943212 | p(HGNC:MARK4, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:11943212 | p(HGNC:MARK4, pmod(Ph)) positiveCorrelation a(HBP:"granulovacuolar degeneration") |
| pmid:22692785 | p(HGNC:MARK4) negativeCorrelation p(HBP:PrPSc) |
| pmid:23666762 | p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22156579 | p(HGNC:MARK4) increases a(HBP:"Tau epitope, 12E8") |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation a(GO:synapse) |
| pmid:22692785 | p(HBP:PrPSc) negativeCorrelation p(HGNC:MARK4) |
| pmid:22692785 | p(HBP:"PrP106-126") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22156579 | p(INTERPRO:"Kinase associated domain 1 (KA1)") positiveCorrelation act(a(HBP:"amyloid-beta oligomers")) |
| pmid:22156579 | act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22156579 | act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:16973293 | p(HBP:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") |
| pmid:16973293 | p(HBP:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) |
| pmid:16973293 | bp(GO:"neuron development") positiveCorrelation p(HBP:"MARK4 isoform 2 (688 aa)") |
| pmid:23666762 | p(HBP:"Tau antibody, AGG5759") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23666762 | p(HBP:"Tau antibody, Tau-13") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23666762 | p(HBP:"CagA peptide") decreases act(p(HGNC:MARK4), ma(kin)) |
| pmid:27094130 | p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713"))) |
| pmid:27094130 | act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713"))) |
| pmid:27094130 | p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_711"))) |
| pmid:27094130 | act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_711"))) |
| pmid:27094130 | act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668)) |
| pmid:27068745 | act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") |
| pmid:25899010 | p(HGNC:DAPK1) positiveCorrelation a(HBP:Excitotoxicity) |
| pmid:25899010 | p(HGNC:DAPK1) negativeCorrelation p(HGNC:PIN1) |
| pmid:27795443 | act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) |
| pmid:27795443 | act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:24853415 | p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) |
| pmid:21311567 | p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) |
| pmid:21311567 | p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) |
| pmid:21311567 | p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") |
| pmid:27094130 | p(HGNC:DAPK1, frag("637_1423")) association p(HGNC:APP) |
| pmid:27094130 | p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) |
| pmid:27094130 | p(HGNC:DAPK1, frag("848_1423")) association p(HGNC:APP) |
| pmid:27094130 | p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) |
| pmid:27094130 | p(HGNC:DAPK1, frag("1271_1423")) association p(HGNC:APP) |
| pmid:27094130 | p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") |
| pmid:27094130 | p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) |
| pmid:27094130 | p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) |
| pmid:27068745 | p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) |
| pmid:27068745 | p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(kin)) |
| pmid:27068745 | p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") |
| pmid:27068745 | p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") |
| pmid:27068745 | p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) |
| pmid:27068745 | p(HGNC:CALML5) decreases p(HGNC:UNC5C, var("p.Thr835Met")) |
| pmid:27068745 | act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) |
| pmid:27068745 | act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) |
| pmid:27068745 | act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) |
| pmid:27068745 | act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) |
| pmid:27068745 | act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) |
| pmid:27068745 | p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK)) |
| pmid:27795443 | act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") |
| pmid:27795443 | act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) |
| pmid:27133022 | p(HBP:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) |
| pmid:27133022 | p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) |
| pmid:27133022 | p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(FPLX:CALM)) |
| pmid:27133022 | act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") |
| pmid:25995053 | p(MGI:Dapk1) association p(MGI:Mapt) |
| pmid:25995053 | p(MGI:Dapk1) directlyIncreases complex(p(MGI:Dapk1), p(MGI:Mapt)) |
| pmid:25995053 | p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) |
| pmid:25995053 | complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") |
| pmid:24853415 | p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1)) |
| pmid:24853415 | p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT) |
| pmid:28137862 | p(MGI:Dcaf1) association p(MGI:Dyrk1a) |
| pmid:28137862 | p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pmid:28137862 | p(MGI:Dcaf1) association p(MGI:Hap1) |
| pmid:28137862 | p(MGI:Dyrk1a) association p(MGI:Dcaf1) |
| pmid:28137862 | p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pmid:28137862 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron")) |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt) |
| pmid:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) |
| pmid:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) |
| pmid:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) |
| pmid:28775333 | p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") |
| pmid:28775333 | p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") |
| pmid:28775333 | p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) |
| pmid:28775333 | p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) |
| pmid:28137862 | complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) |
| pmid:28137862 | p(MGI:Hap1) association p(MGI:Dcaf1) |
| pmid:28137862 | p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:28137862 | p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pmid:29221819 | a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a) |
| pmid:28884684 | a(HBP:"ID-8") decreases act(p(HGNC:DYRK1B), ma(kin)) |
| pmid:28884684 | a(HBP:"ID-8") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:28884684 | a(HBP:"ID-8") decreases act(p(HGNC:DYRK1A), ma(kin)) |
| pmid:28884684 | a(HBP:"ID-8") decreases bp(GO:"neuron differentiation") |
| pmid:28884684 | act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation") |
| pmid:28250274 | p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) |
| pmid:28632203 | p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28167836 | act(p(HGNC:DYRK1A)) regulates a(HBP:Neurites) |
| pmid:28167836 | act(p(HGNC:DYRK1A)) regulates a(GO:axon) |
| pmid:28250274 | a(CHEBI:harmine) decreases p(HGNC:DYRK1A) |
| pmid:28250274 | a(CHEBI:harmine) increases p(HGNC:MME) |
| pmid:29077046 | a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) |
| pmid:28775333 | p(MGI:Mef2d) increases r(MGI:Dyrk1a) |
| pmid:28775333 | p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) |
| pmid:28632203 | composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Arg205del") decreases act(p(HGNC:DYRK1A)) |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Arg205del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Glu239del") decreases act(p(HGNC:DYRK1A)) |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Glu239del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 301)) positiveCorrelation p(MGI:Syk) |
| pmid:18070606 | p(RGD:Syk) increases p(RGD:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") |
| pmid:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") association a(HBP:"GVD bodies") |
| pmid:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles) |
| pmid:26501932 | a(HBP:"GVD bodies") association a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") |
| pmid:25331948 | a(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(HBP:"BAY61-3606") directlyDecreases act(p(HGNC:SYK)) |
| pmid:28176663 | a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:28176663 | a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:28176663 | a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:28176663 | a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:25987199 | act(a(HBP:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25987199 | act(a(HBP:"advanced glycation end product")) negativeCorrelation act(p(MGI:Glp1r)) |
| pmid:26118667 | p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) |
| pmid:26118667 | p(HBP:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) |
| pmid:26118667 | p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26118667 | p(HBP:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:27087442 | p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:14642273 | p(HBP:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(kin)) |
| pmid:14642273 | p(HBP:"CDK5R1 p25") increases p(HBP:"Tau aggregates") |
| pmid:26118667 | p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(HBP:"CDK5R1 p25") |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 202)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 205)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 231)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 422)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(HBP:"CDK5R1 p25") |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") increases complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:App) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Bace1) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Cdk5r1) |
| pmid:26118667 | complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) decreases r(RGD:Cdk5r1) |
| pmid:26118667 | complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | p(RGD:App) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | p(RGD:Bace1) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | p(INTERPRO:"Peptidase C2, calpain, catalytic domain") positiveCorrelation act(p(RGD:Cdk5r1)) |
| pmid:26118667 | act(p(RGD:Cdk5r1)) positiveCorrelation p(INTERPRO:"Peptidase C2, calpain, catalytic domain") |
| pmid:26118667 | p(RGD:Cdk5r1) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:27087442 | path(MESH:Cognition) negativeCorrelation p(MGI:Cdk5) |
| pmid:25987199 | act(p(MGI:Glp1r)) increases act(p(MGI:Ppargc1a)) |
| pmid:25987199 | act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:25987199 | act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:25987199 | act(p(MGI:Glp1r)) negativeCorrelation act(a(HBP:"advanced glycation end product")) |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8) |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:25125464 | p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh) |
| pmid:25125464 | p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1) |
| pmid:25125464 | a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) |
| pmid:19459590 | p(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:19459590 | p(HBP:"Tau epitope, CP13") decreases act(p(HGNC:MAPT)) |
| pmid:23294633 | a(HBP:"Tau epitope, AT100") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Thr, 214)) partOf a(HBP:"Tau epitope, AT100") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 212)) partOf a(HBP:"Tau epitope, AT100") |
| pmid:22833681 | a(HBP:"Thiamet G") directlyDecreases act(p(ECCODE:"3.2.1.169")) |
| pmid:22833681 | act(p(ECCODE:"3.2.1.169")) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:24251416 | p(HGNC:MAPT, pmod(Ph, Ser, 352)) partOf p(HBP:"tubulin-binding repeat 4") |
| pmid:22156579 | act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) |
| pmid:22156579 | p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization") |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp)) |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel) |
| pmid:23722080 | a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) |
| pmid:23722080 | a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(HBP:"CDK5R1 p25") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") |
| pmid:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") |
| pmid:22952452 | p(HGNC:TRAK1) positiveCorrelation act(a(GO:mitochondrion)) |
| pmid:22952452 | p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22952452 | p(HGNC:TRAK1) negativeCorrelation p(HGNC:MARK1) |
| pmid:22952452 | p(HGNC:RHOT1) positiveCorrelation act(a(GO:mitochondrion)) |
| pmid:22952452 | p(HGNC:RHOT1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22952452 | p(HGNC:RHOT1) negativeCorrelation p(HGNC:MARK1) |
| pmid:23001711 | p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22072628 | p(HBP:"proline-rich region 2", pmod(Ph)) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:22072628 | p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:8226987 | p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT)) |
| pmid:24401760 | p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:24401760 | p(HGNC:ITPKB) partOf a(HBP:"dystrophic neurite") |
| pmid:24401760 | p(MGI:Itpkb) increases bp(GO:"apoptotic process") |
| pmid:24401760 | p(MGI:Itpkb) increases p(MGI:Bace1) |
| pmid:24401760 | p(MGI:Itpkb) increases act(p(MGI:Bace1)) |
| pmid:24401760 | p(MGI:Itpkb) increases act(p(MGI:Map2k1)) |
| pmid:24401760 | p(MGI:Itpkb) increases act(p(MGI:Map2k2)) |
| pmid:24401760 | p(MGI:Itpkb) increases a(HBP:Astrogliosis) |
| pmid:24401760 | p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) |
| pmid:24401760 | p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:24401760 | a(HBP:"SL-327") directlyDecreases p(MGI:Map2k1) |
| pmid:24401760 | a(HBP:"SL-327") directlyDecreases p(MGI:Map2k2) |
| pmid:24401760 | a(HBP:"SL-327") decreases a(CHEBI:"amyloid-beta") |
| pmid:23737518 | a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Cdk5)) |
| pmid:23737518 | a(HBP:"LDN-193594") decreases a(HBP:"Tau epitope, PHF1") |
| pmid:23737518 | a(HBP:"LDN-193594") decreases act(p(HBP:"CDK5R1 p25")) |
| pmid:23737518 | a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Gsk3b)) |
| pmid:23737518 | a(HBP:"LDN-193594") isA a(HBP:diaminothiazole) |
| pmid:23737518 | a(HBP:"LDN-193665") isA a(HBP:diaminothiazole) |
| pmid:23737518 | a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5)) |
| pmid:23737518 | a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b)) |
| pmid:23737518 | a(HBP:"LDN-213843") isA a(HBP:diaminothiazole) |
| pmid:23737518 | a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5)) |
| pmid:23737518 | a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b)) |
| pmid:7667312 | p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments") |
| pmid:7667312 | a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:25672970 | a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B)) |
| pmid:25672970 | a(HBP:"C-30-27") increases path(MESH:Cognition) |
| pmid:25672970 | act(p(HGNC:KAT2B)) positiveCorrelation p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) |
| pmid:25546293 | p(HGNC:KAT2B) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:24686445 | act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK)) |
| pmid:24686445 | act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9)) |
| pmid:25672970 | p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) positiveCorrelation act(p(HGNC:KAT2B)) |
| pmid:24844691 | a(HBP:"Tubastatin A") directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:24844691 | a(HBP:"Tubastatin A") decreases a(CHEBI:"amyloid-beta") |
| pmid:24844691 | a(HBP:"Tubastatin A") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:24844691 | a(HBP:"ACY-1215") directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:24844691 | a(HBP:"ACY-1215") decreases a(CHEBI:"amyloid-beta") |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases deg(p(HGNC:CTNNB1)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases deg(p(HGNC:CTNNB1)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases deg(p(HGNC:CTNNB1)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) decreases p(HGNC:CTNNB1, pmod(Ub)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:membrane)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) negativeCorrelation act(p(HGNC:HDAC6)) |
| pmid:25546293 | a(CHEBI:vorinostat) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:25546293 | a(CHEBI:vorinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:25546293 | a(HBP:crebinostat) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:25546293 | a(HBP:crebinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:27917100 | a(HBP:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) |
| pmid:26890116 | a(HBP:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) |
| pmid:18558669 | a(HBP:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(Ac, Lys, 174)) |
| pmid:29540553 | p(MGI:Sirt1) positiveCorrelation a(GO:"neuron to neuron synapse") |
| pmid:29540553 | p(MGI:Sirt1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29540553 | a(GO:"neuron to neuron synapse") positiveCorrelation p(MGI:Sirt1) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation p(HGNC:APP, frag("672_713")) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27550730 | a(HBP:"CM-414") directlyDecreases act(p(MGI:Pde5a)) |
| pmid:27550730 | a(HBP:"CM-414") directlyDecreases act(p(ECCODE:"3.5.1.98")) |
| pmid:27550730 | a(HBP:"CM-414") decreases a(CHEBI:"amyloid-beta") |
| pmid:27550730 | a(HBP:"CM-414") decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:27550730 | a(HBP:"CM-414") decreases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:27550730 | act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) |
| pmid:29559585 | p(MGI:Gapdh, pmod(NO)) increases act(p(MGI:Ep300)) |
| pmid:29559585 | p(MGI:Gapdh, pmod(NO)) positiveCorrelation p(MGI:Mapt, pmod(Ac, Lys, 280)) |
| pmid:29559585 | act(p(MGI:Ep300)) positiveCorrelation p(MGI:Sirt1, pmod(NO)) |
| pmid:29559585 | p(MGI:Sirt1, pmod(NO)) positiveCorrelation act(p(MGI:Ep300)) |
| pmid:29559585 | p(MGI:Sirt1, pmod(NO)) increases act(p(MGI:Sirt1)) |
| pmid:29559585 | p(MGI:Mapt, pmod(Ac, Lys, 280)) positiveCorrelation p(MGI:Gapdh, pmod(NO)) |
| pmid:29559585 | a(HBP:CGP3466B) decreases p(MGI:Gapdh, pmod(NO)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 163)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 281)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 369)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases act(p(HGNC:MAPT)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) negativeCorrelation act(a(CHEBI:"amyloid-beta")) |
| pmid:28287136 | p(HGNC:MAPT, var("p.Lys280Gln")) increases a(HBP:"Tau aggregates") |
| pmid:28002468 | p(HGNC:MAP4, frag("992_999")) equivalentTo p(HBP:"VQIINK motif") |
| pmid:28002468 | p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(HBP:"VQIINK motif") |
| pmid:28002468 | p(HGNC:MAP2, frag("332_339")) equivalentTo p(HBP:"VQIVYK motif") |
| pmid:28002468 | a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAPT, pmod(Ac)) |
| pmid:28002468 | a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac)) |
| pmid:27041503 | p(HGNC:WWC1) negativeCorrelation bp(MESH:"Long-Term Potentiation") |
| pmid:26390242 | a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) |
| pmid:26390242 | a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:26390242 | a(CHEBI:salsalate) decreases p(HGNC:MAPT) |
| pmid:26390242 | a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 225)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 331)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 343)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 347)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 385)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:24686445 | a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF) |
| pmid:24686445 | p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43) |
| pmid:24686445 | p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL) |
| pmid:24686445 | p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF) |
| pmid:23487739 | a(HBP:Tubacin) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:21427723 | a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) |
| pmid:21427723 | a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac)) |
| pmid:20869593 | a(HBP:C646) directlyDecreases act(p(HGNC:EP300)) |
| pmid:20869593 | a(HBP:C646) decreases p(HGNC:MAPT, pmod(Ac)) |
| pmid:29540553 | a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:29226865 | p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) |
| pmid:28771976 | a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3)) |
| pmid:28771976 | a(HBP:RGFP966) association bp(GO:memory) |
| pmid:29844403 | a(HBP:MPT0G211) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:29844403 | a(HBP:MPT0G211) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29844403 | a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:29844403 | a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:29844403 | a(HBP:MPT0G211) increases bp(GO:learning) |
| pmid:29844403 | a(HBP:MPT0G211) increases bp(GO:memory) |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") association bp(MESH:"Hot Temperature") |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:19732809 | g(HGNC:OGT) positiveCorrelation act(complex(GO:"proteasome complex")) |
| pmid:26041011 | a(HBP:"USP14 Aptamer") decreases act(p(HGNC:USP14)) |
| pmid:27325702 | p(HBP:"APP, ACR") association p(HGNC:STUB1) |
| pmid:27325702 | p(HBP:"APP, ACR") association p(HBP:"CRL4 complex") |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") |
| pmid:27325702 | p(HBP:"CRL4 complex") association p(HBP:"APP, ACR") |
| pmid:27325702 | p(HBP:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) |
| pmid:27325702 | p(HBP:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") |
| pmid:27325702 | complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(HBP:"CRL4 complex") |
| pmid:25378699 | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:25378699 | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:16464864 | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:24905733 | p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:27260838 | p(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain") |
| pmid:27260838 | p(HBP:"Tau antibody, TNT2") association p(HBP:"phosphatase-activating domain") |
| pmid:27260838 | p(HBP:pretangles) positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:27601475 | a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers") |
| pmid:27601475 | a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide") |
| pmid:27601475 | act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide") |
| pmid:27373205 | p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11606569 | g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:27716675 | a(HBP:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:27716675 | a(HBP:neuroinflammation) positiveCorrelation g(DBSNP:rs63751438) |
| pmid:27716675 | a(HBP:neuroinflammation) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27716675 | g(DBSNP:rs63751438) positiveCorrelation a(HBP:neuroinflammation) |
| pmid:19765634 | g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19765634 | g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:19765634 | g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:21843595 | p(MGI:Sumo3) negativeCorrelation bp(GO:learning) |
| pmid:21843595 | p(MGI:Sumo3) negativeCorrelation bp(GO:memory) |
| pmid:19782030 | act(p(RGD:Stat1)) increases r(RGD:Irf1) |
| pmid:19782030 | act(p(RGD:Stat1)) increases r(RGD:Tnf) |
| pmid:19782030 | act(p(RGD:Stat1)) increases r(RGD:Il6) |
| pmid:19782030 | p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(Sumo)) |
| pmid:19782030 | p(RGD:Nr1h2, pmod(Sumo)) increases act(p(RGD:Stat1)) |
| pmid:19782030 | p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(Sumo)) |
| pmid:19782030 | p(RGD:Nr1h3, pmod(Sumo)) increases act(p(RGD:Stat1)) |
| pmid:19323834 | complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) |
| pmid:19323834 | p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) |
| pmid:19323834 | p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) |
| pmid:18675254 | p(HGNC:UBE2I) partOf complex(GO:"endoplasmic reticulum") |
| pmid:19323834 | p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) |
| pmid:18675254 | p(HGNC:APP, pmod(Sumo, Lys, 587)) decreases a(CHEBI:"amyloid-beta") |
| pmid:18675254 | p(HGNC:APP, pmod(Sumo, Lys, 595)) decreases a(CHEBI:"amyloid-beta") |
| pmid:18675254 | p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) |
| pmid:18675254 | p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) |
| pmid:17346237 | p(HGNC:SUMO3) increases p(HGNC:BACE1) |
| pmid:17346237 | p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_711")) |
| pmid:17346237 | p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_713")) |
| pmid:16464864 | a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:12506199 | p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta") |
| pmid:12506199 | p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta") |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) |
| pmid:29334120 | p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP)) |
| pmid:29334120 | p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP)) |
| pmid:26142647 | p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Irs1, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Akt1, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Gsk3b, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Mtor, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Ntrk2, pmod(Ph)) |
| pmid:29421605 | p(RGD:Irs1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Akt1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Mtor, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29062069 | p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) |
| pmid:28422052 | a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:28422052 | a(CHEBI:"folic acid") increases p(MGI:Dnmt1) |
| pmid:28422052 | p(MGI:Dnmt1) increases p(MGI:Ppp2ca, pmod(Me, Leu, 309)) |
| pmid:28422052 | p(MGI:Ppp2ca, pmod(Me, Leu, 309)) decreases act(p(MGI:Ppp2ca)) |
| pmid:25143394 | p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:25143394 | p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:23134599 | a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) |
| pmid:23134599 | a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) |
| pmid:23134599 | a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) |
| pmid:23134599 | p(RGD:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:21489990 | act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:21489990 | p(RGD:Egr1) directlyIncreases act(p(RGD:Cdk5)) |
| pmid:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT180") |
| pmid:19623258 | p(HBP:"Tau epitope, AT180") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pmid:19623258 | p(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:25001178 | act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin)) |
| pmid:24964035 | p(HGNC:SMAD2) decreases p(HGNC:PIN1) |
| pmid:24964035 | p(HGNC:SMAD3) decreases p(HGNC:PIN1) |
| pmid:23832849 | act(p(INTERPRO:"FKBP-type peptidyl-prolyl cis-trans isomerase domain")) directlyDecreases p(HBP:"tubulin-binding repeat 3") |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases act(p(HGNC:PIN1)) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 65)) increases act(p(HGNC:PIN1)) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT) |
| pmid:19401603 | complex(GO:"tubulin complex") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:28019679 | bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) |
| pmid:28019679 | complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) |
| pmid:27314526 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) |
| pmid:28019679 | complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") |
| pmid:28019679 | complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF)) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta") |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") |
| pmid:28019679 | a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:28019679 | act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) |
| pmid:28019679 | act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:28019679 | complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) |
| pmid:28019679 | complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027) |
| pmid:23702978 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) |
| pmid:24561250 | complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) |
| pmid:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) |
| pmid:24561250 | complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) |
| pmid:24561250 | complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) |
| pmid:24561250 | complex(GO:"inflammasome complex") increases p(HGNC:IL18) |
| pmid:24561250 | act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) |
| pmid:24561250 | complex(GO:"inflammasome complex") regulates p(HGNC:IL18) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:24561250 | act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) |
| pmid:27314526 | act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) |
| pmid:27314526 | complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pmid:23702978 | p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) |
| pmid:24561250 | p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(HGNC:PYCARD) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:PYCARD) increases p(HGNC:IL1B) |
| pmid:24561250 | p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) |
| pmid:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") |
| pmid:23702978 | complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | bp(GO:"cell activation") increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:NLRP1) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:NLRP1) increases p(HGNC:IL1B) |
| pmid:27314526 | p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta") |
| pmid:27314526 | act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") |
| pmid:23702978 | p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") |
| pmid:23702978 | p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") |
| pmid:23702978 | act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) |
| pmid:24561250 | p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23702978 | complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pmid:23702978 | composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) |
| pmid:23702978 | act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) |
| pmid:23702978 | a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) |
| pmid:27314526 | a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") |
| pmid:23702978 | a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) |
| pmid:23702978 | act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") |
| pmid:23702978 | a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) |
| pmid:23702978 | complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) |
| pmid:23702978 | complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) |
| pmid:23702978 | act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") |
| pmid:24561250 | p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:23702978 | p(HGNC:SCAF11) increases bp(GO:pyroptosis) |
| pmid:23702978 | act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) |
| pmid:23702978 | a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I")) |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) |
| pmid:23702978 | a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL1B)) |
| pmid:23702978 | a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) |
| pmid:23702978 | p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) |
| pmid:23702978 | p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | p(HGNC:CASP8) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) |
| pmid:23702978 | complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) |
| pmid:23702978 | complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) |
| pmid:23702978 | complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) |
| pmid:23702978 | p(HGNC:XIAP) decreases complex(GO:ripoptosome) |
| pmid:23702978 | p(HGNC:BIRC3) decreases complex(GO:ripoptosome) |
| pmid:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) |
| pmid:23702978 | p(FPLX:TNFRSF) increases p(HGNC:NLRP3) |
| pmid:23702978 | p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(Ub)) |
| pmid:23702978 | p(FPLX:IFNB) increases p(HGNC:AIM2) |
| pmid:23702978 | g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") |
| pmid:24561250 | g(HGNC:NLRP3) increases a(CHEBI:"amyloid-beta") |
| pmid:24561250 | g(HGNC:NLRP3) decreases bp(GO:memory) |
| pmid:24561250 | g(HGNC:NLRP3) decreases bp(GO:behavior) |
| pmid:23702978 | path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) |
| pmid:23702978 | bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:23702978 | bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3)) |
| pmid:23702978 | a(MESH:Interferons) increases p(HGNC:AIM2) |
| pmid:23702978 | a(MESH:Interferons) decreases p(HGNC:IL1B) |
| pmid:23702978 | a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | m(HGNC:MIR223) decreases p(HGNC:NLRP3) |
| pmid:23702978 | act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) |
| pmid:23702978 | p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") |
| pmid:23702978 | p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) |
| pmid:23702978 | act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:23702978 | p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9)) |
| pmid:23702978 | p(HGNC:CASP1, pmod(NO)) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) |
| pmid:23702978 | complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:CARD17) decreases p(HGNC:IL1B) |
| pmid:23702978 | p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) |
| pmid:23702978 | p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) |
| pmid:23702978 | p(MGI:Mefv) decreases sec(p(MGI:Il1b)) |
| pmid:23702978 | composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) |
| pmid:24561250 | path(MESH:Stroke) increases complex(GO:"inflammasome complex") |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") |
| pmid:24561250 | p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") |
| pmid:24561250 | p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") |
| pmid:24561250 | p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") |
| pmid:24561250 | p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") |
| pmid:24561250 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") |
| pmid:24561250 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:Alarmins) increases complex(GO:"inflammasome complex") |
| pmid:24561250 | a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") |
| pmid:24561250 | complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:24561250 | a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18)) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) |
| pmid:24561250 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") |
| pmid:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") |
| pmid:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") |
| pmid:27314526 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:27314526 | p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24561250 | p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | p(MGI:P2rx4) increases p(HGNC:IL1B) |
| pmid:24561250 | p(MGI:P2rx4) increases p(HGNC:IL1B) |
| pmid:24561250 | p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) |
| pmid:24561250 | p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(HGNC:PANX1) increases p(HGNC:IL1B) |
| pmid:24561250 | p(HGNC:PANX1) increases p(HGNC:IL18) |
| pmid:24561250 | a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") |
| pmid:24561250 | a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(MGI:Nlrp3) increases p(MGI:Il1b) |
| pmid:24561250 | p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") |
| pmid:24561250 | p(MGI:Nlrp3) increases a(MESH:Neuropathology) |
| pmid:24561250 | p(MGI:Nlrp3) decreases bp(GO:cognition) |
| pmid:24561250 | composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) |
| pmid:24561250 | composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) |
| pmid:24561250 | a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) |
| pmid:24561250 | a(CHEBI:probenecid) decreases p(HGNC:PANX1) |
| pmid:24561250 | a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:probenecid) decreases p(HGNC:IL1B) |
| pmid:24561250 | a(CHEBI:probenecid) decreases p(HGNC:IL18) |
| pmid:24561250 | a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | a(CHEBI:probenecid) increases bp(GO:learning) |
| pmid:24561250 | a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) |
| pmid:24561250 | a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") |
| pmid:24561250 | p(MGI:Casp1) increases a(MESH:Neuropathology) |
| pmid:24561250 | p(MGI:Casp1) decreases bp(GO:cognition) |
| pmid:27314526 | bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") |
| pmid:27314526 | act(p(HGNC:PRSS3)) increases p(HGNC:IL18) |
| pmid:27314526 | act(p(FPLX:ELA)) increases p(HGNC:IL18) |
| pmid:27314526 | act(p(HGNC:CTSG)) increases p(HGNC:IL18) |
| pmid:27314526 | composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pmid:27314526 | path(MESH:Periodontitis) decreases bp(GO:cognition) |
This section lists all of the namespaces that are defined in the original BEL document.
The source BEL document contained references to the following namespaces, but they were never used. It is suggested to delete their definitions from the BEL document to improve readability and parsing speed.
This section lists all of the annotations that are defined in the original BEL document.
The source BEL document contained annotations defined as a list. Click each link to export
the list definition as a BELANNO file that can hosted externally to promote
re-usability and interoperability. After, you can replace the list definition in the source
BEL with a SET ANNOTATION X AS URL "Y" definition.
The source BEL document contained the following list annotations, but no references to the following values. It is suggested to prune these values from the list definitions.
Note: this may be due to errors occurring in all statements with these annotations.
| Annotation | Values |
|---|---|
| HasQuantitativeInformation |
|
| Km_ATP |
|
| MeasurementType |
|
| MeasurementValue |
|
| Method |
|
| PublicationType |
|
| Research_Model |
|
| Tau_Epitope |
|
| Vmax |
|
| Error | Frequency |
|---|---|
"pro-nerve growth factor, human" is not in the MESH namespace |
7 |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
6 |
"latrepirdine" is not in the MESH namespace |
5 |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
5 |
"Nitrosative Stress" is not in the MESH namespace |
4 |
"neuroinflammatory response" is not in the GO namespace |
4 |
"gambogic amide" is not in the MESH namespace |
3 |
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace |
3 |
"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace |
2 |
"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace |
2 |
"3-3' dityrosine cross-linking" is not in the HBP namespace |
2 |
"CA1 interneuron" is not in the HBP namespace |
2 |
| Path | Line | BEL | Message |
|---|---|---|---|
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 365 | path(MESH:D060825) -> a(MESH:"pro-nerve growth factor, human") |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 366 | path(MESH:D000544) -> a(MESH:"pro-nerve growth factor, human") |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 368 | complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) -> bp(GO:"GO:0031175") |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 385 | a(MESH:"pro-nerve growth factor, human") pos path(MESH:D003072) |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 398 | a(MESH:"pro-nerve growth factor, human") biomarkerFor path(MESH:D000544) |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 414 | complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NGFR)) -> bp(GO:"GO:0006915") |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 450 | composite(complex(p(HGNC:NGFR), p(HGNC:SORT1)), a(MESH:"pro-nerve growth factor, human")) -> bp(GO:"GO:0006915") |
"pro-nerve growth factor, human" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 523 | p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(Ph)) -> act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) |
"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 544 | act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) -- bp(GO:"GO:0031175") |
"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 603 | complex(a(MESH:"gambogic amide"), p(HGNC:NTRK1)) => p(HGNC:NTRK1, pmod(Ph)) |
"gambogic amide" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 609 | a(MESH:"gambogic amide") -| bp(HBP:Excitotoxicity) |
"gambogic amide" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 610 | a(MESH:"gambogic amide") -> bp(GO:"GO:0031175") |
"gambogic amide" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 624 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") hasMembers list(p(HGNC:CHRNA1) , p(HGNC:CHRNA2), p(HGNC:CHRNA3), p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNA6), p(HGNC:CHRNA7), p(HGNC:CHRNA9), p(HGNC:CHRNA10), p(HGNC:CHRNB1), p(HGNC:CHRNB2), p(HGNC:CHRNB3), p(HGNC:CHRNB4), p(HGNC:CHRND), p(HGNC:CHRNG)) |
"Cholinergic receptors nicotinic subunits" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 629 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") hasMembers list(p(HGNC:CHRM1), p(HGNC:CHRM2), p(HGNC:CHRM3), p(HGNC:CHRM4), p(HGNC:CHRM5)) |
"Cholinergic receptors muscarinic" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 732 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D060825) |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 733 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D024801) |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 734 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| a(CHEBI:"amyloid-beta polypeptide 42") |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 735 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -> act(p(MGI:Chrm1)) |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 737 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| p(MGI:Bace1) |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 738 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| act(p(MGI:Gsk3b)) |
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 758 | path(MESH:D000544) -| r(HGNCGENEFAMILY:"Synaptotagmins") |
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 762 | p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0031629") |
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 764 | p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0007269") |
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 782 | p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") -> p(HGNC:MAPT, pmod(Ph)) |
"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 783 | act(p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits")) -| bp(HBP:hyperphosphorylation) |
"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 1007 | a(MESH:"latrepirdine") -| act(p(HGNC:BCHE)) |
"latrepirdine" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 1008 | a(MESH:"latrepirdine") -| act(p(HGNC:ACHE)) |
"latrepirdine" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 1010 | a(MESH:"latrepirdine") -| bp(GO:"GO:0098989") |
"latrepirdine" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 1012 | a(MESH:"latrepirdine") -| bp(GO:"GO:0046902") |
"latrepirdine" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/receptors/mufson2008.bel | 1013 | a(MESH:"latrepirdine") -> bp(MESH:D000066829) |
"latrepirdine" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 106 | p(HBP:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 107 | p(HBP:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 108 | p(HBP:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 109 | p(HBP:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 129 | p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(Ph)) -| complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 610 | a(CHEBI:"amyloid-beta") -> bp(MESH:"Nitrosative Stress") |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 611 | bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 612 | bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 852 | a(CHEBI:peroxynitrite) -> bp(MESH:"Nitrosative Stress") |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 920 | a(CHEBI:peroxynitrite) -> a(HBP:"3-3' dityrosine cross-linking") |
"3-3' dityrosine cross-linking" is not in the HBP namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 921 | a(HBP:"3-3' dityrosine cross-linking") pos a(HBP:"paired helical filaments") |
"3-3' dityrosine cross-linking" is not in the HBP namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 1488 | p(MGI:Ttbk1) -> bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 1862 | act(p(MGI:Dapk1)) neg tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) |
"CA1 interneuron" is not in the HBP namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 1863 | tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) pos bp(GO:memory) |
"CA1 interneuron" is not in the HBP namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2478 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) pos a(HBP:"long-term depression") |
"long-term depression" is not in the HBP namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2946 | a(CHEBI:lipopolysaccharide) -> bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2947 | a(CHEBI:"amyloid-beta") -> bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2948 | a(HBP:"C-30-27") -| bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/hbp-universe/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 3396 | a(HBP:MPT0G211) -> p(HBP:"Blood-Brain Barrier") |
"Blood-Brain Barrier" is not in the HBP namespace |
These pairs of nodes represent motifs like A increases B and
B decreases A.
| Node A | Node B |
|---|---|
| complex(GO:"protein phosphatase type 2A complex") | p(HGNC:GSK3B) |
| bp(GO:autophagy) | p(HGNC:SNCA) |
| bp(GO:autophagy) | p(HGNC:MAPT) |
| bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | a(CHEBI:"amyloid-beta") |
| a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") |
| p(HGNC:CHRNA7) | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| p(HGNC:CHRNA7) | a(CHEBI:"amyloid-beta") |
| p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | a(HBP:"Tau aggregates") |
| bp(GO:autophagy) | p(HGNC:HTT, var("?")) |
| p(HGNC:PIN1) | p(HGNC:SMAD2) |
| p(HGNC:RELA) | bp(GO:"long-term synaptic potentiation") |
| p(HGNC:CHRNA7) | a(CHEBI:anandamide) |
| a(GO:synapse) | p(HGNC:MAPT) |
| p(HGNC:MAPT) | bp(HP:Neurodegeneration) |
| bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:MAPT) |
| p(HGNC:NFKB1) | bp(GO:"long-term synaptic potentiation") |
| path(MESH:Tauopathies) | p(MGI:Tfeb) |
| a(CHEBI:"amyloid-beta") | a(MESH:Microglia) |
| complex(GO:"NF-kappaB complex") | a(CHEBI:"amyloid-beta") |
| a(HBP:"Tau oligomers") | a(HBP:"Tau aggregates") |
| bp(GO:"calcium ion homeostasis") | complex(GO:"NF-kappaB complex") |
| bp(GO:"late endosomal microautophagy") | p(MGI:Mapt) |
| p(FPLX:Proteasome) | a(CHEBI:"amyloid-beta") |
| bp(GO:"membrane depolarization") | complex(GO:"NF-kappaB complex") |
| p(HGNC:TNF) | a(CHEBI:nicotine) |
| complex(GO:"proteasome complex") | a(CHEBI:"amyloid-beta") |
| p(MGI:Mapt, var("p.Pro301Leu")) | bp(GO:macroautophagy) |
These pairs of nodes have a contradiction in their causal relationships, meaning they
have more than one of INCREASES, DECREASES, or CAUSES NO
CHANGE. This may be due to different experimental conditions, so these statements
need to be carefully considered in analyses.
| Source | Relations | Target |
|---|---|---|
| a(CHEBI:"amyloid-beta") | causesNoChange, positiveCorrelation, association, decreases, increases | p(HGNC:CHRNA7) |
| bp(GO:"lysosomal protein catabolic process") | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:TTBK2, var("p.Glu450*")) | decreases, increases | p(HGNC:TTBK2) |
| bp(GO:autophagy) | decreases, increases | path(HBP:neurotoxicity) |
| bp(GO:autophagy) | decreases, negativeCorrelation, increases | a(CHEBI:lipid) |
| a(CHEBI:"Evans blue") | causesNoChange, increases | a(PUBCHEM:9832404) |
| a(CHEBI:Thrombin) | causesNoChange, increases | p(HGNC:MAPT, frag("561_685")) |
| p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | decreases, causesNoChange | bp(MESH:"Hand Strength") |
| a(CHEBI:"amyloid-beta") | decreases, increases | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| a(CHEBI:nicotine) | causesNoChange, regulates, association, decreases, increases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| p(HGNC:BSG) | decreases, causesNoChange | a(CHEBI:"amyloid-beta") |
| a(HBP:"Tau antibody, Tau46") | decreases, causesNoChange | p(MGI:Mapt) |
| a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | decreases, increases | a(CHEBI:"amyloid-beta polypeptide 42") |
| a(CHEBI:"amyloid-beta") | causesNoChange, decreases | path(HBP:Neurodegeneration) |
| composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) | decreases, increases | path(MESH:Smell) |
| p(MGI:Chrna7) | decreases, increases | path(MESH:"Spatial Memory") |
| p(HGNC:MAPT) | causesNoChange, increases | bp(GO:"retrograde axonal protein transport") |
| a(MESH:Nicotine) | decreases, increases | p(HGNC:CHRNA7) |
| a(HBP:"amyloid-beta oligomers") | decreases, increases | p(HGNC:MAPT) |
| a(MESH:Liver) | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:WNT3A) | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(MGI:Mapt, var("p.Ala152Thr")) | decreases, increases | p(MGI:Mapt) |
| p(MGI:Mapt, var("p.Pro301Leu")) | decreases, increases | p(MGI:Mapt) |
| a(MESH:antalarmin) | decreases, causesNoChange | path(HBP:"isolation rearing") |
| p(HGNC:PRKN, var("?")) | decreases, increases | p(HGNC:PRKN) |
| p(MGI:Vegfc) | causesNoChange, increases | a(CHEBI:macromolecule) |
| p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | decreases, positiveCorrelation, increases | p(HGNC:MAPT) |
| p(MGI:Crh) | causesNoChange, decreases | a(MESH:Progesterone) |
| path(MESH:"Alzheimer Disease") | negativeCorrelation, positiveCorrelation, association, decreases, increases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| a(CHEBI:ambroxol) | decreases, increases | p(HGNC:SNCA) |
| a(CHEBI:"amyloid-beta") | decreases, increases | a(CHEBI:acetylcholine) |
| p(HGNC:MAPT) | causesNoChange, association, increases | a(HBP:"Tau aggregates") |
| a(CHEBI:donepezil) | decreases, increases | p(HGNC:ACHE) |
| p(HGNC:CHRM1) | causesNoChange, increases | bp(GO:"ERK1 and ERK2 cascade") |
| a(CHEBI:Anatabine) | decreases, increases | path(MESH:Anxiety) |
| a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | decreases, increases | bp(HP:Neurodegeneration) |
| a(CHEBI:Nilvadipine) | decreases, increases | a(CHEBI:"amyloid-beta polypeptide 42") |
| a(CHEBI:chloroquine) | decreases, increases | p(HGNC:MAPT) |
| a(CHEBI:lactacystin) | decreases, increases | p(HGNC:MAPT) |
| p(MGI:Chrna7) | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:BACE1, frag("67_78")) | decreases, increases | a(HBP:"sAPP-alpha") |
| a(CHEBI:"methylene blue") | decreases, increases | p(HGNC:SQSTM1) |
| p(HGNC:TFEB) | decreases, regulates, increases | a(CHEBI:"amyloid-beta") |
| a(CHEBI:rolipram) | decreases, increases | p(HGNC:MAPT) |
| a(MESH:antalarmin) | decreases, increases | p(RGD:Drd2) |
| a(MESH:Nicotine) | decreases, increases | p(MESH:"Receptors, GABA") |
| a(MESH:antalarmin) | causesNoChange, increases | a(MESH:"Embryonic Structures") |
| path(MESH:D060825) | causesNoChange, increases | p(HGNC:CHAT) |
| p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | causesNoChange, increases | path(MESH:"Alcohol Drinking") |
| p(HGNC:CHAT) | decreases, increases, directlyIncreases | a(CHEBI:acetylcholine) |
| a(PUBCHEM:675434) | decreases, increases | p(HGNC:MAPT) |
| p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) | decreases, increases | a(HBP:"huntingtin aggregates") |
| a(CHEBI:"amyloid-beta") | decreases, positiveCorrelation, increases | complex(GO:"NF-kappaB complex") |
| a(CHEBI:rosiglitazone) | causesNoChange, decreases | a(HBP:HBP00018) |
| a(CHEBI:nifedipine) | causesNoChange, increases | bp(GO:"calcium-mediated signaling") |
| complex(a(GO:"proteasome complex"), p(HGNC:USP14)) | decreases, increases | bp(GO:"protein catabolic process") |
| a(HBP:"amyloid-beta oligomers") | decreases, increases | p(HGNC:DLG4) |
| a(HBP:"4-OH-GTS-21") | causesNoChange, decreases | a(MESH:"Cholinergic Neurons") |
| p(HBP:"Tau oligomers", var("p.Lys280del")) | causesNoChange, increases | bp(GO:"cell death") |
| a(MESH:"SNARE Proteins") | causesNoChange, increases | p(HGNC:CHRNA7) |
| p(MGI:Chrna7) | decreases, increases | p(MGI:Map2) |
| bp(MESH:"Oxidative Stress") | causesNoChange, increases | bp(GO:"apoptotic process") |
| r(HGNC:"BACE1-AS") | regulates, decreases, increases | r(HGNC:BACE1) |
| a(PUBCHEM:9832404) | causesNoChange, increases | p(HGNC:SLC17A7) |
| p(HGNC:MAPT) | causesNoChange, decreases, negativeCorrelation | a(GO:synapse) |
| p(HGNC:OTUB1) | decreases, increases | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| a(CHEBI:heparin) | causesNoChange, decreases, negativeCorrelation | a(HBP:"Tau aggregates") |
| p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | decreases, causesNoChange | path(MESH:Smell) |
| path(HBP:"isolation rearing") | decreases, increases | r(RGD:Bdnf) |
| path(MESH:"Alzheimer Disease") | causesNoChange, positiveCorrelation, association, increases | p(HGNC:MAPT) |
| a(CHEBI:rosiglitazone) | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:TTBK2, var("p.Tyr448*")) | decreases, increases | p(HGNC:TTBK2) |
| p(HGNC:TTBK2, var("p.Asp449*")) | decreases, increases | p(HGNC:TTBK2) |
| p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | decreases, causesNoChange | path(MESH:"Motor Activity") |
| p(HGNC:BCHE) | decreases, directlyIncreases | a(CHEBI:acetylcholine) |
| a(CHEBI:methamphetamine) | decreases, association, increases | a(CHEBI:dopamine) |
| a(CHEBI:nicotine) | decreases, causesNoChange | a(CHEBI:"amyloid-beta") |
| a(PUBCHEM:9832404) | decreases, increases | r(HGNC:SLC17A7) |
| a(HBP:HBP00055) | decreases, increases | p(MGI:Mapt) |
| p(FPLX:"CCT_complex") | decreases, increases | a(HBP:"huntingtin aggregates") |
| path(HBP:"isolation rearing") | decreases, increases | r(RGD:Ntrk2) |
| a(CHEBI:Anatabine) | decreases, causesNoChange | p(MGI:Tnf) |
| p(HGNC:MAPT) | causesNoChange, increases | bp(GO:"neuron death") |
| p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) | decreases, causesNoChange, negativeCorrelation | a(MESH:Microglia) |
| p(HGNC:STUB1) | decreases, increases | p(FPLX:Caspase) |
| a(CHEBI:chlorobutanol) | causesNoChange, decreases | path(MESH:Smell) |
| a(MESH:Kidney) | decreases, increases | a(CHEBI:"amyloid-beta") |
| complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) | decreases, increases | bp(GO:"anterograde axonal protein transport") |
| a(GO:"neurofibrillary tangle") | decreases, increases | bp(GO:"cell death") |
| a(CHEBI:nicotine) | decreases, regulates, increases | a(CHEBI:dopamine) |
| a(CHEBI:nicotine) | causesNoChange, increases | a(HBP:"alpha-4-containing nAChR") |
| p(HGNC:MAPT) | causesNoChange, association, regulates, increases | bp(GO:"axonal transport") |
| p(MGI:Tfeb) | causesNoChange, decreases | p(MGI:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| bp(MESH:Autophagy) | decreases, increases | p(HBP:"Tau C3") |
| path(MESH:D000544) | decreases, causesNoChange | p(HGNC:ACHE) |
| a(CHEBI:Anatabine) | causesNoChange, decreases | p(MGI:Ifng) |
| a(PUBCHEM:9576811) | decreases, increases | p(HGNC:APP) |
| a(CHEBI:galanthamine) | decreases, increases | p(HGNC:ACHE) |
| path(MESH:"Alzheimer Disease") | decreases, positiveCorrelation, association, increases | a(CHEBI:"amyloid-beta") |
| a(CHEBI:"amyloid-beta") | decreases, increases | bp(GO:memory) |
| a(PUBCHEM:11249342) | causesNoChange, increases | path(MESH:Nausea) |
| a(CHEBI:"dimethyl fumarate") | causesNoChange, increases | p(HGNC:NFE2L2) |
| composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) | decreases, increases | path(MESH:Smell) |
| p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | causesNoChange, decreases | p(HGNC:SLC17A7) |
| path(MESH:"Alcohol Drinking") | causesNoChange, decreases, increases | p(HGNC:ADNP) |
| complex(GO:"NF-kappaB complex") | regulates, decreases, increases | p(HGNC:BACE1) |
| a(HBP:"Tau antibody, Tau46") | decreases, causesNoChange | p(HGNC:MAPT) |
| p(HGNC:STUB1) | decreases, increases | p(HBP:"Tau C3") |
| p(HGNC:PICALM) | decreases, positiveCorrelation, increases | a(CHEBI:"amyloid-beta") |
| p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) | causesNoChange, increases | p(MGI:Mapt) |
| p(MGI:Vegfc) | causesNoChange, increases | a(MESH:"Lymphatic Vessels") |
| a(HBP:HBP00092) | causesNoChange, increases | bp(GO:"apoptotic process") |
| p(HGNC:RAB5A) | decreases, increases | bp(GO:endocytosis) |
| path(MESH:"Alzheimer Disease") | negativeCorrelation, positiveCorrelation, association, decreases, increases | p(HGNC:CHRNA7) |
| p(HGNC:MAPT) | causesNoChange, increases | bp(GO:"anterograde axonal protein transport") |
| p(HGNC:HSPB1) | decreases, causesNoChange, increases | p(HGNC:MAPT) |
| p(HGNC:CHRNA7) | regulates, decreases, increases | a(CHEBI:"glutamate(2-)") |
| p(HGNC:SYK) | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:AQP4) | decreases, association, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:IDE) | decreases, increases | a(CHEBI:"amyloid-beta") |
| bp(GO:"response to endoplasmic reticulum stress") | decreases, increases | bp(GO:"cell death") |
| p(HGNC:BACE1) | decreases, causesNoChange, association, increases | p(HGNC:APP) |
| bp(GO:aging) | decreases, negativeCorrelation, increases | p(HGNC:MAPT) |
| a(CHEBI:"Hsp90 inhibitor") | decreases, increases | p(HGNC:MAPT) |
| a(CHEBI:epoxomicin) | decreases, increases | p(HGNC:MAPT) |
| p(HGNC:MAPT, var("p.Ala152Thr")) | causesNoChange, decreases | p(HGNC:MAPT) |
| p(FPLX:Proteasome) | decreases, increases | p(HGNC:MAPT) |
| p(HGNC:ABCB1) | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:HSPA1A) | decreases, increases | a(HBP:"Tau aggregates") |
| a(MESH:Nicotine) | decreases, increases | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| p(MGI:Tfeb) | causesNoChange, decreases | p(MGI:Mapt) |
| a(CHEBI:Anatabine) | causesNoChange, decreases | bp(HBP:Astrogliosis) |
| p(HGNC:CHRNA7) | regulates, positiveCorrelation, association, decreases, increases | a(CHEBI:"amyloid-beta") |
| bp(MESH:Autophagy) | causesNoChange, increases | p(HGNC:MAPT) |
| complex(GO:"NF-kappaB complex") | decreases, increases | p(HGNC:BCL2L1) |
| p(HGNC:CDC37) | decreases, increases | p(HGNC:MAPT) |
| bp(MESH:Aging) | decreases, increases | p(FPLX:HSP90) |
| p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | decreases, increases | p(HGNC:TFAP2B) |
| p(HGNC:ACHE) | decreases, increases, directlyIncreases | a(CHEBI:acetylcholine) |
| p(HGNC:OTUB1) | decreases, regulates, increases | p(HGNC:MAPT) |
| a(PUBCHEM:11249342) | causesNoChange, increases | path(MESH:Vomiting) |
| bp(GO:autophagy) | decreases, increases | p(HGNC:MAPT) |
| bp(GO:macroautophagy) | decreases, causesNoChange | p(MGI:Mapt, var("p.Pro301Leu")) |
| complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) | decreases, hasComponent, increases | p(HGNC:BACE1) |
| a(CHEBI:rivastigmine) | decreases, increases | p(HGNC:ACHE) |
| a(CHEBI:"amyloid-beta") | decreases, increases | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| p(FPLX:mTORC1) | decreases, increases | p(HGNC:TFEB) |
| bp(MESH:"Heat-Shock Response") | causesNoChange, increases | p(NCBIGENE:492507) |
| complex(GO:"protein phosphatase type 2A complex") | decreases, increases | p(HGNC:MAPT, pmod(Ph)) |
| p(HGNC:TNF) | causesNoChange, increases | p(HGNC:STAT3, pmod(Ph)) |
| a(PUBCHEM:9832404) | decreases, causesNoChange, association, increases | p(HGNC:DLG4) |
| a(CHEBI:sirolimus) | decreases, increases | p(HGNC:MAPT) |
| a(PUBCHEM:675434) | causesNoChange, increases | p(FPLX:Proteasome) |
| bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | decreases, increases | p(HGNC:PRNP) |
| p(MGI:Tfeb) | causesNoChange, decreases | p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| a(CHEBI:"amyloid-beta polypeptide 42") | decreases, causesNoChange | p(FPLX:AMPK) |
| a(CHEBI:"methylene blue") | decreases, increases | p(HGNC:MARK4) |
| p(FPLX:mTORC1) | decreases, increases | bp(GO:macroautophagy) |
| a(CHEBI:nicotine) | regulates, causesNoChange, increases | p(FPLX:CHRN) |
| a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | decreases, increases | a(CHEBI:"amyloid-beta") |
| p(HGNC:NPEPPS) | decreases, regulates, increases | p(HGNC:MAPT) |
| a(MESH:antalarmin) | decreases, increases | p(RGD:Drd3) |
| bp(GO:macroautophagy) | decreases, increases | p(MGI:Mapt) |
| a(CHEBI:nicotine) | decreases, increases | p(HBP:"alpha-4 beta-2 nAChR") |
| a(MESH:Astrocytes) | decreases, increases | a(CHEBI:"amyloid-beta") |
| a(MESH:antalarmin) | decreases, increases | r(RGD:Ntrk2) |
| p(HGNC:IDE) | decreases, increases | a(HBP:"alpha-synuclein fibrils") |
| p(HGNC:MAPT) | causesNoChange, increases | a(HBP:"Tau fibrils") |
| a(CHEBI:"chondroitin sulfate") | decreases, causesNoChange | a(HBP:"Tau isoform F (441 aa)") |
| p(HGNC:BACE1, frag("228_236")) | decreases, increases | a(HBP:"sAPP-alpha") |
| bp(MESH:Autophagy) | decreases, increases | a(HBP:"Tau aggregates") |
| bp(GO:"chaperone-mediated autophagy") | causesNoChange, increases | p(MGI:Mapt, var("p.Pro301Leu")) |
A increases
B and B increases A.
A decreases
B and B decreases A.
While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.
| Type | Node A | Node B |
|---|---|---|
| Chaotic | a(CHEBI:nicotine) | p(FPLX:"CAMK2_complex") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:IL1B) |
| Chaotic | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) |
| Chaotic | complex(GO:"NF-kappaB complex") | p(HGNC:CNTF) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) |
| Chaotic | a(CHEBI:nicotine) | bp(GO:"ERK1 and ERK2 cascade") |
| Chaotic | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Chaotic | bp(GO:"astrocyte activation") | p(HGNC:IL18) |
| Chaotic | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) | p(HGNC:MAPT, pmod(Ph)) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APP) |
| Chaotic | p(HGNC:PRNP) | p(HGNC:PRNP) |
| Chaotic | a(MESH:"Lymphatic Vessels") | p(MGI:Vegfc) |
| Chaotic | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Chaotic | p(MGI:"oncostatin M") | p(MGI:"signal transducer and activator of transcription 3") |
| Chaotic | a(MESH:Proteins) | a(MESH:Proteins) |
| Chaotic | complex(GO:"NF-kappaB complex") | p(HGNC:LIF) |
| Chaotic | p(MGI:"interleukin 1 alpha") | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") |
| Chaotic | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"interleukin 1 alpha") |
| Chaotic | a(HBP:"Tau fibrils") | p(MGI:Tfeb) |
| Chaotic | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) |
| Chaotic | bp(GO:"apoptotic process") | p(HGNC:CASP6) |
| Chaotic | complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) | p(HGNC:UBA2) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP3) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:nicotine) | p(FPLX:PI3K) |
| Chaotic | p(FPLX:NFkappaB) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:TREM2) |
| Chaotic | a(MESH:Proteins) | p(HGNC:PSMD14) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | r(HGNC:"BACE1-AS") |
| Chaotic | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) |
| Chaotic | p(HGNC:ERN1) | p(HGNC:ERN1, pmod(Ph)) |
| Chaotic | a(HBP:"amyloid-beta aggregates") | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:RELA) |
| Chaotic | p(MESH:Proteins, pmod(Ub)) | p(MESH:Proteins, pmod(Ub)) |
| Chaotic | complex(GO:"filamentous actin") | p(HGNC:MAPT) |
| Chaotic | p(MGI:"interleukin 1 alpha") | p(MGI:"signal transducer and activator of transcription 3") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:BACE1) |
| Chaotic | a(GO:lysosome) | a(GO:lysosome) |
| Chaotic | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") |
| Chaotic | a(CHEBI:"reactive oxygen species") | complex(GO:"NF-kappaB complex") |
| Chaotic | a(MESH:Neurons) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) |
| Chaotic | a(HBP:"Tau aggregates") | p(MGI:Mapt) |
| Chaotic | p(HBP:"Tau C3") | p(HGNC:CASP3) |
| Chaotic | bp(GO:"astrocyte activation") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Chaotic | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) | p(HGNC:SYK) |
| Chaotic | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Ala152Thr")) |
| Chaotic | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Chaotic | a(CHEBI:acetylcholine) | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| Chaotic | p(HGNC:MAPT, pmod(Ac, Lys, 353)) | p(HGNC:MAPT, pmod(Ac, Lys, 353)) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:AK1) |
| Chaotic | bp(GO:"depolarization of postsynaptic membrane") | bp(GO:"long-term synaptic potentiation") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP9) |
| Chaotic | p(HGNC:MAPT, pmod(Ac, Lys, 321)) | p(HGNC:MAPT, pmod(Ac, Lys, 321)) |
| Chaotic | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") |
| Chaotic | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | p(HGNC:MAPT, pmod(Ac, Lys, 290)) | p(HGNC:MAPT, pmod(Ac, Lys, 290)) |
| Chaotic | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Chaotic | p(MGI:Tfeb) | p(MGI:Tfeb) |
| Chaotic | p(HBP:"N-terminal fragment of ATF6") | p(HBP:"N-terminal fragment of ATF6") |
| Chaotic | a(CHEBI:acetylcholine) | p(HGNC:CHRM1) |
| Chaotic | p(HGNC:HSF1) | p(HGNC:HSF1) |
| Chaotic | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") |
| Chaotic | bp(GO:"microglial cell activation") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| Chaotic | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:dextran) | a(CHEBI:dextran) |
| Chaotic | bp(GO:macroautophagy) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Chaotic | a(CHEBI:"reactive oxygen species") | complex(GO:"NADPH oxidase complex") |
| Chaotic | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Chaotic | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) | p(HGNC:PPME1) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") |
| Chaotic | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Pro301Leu")) |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") |
| Chaotic | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | p(HGNC:MAPT, pmod(Ac, Lys, 259)) | p(HGNC:MAPT, pmod(Ac, Lys, 259)) |
| Chaotic | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) |
| Chaotic | complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) | p(HGNC:CDK5) |
| Chaotic | a(CHEBI:methamphetamine) | p(HGNC:MTOR) |
| Chaotic | bp(GO:"microglial cell activation") | p(HGNC:IL18) |
| Chaotic | a(MESH:"Lymphatic Vessels") | bp(MESH:"Cerebrovascular Circulation") |
| Dampened | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") |
| Dampened | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| Dampened | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| Dampened | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280del")) |
| Dampened | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) |
| Dampened | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| Dampened | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) |
| Dampened | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) |
| Dampened | p(HGNC:MAPT, pmod(Ac, Lys, 163)) | p(HGNC:MAPT, pmod(Ac, Lys, 163)) |
| Dampened | bp(GO:autophagy) | p(HGNC:MAPT) |
| Dampened | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Dampened | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Dampened | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") |
| Dampened | p(HGNC:MAPT, pmod(Ac, Lys, 369)) | p(HGNC:MAPT, pmod(Ac, Lys, 369)) |
| Dampened | a(CHEBI:methamphetamine) | bp(GO:autophagy) |
| Dampened | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| Dampened | p(HBP:"cis p-tau") | p(HGNC:PIN1) |
| Dampened | p(HGNC:SNCA, var("?")) | p(HGNC:SNCA, var("?")) |
| Dampened | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") |
| Dampened | p(HGNC:MAPT, pmod(Ac, Lys, 281)) | p(HGNC:MAPT, pmod(Ac, Lys, 281)) |
| Dampened | a(CHEBI:"amyloid-beta") | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Dampened | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) |
| Dampened | a(HBP:"protein aggregates") | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| Dampened | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) |
| Dampened | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Dampened | p(HBP:"UBB+1", pmod(UbPoly)) | p(HBP:"UBB+1", pmod(UbPoly)) |
| Dampened | a(HBP:"amyloid-beta derived diffusible ligands") | a(HBP:"amyloid-beta derived diffusible ligands") |
| Dampened | a(CHEBI:"amyloid-beta") | p(HGNC:BCL2L1) |
| Dampened | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.
A positiveCorrelation B, B negativeCorrelation
C, but C positiveCorrelation A.
A negativeCorrelation B, B negativeCorrelation
C, and C negativeCorrelation A.
A increases B, A decreases C, and C
positiveCorrelation A.
A increases B, A increases C, and C
negativeCorrelation A.
A decreases B, A decreases C, and C
negativeCorrelation A.
| Type | Node A | Node B | Node C |
|---|---|---|---|
| Separate | path(MESH:"Pick Disease of the Brain") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| Separate | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:CHRNA7) | path(MESH:Schizophrenia) |
| Separate | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Separate | path(MESH:"Alzheimer Disease") | bp(GO:aging) | p(HGNC:MAPT) |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Separate | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta polypeptide 42") | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Separate | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Separate | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| Separate | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:BAG1) | p(HGNC:MAPT, pmod(Ph)) |
| Separate | p(HGNC:CHRNA7) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| Separate | p(HGNC:GSK3B) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Separate | path(MESH:"Alzheimer Disease") | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:ANP32A) |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Separate | path(MESH:"Alzheimer Disease") | bp(GO:aging) | p(HGNC:AGER) |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | path(MESH:Dementia) |
| Separate | path(MESH:Tauopathies) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| Separate | path(MESH:Tauopathies) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| Separate | path(MESH:"Alzheimer Disease") | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:SET, frag("?")) |
| Separate | path(MESH:Tauopathies) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| Separate | path(MESH:"Pick Disease of the Brain") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MMP2) | path(MESH:"Plaque, Amyloid") |
| Separate | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Separate | a(CHEBI:"amyloid-beta") | p(HGNC:PICALM) | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Alzheimer Disease") | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:SET) |
| Mutual | bp(GO:"lysosomal protein catabolic process") | bp(GO:endocytosis) | path(MESH:"Alzheimer Disease") |
| Mutual | bp(GO:"proteasomal protein catabolic process") | bp(GO:autophagy) | path(MESH:"Alzheimer Disease") |
| Mutual | bp(GO:autophagy) | p(HGNC:MTOR) | path(MESH:Schizophrenia) |
| Mutual | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) | path(MESH:"Alzheimer Disease") |
| Mutual | bp(GO:aging) | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Jens | a(CHEBI:Temsirolimus) | a(HBP:"alpha-synuclein aggregates") | bp(GO:autophagy) |
| Jens | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:MAPT, pmod(OGlyco)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | bp(GO:"neuron death") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:CHRNA4) |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | bp(MESH:"Oxidative Stress") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) |
| Jens | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Oxidative Stress") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | p(HGNC:TFEB) |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"apoptotic process") | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:OTUB1) |
| Jens | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") | bp(GO:learning) | p(MGI:App, frag("25_35")) |
| Jens | a(GO:"neurofibrillary tangle") | p(HBP:"CDK5R1 p25") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:Schizophrenia) |
| Jens | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"ERK1 and ERK2 cascade") | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(HBP:neurotoxicity) |
| Jens | p(HGNC:BAG1) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"advanced glycation end-product") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) |
| Jens | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| Jens | a(CHEBI:"okadaic acid") | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| Jens | a(HBP:"Tau oligomers") | a(MESH:Neurons) | p(HGNC:MAPT) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:GSK3B) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"lithium atom") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ABCB1) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:macroautophagy) | p(FPLX:mTORC1) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(HBP:"Tau epitope, PHF1") |
| Jens | a(HBP:"Tau aggregates") | bp(GO:aging) | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| Jens | a(GO:"neurofibrillary tangle") | g(HGNC:"MIR9-1") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| Jens | p(HGNC:MAPK1) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | bp(GO:"lysosomal microautophagy") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, frag("?")) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"3',5'-cyclic AMP") | a(CHEBI:rolipram) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:clozapine) | bp(GO:autophagy) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:TREM2) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | a(HBP:neuroinflammation) |
| Jens | bp(GO:"MAPK cascade") | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | p(HGNC:IL18) |
| Jens | a(MESH:Neurons) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | bp(MESH:Autophagy) |
| Jens | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) |
| Jens | bp(GO:"neuron death") | complex(GO:"protein phosphatase type 2A complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"nitric oxide") | a(CHEBI:peroxynitrite) | complex(GO:"NF-kappaB complex") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Brain Injuries, Traumatic") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00074) | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") |
| Jens | a(MESH:Trehalose) | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"trichostatin A") | p(FPLX:HDAC) | p(HGNC:MAPT, pmod(Ac)) |
| Jens | a(CHEBI:sirolimus) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:galanthamine) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:WNT3A) |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"methylene blue") | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"methylene blue") | bp(GO:macroautophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | bp(GO:autophagy) | p(HGNC:SQSTM1) | p(MESH:Proteins, pmod(HBP:misfolding)) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Aging) | p(HGNC:AHSA1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:lactacystin) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"iron(0)") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IDE) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:MAPT, pmod(NGlyco)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | p(HGNC:IL6) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:cognition) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rivastigmine) | p(HGNC:LRP1) |
| Jens | a(HBP:"Tau aggregates") | p(HGNCGENEFAMILY:Caspases) | path(MESH:"Neurofibrillary Tangles") |
| Jens | a(MESH:methyllycaconitine) | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(PUBCHEM:16057918) | p(HGNC:BCL2L1) |
| Jens | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) | p(HGNC:HSPB1) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:TNF) |
| Jens | bp(MESH:Aging) | p(FPLX:Proteasome) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | a(CHEBI:sirolimus) | bp(GO:macroautophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | bp(MESH:Aging) | p(FPLX:HSPA) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:memory) |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(GO:lysosome) | a(GO:lysosome) | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:donepezil) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) |
| Jens | a(CHEBI:cilostazol) | bp(GO:macroautophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"neuron death") | p(HGNC:RAB5A) |
| Jens | bp(GO:macroautophagy) | p(FPLX:mTORC1) | p(HGNC:TFEB) |
| Jens | a(CHEBI:"methylene blue") | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"D-ribose") | a(HBP:"advanced glycation end product") | p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| Jens | p(HGNC:BACE1) | p(HGNC:RELA) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"glutamate(1-)") | a(GO:"excitatory synapse") | complex(GO:"NF-kappaB complex") |
| Jens | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:Liver) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PPP2R2A) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPK1) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | r(HGNC:"BACE1-AS") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Jens | p(HGNC:MAPT, pmod(Ph, Ser, 422)) | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") |
| Jens | p(HGNC:PTGS2) | path(MESH:"Alzheimer Disease") | path(MESH:Inflammation) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:sirolimus) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:JNK) | p(HGNC:DKK1) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Nilvadipine) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| Jens | bp(GO:"microtubule depolymerization") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | bp(GO:"MAPK cascade") | p(HBP:"alpha-4 beta-2 nAChR") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(MESH:Autophagosomes) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:autolysosome) | bp(GO:"lysosomal protein catabolic process") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Corticobasal Degeneration") | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:LRP1) |
| Jens | a(CHEBI:"proteasome inhibitor") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(MESH:Lysosomes) | bp(MESH:Proteolysis) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 163)) | p(HGNC:MAPT, pmod(Ac, Lys, 163)) | p(HGNC:MAPT, pmod(Ac, Lys, 163)) |
| Jens | a(CHEBI:"potassium(1+)") | complex(GO:"inflammasome complex") | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"D-ribose") | a(HBP:"advanced glycation end product") | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:APP) |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT, var("p.Lys280del")) |
| Jens | a(CHEBI:sirolimus) | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | a(HBP:"protein aggregates") | bp(GO:autophagy) | path(MESH:"Neurodegenerative Diseases") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | p(HGNC:IL1B) |
| Jens | complex(p(HGNC:FYN), p(HGNC:MAPT)) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:epoxomicin) | p(FPLX:Proteasome) | p(HGNC:MAPT) |
| Jens | a(CHEBI:rivastigmine) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:Anatabine) | a(GO:"myelin sheath") | path(MESH:Encephalomyelitis) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:CDKN2A) | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(HBP:HBP00093) | bp(GO:autophagy) | p(HGNC:TFEB) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:rosiglitazone) | a(MESH:Microglia) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:simvastatin) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) |
| Jens | g(HBP:"APOE e4") | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") | p(HGNC:APP) |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Oxidative Stress") | complex(GO:"NF-kappaB complex") |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Chronic Traumatic Encephalopathy") |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:GSK3B) | p(HGNC:MAPT) |
| Jens | p(FPLX:Proteasome) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:chlorobutanol) | a(PUBCHEM:9832404) | path(MESH:Smell) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(FPLX:CHRN) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:BCL2L1) |
| Jens | a(CHEBI:"D-ribose") | a(HBP:"advanced glycation end product") | p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(GO:"TOR complex") |
| Jens | a(CHEBI:staurosporine) | bp(GO:"apoptotic process") | p(HGNC:CDK5) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:NFKB1) | path(MESH:Anxiety) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(FPLX:CHRN) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | bp(GO:"learning or memory") |
| Jens | bp(GO:cognition) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"apoptotic process") | p(HGNC:BCL2L1) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | p(HGNC:BACE1) |
| Jens | a(HBP:HBP00089) | bp(GO:"microglial cell activation") | p(HGNC:IL1B) |
| Jens | a(CHEBI:sirolimus) | bp(MESH:Autophagy) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL1B) |
| Jens | p(HGNC:MAPT) | p(HGNC:TGM2) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:BCHE) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | p(HGNC:IDE) |
| Jens | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) |
| Jens | path(MESH:"Alzheimer Disease") | r(HGNC:"BACE1-AS") | r(HGNC:BACE1) |
| Jens | a(HBP:"amyloid-beta aggregates") | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | m(HGNC:MIR125B1) | p(HGNC:CDKN2A) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"alpha-synuclein aggregates") | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:methamphetamine) | a(CHEBI:sirolimus) | bp(GO:autophagy) |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | p(HGNC:STIP1) |
| Jens | a(MESH:Morphine) | p(FPLX:IKB) | p(FPLX:NFkappaB) |
| Jens | a(CHEBI:chloroquine) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta") | r(HGNC:BACE1) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:RELA) |
| Jens | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | p(FPLX:PPP2) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"microglial cell activation") | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:galanthamine) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"proteasome complex") | p(HGNC:MAPT, pmod(Ph)) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"response to oxidative stress") | bp(GO:autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rivastigmine) | p(HGNC:ACHE) |
| Jens | a(CHEBI:palbociclib) | a(HBP:"Tau isoform F (441 aa)") | p(HGNC:CDK4) |
| Jens | a(CHEBI:galanthamine) | p(HGNC:HMOX1) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:PKA) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | p(HGNC:SYK) |
| Jens | a(CHEBI:"methylene blue") | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BIN1) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Jens | a(GO:mitochondrion) | bp(MESH:"Oxidative Stress") | p(HGNC:GLP1R) |
| Jens | p(HGNC:MAPT, frag("?")) | p(HGNC:MAPT, pmod(Ph, Ser, 422)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"Hsp90 inhibitor") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"interleukin 1 alpha") | p(MGI:"oncostatin M") |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | complex(GO:"NLRP3 inflammasome complex") |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MTOR) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 353)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:locomotion) | p(HGNC:MAPT) | p(HGNC:ZC3H14) |
| Jens | p(HGNC:PRKN) | p(HGNC:SNCA) | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cell death") | p(FPLX:HSPA) |
| Jens | bp(GO:"microglial cell activation") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:GSK3B) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:PPP1CA) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"neuron death") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:IDE) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT) | p(HGNC:SYK) |
| Jens | bp(GO:autophagy) | p(FPLX:mTORC1) | p(HGNC:ULK1, pmod(Ph)) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | p(HGNC:BAG3) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) |
| Jens | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280del")) |
| Jens | a(CHEBI:donepezil) | p(HGNC:ABCB1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:Temsirolimus) | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:dopamine) | p(HGNC:DISC1, var("?")) | path(MESH:Schizophrenia) |
| Jens | a(MESH:"Embryonic Structures") | a(MESH:antalarmin) | bp(MESH:"Heat-Shock Response") |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") |
| Jens | bp(GO:"microtubule polymerization") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") | p(HGNC:CHRM1) |
| Jens | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL18) |
| Jens | bp(GO:"anterograde axonal protein transport") | p(HBP:"6D tau", frag("2_18")) | p(MESH:"Glycogen Synthase Kinase 3") |
| Jens | a(CHEBI:cholesterol) | bp(GO:endocytosis) | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") |
| Jens | bp(GO:"long-term synaptic potentiation") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| Jens | a(CHEBI:"okadaic acid") | p(FPLX:PPP2) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"proteasome inhibitor") | p(HGNC:BAG3) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rivastigmine) | p(HGNC:ABCB1) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, pmod(Ph)) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") | bp(GO:memory) |
| Jens | p(HGNC:CDK2) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | g(HGNC:APOE) | p(HGNC:APOE) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 321)) | p(HGNC:MAPT, pmod(Ac, Lys, 321)) | p(HGNC:MAPT, pmod(Ac, Lys, 321)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | a(HBP:"alpha-4 beta-2 nAChR") |
| Jens | bp(MESH:Autophagy) | p(HBP:"Tau epitope, AT8") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:Microglia) | p(MESH:"I-kappa B Proteins", pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(MESH:D002800) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | g(HGNC:NLRP3) |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | p(HGNC:MAPT, var("?")) |
| Jens | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") |
| Jens | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:JAK2) |
| Jens | a(CHEBI:scopolamine) | a(MESH:VU0357017) | bp(GO:"behavioral fear response") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00006) | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280delinsProPro")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(MESH:"Cholinesterase Inhibitors") |
| Jens | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"okadaic acid") | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:MAPT, pmod(Ph)) |
| Jens | bp(GO:"neuron death") | p(HGNC:PARK7) | path(MESH:"Parkinson Disease") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | bp(HBP:neurotoxicity) |
| Jens | p(HGNC:AK1) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | bp(MESH:Neuroprotection) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(HGNC:CHRM1) |
| Jens | p(HGNC:BAG1) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:Temsirolimus) | bp(GO:macroautophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | p(HGNC:PTGES3) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:Calpeptin) | bp(GO:autophagy) | p(HGNC:CAPN1) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:"Tau epitope, PHF1") | p(HGNC:MAPT) |
| Jens | bp(GO:autophagy) | p(MESH:Proteins, pmod(HBP:misfolding)) | path(MESH:"Neurodegenerative Diseases") |
| Jens | bp(GO:autophagy) | p(FPLX:mTORC1) | p(HGNC:TFEB) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:ERK) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:CHRNA4) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:BAX) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(FPLX:PI3K) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:Tauopathies) |
| Jens | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") | path(MESH:"Plaque, Amyloid") |
| Jens | a(MESH:Microglia) | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Jens | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) | p(HGNC:GSK3B) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | g(HBP:"APOE e4") |
| Jens | complex(GO:"filamentous actin") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:SIRT1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:autophagy) | p(FPLX:mTORC1) | p(HGNC:MAPT) |
| Jens | bp(GO:"neuron death") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00074) | bp(GO:aging) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:ambroxol) | bp(GO:macroautophagy) | p(HGNC:SNCA) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("p.Lys280del")) |
| Jens | a(CHEBI:nicotine) | a(HBP:"Tau aggregates") | path(HBP:neurotoxicity) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 422)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"long-term synaptic potentiation") |
| Jens | a(GO:lysosome) | a(HBP:"Tau aggregates") | path(HBP:Neurodegeneration) |
| Jens | complex(GO:"proteasome complex") | p(FPLX:PKA) | p(HGNC:PSMC5, pmod(Ph, Ser, 120)) |
| Jens | a(MESH:D002800) | bp(GO:"GO:0014047") | path(MESH:D000544) |
| Jens | bp(GO:"response to misfolded protein") | p(HGNC:ERN1) | p(HGNC:XBP1) |
| Jens | bp(GO:autophagy) | p(HGNC:HSPB1) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Cholinesterase Inhibitors") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:resveratrol) | p(FPLX:AMPK) |
| Jens | a(CHEBI:sirolimus) | bp(GO:cognition) | p(HGNC:MTOR) |
| Jens | bp(GO:"long-term synaptic potentiation") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:rolipram) | complex(GO:"proteasome complex") | p(FPLX:PKA) |
| Jens | a(GO:"neurofibrillary tangle") | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) | p(MGI:Mapt) |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:synapse) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | p(FPLX:NFkappaB) | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:Proteins) | a(MESH:Proteins) | p(HGNC:RAB5A) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:Schizophrenia) |
| Jens | p(HGNC:BACE1) | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(CHEBI:lipid) | bp(GO:endocytosis) | p(HGNC:RAB5A) |
| Jens | a(HBP:"protein aggregates") | bp(GO:autophagy) | path(MESH:"Amyotrophic Lateral Sclerosis") |
| Jens | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:BAG1) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:lysosome) | g(HGNC:APP, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | bp(MESH:Neuroprotection) | complex(GO:"NF-kappaB complex") |
| Jens | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| Jens | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | bp(GO:autophagy) | p(FPLX:AMPK) | p(FPLX:mTORC1) |
| Jens | bp(GO:aging) | bp(GO:locomotion) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:IDE) |
| Jens | a(CHEBI:"potassium(1+)") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL1B) |
| Jens | complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) | p(HGNC:PTPA) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ac, Lys, 353)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:Tauopathies) |
| Jens | bp(GO:"microtubule polymerization") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) | p(HGNC:BIN1) |
| Jens | p(HGNC:BACE1) | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") | p(HGNC:ACHE) |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(FPLX:CHRN) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:NPEPPS) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:Anatabine) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | p(HGNC:MAPT, pmod(Ph)) |
| Jens | p(HGNC:HSPB1) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:TFEB) |
| Jens | p(HGNC:CDK1) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:endocytosis) | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") | p(HGNC:APP) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL18) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) | g(HBP:"APOE e4") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(HBP:"Tau aggregates") | bp(GO:aging) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | complex(GO:"inflammasome complex") |
| Jens | a(CHEBI:nicotine) | p(FPLX:PI3K) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:SYK) |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Neuronal Outgrowth") | complex(GO:"NF-kappaB complex") |
| Jens | a(GO:autophagosome) | a(GO:lysosome) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:dextran) | a(CHEBI:dextran) | a(CHEBI:dextran) |
| Jens | p(HGNC:CHAT) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:ANP32A) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:lysosome) | p(HGNC:TFEB) |
| Jens | p(HGNC:HSPB1) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(MESH:Hippocampus) | p(HGNC:CHRNA7) | path(MESH:Schizophrenia) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | bp(GO:"microglial cell activation") | p(HGNC:NR1H3) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"MAPK cascade") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | p(HGNC:TREM2, var("p.Arg47His")) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:RELA) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:methamphetamine) | bp(GO:autophagy) | p(HGNC:DRD1) |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"apoptotic process") |
| Jens | bp(GO:macroautophagy) | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 259)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | path(MESH:"Diabetes Mellitus") |
| Jens | p(HGNC:CDK2) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:NFkappaB) | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | p(HGNC:BIN1) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"lysosomal protein catabolic process") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:Microglia) | complex(GO:"NF-kappaB complex") |
| Jens | a(HBP:HBP00074) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HBP:"APOE e4") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:ACHE) |
| Jens | p(MGI:Rela, pmod(Ph)) | p(MGI:Stat3, pmod(Ph)) | path(MESH:Encephalomyelitis) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | bp(GO:phagocytosis) |
| Jens | p(HGNC:FYN) | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | g(HBP:"APOE e4") | p(HGNC:APP) |
| Jens | a(GO:"neurofibrillary tangle") | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"alpha-synuclein aggregates") | a(MESH:"HSP70 Heat-Shock Proteins") | g(NCBIGENE:406950) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ACE) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:OGT) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 40") | a(CHEBI:nicotine) | a(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:galanthamine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | a(MESH:"Amyloid beta-Peptides") | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | complex(GO:"calcium- and calmodulin-dependent protein kinase complex") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:WNT3A) |
| Jens | a(CHEBI:resveratrol) | p(HGNC:MID1) | p(HGNC:PPP2CA) |
| Jens | bp(GO:"microtubule polymerization") | complex(GO:microtubule) | p(HGNC:MAPT) |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:PICALM) |
| Jens | a(CHEBI:"amyloid-beta") | p(HBP:"Tau aggregates") | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau oligomers") | bp(GO:"long-term synaptic potentiation") | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("p.Val337Met")) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("p.Pro301Leu")) |
| Jens | bp(GO:"chaperone-mediated autophagy") | bp(MESH:Aging) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | p(HGNC:CDC37) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:OGT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"methylene blue") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:geldanamycin) | p(FPLX:HSP90) | p(HGNC:HSF1) |
| Jens | a(HBP:"Tau fibrils") | p(MGI:Tfeb) | p(MGI:Tfeb) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | p(HGNC:MAPT) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:sirolimus) | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) | bp(GO:memory) |
| Jens | a(CHEBI:galanthamine) | bp(GO:"synaptic transmission, cholinergic") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:"lysosomal protein catabolic process") |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:NFkappaB) | p(HGNC:BACE1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:oleocanthal) | p(HGNC:ABCB1) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") |
| Jens | a(HBP:HBP00089) | bp(GO:"microglial cell activation") | p(HGNC:CCL2) |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cell death") | p(HGNC:CHRM1) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:ACHE) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:IL1B) |
| Jens | p(FPLX:ERK) | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Jens | bp(GO:"apoptotic process") | p(HGNC:CDK5) | p(HGNC:MAPK1) |
| Jens | a(HBP:"granulovacuolar degeneration") | p(HGNC:MAPT, pmod(Ph, Ser, 262)) | p(HGNC:MARK4, pmod(Ph)) |
| Jens | bp(HBP:"protein aggregation") | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) | p(MESH:Proteins, pmod(HBP:misfolding)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:Anatabine) | path(MESH:"Interpersonal Relations") |
| Jens | complex(GO:"inflammasome complex") | p(HGNC:CASP1) | p(HGNC:IL18) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:CTSD) | p(HGNC:MAPT) | path(MESH:"Frontotemporal Dementia") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:galanthamine) | p(HGNC:CHRNA7) |
| Jens | bp(GO:aging) | p(HGNC:FKBP5) | p(HGNC:MAPT) |
| Jens | a(CHEBI:peroxynitrite) | bp(GO:"inflammatory response") | complex(GO:"NF-kappaB complex") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ac, Lys, 290)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:resveratrol) | p(HGNC:CAMKK2) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:dopamine) | a(CHEBI:methamphetamine) | a(CHEBI:nicotine) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:Tauopathies) |
| Jens | bp(GO:"neuron death") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:Neurons) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"amyloid-beta derived diffusible ligands") | a(HBP:"amyloid-beta derived diffusible ligands") | a(HBP:"amyloid-beta derived diffusible ligands") |
| Jens | p(HBP:"4R tau") | p(HGNC:MAPT, var("p.Gly272Val")) | path(MESH:"Frontotemporal Dementia") |
| Jens | p(HGNC:MAPT, pmod(OGlyco)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:nicotine) | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | bp(GO:cognition) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, var("p.Lys280del")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:pioglitazone) | p(HGNC:PPARG) |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"methylene blue") | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:acetylcholine) | p(HGNC:BCHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau aggregates") | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| Jens | a(CHEBI:palbociclib) | a(HBP:"Tau isoform F (441 aa)") | p(HGNC:CDK6) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(HGNC:NFKB1) |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:methamphetamine) | bp(GO:autophagy) | p(HGNC:MTOR) |
| Jens | bp(GO:aging) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(HGNC:FYN) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:NFkappaB) | p(HGNC:BACE1) | p(HGNC:UCHL1) |
| Jens | a(CHEBI:"okadaic acid") | p(FPLX:PPP2) | path(MESH:Neoplasms) |
| Jens | a(GO:"neurofibrillary tangle") | p(ECCODE:"2.3.2.13") | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) |
| Jens | p(HGNC:CDK2) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:LRP1) | path(MESH:Sleep) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:MMP9) |
| Jens | a(PUBCHEM:155160) | bp(GO:memory) | p(HGNC:BACE1) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | bp(GO:"mitochondrion transport along microtubule") | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) | p(HBP:"Tau isoform F (441 aa)") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:sirolimus) | bp(GO:macroautophagy) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) |
| Jens | a(HBP:"Tau oligomers") | bp(GO:"mitochondrion organization") | bp(HP:Neurodegeneration) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(HGNC:SNCA) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Nilvadipine) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | p(FPLX:NFkappaB) | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:Proteins) | a(MESH:Proteins) | a(MESH:Proteins) |
| Jens | a(GO:presynapse) | a(PUBCHEM:64627) | p(MGI:Adora1) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(FPLX:PPP2, pmod(Ph, Tyr, 307)) | p(HGNC:PTPA) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"alpha-synuclein aggregates") | p(HGNC:IDE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"methylene blue") | a(HBP:"Tau oligomers") | bp(MESH:Autophagy) |
| Jens | complex(GO:"proteasome complex") | p(FPLX:PKA) | p(FPLX:PKA, pmod(Ub)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | p(MGI:"interleukin 1 alpha") | p(MGI:"oncostatin M") | p(MGI:"signal transducer and activator of transcription 3") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) | p(HGNC:APP) |
| Jens | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:pioglitazone) | bp(GO:memory) |
| Jens | p(HBP:HBP00065) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:AHSA1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) |
| Jens | a(MESH:Proteins) | a(MESH:Proteins) | p(HGNC:PSMD14) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:OTUB1) |
| Jens | a(CHEBI:heparin) | a(HBP:"Tau aggregates") | p(HGNC:MAPT, var("?")) |
| Jens | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | a(MESH:"Cholinergic Neurons") | bp(GO:memory) |
| Jens | a(CHEBI:simvastatin) | bp(GO:"ERK1 and ERK2 cascade") | bp(GO:"apoptotic process") |
| Jens | a(MESH:Proteins) | a(MESH:Proteins) | bp(GO:endocytosis) |
| Jens | a(PUBCHEM:675434) | p(HGNC:MAPT) | p(HGNC:USP14) |
| Jens | p(FPLX:AKT) | p(HGNC:DRD1) | path(MESH:Schizophrenia) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(MGI:Crhr1) |
| Jens | a(HBP:"Tau aggregates") | bp(GO:"lysosomal microautophagy") | p(HGNC:MAPT, frag("?")) |
| Jens | bp(GO:"axonal transport") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(HBP:Neurodegeneration) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, var("p.Ala152Thr")) | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | p(HGNC:CDK2) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:aging) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 40") | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | p(HGNC:MAPT) | p(HGNC:NPEPPS) | path(MESH:"Frontotemporal Dementia") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:donepezil) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK2) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:"Oxidative Stress") | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:nicotine) | bp(GO:cognition) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"ERK1 and ERK2 cascade") |
| Jens | a(CHEBI:"potassium(1+)") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL1B) |
| Jens | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") | path(MESH:Aging) |
| Jens | bp(GO:"long-term synaptic potentiation") | p(HGNC:HSPB1) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") | path(MESH:"Neurofibrillary Tangles") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Jens | a(MESH:"Cholinergic Neurons") | bp(GO:memory) | complex(GO:"NF-kappaB complex") |
| Jens | a(MESH:"Amyloid beta-Peptides") | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:BCL2L1) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(OGlyco)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | r(HGNC:"BACE1-AS") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, var("p.Lys280del")) |
| Jens | a(CHEBI:"amyloid-beta") | r(HGNC:"BACE1-AS") | r(HGNC:BACE1) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") | bp(MESH:Neuroprotection) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) | p(HGNC:IL1B) |
| Jens | m(MIRBASE:"hsa-mir-155") | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:"4R tau") | p(HGNC:TARDBP) | path(MESH:"Frontotemporal Dementia") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"apoptotic process") | p(HGNC:BCL2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:aging) | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:GSK3B) | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) | p(HGNC:PPP1CA) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:wortmannin) | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph)) |
| Jens | complex(GO:"neuron projection") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(FPLX:HSP90) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | path(MESH:Tauopathies) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:JNK) | p(HGNC:AGER) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:CHRM1) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | bp(GO:"protein folding") | bp(MESH:Aging) | p(FPLX:HSP90) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:Microglia) | bp(GO:phagocytosis) |
| Jens | a(GO:lysosome) | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:learning) | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | bp(MESH:Aging) | p(HGNC:PTGES3) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Jens | a(CHEBI:"okadaic acid") | p(FPLX:PPP2) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA4) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cerebrospinal fluid circulation") | bp(GO:aging) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") | p(HGNC:CHRNA7) |
| Jens | bp(GO:"clathrin-dependent endocytosis") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | path(MESH:"Plaque, Amyloid") |
| Jens | bp(GO:endocytosis) | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") | p(HGNC:RAB5A) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | p(HGNC:MAPK8) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:dopamine) | a(CHEBI:nicotine) |
| Jens | p(HGNC:CDK5) | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Corticobasal Degeneration") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"D-ribose") | a(CHEBI:"advanced glycation end-product") | p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:sirolimus) | bp(GO:autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cell death") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"Hsp90 inhibitor") | a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") | p(HGNC:MAPT) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:CHAT) |
| Jens | a(CHEBI:"reactive oxygen species") | complex(GO:"NF-kappaB complex") | p(FPLX:PKC) |
| Jens | complex(GO:"proteasome complex") | p(HGNC:PRKN) | p(HGNC:SNCA) |
| Jens | a(CHEBI:galanthamine) | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acrolein) | a(GO:"neurofibrillary tangle") | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau fibrils") | p(MGI:Tfeb) |
| Jens | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| Jens | bp(GO:cognition) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"microglial cell activation") | p(HGNC:IL6) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"alpha-synuclein aggregates") | bp(GO:"neuron death") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") | path(MESH:Inflammation) |
| Jens | bp(GO:memory) | p(HGNC:BACE1) | p(HGNC:UCHL1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:SYK) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:MMP3) |
| Jens | a(CHEBI:rolipram) | a(HBP:"Tau aggregates") | p(HGNC:MAPT) |
| Jens | a(GO:microtubule) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | bp(GO:autophagy) | p(HGNC:MTOR) | path(MESH:"Neurodegenerative Diseases") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:dorsomorphin) | p(FPLX:AMPK) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | bp(GO:"MAPK cascade") | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | p(HGNC:MAPT, var("p.Glu391*")) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Frontotemporal Dementia") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL1B) |
| Jens | p(FPLX:NFkappaB) | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | bp(GO:"synaptic transmission, cholinergic") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Niemann-Pick Diseases") |
| Jens | a(CHEBI:"lithium(1+)") | bp(GO:autophagy) | p(HGNC:SNCA) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:wogonin) | bp(GO:autophagy) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:NFkappaB) | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") | r(HGNC:BACE1) |
| Jens | bp(GO:aging) | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:wogonin) | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(NGlyco)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"JNK cascade") | complex(GO:"NF-kappaB complex") |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT) | p(HGNC:NPEPPS) |
| Jens | p(HGNC:MAPT, pmod(Ph, Thr, 205)) | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Frontotemporal Dementia") |
| Jens | p(HGNC:HSPB1) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | p(HGNC:SNCA) | p(HGNC:SNCA, pmod(Ub)) | path(MESH:"Parkinson Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:RELA) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:nicotine) | a(HBP:"alpha-4 beta-2 nAChR") | a(MESH:"Dopaminergic Neurons") |
| Jens | p(HGNC:IL1B) | p(HGNC:PYCARD) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HBP:"Tau epitope, AT8") | p(MGI:Crhr1) |
| Jens | a(CHEBI:epoxomicin) | p(HGNC:CASP3) | p(HGNC:MAPT) |
| Jens | p(HBP:"CDK5R1 p25") | p(HBP:"Tau epitope, AT8") | p(MGI:Cdk5) |
| Jens | bp(GO:"apoptotic process") | p(FPLX:AKT) | p(HGNC:RELA) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"lysosomal protein catabolic process") | bp(GO:autophagy) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"glutamate(2-)") | p(HGNC:CHRNA7) |
| Jens | bp(GO:"neuron death") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Anatabine) | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| Jens | a(CHEBI:sirolimus) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(GO:presynapse) | a(HBP:"Tau aggregates") | a(MESH:"BSc 3094") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MTOR) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:"Pick Disease of the Brain") |
| Jens | p(HGNC:PRNP) | p(HGNC:PRNP) | p(HGNC:PRNP) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | path(MESH:"Diabetes Mellitus") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:sirolimus) | path(MESH:"Interpersonal Relations") |
| Jens | a(CHEBI:wortmannin) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| Jens | a(CHEBI:epoxomicin) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:TNF) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:synapse) | bp(GO:endocytosis) |
| Jens | p(HGNC:CAPN1) | p(HGNC:CAST) | p(HGNC:HTT, var("?")) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | bp(GO:"neuron apoptotic process") | bp(GO:cognition) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:Temsirolimus) | bp(GO:macroautophagy) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MARK4) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"lysosomal protein catabolic process") | p(HGNC:PSEN1, var("?")) |
| Jens | a(MESH:"Amyloid beta-Peptides") | p(HGNC:BECN1) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 281)) | p(HGNC:MAPT, pmod(Ac, Lys, 281)) | p(HGNC:MAPT, pmod(Ac, Lys, 281)) |
| Jens | a(CHEBI:rivastigmine) | p(HGNC:ABCB1) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PPP2CA) |
| Jens | bp(GO:"proteasomal protein catabolic process") | p(HGNC:HSPB1) | p(HGNC:MAPT) |
| Jens | bp(GO:cognition) | p(HGNC:FYN) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:sirolimus) | bp(GO:macroautophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(MGI:Bace1) |
| Jens | a(HBP:"amyloid-beta aggregates") | p(HGNC:IDE) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:cognition) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MTOR) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:MAPT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) | a(MESH:Microglia) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | bp(GO:locomotion) | p(HGNC:MAPT) | p(HGNC:MAPT, var("p.Lys280del")) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL1B) |
| Jens | bp(MESH:"Oxidative Stress") | path(MESH:"Alzheimer Disease") | path(MESH:Aging) |
| Jens | bp(GO:autophagy) | p(FPLX:HSP90) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:bortezomib) | p(FPLX:PPP2C) | p(HGNC:CIP2A) |
| Jens | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
| Jens | bp(GO:macroautophagy) | p(FPLX:AMPK) | p(FPLX:mTORC1) |
| Jens | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"phosphatase-activating domain") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | path(MESH:"Plaque, Amyloid") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | complex(GO:"proteasome complex") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | complex(p(HGNC:FYN), p(HGNC:MAPT)) | p(HGNC:FYN) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") |
| Jens | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"MAPK cascade") |
| Jens | a(CHEBI:nicotine) | bp(GO:"MAPK cascade") | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | complex(GO:"proteasome complex") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:SQSTM1) |
| Jens | a(MESH:"Cholinergic Neurons") | path(MESH:"Alzheimer Disease") | path(MESH:Apathy) |
| Jens | a(HBP:HBP00018) | a(HBP:HBP00030) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"neuron death") | bp(GO:proteolysis) |
| Jens | a(PUBCHEM:377503130) | p(FPLX:"CCT_complex") | p(HGNC:HSF1) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(HBP:"Corticobasal Degeneration") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:Temsirolimus) | bp(GO:autophagy) |
| Jens | a(CHEBI:nicotine) | bp(GO:"MAPK cascade") | p(FPLX:NFkappaB) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ADAM10) | p(HGNC:APP) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:GSK3B) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:dorsomorphin) | p(FPLX:AMPK) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | bp(GO:"axonal transport") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") | path(MESH:"Protein Aggregation, Pathological") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:dopamine) | a(HBP:HBP00093) |
| Jens | bp(HBP:"protein aggregation") | complex(p(HGNC:BAG6), p(HGNC:UBA3)) | p(MESH:Proteins, pmod(HBP:misfolding)) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Frontotemporal Dementia") |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PPP5C) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CASP3) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"okadaic acid") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PPP2CA) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(HGNC:SYK, pmod(Ph)) |
| Jens | bp(GO:"apoptotic process") | bp(MESH:"Oxidative Stress") | p(HGNC:GSK3B) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 290)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("p.Gly272Val")) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:galanthamine) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:synapse) | path(MESH:"Plaque, Amyloid") |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | p(HGNC:CHRNA7) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:Schizophrenia) |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | path(MESH:Anxiety) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:BCL2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:ACHE) |
| Jens | p(HGNC:DAPK1) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL18) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CHRNA7) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"late endosome") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:BCL2) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) | p(HGNC:MAPT, pmod(Ub)) |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | p(FPLX:CHRN) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:ACHE) |
| Jens | a(HBP:HBP00074) | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:galanthamine) | p(HGNC:ACHE) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | p(HGNC:IL1B) |
| Jens | bp(GO:"depolarization of postsynaptic membrane") | complex(GO:"voltage-gated calcium channel complex") | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"Fas signaling pathway") | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | bp(GO:"synaptic transmission, cholinergic") | p(HGNC:ACHE) |
| Jens | bp(GO:"neuron death") | p(HGNC:RAB5A) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(p(HGNC:APP), p(HGNC:LRP1)) | p(HGNC:APP) |
| Jens | a(PUBCHEM:675434) | p(FPLX:Proteasome) | p(HGNC:MAPT) |
| Jens | bp(GO:"neuron death") | p(HGNC:CASP3) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CHRNA4) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(FPLX:CHRN) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) | p(HGNC:OTUB1) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:SYK) |
| Jens | m(MIRBASE:"hsa-mir-146a") | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"amyloid-beta aggregates") | p(HGNC:APP, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:donepezil) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | a(MESH:Autophagosomes) |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT) | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) |
| Jens | p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) | path(MESH:"Alcohol Drinking") | r(HGNC:ADNP) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | p(HGNC:PPARG) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Lymphatic Vessels") | bp(GO:memory) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:Tauopathies) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ac, Lys, 174)) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Jens | a(CHEBI:acrolein) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Jens | bp(GO:aging) | p(HGNC:FKBP5) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:macroautophagy) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, var("p.Ala152Thr")) |
| Jens | p(MESH:Proteins, pmod(Ub)) | p(MESH:Proteins, pmod(Ub)) | p(MESH:Proteins, pmod(Ub)) |
| Jens | complex(p(HGNC:FYN), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | a(MESH:Microglia) |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(HGNC:MTOR) |
| Jens | p(FPLX:CALM) | p(HBP:"DAPK, basic loop (BL) motif") | p(HGNC:DAPK2) |
| Jens | bp(GO:"microtubule polymerization") | p(HGNC:DAPK1) | p(HGNC:MAPT) |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:BCL2L1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:memory) |
| Jens | p(HGNC:FYN) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:Thrombin) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Jens | bp(GO:macroautophagy) | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | bp(MESH:"Oxidative Stress") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"lysosomal protein catabolic process") | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:oleocanthal) | p(HGNC:LRP1) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 174)) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) | p(HGNC:TNF) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 353)) | p(HGNC:MAPT, pmod(Ac, Lys, 353)) | p(HGNC:MAPT, pmod(Ac, Lys, 353)) |
| Jens | a(GO:"neurofibrillary tangle") | bp(GO:"apoptotic process") | p(HGNC:NFKB1) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(HGNC:MAPT, frag("561_685")) |
| Jens | p(MGI:Tfeb) | p(MGI:Tfeb) | p(MGI:Tfeb) |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL1B) |
| Jens | a(CHEBI:"potassium(1+)") | p(HGNC:IL1B) | p(HGNC:PYCARD) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:TFEB) | path(MESH:"Plaque, Amyloid") |
| Jens | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") | p(HGNC:CXCL8) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:SET) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00074) | p(HGNC:NGFR) | path(MESH:"Cognitive Dysfunction") |
| Jens | bp(GO:"MAPK cascade") | p(HGNC:AGER) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:endocytosis) | g(HBP:"APOE e4") | p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HBP:"Tau aggregates") |
| Jens | a(GO:"neurofibrillary tangle") | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Jens | a(CHEBI:rivastigmine) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | bp(GO:"ERK1 and ERK2 cascade") | p(FPLX:NFkappaB) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | bp(MESH:Neuroprotection) |
| Jens | bp(GO:"long-term synaptic potentiation") | complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"neuron death") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Jens | bp(GO:aging) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | a(CHEBI:chlorpromazine) | bp(GO:autophagy) | p(HGNC:MTOR) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(HGNC:RELA) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta") | p(HGNC:SYK) |
| Jens | p(HGNC:AK1) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:dopamine) | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | a(PUBCHEM:675434) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(MGI:Syk) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ac, Lys, 321)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") | r(HGNC:BACE1) |
| Jens | a(HBP:"amyloid-beta aggregates") | p(MGI:Syk, pmod(Ph)) | path(MESH:"Plaque, Amyloid") |
| Jens | bp(GO:"mitochondrion transport along microtubule") | composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) | p(HBP:"Tau C3") |
| Jens | a(CHEBI:"glutamate(2-)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:simvastatin) | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | p(HGNC:RELA) | path(MESH:"Alzheimer Disease") | r(HGNC:BACE1) |
| Jens | a(HBP:"protein aggregates") | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA3) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:PPP2) | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:lysosome) | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(CHEBI:nilotinib) | bp(GO:macroautophagy) | p(HGNC:ABL1) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Pro301Leu")) | path(MESH:"Proteostasis Deficiencies") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(HBP:Neurodegeneration) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(HGNC:HSPA1A) |
| Jens | a(CHEBI:Thrombin) | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:Calpeptin) | bp(GO:autophagy) | p(HGNC:CAPN2) |
| Jens | p(HBP:"4R tau") | p(HGNC:SRSF2) | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRM1) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph, Thr, 231)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | a(HBP:HBP00018) |
| Jens | bp(GO:memory) | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) | p(MESH:Endopeptidases) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRM2) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:BCL2) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | p(FPLX:Proteasome) |
| Jens | a(CHEBI:"okadaic acid") | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:dopamine) | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ph, Ser, 262)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Jens | p(HGNC:MME) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:lysosome) | bp(GO:endocytosis) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) |
| Jens | p(HGNC:ITPKB) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Nilvadipine) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | p(MGI:"interleukin 1 alpha") | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") | p(MGI:"oncostatin M") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:RAB5A) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:macroautophagy) | p(HGNC:MAPT, var("p.Ala152Thr")) | p(MGI:Mapt) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Anatabine) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(MGI:Mapt) |
| Jens | a(MESH:Proteins) | bp(GO:endocytosis) | p(HGNC:RAB5A) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:AQP4) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:TNF) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Lymphatic Vessels") | bp(GO:aging) |
| Jens | p(HGNC:IL18) | p(HGNC:PYCARD) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:sirolimus) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"protein aggregates") | bp(GO:autophagy) | path(HBP:Neurodegeneration) |
| Jens | bp(GO:"MAPK cascade") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Synapses) | p(FPLX:PI3K) |
| Jens | a(CHEBI:nicotine) | bp(GO:cognition) | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | complex(GO:axon) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | path(MESH:Inflammation) |
| Jens | bp(GO:"neuron death") | p(HGNC:MMP2) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, frag("?")) | path(MESH:Tauopathies) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:PPID) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"reactive oxygen species") | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | p(HGNC:IL1B) |
| Jens | a(MESH:"Cholinergic Neurons") | path(MESH:"Alzheimer Disease") | path(MESH:Depression) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:"Frontotemporal Dementia") |
| Jens | a(HBP:"Tau oligomers") | complex(GO:"proteasome complex") | path(HBP:Neurodegeneration) |
| Jens | a(HBP:"amyloid-beta oligomers") | p(FPLX:Proteasome) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("p.Asn279Lys")) |
| Jens | a(HBP:"Tau aggregates") | a(PUBCHEM:9804992) | p(FPLX:HDAC) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:Anatabine) | path(MESH:Anxiety) |
| Jens | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:MAPT, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:FOLH1) | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:CDK5) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:mitophagy) | p(HGNC:PRKN) | p(HGNC:PRKN, var("?")) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PPP2CA) |
| Jens | a(HBP:HBP00074) | bp(GO:"neuron death") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CTSD) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:IL1B) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | p(HBP:"phosphatase-activating domain") |
| Jens | a(CHEBI:sirolimus) | bp(GO:macroautophagy) | p(HGNC:SNCA) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 321)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"canonical Wnt signaling pathway") | p(HGNC:DKK1) |
| Jens | p(FPLX:PPP2) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MTOR) | p(HGNC:SNCA) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| Jens | a(GO:lysosome) | a(GO:lysosome) | a(GO:lysosome) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | a(HBP:"Tau aggregates") | bp(GO:macroautophagy) |
| Jens | a(CHEBI:"D-ribose") | a(CHEBI:"advanced glycation end-product") | p(MGI:Mapt, pmod(Ph, Ser, 214)) |
| Jens | p(FPLX:ERK) | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00018) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPK1) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:DAPK1) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:TREM2) |
| Jens | a(CHEBI:galanthamine) | bp(GO:"synaptic transmission, cholinergic") | path(MESH:Schizophrenia) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | complex(GO:"NF-kappaB complex") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:donepezil) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"innate immune response") | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Neuronal Outgrowth") | p(MGI:Chrna7) |
| Jens | a(CHEBI:"calcium(2+)") | bp(MESH:"Oxidative Stress") | p(HGNC:S100B) |
| Jens | a(CHEBI:curcumin) | bp(GO:macroautophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | bp(GO:autophagy) | bp(MESH:Aging) | p(FPLX:HSP90) |
| Jens | a(GO:"late endosome") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:water) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) | p(HGNC:JAK2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") | p(HGNC:PIN1) |
| Jens | a(HP:"glymphatic system") | p(HGNC:MAPT) | path(MESH:"Brain Injuries, Traumatic") |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | r(HGNC:BACE1) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:TGM2) |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:lysosome) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:BACE1) |
| Jens | bp(GO:"apoptotic process") | p(HGNC:SNCA) | p(HGNCGENEFAMILY:Calpains) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) |
| Jens | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(HBP:"Tau aggregates") | bp(GO:"axonal transport") | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:chloroquine) | bp(GO:autophagy) | p(HGNC:SQSTM1) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:CHRM1) |
| Jens | bp(GO:macroautophagy) | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | bp(GO:macroautophagy) | p(HGNC:TFEB) | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"lithium(1+)") | bp(GO:autophagy) | p(HGNC:MTOR) |
| Jens | a(HBP:"Tau aggregates") | bp(GO:aging) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:SQSTM1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HBP:"APOE e4") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"reactive oxygen species") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | bp(GO:aging) |
| Jens | p(HGNC:HSF1) | p(HGNC:HSF1) | p(HGNC:HSF1) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 369)) | p(HGNC:MAPT, pmod(Ac, Lys, 369)) | p(HGNC:MAPT, pmod(Ac, Lys, 369)) |
| Jens | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MME) | path(MESH:"Plaque, Amyloid") |
| Jens | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:PRNP) | p(HGNC:PRNP) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | p(HGNC:HDAC6) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IL1B) | p(HGNC:NFKB1) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IL6) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"alpha-synuclein aggregates") | a(HBP:"alpha-synuclein fibrils") | p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) |
| Jens | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") | p(HGNC:IL1B) |
| Jens | a(CHEBI:Thrombin) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:galanthamine) | bp(GO:cognition) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:CAPN2) | p(HGNC:CAST) | p(HGNC:HTT, var("?")) |
| Jens | a(PUBCHEM:442534) | bp(GO:memory) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau fibrils") | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| Jens | a(GO:lysosome) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) | complex(GO:"NLRP3 inflammasome complex") |
| Jens | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) | path(HBP:Neurodegeneration) |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) | p(HGNC:PRKN, var("p.Arg42")) | path(MESH:"Parkinsonian Disorders") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(MGI:Chrna7) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Jens | complex(GO:"proteasome complex") | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"canonical Wnt signaling pathway") | composite(p(HGNC:APP), p(HGNC:VANGL2)) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("p.Arg406Trp")) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") |
| Jens | a(GO:"neurofibrillary tangle") | p(ECCODE:"2.3.2.13") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:AK1) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:SYK) |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | path(MESH:"Alzheimer Disease") |
| Jens | a(PUBCHEM:71361092) | p(FPLX:PPP2) | path(MESH:Neoplasms) |
| Jens | a(CHEBI:"methylene blue") | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Jens | complex(GO:"proteasome complex") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(HBP:Neurodegeneration) |
| Jens | bp(GO:autophagy) | p(HGNC:CAPN2) | p(HGNC:CAST) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL18) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:Microglia) | bp(GO:"peroxisome proliferator activated receptor signaling pathway") |
| Jens | a(CHEBI:donepezil) | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) |
| Jens | p(FPLX:ERK) | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 174)) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ac, Lys, 174)) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:Nicotine) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"lithium(1+)") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:sirolimus) | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:ABCB1) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) | p(HGNC:IL1B) |
| Jens | complex(p(HGNC:APP), p(HGNC:HSD17B10)) | p(HGNC:HSD17B10) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"lysosomal microautophagy") | complex(GO:"TOR complex") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) |
| Jens | a(HBP:"alpha-synuclein aggregates") | a(HBP:"alpha-synuclein fibrils") | p(HGNC:IDE) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ac, Lys, 259)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"okadaic acid") | bp(GO:cognition) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:methamphetamine) | bp(GO:"response to oxidative stress") | bp(GO:autophagy) |
| Jens | a(MESH:Microglia) | bp(GO:"neuron death") | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:macroautophagy) | p(HGNC:IDE) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | a(CHEBI:Nilvadipine) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | bp(GO:phagocytosis) |
| Jens | a(CHEBI:"calcium(2+)") | p(HGNC:MAPT) | p(HGNCGENEFAMILY:Calpains) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MTOR) |
| Jens | p(HGNC:CTSD) | p(HGNC:MAPT) | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Cerebrospinal Fluid") | p(HGNC:AQP1) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | a(HBP:"alpha-synuclein aggregates") | bp(GO:autophagy) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau oligomers") | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(MESH:"Receptors, Nicotinic") |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | complex(a(GO:"membrane attack complex"), p(HGNC:C5)) |
| Jens | p(FPLX:HSP90) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PTGES3) |
| Jens | p(HGNC:HMOX1) | p(HGNC:NFE2L2) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"mitochondrion transport along microtubule") | composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) | p(HBP:"4R tau", var("p.Lys280del")) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| Jens | a(HBP:"alpha-synuclein aggregates") | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:IDE) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:ABCB1) |
| Jens | a(MESH:Microglia) | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 259)) | p(HGNC:MAPT, pmod(Ac, Lys, 259)) | p(HGNC:MAPT, pmod(Ac, Lys, 259)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | p(FPLX:AMPK) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | a(CHEBI:epoxomicin) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) | p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) |
| Jens | a(CHEBI:rolipram) | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") |
| Jens | a(CHEBI:lactacystin) | p(FPLX:Proteasome) | p(HGNC:MAPT) |
| Jens | a(GO:microtubule) | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:AGER) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:sirolimus) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:metformin) | bp(GO:macroautophagy) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | p(HGNC:MAPT) |
| Jens | bp(GO:"MAPK cascade") | p(HGNC:TNF) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:RNF19A) | p(HGNC:SOD1, var("?")) | path(MESH:"Amyotrophic Lateral Sclerosis") |
| Jens | a(MESH:"Amyloid beta-Peptides") | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:Calpeptin) | p(HGNC:CAPN1) | p(HGNC:HTT, var("?")) |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau oligomers") | bp(MESH:"Cell Survival") |
| Jens | a(CHEBI:galanthamine) | bp(GO:learning) | p(MGI:App, frag("25_35")) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | bp(GO:locomotion) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | p(HBP:"Tau C3") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:CHRM1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau oligomers") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Nilvadipine) | p(HGNC:BACE1) |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"action potential initiation") | p(HGNC:CHRNA7) |
| Jens | p(HGNC:APP, frag("672_713")) | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | path(HBP:neurotoxicity) |
| Jens | a(HBP:"amyloid-beta aggregates") | path(HBP:"mitochondrial dysfunction") | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:"UBB+1", pmod(UbPoly)) | p(HBP:"UBB+1", pmod(UbPoly)) | p(HBP:"UBB+1", pmod(UbPoly)) |
| Jens | a(HBP:HBP00093) | bp(GO:autophagy) | p(HGNC:HDAC6) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:TGM2) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:ABL1) | p(HGNC:MAPT, pmod(Ph, Tyr, 394)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:Microglia) | bp(GO:"positive regulation of advanced glycation end-product receptor activity") |
| Jens | a(CHEBI:nicotine) | a(MESH:Neurons) | p(MGI:Lynx1) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(HBP:glycation)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, pmod(Ub)) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(MGI:Chrm1) |
| Jens | bp(GO:locomotion) | composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:Nilvadipine) | complex(GO:"NF-kappaB complex") |
| Jens | a(CHEBI:nicotine) | bp(GO:memory) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BCL2) | p(HGNC:TNF) |
| Jens | a(CHEBI:chloroquine) | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Pick Disease of the Brain") |
| Jens | a(CHEBI:dopamine) | a(HBP:HBP00093) | path(MESH:"Parkinson Disease") |
| Jens | a(CHEBI:rolipram) | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Neuronal Outgrowth") | p(HGNC:APP) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, pmod(Ub)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:Calpeptin) | p(HGNC:CAPN2) | p(HGNC:HTT, var("?")) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, var("p.Ala152Thr")) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| Jens | a(CHEBI:nicotine) | a(MESH:"Dopaminergic Neurons") | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | bp(GO:endocytosis) | g(HBP:"APOE e4") |
| Jens | a(CHEBI:"reactive oxygen species") | bp(GO:"inflammatory response") | p(FPLX:NFkappaB) |
| Jens | complex(GO:"filamentous actin") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(HBP:"Tau aggregates") | a(MESH:Trehalose) | bp(MESH:Autophagy) |
| Jens | a(MESH:Lysosomes) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"mitochondrion transport along microtubule") | composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) | p(HBP:"Tau C3") |
| Jens | a(CHEBI:nicotine) | bp(GO:"ERK1 and ERK2 cascade") | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:sirolimus) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:DKK1) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(FPLX:ERK) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:TNF) |
| Jens | a(CHEBI:nicotine) | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"methylene blue") | a(HBP:"Tau aggregates") | bp(GO:macroautophagy) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:"Pick Disease of the Brain") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"apoptotic process") | p(HGNC:CHRNA7) |
| Jens | p(FPLX:Proteasome) | p(HGNC:MAPT) | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | complex(GO:"NF-kappaB complex") | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:macroautophagy) | p(HGNC:TFEB) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, var("p.Lys280del")) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"cell death") | p(HGNC:RNF19A) | p(HGNC:SOD1, var("?")) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:CDKN2A) | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:"N-terminal fragment of ATF6") | p(HBP:"N-terminal fragment of ATF6") | p(HBP:"N-terminal fragment of ATF6") |
| Jens | a(CHEBI:"methylene blue") | a(HBP:"Tau oligomers") | bp(GO:cognition) |
| Jens | a(CHEBI:"reactive oxygen species") | p(FPLX:ERK) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"canonical Wnt signaling pathway") | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| Jens | a(CHEBI:"reactive oxygen species") | bp(GO:"inflammatory response") | complex(GO:"NF-kappaB complex") |
| Jens | bp(GO:macroautophagy) | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:TREM2) |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ABCB1) | p(HGNC:APOE) |
| Jens | a(CHEBI:scopolamine) | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") | bp(GO:"behavioral fear response") |
| Jens | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") | r(HGNC:"BACE1-AS") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"interleukin 1 alpha") | path(MESH:Glioblastoma) |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:GSK3B) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | p(HGNC:MAPT) | p(HGNC:NPEPPS) | path(MESH:Tauopathies) |
| Jens | a(CHEBI:"reactive oxygen species") | p(FPLX:NFkappaB) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:Neurons) | a(PUBCHEM:64627) | p(MGI:Adora1) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | a(MESH:"SNARE Proteins") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:galanthamine) | bp(GO:"synaptic transmission, cholinergic") | p(HGNC:ACHE) |
| Jens | a(PUBCHEM:9832404) | bp(GO:"synaptic transmission, glutamatergic") | p(HGNC:ADNP) |
| Jens | a(CHEBI:"dimethyl fumarate") | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:BACE1) |
| Jens | p(FPLX:PPP2) | p(HGNC:CDK5) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:resveratrol) | bp(GO:"autophagosome assembly") |
| Jens | p(HGNC:PRKN) | p(HGNC:SNCA) | path(MESH:"Parkinson Disease") |
| Jens | bp(GO:endocytosis) | g(HBP:"APOE e4") | p(HGNC:APP) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"inflammatory response") | p(HGNC:DKK1) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, frag("?")) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:chloroquine) | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | bp(GO:"neuron death") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, var("p.Ala152Thr")) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph)) | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IDE) | p(HGNC:INS) |
| Jens | complex(GO:"inflammasome complex") | p(HGNC:CASP1) | p(HGNC:IL1B) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:fisetin) | bp(GO:macroautophagy) |
| Jens | a(HBP:"Tau aggregates") | bp(GO:macroautophagy) | p(MGI:Mapt) |
| Jens | bp(GO:autophagy) | p(HGNC:CAPN1) | p(HGNC:CAST) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(FPLX:NFkappaB) |
| Jens | a(HBP:"amyloid-beta oligomers") | p(FPLX:Proteasome) | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:DKK1) | p(HGNC:WNT3A) |
| Jens | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:rolipram) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | p(HGNC:IL6) | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:SNCA, var("?")) | p(HGNC:SNCA, var("?")) | p(HGNC:SNCA, var("?")) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | p(FPLX:AMPK) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:tanespimycin) | bp(GO:memory) |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) | path(MESH:"Alzheimer Disease") |
| Jens | a(PUBCHEM:164676) | p(FPLX:IKB) | p(FPLX:NFkappaB) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | a(CHEBI:"amyloid-beta") | bp(GO:macroautophagy) |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | path(HBP:Neurodegeneration) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | path(MESH:Anxiety) |
| Jens | a(PUBCHEM:675434) | p(FPLX:Proteasome) | p(HGNC:USP14) |
| Jens | a(CHEBI:"amyloid-beta") | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | a(MESH:Microglia) |
| Jens | a(PUBCHEM:16057918) | complex(GO:"NF-kappaB complex") | p(HGNC:BCL2L1) |
| Jens | bp(GO:autophagy) | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Jens | a(CHEBI:dopamine) | a(CHEBI:methamphetamine) | bp(GO:autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) |
| Jens | a(CHEBI:"amyloid-beta") | a(HP:"interstitial fluid") | bp(GO:aging) |
| Jens | bp(GO:autophagy) | p(HGNC:HSPB1) | p(HGNC:MAPT) |
| Jens | p(HGNC:CDK5) | p(HGNC:DRD1) | path(MESH:Schizophrenia) |
| Jens | a(MESH:antalarmin) | path(HBP:"isolation rearing") | r(RGD:Ntrk2) |
| Jens | p(HGNC:MAPT) | p(HGNC:NPEPPS) | p(HGNCGENEFAMILY:Aminopeptidases) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPK14) | p(HGNC:RELA) |
| Jens | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") | p(MGI:App, frag("25_35")) | path(MESH:"Spatial Memory") |
| Jens | a(CHEBI:galanthamine) | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 214)) | path(MESH:"Alzheimer Disease") |
| Jens | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"oncostatin M") | path(MESH:Glioblastoma) |
| Jens | bp(GO:"neuron death") | p(HGNC:MAPT) | path(MESH:Tauopathies) |
| Jens | a(HBP:"alpha-synuclein aggregates") | bp(GO:"neuron death") | path(MESH:"Parkinson Disease") |
| Jens | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Oxidative Stress") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"alpha-tocopherol") | a(CHEBI:"amyloid-beta") | bp(GO:memory) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 290)) | p(HGNC:MAPT, pmod(Ac, Lys, 290)) | p(HGNC:MAPT, pmod(Ac, Lys, 290)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:Kidney) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") |
| Jens | a(HBP:"Corticobasal Degeneration") | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") |
| Jens | a(CHEBI:ceramide) | complex(GO:"protein phosphatase type 2A complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"calcium(2+)") | a(MESH:"Receptors, Nicotinic") | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) |
| Jens | bp(GO:memory) | complex(GO:"NF-kappaB complex") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:endocytosis) | p(HGNC:RAB5A) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:galanthamine) | bp(GO:learning) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") |
| Jens | a(CHEBI:nicotine) | a(MESH:"Dopaminergic Neurons") | p(FPLX:CHRN) |
| Jens | bp(GO:autophagy) | p(HGNC:HDAC6) | p(HGNC:MAPT) |
| Jens | a(CHEBI:galanthamine) | p(FPLX:CHRN) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:rolipram) | p(FPLX:Proteasome) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:Proteasome) | path(HBP:neurotoxicity) |
| Jens | a(HBP:"sonicated tau fibrils") | a(HBP:"sonicated tau fibrils") | a(HBP:"sonicated tau fibrils") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:BAG1) | p(HGNC:MAPT) |
| Jens | bp(MESH:"Oxidative Stress") | p(HGNC:GSK3B) | p(HGNC:MAPT) |
| Jens | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | bp(GO:phagocytosis) | p(HGNC:TREM2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(FPLX:CHRM) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 181)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | complex(GO:axon) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(FPLX:CHRN) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00018) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:memantine) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:galanthamine) | p(MGI:App, frag("25_35")) | path(MESH:"Spatial Memory") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | path(HBP:neurotoxicity) |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | p(HGNC:RELA) | bp(GO:"apoptotic process") |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) | path(MESH:"Plaque, Amyloid") |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | p(HGNC:CHRNA3) |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | p(HGNC:CHRNA7) |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | p(HGNC:CHRNA4) |
| Increase Mismatch | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) | p(HGNC:MAPT) |
| Increase Mismatch | path(MESH:"Alzheimer Disease") | a(GO:lysosome) | p(HGNC:CTSD) |
| Increase Mismatch | path(MESH:"Alzheimer Disease") | a(GO:autophagosome) | p(HGNC:CTSD) |
| Increase Mismatch | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Increase Mismatch | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") | bp(GO:cognition) |
| Increase Mismatch | p(HGNC:MAPT) | a(GO:microtubule) | p(HGNC:MAPT) |
| Increase Mismatch | p(HGNC:MAPT) | p(HGNC:MAPT) | a(MESH:Neurons) |
| Increase Mismatch | p(HGNC:MAPT) | p(HGNC:GSK3B) | bp(GO:neurogenesis) |
| Increase Mismatch | p(HGNC:MAPT) | complex(a(GO:microtubule), p(HGNC:MAPT)) | a(HBP:"Tau aggregates") |
| Increase Mismatch | a(CHEBI:"reactive oxygen species") | p(FPLX:ERK) | bp(GO:neurogenesis) |
| Increase Mismatch | a(CHEBI:galanthamine) | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | bp(GO:autophagy) | a(HBP:"alpha-synuclein oligomers") | a(HBP:"alpha-synuclein aggregates") |
| Increase Mismatch | m(MIRBASE:"hsa-mir-125b-1") | p(HGNC:CDK5) | p(HGNC:CDK5R1) |
| Increase Mismatch | g(HBP:"APOE e4") | path(MESH:"Alzheimer Disease") | a(CHEBI:"amyloid-beta polypeptide 42") |
| Increase Mismatch | p(HGNC:APP, var("?")) | bp(GO:endocytosis) | path(MESH:"Alzheimer Disease") |
| Increase Mismatch | p(HGNC:LRP1) | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Increase Mismatch | p(HGNC:DISC1, var("?")) | path(MESH:Schizophrenia) | p(HGNC:MTOR) |
| Increase Mismatch | a(CHEBI:nicotine) | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | a(MESH:"Cholinesterase Inhibitors") | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | p(HBP:"APOE e4") | p(MGI:Cdk5) | p(MGI:Cdk5r1) |
| Increase Mismatch | p(HGNC:CHRM1) | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | a(CHEBI:"nicotinic acetylcholine receptor agonist") | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | a(PUBCHEM:9867750) | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | p(HGNC:PPARG) | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Increase Mismatch | p(HGNC:NR1H3) | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Increase Mismatch | p(HGNC:IDE) | a(CHEBI:"amyloid-beta") | bp(GO:macroautophagy) |
| Increase Mismatch | p(HGNC:SQSTM1) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) |
| Increase Mismatch | complex(GO:"protein phosphatase type 2A complex") | rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) | p(HGNC:MAPT, pmod(Ph)) |
| Increase Mismatch | p(FPLX:HSP90) | bp(GO:"proteasomal protein catabolic process") | bp(GO:autophagy) |
| Increase Mismatch | p(HGNC:HSPB1) | bp(GO:"proteasomal protein catabolic process") | bp(GO:autophagy) |
| Increase Mismatch | p(HGNC:TFEB) | a(CHEBI:"amyloid-beta") | bp(GO:macroautophagy) |
| Increase Mismatch | bp(GO:"protein K63-linked ubiquitination") | complex(GO:"proteasome complex") | bp(GO:autophagy) |
| Increase Mismatch | bp(GO:"proteasomal protein catabolic process") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Increase Mismatch | a(MESH:"Heat-Shock Proteins") | bp(GO:"proteasomal protein catabolic process") | bp(GO:autophagy) |
| Increase Mismatch | p(INTERPRO:"Heat shock protein 70 family") | bp(GO:"proteasomal protein catabolic process") | bp(GO:autophagy) |
| Increase Mismatch | a(CHEBI:rolipram) | p(HGNC:MAPT) | complex(GO:"proteasome complex") |
| Increase Mismatch | p(HGNCGENEFAMILY:Proteasome) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Increase Mismatch | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) | p(HGNC:MAPT, pmod(Ph)) | rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| Increase Mismatch | p(HGNC:ABCB1) | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Increase Mismatch | p(HGNC:TTBK1) | p(HGNC:CDK5) | p(HGNC:CDK5R1) |
| Increase Mismatch | p(HGNC:DAPK1) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| Increase Mismatch | p(HGNC:DAPK1) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Increase Mismatch | p(HGNC:DAPK1) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Decrease Mismatch | a(CHEBI:"amyloid-beta") | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | path(HBP:Neurodegeneration) |
| Decrease Mismatch | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(GO:"proteasome complex") |
| Decrease Mismatch | path(MESH:"Alzheimer Disease") | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Decrease Mismatch | path(MESH:"Alzheimer Disease") | a(MESH:Neurons) | p(FPLX:CHRN) |
| Decrease Mismatch | bp(MESH:Aging) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) |
| Decrease Mismatch | a(CHEBI:sirolimus) | p(HGNC:MTOR) | path(MESH:Schizophrenia) |
| Decrease Mismatch | p(HGNC:MAPT, pmod(Ph)) | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Decrease Mismatch | p(HGNC:MAPT) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | path(HBP:Neurodegeneration) |
| Decrease Mismatch | p(HGNC:MAPT) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) |
| Decrease Mismatch | p(HGNC:LRRK2, var("?")) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) |
| Decrease Mismatch | p(HGNC:HTT, var("?")) | complex(GO:"proteasome complex") | bp(GO:autophagy) |
| Decrease Mismatch | p(HGNC:HTT, var("?")) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) |
| Decrease Mismatch | a(PUBCHEM:155160) | a(HBP:"amyloid-beta aggregates") | a(CHEBI:"amyloid-beta polypeptide 42") |
| Decrease Mismatch | a(CHEBI:galanthamine) | path(MESH:"Alzheimer Disease") | p(HGNC:ACHE) |
| Decrease Mismatch | a(PUBCHEM:164676) | bp(GO:"apoptotic process") | p(HGNC:RELA) |
| Decrease Mismatch | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:MAPT) | a(GO:synapse) |
| Decrease Mismatch | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:MAPT) | a(GO:microtubule) |
| Decrease Mismatch | a(CHEBI:donepezil) | path(MESH:"Alzheimer Disease") | p(HGNC:ACHE) |
| Decrease Mismatch | a(CHEBI:rivastigmine) | path(MESH:"Alzheimer Disease") | p(HGNC:ACHE) |
| Decrease Mismatch | a(CHEBI:"lithium(1+)") | p(HGNC:MTOR) | path(MESH:Schizophrenia) |
| Decrease Mismatch | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Decrease Mismatch | a(CHEBI:"okadaic acid") | p(HGNC:PPME1) | complex(GO:"protein phosphatase type 2A complex") |
| Decrease Mismatch | a(CHEBI:"microcystin-LR") | complex(GO:"protein phosphatase type 2A complex") | p(HGNC:PPME1) |
| Decrease Mismatch | p(HGNC:OTUB1) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Decrease Mismatch | p(HGNC:STIP1) | p(HGNC:MAPT) | p(FPLX:HSP90) |
| Decrease Mismatch | a(CHEBI:lactacystin) | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Decrease Mismatch | p(HGNC:CDC37) | p(HGNC:MAPT) | p(FPLX:HSP90) |
| Decrease Mismatch | p(HGNC:USP14) | p(HGNC:MAPT) | complex(GO:"proteasome complex") |
| Decrease Mismatch | a(CHEBI:tanespimycin) | p(HGNC:MAPT) | p(FPLX:HSP90) |
| Decrease Mismatch | p(FPLX:mTORC1) | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | bp(GO:autophagy) |
| Decrease Mismatch | a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") | a(HBP:"amyloid-beta aggregates") | a(CHEBI:"amyloid-beta polypeptide 42") |
| Decrease Mismatch | a(CHEBI:celastrol) | p(HGNC:MAPT) | p(FPLX:HSP90) |
| Decrease Mismatch | a(PUBCHEM:135566354) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Decrease Mismatch | a(CHEBI:"withaferin A") | p(HGNC:MAPT) | p(FPLX:HSP90) |
Like unstable pairs, unstable triplets require additional context to understand their mechanisms of regulation.
A
increases B, B increases C, and C increases A.
A
decreases B, B decreases C, and C decreases A.
| Type | Node A | Node B | Node C |
|---|---|---|---|
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Chaotic | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | bp(GO:phagocytosis) |
| Chaotic | a(HBP:"Tau aggregates") | p(HGNC:MAPT, frag("?")) | path(MESH:Tauopathies) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"calcium(2+)") | p(HGNC:MAPT) | p(HGNCGENEFAMILY:Calpains) |
| Chaotic | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(FPLX:CHRN) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | complex(GO:"calcium- and calmodulin-dependent protein kinase complex") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL18) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:autophagy) | p(HGNC:MAPK8) |
| Chaotic | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:JAK2) |
| Chaotic | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(MESH:"Oxidative Stress") | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) | path(MESH:"Plaque, Amyloid") |
| Chaotic | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Chaotic | a(HBP:"Tau fibrils") | p(MGI:Tfeb) | p(MGI:Tfeb) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) | p(HGNC:IL1B) |
| Chaotic | p(HGNC:AK1) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(MESH:"Receptors, Nicotinic") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"Fas signaling pathway") | complex(GO:"NF-kappaB complex") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:IL1B) |
| Chaotic | p(MGI:"interleukin 1 alpha") | p(MGI:"oncostatin M") | p(MGI:"signal transducer and activator of transcription 3") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:FOLH1) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | complex(a(GO:"membrane attack complex"), p(HGNC:C5)) |
| Chaotic | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | a(MESH:Proteins) | a(MESH:Proteins) | p(HGNC:PSMD14) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL18) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"glutamate(1-)") | a(GO:"excitatory synapse") | complex(GO:"NF-kappaB complex") |
| Chaotic | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) |
| Chaotic | a(CHEBI:"reactive oxygen species") | bp(GO:"inflammatory response") | p(FPLX:NFkappaB) |
| Chaotic | a(CHEBI:"reactive oxygen species") | complex(GO:"NF-kappaB complex") | p(FPLX:PKC) |
| Chaotic | a(MESH:Microglia) | complex(GO:"NF-kappaB complex") | p(HGNC:IL6) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:IL1B) | p(HGNC:NFKB1) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:NFkappaB) | p(HGNC:BACE1) |
| Chaotic | a(CHEBI:nicotine) | p(FPLX:PI3K) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | bp(GO:autophagy) | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:DKK1) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MAPK14) | p(HGNC:RELA) |
| Chaotic | a(GO:"neurofibrillary tangle") | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:TNF) |
| Chaotic | p(FPLX:ERK) | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"response to oxidative stress") | bp(GO:autophagy) |
| Chaotic | a(MESH:Microglia) | complex(GO:"NF-kappaB complex") | p(HGNC:TNF) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:JNK) | p(HGNC:DKK1) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"interleukin 1 alpha") | p(MGI:"oncostatin M") |
| Chaotic | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:acetylcholine) | a(CHEBI:galanthamine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"reactive oxygen species") | bp(GO:"inflammatory response") | complex(GO:"NF-kappaB complex") |
| Chaotic | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"oncostatin M") | path(MESH:Glioblastoma) |
| Chaotic | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"ERK1 and ERK2 cascade") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL1B) |
| Chaotic | complex(GO:"filamentous actin") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | p(HGNC:MAPT) |
| Chaotic | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:SQSTM1) |
| Chaotic | p(HGNC:RNF19A) | p(HGNC:SOD1, var("?")) | path(MESH:"Amyotrophic Lateral Sclerosis") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(MESH:"Oxidative Stress") | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | p(HGNC:AK1) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Chaotic | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") | p(MGI:"interleukin 1 alpha") | path(MESH:Glioblastoma) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"innate immune response") | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL18) |
| Chaotic | bp(GO:"MAPK cascade") | p(FPLX:NFkappaB) | p(HGNC:TNF) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Chaotic | complex(p(HGNC:FYN), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(MESH:Neurons) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:nicotine) | a(MESH:"SNARE Proteins") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Chaotic | p(HGNC:CDK2) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:NFkappaB) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(MESH:"Receptors, Nicotinic") | p(HGNC:CHRNA7) |
| Chaotic | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Brain Injuries, Traumatic") |
| Chaotic | bp(GO:"response to misfolded protein") | p(HGNC:ERN1) | p(HGNC:XBP1) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:BACE1) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"action potential initiation") | p(HGNC:CHRNA7) |
| Chaotic | p(HGNC:APP, frag("672_713")) | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | r(HGNC:BACE1) |
| Chaotic | a(HBP:"amyloid-beta aggregates") | path(HBP:"mitochondrial dysfunction") | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | bp(GO:phagocytosis) |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"JNK cascade") | complex(GO:"NF-kappaB complex") |
| Chaotic | a(CHEBI:"amyloid-beta") | a(CHEBI:simvastatin) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Chaotic | bp(GO:autophagy) | p(HGNC:SQSTM1) | p(MESH:Proteins, pmod(HBP:misfolding)) |
| Chaotic | p(FPLX:NFkappaB) | p(FPLX:NFkappaB) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(MESH:"Oxidative Stress") | complex(GO:"NF-kappaB complex") |
| Chaotic | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL18) |
| Chaotic | p(MGI:"interleukin 1 alpha") | p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") | p(MGI:"oncostatin M") |
| Chaotic | p(HGNC:FYN) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"inflammatory response") | p(HGNC:DKK1) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | bp(GO:phagocytosis) | p(HGNC:TREM2) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Chaotic | bp(GO:"apoptotic process") | p(HGNC:SNCA) | p(HGNCGENEFAMILY:Calpains) |
| Chaotic | p(HGNC:GSK3B) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:CHRNA7) |
| Chaotic | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(MGI:Mapt) |
| Chaotic | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:dopamine) | a(HBP:HBP00093) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:RELA) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:TNF) |
| Chaotic | a(CHEBI:nicotine) | a(MESH:Neurons) | p(MGI:Lynx1) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(FPLX:CHRN) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | p(HGNC:WNT3A) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:TNF) |
| Dampened | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") | p(HGNC:PIN1) |
| Dampened | a(CHEBI:methamphetamine) | bp(GO:autophagy) | p(HGNC:DRD1) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) |
| Dampened | a(CHEBI:"amyloid-beta") | complex(GO:"NF-kappaB complex") | p(HGNC:BCL2L1) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:BCL2L1) |
| Dampened | a(HBP:"Tau aggregates") | complex(a(GO:microtubule), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.
| Source | Relation | Target |
|---|---|---|
| path(HBP:"high-fat prenatal maternal diet") | decreases | a(CHEBI:"amyloid-beta") |
| path(HBP:"isolation rearing") | increases | p(RGD:Drd2) |
| path(HBP:"isolation rearing") | increases | p(RGD:Drd3) |
| path(HBP:"isolation rearing") | decreases | r(RGD:Bdnf) |
| path(HBP:"isolation rearing") | increases | r(RGD:Bdnf) |
| path(HBP:"isolation rearing") | decreases | r(RGD:Ntrk2) |
| path(HBP:"isolation rearing") | increases | r(RGD:Ntrk2) |
| path(HBP:"mitochondrial dysfunction") | increases | a(CHEBI:"amyloid-beta") |
| path(HBP:"mitochondrial dysfunction") | increases | a(CHEBI:"reactive oxygen species") |
| path(HBP:"mitochondrial dysfunction") | decreases | a(CHEBI:ATP) |
| path(HBP:"mitochondrial dysfunction") | increases | p(HGNC:MAPT) |
| path(HBP:Excitotoxicity) | increases | a(CHEBI:"calcium(2+)") |
| path(HP:"Ischemic stroke") | increases | complex(GO:"NF-kappaB complex") |
| path(HP:"Neurofibrillary tangles") | decreases | p(FPLX:Proteasome) |
| path(HP:Seizures) | increases | complex(GO:"NF-kappaB complex") |
| path(MESH:"Alcohol Drinking") | decreases | p(HGNC:ADNP) |
| path(MESH:"Alcohol Drinking") | increases | p(HGNC:ADNP) |
| path(MESH:"Alcohol Drinking") | decreases | p(HGNC:TFAP2B) |
| path(MESH:"Alcohol Drinking") | increases | r(HGNC:ADNP) |
| path(MESH:"Alzheimer Disease") | decreases | a(CHEBI:"amyloid-beta") |
| path(MESH:"Alzheimer Disease") | increases | a(CHEBI:"amyloid-beta") |
| path(MESH:"Alzheimer Disease") | increases | a(CHEBI:"iron(0)") |
| path(MESH:"Alzheimer Disease") | increases | a(CHEBI:Thrombin) |
| path(MESH:"Alzheimer Disease") | decreases | a(CHEBI:acetylcholine) |
| path(MESH:"Alzheimer Disease") | decreases | a(CHEBI:water) |
| path(MESH:"Alzheimer Disease") | increases | a(GO:autolysosome) |
| path(MESH:"Alzheimer Disease") | increases | a(GO:autophagosome) |
| path(MESH:"Alzheimer Disease") | increases | a(GO:lysosome) |
| path(MESH:"Alzheimer Disease") | increases | a(HBP:"Tau oligomers") |
| path(MESH:"Alzheimer Disease") | decreases | a(HBP:"alpha-4 beta-2 nAChR") |
| path(MESH:"Alzheimer Disease") | increases | a(HBP:"amyloid-beta aggregates") |
| path(MESH:"Alzheimer Disease") | increases | a(HBP:HBP00018) |
| path(MESH:"Alzheimer Disease") | increases | a(MESH:"Basal Nucleus of Meynert") |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:"Cholinergic Neurons") |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:"Cholinesterase Inhibitors") |
| path(MESH:"Alzheimer Disease") | increases | a(MESH:"Neurofibrillary Tangles") |
| path(MESH:"Alzheimer Disease") | increases | a(MESH:Autophagosomes) |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:Neurons) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:nicotine), p(FPLX:CHRM)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| path(MESH:"Alzheimer Disease") | increases | complex(a(GO:autophagosome), a(HBP:"dystrophic neurite")) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(GO:microtubule), p(HGNC:MAPT)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| path(MESH:"Alzheimer Disease") | increases | complex(p(HGNC:ESR1), p(HGNC:MAPT)) |
| path(MESH:"Alzheimer Disease") | increases | complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| path(MESH:"Alzheimer Disease") | increases | complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) |
| path(MESH:"Alzheimer Disease") | decreases | g(HGNC:"MIR9-1") |
| path(MESH:"Alzheimer Disease") | increases | p(ECCODE:"3.1.1.89") |
| path(MESH:"Alzheimer Disease") | decreases | p(FPLX:CHRM) |
| path(MESH:"Alzheimer Disease") | decreases | p(FPLX:CHRN) |
| path(MESH:"Alzheimer Disease") | increases | p(FPLX:HSPB) |
| path(MESH:"Alzheimer Disease") | decreases | p(FPLX:PPP2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HBP:"alpha-4 beta-2 nAChR") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:ABCB1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:ABL1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:ACHE) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:ACLY) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:AGRN) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:AK1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:ANP32A) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:ATAD2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:ATP1A1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BACE1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BAX) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BCHE) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:BECN1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BGN) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BRCA1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CADPS2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CANX) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CAPN1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CAPN2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CCNB1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CDK1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CDK2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CDKN2A) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHAT) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNA3) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNA4) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNA7) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CHRNA7) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNB4) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CRYAB) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CTSD) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CXCR4) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:DHCR24) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:EIF4EBP1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:FGF2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:FKBP4) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:FKBP5) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:FOLH1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:FYN) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:GABRB3) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:GCNT2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:GLRX) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:HMOX1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:HOMER1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:HRH1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HSP90AB1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HSPA14) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HSPA8) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:HSPB1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HTRA1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:IDE) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:IGF2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:IGFBP2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:IL6R) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:ITPKB) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:LCMT1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:LDLR) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAOA) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPK1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, frag("?")) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MAPT, pmod(Ac, Lys, 259)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MAPT, pmod(Ac, Lys, 290)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MAPT, pmod(Ac, Lys, 321)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MAPT, pmod(Ac, Lys, 353)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MAPT, pmod(HBP:misfolded)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MAPT, pmod(OGlyco)) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, pmod(Ph)) |
| path(MESH:"Alzheimer Disease") | regulates | p(HGNC:MAPT, pmod(Ph)) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MME) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MMP1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:NEFH) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:NFE2L2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:NPDC1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:NPTX1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:NQO1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:NR3C1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:NRGN) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:OGT) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PHF1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PPARA) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PPID) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PPP5C) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PREP) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PRKCB) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PRKCD) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PRKCE) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PRKDC) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PROS1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PTGS1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PTGS2) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:RANBP9) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:SCD) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:SELENBP1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:SET) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:SIRT1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:SLC6A6) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:SOD1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:SYVN1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:TAGLN) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:TCP1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:TGFB1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:TGM2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:TSHZ1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:TUBB) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:TUBB3) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:TXN) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:UNG) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:VKORC1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| path(MESH:"Alzheimer Disease") | increases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| path(MESH:"Alzheimer Disease") | increases | p(MGI:Il6) |
| path(MESH:"Alzheimer Disease") | increases | p(MGI:Stat3, pmod(Ph)) |
| path(MESH:"Alzheimer Disease") | increases | p(MGI:Tnf) |
| path(MESH:"Amyotrophic Lateral Sclerosis") | decreases | a(MESH:"Brain Stem") |
| path(MESH:"Amyotrophic Lateral Sclerosis") | decreases | a(MESH:"Pyramidal Tracts") |
| path(MESH:"Amyotrophic Lateral Sclerosis") | increases | p(HGNC:RNF19A) |
| path(MESH:"Brain Injuries, Traumatic") | decreases | a(HP:"glymphatic system") |
| path(MESH:"Brain Injuries, Traumatic") | increases | complex(GO:"NF-kappaB complex") |
| path(MESH:"Brain Injuries, Traumatic") | decreases | p(HGNC:AQP4) |
| path(MESH:"Brain Injuries, Traumatic") | increases | p(HGNC:MAPT) |
| path(MESH:"Breast Neoplasms") | increases | p(HGNC:CHRNA10) |
| path(MESH:"Breast Neoplasms") | increases | p(HGNC:CHRNA5) |
| path(MESH:"Breast Neoplasms") | increases | p(HGNC:CHRNA9) |
| path(MESH:"Calcification, Physiologic") | decreases | a(MESH:"Cerebrospinal Fluid") |
| path(MESH:"Cerebral Infarction") | increases | complex(GO:"NF-kappaB complex") |
| path(MESH:"Colorectal Neoplasms") | decreases | p(HGNC:ABCD3) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:ACLY) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:ANTXR1) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:C20orf27) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:CCNA2) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:CHAF1A) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:DHFR) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:EFCAB11) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:FEN1) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:GINS2) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:GLRX2) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:MCM10) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:MCM4) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:MICB) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:NQO1) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:RNASEH2A) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:SLIT2) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:SPC25) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TFRC) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TK1) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TMEM97) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TRIP13) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TUBB) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TUBB3) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:TYMS) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:UBA1) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:UNG) |
| path(MESH:"Colorectal Neoplasms") | increases | p(HGNC:VRK1) |
| path(MESH:"Down Syndrome") | increases | a(HBP:HBP00018) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:ABL1) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:CTSD) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:LAMP1) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:TFEB) |
| path(MESH:"Frontotemporal Dementia") | increases | r(HGNC:LAMP1) |
| path(MESH:"Frontotemporal Dementia") | increases | r(HGNC:TFEB) |
| path(MESH:"Huntington Disease") | increases | g(HGNC:MIR1247) |
| path(MESH:"Huntington Disease") | increases | g(HGNC:MIR196A1) |
| path(MESH:"Huntington Disease") | increases | g(HGNC:MIR196B) |
| path(MESH:"Huntington Disease") | increases | g(HGNC:MIR615) |
| path(MESH:"Huntington Disease") | decreases | g(MGI:"Mir128-1") |
| path(MESH:"Huntington Disease") | decreases | g(MGI:"Mir138-1") |
| path(MESH:"Huntington Disease") | decreases | g(MGI:"Mir218-1") |
| path(MESH:"Huntington Disease") | decreases | g(MGI:Mir132) |
| path(MESH:"Huntington Disease") | decreases | g(MGI:Mir22) |
| path(MESH:"Huntington Disease") | decreases | g(MGI:Mir222) |
| path(MESH:"Huntington Disease") | decreases | g(MGI:Mir29c) |
| path(MESH:"Huntington Disease") | increases | g(MIRBASE:"hsa-mir-10b") |
| path(MESH:"Huntington Disease") | decreases | g(NCBIGENE:406915) |
| path(MESH:"Huntington Disease") | decreases | g(NCBIGENE:723931) |
| path(MESH:"Huntington Disease") | decreases | g(NCBIGENE:732489) |
| path(MESH:"Huntington Disease") | increases | p(HGNC:CTSD) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:HSP90AB1) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:HSPA14) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:HSPA8) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:TCP1) |
| path(MESH:"Lung Neoplasms") | increases | p(HGNC:CHRNA10) |
| path(MESH:"Lung Neoplasms") | increases | p(HGNC:CHRNA5) |
| path(MESH:"Lung Neoplasms") | increases | p(HGNC:CHRNA9) |
| path(MESH:"Parkinson Disease") | increases | a(CHEBI:"iron(0)") |
| path(MESH:"Parkinson Disease") | decreases | a(MESH:"Dopaminergic Neurons") |
| path(MESH:"Parkinson Disease") | decreases | g(HGNC:MIR205) |
| path(MESH:"Parkinson Disease") | decreases | g(HGNC:MIR34B) |
| path(MESH:"Parkinson Disease") | decreases | g(HGNC:MIR34C) |
| path(MESH:"Parkinson Disease") | increases | g(HGNC:MIR494) |
| path(MESH:"Parkinson Disease") | decreases | p(HGNC:PARK7) |
| path(MESH:"Plaque, Amyloid") | increases | a(MESH:Astrocytes) |
| path(MESH:"Prion Diseases") | increases | a(HBP:"amyloid-beta aggregates") |
| path(MESH:"Protein Aggregation, Pathological") | decreases | p(HGNC:HSPA8) |
| path(MESH:"Proteostasis Deficiencies") | decreases | p(MGI:Mapt, var("p.Pro301Leu")) |
| path(MESH:"RING Finger Domains") | increases | complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| path(MESH:"Spinal Cord Injuries") | increases | a(CHEBI:ATP) |
| path(MESH:"Spinal Cord Injuries") | increases | complex(GO:"NLRP1 inflammasome complex") |
| path(MESH:"Spinal Cord Injuries") | increases | p(HGNC:IL18) |
| path(MESH:"Spinal Cord Injuries") | increases | p(HGNC:IL1B) |
| path(MESH:"Stress Disorders, Traumatic") | increases | p(MESH:"corticotropin releasing factor-binding protein") |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | a(GO:"neurofibrillary tangle") |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | a(HBP:HBP00045) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | p(ECCODE:"3.1.1.89") |
| path(MESH:"Supranuclear Palsy, Progressive") | decreases | p(HGNC:LCMT1) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | p(HGNC:TGM1) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | r(HBP:"TGM2 Isoform 3 (349 aa)") |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | r(HGNC:TGM1) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | r(HGNC:TGM2) |
| path(MESH:"Thyroiditis, Autoimmune") | increases | p(HGNC:IL1R2) |
| path(MESH:"Tobacco Use Disorder") | increases | a(HBP:"alpha-4 beta-2 nAChR") |
| path(MESH:"Trauma, Nervous System") | increases | complex(GO:"inflammasome complex") |
| path(MESH:"Trauma, Nervous System") | increases | r(HGNC:CHRNA3) |
| path(MESH:"Vitamin B Deficiency") | decreases | p(FPLX:PPP2, pmod(Me)) |
| path(MESH:"Vitamin B Deficiency") | increases | p(HGNC:APP, pmod(Ph)) |
| path(MESH:"Vitamin B Deficiency") | increases | p(HGNC:MAPT, pmod(Ph)) |
| path(MESH:Aging) | increases | a(GO:"cytoplasmic vesicle") |
| path(MESH:Aging) | decreases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| path(MESH:Aging) | increases | p(MESH:"Membrane Transport Proteins") |
| path(MESH:Aging) | decreases | p(MESH:"Mitogen-Activated Protein Kinases") |
| path(MESH:Aging) | decreases | p(MGI:Chrna4) |
| path(MESH:Aging) | increases | p(MGI:Hif1an) |
| path(MESH:Aging) | increases | p(MGI:Nfkb1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:CTNNB1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:DHFR) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:EDN1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:EGR1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:ITGB3) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:MKI67) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:MMP11) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:MMP14) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:MMP2) |
| path(MESH:Atherosclerosis) | decreases | p(HGNC:NR3C1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:PDE7A) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:PDE7B) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:PLAU) |
| path(MESH:Atherosclerosis) | decreases | p(HGNC:PPARA) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:PTGS1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:PTGS2) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:SCARB1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:SOAT1) |
| path(MESH:Atherosclerosis) | increases | p(HGNC:TUBB3) |
| path(MESH:D000544) | decreases | a(HBP:"3R tau") |
| path(MESH:D000544) | decreases | a(MESH:D059329) |
| path(MESH:D000544) | decreases | complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| path(MESH:D000544) | increases | g(HGNC:NGFR) |
| path(MESH:D000544) | decreases | g(HGNC:NTRK1) |
| path(MESH:D000544) | decreases | g(HGNC:NTRK2) |
| path(MESH:D000544) | decreases | g(HGNC:NTRK3) |
| path(MESH:D000544) | decreases | p(HGNC:ACHE) |
| path(MESH:D000544) | increases | p(HGNC:BCHE) |
| path(MESH:D000544) | decreases | p(HGNC:CHAT) |
| path(MESH:D000544) | increases | p(HGNC:MMP9) |
| path(MESH:D000544) | increases | p(HGNC:NGF) |
| path(MESH:D000544) | decreases | p(HGNC:NTRK1) |
| path(MESH:D000544) | increases | r(HGNC:CHRNA7) |
| path(MESH:D000544) | increases | r(HGNC:CTSD) |
| path(MESH:D000544) | decreases | r(HGNC:PPP1CA) |
| path(MESH:D000544) | decreases | r(HGNC:PPP1CC) |
| path(MESH:D000544) | decreases | r(HGNC:SYP) |
| path(MESH:D003704) | decreases | p(HGNC:ACHE) |
| path(MESH:D060825) | decreases | a(HBP:"3R tau") |
| path(MESH:D060825) | decreases | a(MESH:D013569) |
| path(MESH:D060825) | increases | p(HGNC:CHAT) |
| path(MESH:D060825) | increases | p(HGNC:MMP9) |
| path(MESH:Depression) | increases | a(CHEBI:choline) |
| path(MESH:Encephalomyelitis) | decreases | a(GO:"myelin sheath") |
| path(MESH:Encephalomyelitis) | increases | a(MESH:Leukocytes) |
| path(MESH:Encephalomyelitis) | increases | a(MESH:Microglia) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Ifng) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Il1b) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Rela, pmod(Ph)) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Stat3, pmod(Ph)) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Tnf) |
| path(MESH:Fasting) | decreases | p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| path(MESH:Fasting) | increases | p(MGI:Mapt, pmod(Ph)) |
| path(MESH:Fear) | increases | a(CHEBI:dopamine) |
| path(MESH:Fibrosis) | decreases | a(MESH:"Cerebrospinal Fluid") |
| path(MESH:Glioblastoma) | increases | p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") |
| path(MESH:Glioblastoma) | increases | p(MGI:"chitinase-like 1") |
| path(MESH:Hyperglycemia) | increases | p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) |
| path(MESH:Hypoxia) | increases | complex(GO:"NF-kappaB complex") |
| path(MESH:Inflammation) | decreases | a(CHEBI:"amyloid-beta") |
| path(MESH:Inflammation) | increases | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| path(MESH:Inflammation) | increases | p(HGNCGENEFAMILY:Caspases) |
| path(MESH:Neoplasms) | increases | p(HGNCGENEFAMILY:"Small heat shock proteins") |
| path(MESH:Schizophrenia) | increases | a(CHEBI:dopamine) |
| path(MESH:Schizophrenia) | decreases | a(GO:dendrite) |
| path(MESH:Schizophrenia) | increases | a(MESH:Hippocampus) |
| path(MESH:Schizophrenia) | decreases | p(FPLX:AKT) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:ADNP) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:ADNP2) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:ATG3) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:BECN1) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:CHRNA7) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:MAP2) |
| path(MESH:Schizophrenia) | increases | p(HGNC:MAPT) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:SLC6A3) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:ULK2) |
| path(MESH:Sleep) | decreases | a(CHEBI:"amyloid-beta") |
| path(MESH:Sleep) | increases | a(MESH:"Blood-Brain Barrier") |
| path(MESH:Sleep) | increases | p(HGNC:LRP1) |
| path(MESH:Smoking) | increases | a(MESH:"Blood Glucose") |
| path(MESH:Starvation) | increases | complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) |
| path(MESH:Starvation) | increases | p(HGNC:MAPT) |
| path(MESH:Starvation) | increases | p(HGNC:TFEB) |
| path(MESH:Starvation) | increases | p(HGNC:WDFY3) |
| path(MESH:Starvation) | increases | rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"))) |
| path(MESH:Stroke) | increases | complex(GO:"inflammasome complex") |
| path(MESH:Tauopathies) | increases | p(HGNC:MAPT, frag("?")) |
| path(MESH:Tauopathies) | increases | p(MGI:Ctsd) |
| path(MESH:Tauopathies) | increases | p(MGI:Lamp1) |
| path(MESH:Tauopathies) | increases | p(MGI:Tfeb) |